Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0199 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.4148 | 0.6016 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0199 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0795 | 0.1153 |
Schistosoma mansoni | hypothetical protein | 0.0334 | 0.6895 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1198 | 0.1216 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0468 | 0.9855 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1076 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0199 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0728 | 0.1056 |
Onchocerca volvulus | 0.0475 | 1 | 1 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.2128 | 0.1971 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1198 | 0.1022 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0728 | 0.0739 |
Echinococcus multilocularis | geminin | 0.0334 | 0.6895 | 0.6996 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0606 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0258 | 0.5217 | 0.5294 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0728 | 0.0543 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1076 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0728 | 0.0739 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.0606 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1198 | 0.1738 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1198 | 0.1022 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0795 | 0.0611 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0031 | 0.0196 | 0.0199 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1198 | 0.1022 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0258 | 0.5217 | 0.5294 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0284 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0728 | 0.0739 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0728 | 0.1056 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0606 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0199 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.0606 | 1 |
Brugia malayi | hypothetical protein | 0.005 | 0.0606 | 0.0418 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.1076 | 0.1091 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.2128 | 0.1971 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1198 | 0.1738 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0199 |
Brugia malayi | hypothetical protein | 0.0071 | 0.1076 | 0.0897 |
Echinococcus granulosus | geminin | 0.0334 | 0.6895 | 0.6996 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.0606 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0258 | 0.5217 | 0.5122 |
Onchocerca volvulus | 0.0203 | 0.3991 | 0.3472 | |
Echinococcus multilocularis | jun protein | 0.0258 | 0.5217 | 0.5294 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1198 | 0.1738 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0728 | 0.1056 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1076 | 0.156 |
Brugia malayi | hypothetical protein | 0.0286 | 0.5819 | 0.5736 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1198 | 0.1022 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1198 | 0.1022 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0475 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.1076 | 0.156 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1198 | 0.1738 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0606 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0728 | 0.0739 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.5819 | 0.5905 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1076 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1198 | 0.1738 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0606 | 1 |
Brugia malayi | hypothetical protein | 0.0203 | 0.3991 | 0.3871 |
Schistosoma mansoni | hypothetical protein | 0.0334 | 0.6895 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0795 | 0.1153 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1198 | 0.1022 |
Echinococcus granulosus | jun protein | 0.0258 | 0.5217 | 0.5294 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.2128 | 0.1971 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0217 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0606 | 0.0418 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0606 | 1 |
Schistosoma mansoni | jun-related protein | 0.021 | 0.4148 | 0.6016 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1198 | 0.1216 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.1076 | 0.1091 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1076 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0031 | 0.0196 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0728 | 0.0543 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0468 | 0.9855 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.5819 | 0.5736 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.5061 | 0.4962 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.5819 | 0.5905 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 20 uM | Inhibitory activity against HIV-1 reverse transcriptase | ChEMBL. | 11384233 |
IC50 (binding) | > 20 uM | Inhibitory activity against HIV-1 reverse transcriptase | ChEMBL. | 11384233 |
IC50 (functional) | = 93.5000000000002 uM | Antiviral activity against HIV-1 infected human MT-4 cells. | ChEMBL. | 11384233 |
IC50 (functional) | > 200 uM | Cell culture cytotoxicity against MT-4 cells. | ChEMBL. | 11384233 |
IC50 (functional) | > 200 uM | Cell culture cytotoxicity against MT-4 cells. | ChEMBL. | 11384233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.