TDR Targets

Basic information

Technical information

TDR Targets ID: 831047
Name: N-(4-methylsulfanylphenyl)-1-pyrazin-2-ylpipe ridine-4-carboxamide
MW: 328.432 | Formula: C17H20N4OS
H donors: 1 H acceptors: 3 LogP: 2.08 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CSc1ccc(cc1)NC(=O)C1CCN(CC1)c1nccnc1
InChi: 1S/C17H20N4OS/c1-23-15-4-2-14(3-5-15)20-17(22)13-6-10-21(11-7-13)16-12-18-8-9-19-16/h2-5,8-9,12-13H,6-7,10-11H2,1H3,(H,20,22)
InChiKey: XPXYQRWSZPVCQD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-(4-methylsulfanylphenyl)-1-pyrazin-2-yl-piperidine-4-carboxamide
N-[4-(methylthio)phenyl]-1-(2-pyrazinyl)-4-piperidinecarboxamide
N-[4-(methylthio)phenyl]-1-pyrazin-2-yl-isonipecotamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0075	0.0128
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.011	0.0116
Echinococcus granulosus	fidgetin protein 1	0.0042	0.0304	0.0128
Loa Loa (eye worm)	vps4b-prov protein	0.0042	0.0304	0.0527
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0075	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0075	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Schistosoma mansoni	hypothetical protein	0.0035	0.0221	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0742	0.0639
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0075	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0075	0.0128
Echinococcus multilocularis	survival motor neuron protein 1	0.023	0.2693	0.256
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Brugia malayi	hypothetical protein	0.0032	0.0179	0.0181
Leishmania major	katanin-like protein,serine peptidase, Clan SJ, family S16, putative	0.0042	0.0304	0.0243
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0742	0.0783
Brugia malayi	ATPase, AAA family protein	0.0042	0.0304	0.0402
Entamoeba histolytica	ATPase, Vps4 oligomerisation domain containing protein	0.0042	0.0304	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Brugia malayi	Dopamine receptor	0.0032	0.0179	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0075	0.013
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0342	0.0166
Loa Loa (eye worm)	VCP protein	0.0334	0.4005	0.6938
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0742	0.1258
Echinococcus granulosus	katanin p60 ATPase containing subunit A1	0.0042	0.0304	0.0128
Brugia malayi	hypothetical protein	0.0032	0.0179	0.0181
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0742	1
Brugia malayi	valosin containing protein	0.0473	0.5773	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0032	0.0179	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Onchocerca volvulus		0.0047	0.0372	0.0299
Onchocerca volvulus		0.0032	0.0179	0.0104
Onchocerca volvulus	Transitional endoplasmic reticulum ATPase homolog	0.0807	1	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.011	0.0116
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0742	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0342	0.0166
Onchocerca volvulus		0.0032	0.0179	0.0104
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0742	0.1258
Loa Loa (eye worm)	melatonin receptor type 1A	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0473	0.5773	1
Loa Loa (eye worm)	vesicle-fusing ATPase	0.0473	0.5773	1
Onchocerca volvulus		0.0032	0.0179	0.0104
Brugia malayi	ORL1-like opioid receptor	0.0032	0.0179	0.0181
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0075	0.0128
Trypanosoma cruzi	Valosin-containing protein, putative	0.0765	0.9474	1
Onchocerca volvulus		0.0032	0.0179	0.0104
Brugia malayi	hypothetical protein	0.0032	0.0179	0.0181
Onchocerca volvulus		0.0032	0.0179	0.0104
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0032	0.0179	0.0181
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0342	0.0166
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0342	0.0468
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0342	0.0166
Brugia malayi	hypothetical protein	0.0032	0.0179	0.0181
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0372	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.041	0.0235
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0032	0.0179	0.0181
Brugia malayi	sulfakinin receptor protein	0.0032	0.0179	0.0181
Brugia malayi	transitional endoplasmic reticulum ATPase TER94, putative	0.0334	0.4005	0.6898
Brugia malayi	neuropeptide F receptor	0.0032	0.0179	0.0181
Trypanosoma cruzi	metalloprotease, putative	0.0042	0.0304	0.0000043848
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0075	0.013
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Brugia malayi	G protein-coupled receptor	0.0032	0.0179	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Trypanosoma cruzi	katanin-like protein, putative	0.0042	0.0304	0.0000043848
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0032	0.0179	0.0104
Brugia malayi	vesicle-fusing ATPase	0.0473	0.5773	1
Echinococcus granulosus	vacuolar protein sorting associated protein 4A	0.0042	0.0304	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0742	0.1285
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Onchocerca volvulus		0.0032	0.0179	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Entamoeba histolytica	transitional endoplasmic reticulum ATPase, putative	0.0765	0.9474	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0075	0.0128
Loa Loa (eye worm)	hypothetical protein	0.023	0.2693	0.4665
Brugia malayi	RE15519p	0.0032	0.0179	0.0181
Mycobacterium tuberculosis	Putative conserved ATPase	0.0483	0.5895	1
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0807	1	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0742	0.0574
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0742	0.5
Trypanosoma cruzi	vacuolar protein sorting-associated protein 4, putative	0.0042	0.0304	0.0000043848
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0032	0.0179	0.0181
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0075	0.0128
Entamoeba histolytica	hypothetical protein	0.0035	0.0221	0.0155
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0342	0.0592
Brugia malayi	Serotonin receptor	0.0032	0.0179	0.0181
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0342	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Brugia malayi	hypothetical protein	0.023	0.2693	0.4595
Trypanosoma cruzi	vesicular transport protein (CDC48 homologue), putative	0.0042	0.0304	0.0000043848
Trichomonas vaginalis	spermatogenesis associated factor, putative	0.0807	1	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0742	1
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0334	0.4005	0.3896
Trypanosoma cruzi	katanin, putative	0.0042	0.0304	0.0000043848
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0742	0.0783
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0765	0.9474	0.9464
Toxoplasma gondii	cell division protein CDC48CY	0.0807	1	1
Brugia malayi	putative neuropeptide receptor	0.0032	0.0179	0.0181
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0342	0.0166
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0807	1	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0179	0.0309
Onchocerca volvulus		0.0032	0.0179	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	TYRA-2 protein	0.0032	0.0179	0.0309
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0221	0.0044
Leishmania major	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	0.0765	0.9474	1
Brugia malayi	hypothetical protein	0.0032	0.0179	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Giardia lamblia	AAA family ATPase	0.0483	0.5895	1
Brugia malayi	G-protein coupled receptor	0.0032	0.0179	0.0181
Trichomonas vaginalis	proteasome-activating nucleotidase, putative	0.0191	0.2194	0.195
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Leishmania major	vacuolar protein sorting-associated protein 4	0.0042	0.0304	0.0243
Mycobacterium ulcerans	ATPase	0.0483	0.5895	1
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0334	0.4005	0.3896
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Brugia malayi	vps4b-prov protein	0.0042	0.0304	0.0402
Brugia malayi	hypothetical protein	0.0032	0.0179	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	ATPase	0.0042	0.0304	0.0527
Trypanosoma cruzi	vacuolar transport protein 4A, putative	0.0042	0.0304	0.0000043848
Trypanosoma cruzi	katanin, putative	0.0042	0.0304	0.0000043848
Trypanosoma brucei	Valosin-containing protein	0.0765	0.9474	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0342	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Onchocerca volvulus		0.0032	0.0179	0.0104
Brugia malayi	Dopamine receptor protein 2	0.0032	0.0179	0.0181
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0032	0.0179	0.0309
Brugia malayi	AKH receptor	0.0032	0.0179	0.0181
Entamoeba histolytica	vacuolar sorting protein-associating protein 4A (VPS4), putative	0.0042	0.0304	0.0243
Brugia malayi	hypothetical protein	0.0032	0.0179	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Brugia malayi	putative neuropeptide receptor NPR1	0.0032	0.0179	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0372	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Brugia malayi	Dopamine receptor protein 1	0.0032	0.0179	0.0181
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0032	0.0179	0.0181
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0179	0.0309
Plasmodium falciparum	cell division cycle protein 48 homologue, putative	0.0765	0.9474	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0221	0.0155
Onchocerca volvulus		0.0032	0.0179	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Onchocerca volvulus		0.0032	0.0179	0.0104
Brugia malayi	G-protein coupled receptor	0.0032	0.0179	0.0181
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0742	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0221	0.0155
Onchocerca volvulus		0.0032	0.0179	0.0104
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.041	0.0695
Leishmania major	katanin, putative,serine peptidase, Clan SJ, family S16, putative	0.0042	0.0304	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0032	0.0179	0.0309
Schistosoma mansoni	skd/vacuolar sorting	0.0042	0.0304	0.0128
Plasmodium vivax	cell division cycle ATPase, putative	0.0292	0.3479	0.3672
Brugia malayi	follicle stimulating hormone receptor	0.0032	0.0179	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Leishmania major	katanin-like protein,serine peptidase, Clan SJ, family S16, putative	0.0042	0.0304	0.0243
Brugia malayi	hypothetical protein	0.0032	0.0179	0.0181
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0075	0.0128
Plasmodium vivax	cell division cycle protein 48 homologue, putative	0.0765	0.9474	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0032	0.0179	0.0181
Brugia malayi	Serotonin receptor	0.0032	0.0179	0.0181
Brugia malayi	neuropeptide F receptor	0.0032	0.0179	0.0181
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0742	0.0574
Trypanosoma cruzi	katanin, putative	0.0042	0.0304	0.0000043848
Toxoplasma gondii	cell division protein CDC48AP	0.0483	0.5895	0.585
Plasmodium falciparum	vacuolar protein sorting-associated protein 4	0.0042	0.0304	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0075	0.013
Toxoplasma gondii	katanin-like family protein	0.0042	0.0304	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Entamoeba histolytica	cdc48-like protein, putative	0.0765	0.9474	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0075	0.0128
Brugia malayi	Melatonin receptor type 1A	0.0032	0.0179	0.0181
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.041	0.0695
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0026	0.011	0.052
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0179	0.0309
Brugia malayi	hypothetical protein	0.0032	0.0179	0.0181
Trichomonas vaginalis	26S protease regulatory subunit S10b, putative	0.0191	0.2194	0.195
Brugia malayi	fidgetin protein	0.0042	0.0304	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Brugia malayi	hypothetical protein	0.0032	0.0179	0.0181
Onchocerca volvulus		0.0032	0.0179	0.0104
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0221	0.0044
Loa Loa (eye worm)	fidgetin protein	0.0042	0.0304	0.0527
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.041	0.5017
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0742	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Schistosoma mansoni	hypothetical protein	0.0042	0.0304	0.0128
Brugia malayi	larval opioid receptor	0.0032	0.0179	0.0181
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0742	0.0574
Onchocerca volvulus		0.0032	0.0179	0.0104
Echinococcus multilocularis	fidgetin protein 1	0.0042	0.0304	0.0128
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0221	0.0044
Trypanosoma cruzi	katanin, putative	0.0042	0.0304	0.0000043848
Brugia malayi	G protein-coupled receptor F59B2.13	0.0032	0.0179	0.0181
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0179	0.0309
Trypanosoma cruzi	katanin, putative	0.0042	0.0304	0.0000043848
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0032	0.0179	0.0181
Brugia malayi	Probable ClpP-like protease	0.0076	0.0742	0.117
Brugia malayi	SAP1 protein	0.0042	0.0304	0.0402
Onchocerca volvulus		0.0032	0.0179	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Echinococcus multilocularis	vacuolar protein sorting associated protein 4A	0.0042	0.0304	0.0128
Entamoeba histolytica	hypothetical protein	0.0035	0.0221	0.0155
Onchocerca volvulus		0.0032	0.0179	0.0104
Brugia malayi	GnHR receptor homolog	0.0032	0.0179	0.0181
Onchocerca volvulus		0.0032	0.0179	0.0104
Schistosoma mansoni	hypothetical protein	0.0047	0.0372	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309
Echinococcus multilocularis	katanin p60 ATPase containing subunit A1	0.0042	0.0304	0.0128
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0032	0.0179	0.0309
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.041	0.0235
Toxoplasma gondii	transitional endoplasmic reticulum ATPase, putative	0.0483	0.5895	0.585
Onchocerca volvulus		0.0032	0.0179	0.0104
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0032	0.0179	0.0309
Brugia malayi	hypothetical protein	0.0035	0.0221	0.0256
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0032	0.0179	0.0309
Echinococcus granulosus	survival motor neuron protein 1	0.023	0.2693	0.256
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0309

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 831047