Detailed information for compound 830275

Basic information

Technical information
  • TDR Targets ID: 830275
  • Name: N-(furan-2-ylmethyl)-4-methoxy-N-[(3-methylth iophen-2-yl)methyl]benzamide
  • MW: 341.424 | Formula: C19H19NO3S
  • H donors: 0 H acceptors: 1 LogP: 3.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)N(Cc1sccc1C)Cc1ccco1
  • InChi: 1S/C19H19NO3S/c1-14-9-11-24-18(14)13-20(12-17-4-3-10-23-17)19(21)15-5-7-16(22-2)8-6-15/h3-11H,12-13H2,1-2H3
  • InChiKey: ZKUIYIXBGWUIRJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-furylmethyl)-4-methoxy-N-[(3-methyl-2-thienyl)methyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tubulin subunit beta 0.0205 0.6339 1
Onchocerca volvulus 0.0074 0.1573 0.5797
Entamoeba histolytica tubulin family protein 0.0205 0.6339 0.6329
Schistosoma mansoni opsin-like receptor 0.0074 0.1573 0.2064
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0033 0.0062 0.0081
Brugia malayi hypothetical protein 0.0074 0.1573 0.2064
Echinococcus multilocularis Tubulin beta 2C chain 0.0205 0.6339 1
Onchocerca volvulus 0.0106 0.2714 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1573 0.2064
Echinococcus granulosus peptide allatostatin:somatostatin 0.0074 0.1573 0.2482
Echinococcus multilocularis Niemann Pick C1 protein 0.0057 0.094 0.1482
Echinococcus multilocularis inhibitor of apoptosis protein 0.0106 0.2714 0.4282
Echinococcus granulosus g-protein coupled receptor 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Brugia malayi hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) MH2 domain-containing protein 0.0105 0.2696 0.3536
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0074 0.1573 0.2482
Echinococcus multilocularis beta tubulin 0.0205 0.6339 1
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0106 0.2714 0.3561
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0074 0.1573 0.2482
Echinococcus granulosus Tubulin beta 2C chain 0.0205 0.6339 1
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.1573 0.2064
Giardia lamblia Beta tubulin 0.0205 0.6339 0.5826
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0057 0.094 0.1232
Brugia malayi CHE-14 protein 0.0057 0.094 0.1232
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Echinococcus multilocularis neuropeptide s receptor 0.0074 0.1573 0.2482
Onchocerca volvulus 0.0074 0.1573 0.5797
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0027 0.0042
Echinococcus granulosus Tubulin beta 2C chain 0.0205 0.6339 1
Brugia malayi putative neuropeptide receptor 0.0074 0.1573 0.2064
Echinococcus multilocularis geminin 0.0149 0.4298 0.678
Schistosoma mansoni hypothetical protein 0.0032 0.0027 0.0035
Echinococcus granulosus inhibitor of apoptosis protein 0.0106 0.2714 0.4282
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0074 0.1573 0.2482
Echinococcus granulosus sex peptide receptor 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0074 0.1573 0.2064
Brugia malayi G-protein coupled receptor 0.0074 0.1573 0.2064
Schistosoma mansoni opsin-like receptor 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0045 0.0528 0.0693
Echinococcus granulosus neuropeptide s receptor 0.0074 0.1573 0.2482
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.1573 0.2482
Schistosoma mansoni amine GPCR 0.0074 0.1573 0.2064
Echinococcus granulosus g protein coupled receptor 0.0074 0.1573 0.2482
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0205 0.6339 1
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.1573 0.2482
Onchocerca volvulus 0.0074 0.1573 0.5797
Echinococcus multilocularis neuropeptide receptor 0.0074 0.1573 0.2482
Onchocerca volvulus 0.0074 0.1573 0.5797
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.1573 0.2482
Echinococcus granulosus disco interacting protein 2 0.0036 0.0168 0.0266
Brugia malayi Dopamine receptor protein 2 0.0074 0.1573 0.2064
Schistosoma mansoni alpha-1 adrenergic receptor 0.0074 0.1573 0.2064
Brugia malayi neuropeptide F receptor 0.0074 0.1573 0.2064
Echinococcus multilocularis g-protein coupled receptor 0.0074 0.1573 0.2482
Brugia malayi hypothetical protein 0.0074 0.1573 0.2064
Trichomonas vaginalis tubulin alpha chain, putative 0.0205 0.6339 0.8078
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) tubulin beta chain 0.0205 0.6339 0.8315
Echinococcus granulosus g protein coupled receptor 0.0074 0.1573 0.2482
Echinococcus granulosus G protein coupled receptor 139 0.0074 0.1573 0.2482
Loa Loa (eye worm) glutaminase 0.0241 0.7623 1
Echinococcus multilocularis g protein coupled receptor 0.0074 0.1573 0.2482
Echinococcus granulosus hypothetical protein 0.0074 0.1573 0.2482
Onchocerca volvulus 0.0074 0.1573 0.5797
Onchocerca volvulus Neuropeptide F receptor homolog 0.0074 0.1573 0.5797
Brugia malayi Melatonin receptor type 1A 0.0074 0.1573 0.2064
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0047 0.0568 0.0745
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0074 0.1573 0.2482
Toxoplasma gondii beta-1 tubulin, putative 0.0205 0.6339 1
Giardia lamblia DNA repair protein RAD52 0.0306 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0044 0.0471 0.0618
Schistosoma mansoni neuropeptide receptor 0.0074 0.1573 0.2064
Schistosoma mansoni hypothetical protein 0.0149 0.4298 0.5638
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni patched 1 0.0057 0.094 0.1232
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0138 0.3889 0.5784
Echinococcus granulosus beta tubulin 0.0205 0.6339 1
Brugia malayi neuropeptide F receptor 0.0074 0.1573 0.2064
Onchocerca volvulus 0.0036 0.0168 0.062
Brugia malayi hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0074 0.1573 0.2064
Echinococcus granulosus somatostatin receptor 0.0074 0.1573 0.2482
Schistosoma mansoni hypothetical protein 0.0074 0.1573 0.2064
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0074 0.1573 0.2482
Echinococcus multilocularis Tubulin beta 2C chain 0.0205 0.6339 1
Leishmania major beta tubulin 0.0205 0.6339 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.1573 0.2482
Plasmodium vivax tubulin beta chain, putative 0.0205 0.6339 1
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.1573 0.2482
Loa Loa (eye worm) glutaminase 2 0.0241 0.7623 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0074 0.1573 0.2064
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.1573 0.2482
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0074 0.1573 0.2064
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0036 0.0168 0.0221
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Echinococcus granulosus alpha 1A adrenergic receptor 0.0074 0.1573 0.2482
Brugia malayi hypothetical protein 0.0046 0.0559 0.0734
Onchocerca volvulus Protein cycle homolog 0.0033 0.0062 0.0229
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni glutaminase 0.0241 0.7623 1
Brugia malayi G protein-coupled receptor 0.0074 0.1573 0.2064
Schistosoma mansoni hypothetical protein 0.0074 0.1573 0.2064
Echinococcus multilocularis g protein coupled receptor 0.0074 0.1573 0.2482
Leishmania major beta tubulin 0.0205 0.6339 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0074 0.1573 0.2064
Echinococcus multilocularis G-protein coupled receptor, putative 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Brugia malayi sulfakinin receptor protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Echinococcus multilocularis tubulin beta 1 chain 0.0205 0.6339 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.3889 0.5102
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0074 0.1573 0.2064
Brugia malayi hypothetical protein 0.0045 0.0528 0.0693
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0074 0.1573 0.2064
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0074 0.1573 0.2482
Trichomonas vaginalis tubulin epsilon chain, putative 0.0205 0.6339 0.8078
Loa Loa (eye worm) BEN-1 protein 0.0205 0.6339 0.8315
Brugia malayi AKH receptor 0.0074 0.1573 0.2064
Loa Loa (eye worm) tubulin beta-4 chain 0.0205 0.6339 0.8315
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) tubulin beta-2A chain 0.0205 0.6339 0.8315
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1573 0.2064
Trypanosoma brucei beta tubulin 0.0205 0.6339 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0074 0.1573 0.2064
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0074 0.1573 0.2064
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.1573 0.2064
Entamoeba histolytica tubulin family protein 0.0205 0.6339 0.6329
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0065 0.1228 0.0431
Echinococcus multilocularis allatostatin A receptor 0.0074 0.1573 0.2482
Echinococcus multilocularis serotonin receptor 0.0074 0.1573 0.2482
Echinococcus multilocularis sex peptide receptor 0.0074 0.1573 0.2482
Brugia malayi glutaminase DH11.1 0.0241 0.7623 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni neuropeptide receptor 0.0074 0.1573 0.2064
Trypanosoma cruzi beta tubulin, putative 0.0205 0.6339 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0074 0.1573 0.2482
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Brugia malayi putative neuropeptide receptor NPR1 0.0074 0.1573 0.2064
Echinococcus granulosus Niemann Pick C1 protein 0.0057 0.094 0.1482
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.007
Brugia malayi follicle stimulating hormone receptor 0.0074 0.1573 0.2064
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0065 0.1228 0.0431
Echinococcus multilocularis neuropeptide FF receptor 2 0.0074 0.1573 0.2482
Leishmania major beta tubulin 0.0205 0.6339 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0074 0.1573 0.2482
Leishmania major beta tubulin 0.0205 0.6339 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) tubulin beta-1 chain 0.0205 0.6339 0.8315
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.1573 0.2482
Onchocerca volvulus 0.0074 0.1573 0.5797
Schistosoma mansoni neuropeptide f receptor 76f 0.0074 0.1573 0.2064
Echinococcus multilocularis orexin receptor type 2 0.0074 0.1573 0.2482
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0033 0.0062 0.0081
Leishmania major beta tubulin 0.0205 0.6339 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0074 0.1573 0.2064
Schistosoma mansoni growth hormone secretagogue receptor 0.0074 0.1573 0.2064
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.1573 0.2482
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.1573 0.2482
Brugia malayi hypothetical protein 0.0074 0.1573 0.2064
Echinococcus granulosus g protein coupled receptor 0.0074 0.1573 0.2482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1573 0.2064
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Brugia malayi G-protein coupled receptor 0.0074 0.1573 0.2064
Brugia malayi hypothetical protein 0.0032 0.0054 0.007
Entamoeba histolytica hypothetical protein 0.0087 0.2041 0.2019
Echinococcus multilocularis fmrfamide receptor 0.0074 0.1573 0.2482
Brugia malayi Tachykinin-like peptides receptor 99D 0.0074 0.1573 0.2064
Echinococcus multilocularis g protein coupled receptor 0.0074 0.1573 0.2482
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.1573 0.2482
Toxoplasma gondii hypothetical protein 0.0078 0.1715 0.2043
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni tubulin subunit beta 0.0205 0.6339 0.8315
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.1573 0.2064
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0106 0.2714 0.4282
Echinococcus granulosus Protein patched homolog 1 0.0057 0.094 0.1482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Onchocerca volvulus 0.0074 0.1573 0.5797
Onchocerca volvulus 0.0074 0.1573 0.5797
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0065 0.1228 0.0431
Echinococcus granulosus serotonin receptor 0.0074 0.1573 0.2482
Leishmania major beta tubulin 0.0205 0.6339 1
Brugia malayi RE15519p 0.0074 0.1573 0.2064
Schistosoma mansoni amine GPCR 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.1573 0.2064
Trichomonas vaginalis tubulin, putative 0.0205 0.6339 0.8078
Schistosoma mansoni inhibitor of apoptosis protein 0.0106 0.2714 0.3561
Toxoplasma gondii beta-tubulin, putative 0.0205 0.6339 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.1573 0.2064
Echinococcus granulosus allatostatin A receptor 0.0074 0.1573 0.2482
Schistosoma mansoni myosin xvIII 0.0074 0.1573 0.2064
Echinococcus multilocularis beta tubulin 0.0205 0.6339 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Echinococcus multilocularis dro:myosuppressin receptor 0.0074 0.1573 0.2482
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.1573 0.2482
Brugia malayi Disco-interacting protein 2 homolog 0.0036 0.0168 0.0221
Schistosoma mansoni hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1573 0.2064
Onchocerca volvulus 0.0074 0.1573 0.5797
Echinococcus multilocularis neuropeptide receptor A26 0.0074 0.1573 0.2482
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.1573 0.2064
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.1573 0.2482
Brugia malayi Dopamine receptor protein 1 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Brugia malayi Tubulin beta-1 chain 0.0205 0.6339 0.8315
Plasmodium falciparum tubulin beta chain 0.0205 0.6339 1
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0138 0.3889 0.5784
Schistosoma mansoni tubulin subunit beta 0.0205 0.6339 0.8315
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0106 0.2714 0.3561
Schistosoma mansoni tubulin subunit beta 0.0205 0.6339 0.8315
Echinococcus granulosus geminin 0.0149 0.4298 0.678
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0057 0.094 0.1232
Echinococcus multilocularis disco interacting protein 2 0.0036 0.0168 0.0266
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Onchocerca volvulus 0.0074 0.1573 0.5797
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1573 0.2064
Echinococcus granulosus tubulin beta 4A class IVa 0.0205 0.6339 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Schistosoma mansoni hypothetical protein 0.0106 0.2714 0.3561
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0044 0.0471 0.0618
Echinococcus granulosus 7tm_1 domain containing protein 0.0074 0.1573 0.2482
Echinococcus multilocularis aryl hydrocarbon receptor 0.0047 0.0568 0.0896
Onchocerca volvulus 0.0046 0.0559 0.2061
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.007
Echinococcus multilocularis somatostatin receptor 0.0074 0.1573 0.2482
Brugia malayi hypothetical protein 0.0074 0.1573 0.2064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0138 0.3889 0.5784
Brugia malayi hypothetical protein 0.0074 0.1573 0.2064
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.1573 0.2482
Brugia malayi Serotonin receptor 0.0074 0.1573 0.2064
Brugia malayi Serotonin receptor 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Toxoplasma gondii beta tubulin 0.0205 0.6339 1
Echinococcus multilocularis G protein coupled receptor 139 0.0074 0.1573 0.2482
Onchocerca volvulus 0.0074 0.1573 0.5797
Trypanosoma brucei beta tubulin 0.0205 0.6339 1
Schistosoma mansoni hypothetical protein 0.0149 0.4298 0.5638
Echinococcus granulosus tubulin subunit beta 0.0205 0.6339 1
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0138 0.3889 0.6135
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Brugia malayi GnHR receptor homolog 0.0074 0.1573 0.2064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1573 0.2064
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni neuropeptide receptor 0.0074 0.1573 0.2064
Schistosoma mansoni opsin-like receptor 0.0074 0.1573 0.2064
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0078 0.1715 0.2043
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni amine GPCR 0.0074 0.1573 0.2064
Echinococcus granulosus Tubulin beta 2C chain 0.0205 0.6339 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0168 0.0221
Leishmania major beta tubulin 0.0205 0.6339 1
Schistosoma mansoni histamine h1 receptor 0.0074 0.1573 0.2064
Brugia malayi beta-tubulin, identical 0.0205 0.6339 0.8315
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Schistosoma mansoni tubulin subunit beta 0.0205 0.6339 0.8315
Onchocerca volvulus 0.0074 0.1573 0.5797
Echinococcus multilocularis protein dispatched 1 0.0057 0.094 0.1482
Echinococcus granulosus dro:myosuppressin receptor 0.0074 0.1573 0.2482
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0074 0.1573 0.2482
Schistosoma mansoni adenoreceptor 0.0074 0.1573 0.2064
Echinococcus granulosus neuropeptide receptor A26 0.0074 0.1573 0.2482
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0138 0.3889 0.5102
Echinococcus granulosus sterol regulatory element binding protein 0.0057 0.094 0.1482
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0074 0.1573 0.2064
Trichomonas vaginalis tubulin epsilon chain, putative 0.0205 0.6339 0.8078
Schistosoma mansoni biogenic amine receptor 0.0074 0.1573 0.2064
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0138 0.3889 0.5784
Trypanosoma brucei beta tubulin 0.0205 0.6339 1
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0138 0.3889 0.6135
Loa Loa (eye worm) beta-tubulin 0.0205 0.6339 0.8315
Loa Loa (eye worm) hypothetical protein 0.0046 0.0559 0.0734
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Onchocerca volvulus Deterin homolog 0.0106 0.2714 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.094 0.1232
Echinococcus multilocularis neuropeptide receptor 0.0074 0.1573 0.2482
Schistosoma mansoni biogenic amine receptor 0.0074 0.1573 0.2064
Schistosoma mansoni tubulin subunit beta 0.0205 0.6339 0.8315
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Echinococcus granulosus Tubulin beta 2C chain 0.0205 0.6339 1
Giardia lamblia Beta tubulin 0.0205 0.6339 0.5826
Echinococcus granulosus 7TM GPCR rhodopsin 0.0074 0.1573 0.2482
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0074 0.1573 0.2064
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Schistosoma mansoni amine GPCR 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.1573 0.2064
Trypanosoma brucei beta tubulin 0.0205 0.6339 1
Loa Loa (eye worm) TYRA-2 protein 0.0074 0.1573 0.2064
Onchocerca volvulus 0.0074 0.1573 0.5797
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0033 0.0062 0.0081
Schistosoma mansoni amine GPCR 0.0074 0.1573 0.2064
Mycobacterium ulcerans glutaminase 0.0241 0.7623 1
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0032 0.0054 0.007
Echinococcus granulosus tachykinin peptides receptor 99D 0.0074 0.1573 0.2482
Brugia malayi hypothetical protein 0.0074 0.1573 0.2064
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.1573 0.2482
Echinococcus multilocularis Tubulin beta 2C chain 0.0205 0.6339 1
Onchocerca volvulus 0.0074 0.1573 0.5797
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0074 0.1573 0.2064
Brugia malayi Dopamine receptor 0.0074 0.1573 0.2064
Echinococcus granulosus aryl hydrocarbon receptor 0.0047 0.0568 0.0896
Brugia malayi Calcitonin receptor-like protein seb-1 0.0044 0.0471 0.0618
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.6339 0.8078
Loa Loa (eye worm) hypothetical protein 0.0106 0.2714 0.3561
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0074 0.1573 0.2482
Giardia lamblia Beta tubulin 0.0205 0.6339 0.5826
Echinococcus granulosus Tubulin beta 2C chain 0.0205 0.6339 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1573 0.2064
Echinococcus multilocularis sterol regulatory element binding protein 0.0057 0.094 0.1482
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0033 0.0062 0.0081
Onchocerca volvulus 0.0074 0.1573 0.5797
Echinococcus granulosus beta tubulin 0.0205 0.6339 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Loa Loa (eye worm) BEN-1 protein 0.0205 0.6339 0.8315
Brugia malayi hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0074 0.1573 0.2064
Echinococcus granulosus orexin receptor type 2 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.1573 0.2064
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0106 0.2714 0.3561
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0074 0.1573 0.5797
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.1573 0.2482
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0044 0.0471 0.0618
Brugia malayi MH2 domain containing protein 0.0105 0.2696 0.3536
Echinococcus multilocularis Tubulin beta 2C chain 0.0205 0.6339 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0074 0.1573 0.2482
Schistosoma mansoni neuropeptide receptor 0.0074 0.1573 0.2064
Schistosoma mansoni biogenic amine receptor 0.0074 0.1573 0.2064
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0106 0.2714 0.3561
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0074 0.1573 0.2064
Echinococcus granulosus neuropeptide receptor 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Brugia malayi hypothetical protein 0.0033 0.0062 0.0081
Echinococcus granulosus tubulin beta 1 chain 0.0205 0.6339 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.007
Schistosoma mansoni hypothetical protein 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Echinococcus granulosus fmrfamide receptor 0.0074 0.1573 0.2482
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0027 0.0035
Trichomonas vaginalis glutaminase, putative 0.0241 0.7623 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1573 0.2064
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Leishmania major beta tubulin 0.0205 0.6339 1
Brugia malayi hypothetical protein 0.0074 0.1573 0.2064
Onchocerca volvulus 0.0074 0.1573 0.5797
Loa Loa (eye worm) transcription factor SMAD2 0.0105 0.2696 0.3536
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0138 0.3889 0.5102
Echinococcus multilocularis protein patched 0.0057 0.094 0.1482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Brugia malayi ORL1-like opioid receptor 0.0074 0.1573 0.2064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1573 0.2482
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0074 0.1573 0.2064
Echinococcus granulosus neuropeptide FF receptor 2 0.0074 0.1573 0.2482
Echinococcus multilocularis serotonin receptor 0.0074 0.1573 0.2482
Trichomonas vaginalis tubulin gamma chain, putative 0.0205 0.6339 0.8078
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0074 0.1573 0.2482
Schistosoma mansoni tubulin subunit beta 0.0205 0.6339 0.8315
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.1573 0.2064
Echinococcus granulosus neuropeptide receptor 0.0074 0.1573 0.2482
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.1573 0.2482
Onchocerca volvulus 0.0074 0.1573 0.5797
Echinococcus multilocularis Tubulin beta 2C chain 0.0205 0.6339 1
Echinococcus multilocularis fmrfamide receptor 0.0074 0.1573 0.2482
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.007
Brugia malayi hypothetical protein 0.0032 0.0027 0.0035
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0087 0.2041 0.2019
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0106 0.2714 0.4282
Brugia malayi larval opioid receptor 0.0074 0.1573 0.2064
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.1573 0.2482

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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