Detailed information for compound 83217

Basic information

Technical information
  • TDR Targets ID: 83217
  • Name: ethyl 4-oxo-2-[3-(trifluoromethyl)anilino]fur an-3-carboxylate
  • MW: 315.245 | Formula: C14H12F3NO4
  • H donors: 1 H acceptors: 2 LogP: 3.67 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(OCC1=O)Nc1cccc(c1)C(F)(F)F
  • InChi: 1S/C14H12F3NO4/c1-2-21-13(20)11-10(19)7-22-12(11)18-9-5-3-4-8(6-9)14(15,16)17/h3-6,18H,2,7H2,1H3
  • InChiKey: DMWCEVQSKKAFNB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-oxo-2-[3-(trifluoromethyl)anilino]-3-furancarboxylic acid ethyl ester
  • ethyl 4-oxo-2-[[3-(trifluoromethyl)phenyl]amino]furan-3-carboxylate
  • 4-keto-2-[3-(trifluoromethyl)anilino]furan-3-carboxylic acid ethyl ester
  • 4-oxo-2-[[3-(trifluoromethyl)phenyl]amino]-3-furancarboxylic acid ethyl ester
  • 4-keto-2-[[3-(trifluoromethyl)phenyl]amino]furan-3-carboxylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis glycine receptor subunit beta 0.0246 0.0315 0.0397
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0252 0.0325 0.041
Brugia malayi hypothetical protein 0.0113 0.0101 0.0092
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0252 0.0325 0.041
Schistosoma mansoni tyrosine kinase 0.0056 0.0009 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Brugia malayi larval opioid receptor 0.0252 0.0325 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0252 0.0325 0.041
Onchocerca volvulus 0.0252 0.0325 0.1431
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Onchocerca volvulus 0.0176 0.0203 0.0806
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Schistosoma mansoni voltage-gated cation channel 0.0126 0.0122 0.0148
Schistosoma mansoni neurotransmitter gated ion channel 0.0113 0.0101 0.0122
Brugia malayi Trypsin family protein 0.0202 0.0245 0.0236
Loa Loa (eye worm) integrin alpha pat-2 0.2399 0.3789 0.3789
Loa Loa (eye worm) hypothetical protein 0.0079 0.0046 0.0046
Onchocerca volvulus 0.0252 0.0325 0.1431
Brugia malayi Trypsin family protein 0.0202 0.0245 0.0236
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Echinococcus granulosus glycine receptor subunit beta 0.0246 0.0315 0.0397
Echinococcus granulosus glycine receptor subunit beta 0.0246 0.0315 0.0397
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0252 0.0325 0.0325
Onchocerca volvulus 0.0113 0.0101 0.0283
Echinococcus multilocularis epidermal growth factor receptor 0.0088 0.006 0.0067
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0113 0.0101 0.0092
Echinococcus multilocularis Mastin 0.0202 0.0245 0.0306
Mycobacterium ulcerans hypothetical protein 0.0202 0.0245 1
Loa Loa (eye worm) LGC-31 protein 0.0246 0.0315 0.0315
Echinococcus multilocularis rhodopsin orphan GPCR 0.0252 0.0325 0.041
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0252 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1072 0.1648 0.1641
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0315 0.0307
Toxoplasma gondii microneme protein MIC17B 0.0197 0.0237 0.0104
Onchocerca volvulus 0.0215 0.0265 0.1125
Echinococcus multilocularis integrin beta 2 0.4838 0.7726 1
Brugia malayi EGF-like domain containing protein 0.0176 0.0203 0.0195
Echinococcus granulosus 7TM GPCR rhodopsin 0.0252 0.0325 0.041
Onchocerca volvulus 0.0252 0.0325 0.1431
Onchocerca volvulus 0.0197 0.0237 0.0979
Echinococcus multilocularis G protein coupled receptor 139 0.0406 0.0574 0.0733
Schistosoma mansoni biogenic amine receptor 0.0252 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.1072 0.1648 0.1648
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0252 0.0325 0.041
Echinococcus granulosus 7tm_1 domain containing protein 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus multilocularis fibrillin 1 0.0176 0.0203 0.0252
Brugia malayi Furin-like cysteine rich region family protein 0.0156 0.017 0.0162
Loa Loa (eye worm) hypothetical protein 0.0133 0.0132 0.0132
Onchocerca volvulus 0.0197 0.0237 0.0979
Loa Loa (eye worm) hypothetical protein 0.0215 0.0265 0.0265
Schistosoma mansoni biogenic amine receptor 0.0252 0.0325 0.0398
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0252 0.0325 0.041
Brugia malayi Serotonin receptor 0.0252 0.0325 0.0317
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Onchocerca volvulus 0.0215 0.0265 0.1125
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0056 0.0061
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) PAN domain-containing protein 0.0197 0.0237 0.0237
Brugia malayi neuropeptide F receptor 0.0252 0.0325 0.0317
Schistosoma mansoni biogenic amine (5HT) receptor 0.0252 0.0325 0.0398
Loa Loa (eye worm) integrin beta-2 0.6247 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Schistosoma mansoni opsin-like receptor 0.0252 0.0325 0.0398
Onchocerca volvulus 0.0252 0.0325 0.1431
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Echinococcus multilocularis kelch ECH associated protein 1 0.0096 0.0073 0.0083
Echinococcus multilocularis voltage dependent calcium channel 0.0126 0.0122 0.0147
Loa Loa (eye worm) PAN domain-containing protein 0.0197 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0219 0.0272 0.0272
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0246 0.0315 0.0397
Giardia lamblia Tenascin-like 0.0176 0.0203 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1289 0.1998 0.2462
Brugia malayi jmjC domain containing protein 0.0096 0.0074 0.0065
Onchocerca volvulus 0.0835 0.1266 0.6249
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0056 0.0056
Echinococcus granulosus alpha 1A adrenergic receptor 0.0252 0.0325 0.041
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0074 0.0085
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0315 0.0307
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0176 0.0203 0.5
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0126 0.0122 0.0147
Echinococcus multilocularis fmrfamide receptor 0.0252 0.0325 0.041
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0252 0.0325 0.041
Toxoplasma gondii hypothetical protein 0.0197 0.0237 0.0104
Echinococcus multilocularis integrin alpha ps 0.092 0.1404 0.1808
Echinococcus granulosus fibrillin 2 0.0176 0.0203 0.0252
Schistosoma mansoni opsin-like receptor 0.0252 0.0325 0.0398
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0252 0.0325 0.041
Schistosoma mansoni amine GPCR 0.0252 0.0325 0.0398
Toxoplasma gondii microneme protein, putative 0.0197 0.0237 0.0104
Onchocerca volvulus 0.0197 0.0237 0.0979
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0079 0.0046 0.0046
Brugia malayi Tachykinin-like peptides receptor 99D 0.0252 0.0325 0.0317
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Schistosoma mansoni tyrosine kinase 0.0088 0.006 0.0071
Brugia malayi Integrin alpha pat-2 precursor 0.1831 0.2873 0.2866
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Echinococcus multilocularis glutamate receptor 2 0.0079 0.0046 0.0048
Schistosoma mansoni hypothetical protein 0.0085 0.0056 0.0066
Loa Loa (eye worm) melatonin receptor type 1A 0.0252 0.0325 0.0325
Onchocerca volvulus 0.0109 0.0095 0.0252
Brugia malayi hypothetical protein 0.0202 0.0245 0.0236
Echinococcus granulosus rhodopsin orphan GPCR 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Onchocerca volvulus 0.0197 0.0237 0.0979
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0246 0.0315 0.0397
Echinococcus granulosus adam 0.0176 0.0203 0.0252
Echinococcus multilocularis sodium channel protein 0.0065 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus granulosus tm gpcr rhodopsin 0.0252 0.0325 0.041
Onchocerca volvulus 0.0202 0.0245 0.1019
Toxoplasma gondii microneme protein MIC4 0.0197 0.0237 0.0104
Brugia malayi PAN domain containing protein 0.0197 0.0237 0.0228
Echinococcus granulosus glycine receptor subunit alpha 1 0.0246 0.0315 0.0397
Loa Loa (eye worm) hypothetical protein 0.0176 0.0203 0.0203
Schistosoma mansoni tyrosine kinase 0.0089 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0113 0.0101 0.012
Echinococcus multilocularis glycine receptor subunit beta 0.0246 0.0315 0.0397
Loa Loa (eye worm) hypothetical protein 0.0202 0.0245 0.0245
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0246 0.0315 0.0307
Onchocerca volvulus 0.0219 0.0272 0.116
Echinococcus multilocularis neuropeptide FF receptor 2 0.0252 0.0325 0.041
Loa Loa (eye worm) GABA receptor subunit 0.0133 0.0132 0.0132
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0009 0.0000013485
Schistosoma mansoni integrin alpha-ps 0.092 0.1404 0.1729
Echinococcus multilocularis receptor type guanylyl cyclase 0.0257 0.0333 0.042
Echinococcus granulosus neuropeptide receptor 0.0406 0.0574 0.0733
Loa Loa (eye worm) hypothetical protein 0.0133 0.0132 0.0132
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0252 0.0325 0.041
Brugia malayi sulfakinin receptor protein 0.0252 0.0325 0.0317
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0079 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0542 0.0793 0.0793
Schistosoma mansoni neuropeptide receptor 0.0252 0.0325 0.0398
Echinococcus multilocularis potassium voltage gated channel protein 0.0521 0.076 0.0974
Trypanosoma cruzi hypothetical protein, conserved 0.0321 0.0437 1
Brugia malayi hypothetical protein 0.0113 0.0101 0.0092
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0246 0.0315 0.0397
Loa Loa (eye worm) acetylcholine receptor protein 0.0113 0.0101 0.0101
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0246 0.0315 0.0315
Brugia malayi G protein-coupled receptor 0.0252 0.0325 0.0317
Onchocerca volvulus 0.0133 0.0132 0.0444
Echinococcus multilocularis nmda type glutamate receptor 0.0079 0.0046 0.0048
Loa Loa (eye worm) hypothetical protein 0.0074 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0113 0.0101 0.012
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0126 0.0122 0.0147
Brugia malayi ORL1-like opioid receptor 0.0252 0.0325 0.0317
Schistosoma mansoni neuropeptide F-like receptor 0.0252 0.0325 0.0398
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0113 0.0101 0.012
Brugia malayi Trypsin-like protease protein 5 0.0202 0.0245 0.0236
Echinococcus granulosus transmembrane protease serine 3 0.0202 0.0245 0.0306
Loa Loa (eye worm) G-protein coupled receptor 0.0252 0.0325 0.0325
Echinococcus granulosus voltage dependent calcium channel 0.0126 0.0122 0.0147
Brugia malayi hypothetical protein 0.0252 0.0325 0.0317
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0252 0.0325 0.1431
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0252 0.0325 0.041
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0202 0.0245 0.0306
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Brugia malayi PAN domain containing protein 0.0197 0.0237 0.0228
Echinococcus multilocularis neuropeptides capa receptor 0.0252 0.0325 0.041
Schistosoma mansoni amine GPCR 0.0252 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0321 0.0437 0.0437
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0126 0.0122 0.0147
Echinococcus multilocularis g protein coupled receptor 0.0252 0.0325 0.041
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0314 0.0426 0.054
Echinococcus granulosus glutamate receptor 2 0.0079 0.0046 0.0048
Schistosoma mansoni neuropeptide f receptor 76f 0.0252 0.0325 0.0398
Echinococcus multilocularis g protein coupled receptor 0.0252 0.0325 0.041
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0056 0.0061
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0246 0.0315 0.0397
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0252 0.0325 0.0398
Onchocerca volvulus 0.1289 0.1998 1
Onchocerca volvulus 0.0197 0.0237 0.0979
Echinococcus multilocularis neuropeptide Y receptor 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0079 0.0046 0.0048
Echinococcus granulosus orexin receptor type 2 0.0252 0.0325 0.041
Onchocerca volvulus 0.0113 0.0101 0.0283
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0245 0.0299
Echinococcus granulosus rhodopsin orphan GPCR 0.0252 0.0325 0.041
Echinococcus multilocularis nAChR subunit 0.0246 0.0315 0.0397
Brugia malayi PAN domain containing protein 0.0197 0.0237 0.0228
Echinococcus granulosus nmda type glutamate receptor 0.0079 0.0046 0.0048
Onchocerca volvulus 0.0252 0.0325 0.1431
Echinococcus granulosus peptide allatostatin:somatostatin 0.0252 0.0325 0.041
Echinococcus granulosus kelch ECH associated protein 1 like 0.0096 0.0073 0.0083
Loa Loa (eye worm) neuropeptide F receptor 0.0252 0.0325 0.0325
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0197 0.0237 0.0104
Echinococcus granulosus G protein coupled receptor 139 0.0252 0.0325 0.041
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0252 0.0325 0.0398
Brugia malayi hypothetical protein 0.1 0.1532 0.1524
Loa Loa (eye worm) hypothetical protein 0.0722 0.1083 0.1083
Echinococcus granulosus tissue type plasminogen activator 0.0321 0.0437 0.0555
Schistosoma mansoni tyrosine kinase 0.0088 0.006 0.0071
Echinococcus granulosus glutamate receptor 2 0.0079 0.0046 0.0048
Schistosoma mansoni nAChR subunit 0.0246 0.0315 0.0386
Onchocerca volvulus 0.1086 0.1672 0.8329
Echinococcus granulosus g protein coupled receptor 0.0252 0.0325 0.041
Brugia malayi Melatonin receptor type 1A 0.0252 0.0325 0.0317
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0226 0.0284 0.0357
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0079 0.0046 0.0046
Echinococcus granulosus sex peptide receptor 0.0252 0.0325 0.041
Onchocerca volvulus 0.0202 0.0245 0.1019
Brugia malayi Serotonin receptor 0.0252 0.0325 0.0317
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0252 0.0325 0.041
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0252 0.0325 0.0398
Echinococcus granulosus integrin alpha 3 0.1351 0.2099 0.2709
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0079 0.0046 0.0037
Echinococcus granulosus receptor type guanylyl cyclase 0.0257 0.0333 0.042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0252 0.0325 0.0398
Schistosoma mansoni amine GPCR 0.0252 0.0325 0.0398
Brugia malayi Dopamine receptor protein 1 0.0252 0.0325 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0252 0.0325 0.041
Schistosoma mansoni tyrosine kinase 0.0056 0.0009 0.0008
Toxoplasma gondii PAN domain-containing protein 0.0197 0.0237 0.0104
Giardia lamblia Neurogenic locus notch-like protein 0.0176 0.0203 0.5
Brugia malayi EGF-like domain containing protein 0.0176 0.0203 0.0195
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus granulosus neuropeptide s receptor 0.0252 0.0325 0.041
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0835 0.1266 0.1559
Loa Loa (eye worm) G-protein coupled receptor 0.0252 0.0325 0.0325
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0246 0.0315 0.0397
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0246 0.0315 0.0307
Loa Loa (eye worm) hypothetical protein 0.0835 0.1266 0.1266
Echinococcus multilocularis neuropeptide receptor A26 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0197 0.0237 0.0237
Onchocerca volvulus 0.0252 0.0325 0.1431
Brugia malayi Cation transporter family protein 0.0246 0.0315 0.0307
Brugia malayi Guanylyl cyclase protein 23 0.0109 0.0095 0.0086
Onchocerca volvulus 0.0321 0.0437 0.2005
Brugia malayi PAN domain containing protein 0.0197 0.0237 0.0228
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0202 0.0245 0.0245
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0056 0.0066
Onchocerca volvulus 0.0252 0.0325 0.1431
Brugia malayi neuropeptide F receptor 0.0252 0.0325 0.0317
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0252 0.0325 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0252 0.0325 0.0398
Brugia malayi Receptor family ligand binding region containing protein 0.0079 0.0046 0.0037
Echinococcus granulosus neuropeptide receptor A26 0.0252 0.0325 0.041
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0246 0.0315 0.0307
Echinococcus multilocularis somatostatin receptor 0.0252 0.0325 0.041
Giardia lamblia Tenascin-37 0.0176 0.0203 0.5
Brugia malayi Protein kinase domain containing protein 0.0331 0.0453 0.0445
Schistosoma mansoni hypothetical protein 0.0441 0.0631 0.0775
Onchocerca volvulus Putative nachr subunit 0.0314 0.0426 0.1945
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Schistosoma mansoni neurotransmitter gated ion channel 0.0133 0.0132 0.016
Echinococcus granulosus integrin beta 2 0.4838 0.7726 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0314 0.0426 0.0417
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0133 0.0132 0.0124
Echinococcus granulosus glycine receptor subunit alpha 1 0.0246 0.0315 0.0397
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0252 0.0325 0.0398
Schistosoma mansoni myosin xvIII 0.0252 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.017 0.021
Schistosoma mansoni hypothetical protein 0.0085 0.0056 0.0066
Onchocerca volvulus 0.0835 0.1266 0.6249
Giardia lamblia hypothetical protein 0.0176 0.0203 0.5
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0521 0.076 0.0752
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0245 0.0306
Echinococcus granulosus neuropeptides capa receptor 0.0252 0.0325 0.041
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0084 0.0055 0.0231
Schistosoma mansoni voltage-gated potassium channel 0.0521 0.076 0.0935
Loa Loa (eye worm) hypothetical protein 0.0079 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0252 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0197 0.0237 0.0237
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0314 0.0426 0.054
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0113 0.0101 0.0092
Schistosoma mansoni hypothetical protein 0.0202 0.0245 0.0299
Echinococcus granulosus nAChR subunit 0.0246 0.0315 0.0397
Loa Loa (eye worm) PAN domain-containing protein 0.0197 0.0237 0.0237
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0252 0.0325 0.0398
Echinococcus multilocularis allatostatin A receptor 0.0252 0.0325 0.041
Onchocerca volvulus 0.0252 0.0325 0.1431
Onchocerca volvulus 0.0197 0.0237 0.0979
Brugia malayi Trypsin family protein 0.0202 0.0245 0.0236
Schistosoma mansoni nAChR subunit 0.0246 0.0315 0.0386
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0246 0.0315 0.0397
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0246 0.0315 0.0315
Echinococcus granulosus metabotropic glutamate receptor 5 0.0079 0.0046 0.0048
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0245 0.0299
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1362 0.2117 0.2609
Loa Loa (eye worm) hypothetical protein 0.0197 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus multilocularis transmembrane protease serine 3 0.0202 0.0245 0.0306
Onchocerca volvulus 0.0202 0.0245 0.1019
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0113 0.0101 0.0101
Toxoplasma gondii microneme protein MIC17A 0.0197 0.0237 0.0104
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0246 0.0315 0.0307
Echinococcus multilocularis integrin alpha ps 0.0983 0.1505 0.1938
Schistosoma mansoni hypothetical protein 0.0096 0.0073 0.0087
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.017 0.021
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.0325 0.0325
Brugia malayi follicle stimulating hormone receptor 0.0252 0.0325 0.0317
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0084 0.0055 0.5
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Loa Loa (eye worm) TYRA-2 protein 0.0252 0.0325 0.0325
Echinococcus multilocularis sex peptide receptor 0.0252 0.0325 0.041
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0113 0.0101 0.0092
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0246 0.0315 0.0315
Schistosoma mansoni hypothetical protein 0.0252 0.0325 0.0398
Onchocerca volvulus 0.0246 0.0315 0.1379
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0042 0.0049
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Echinococcus granulosus fibrillin 1 0.0176 0.0203 0.0252
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0252 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Brugia malayi PAN domain containing protein 0.0197 0.0237 0.0228
Echinococcus multilocularis kelch ECH associated protein 1 0.0096 0.0073 0.0083
Schistosoma mansoni tyrosine kinase 0.0078 0.0045 0.0052
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0315 0.0307
Loa Loa (eye worm) hypothetical protein 0.0197 0.0237 0.0237
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0252 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0176 0.0203 0.0203
Schistosoma mansoni nAChR subunit 0.0246 0.0315 0.0386
Onchocerca volvulus 0.0252 0.0325 0.1431
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0246 0.0315 0.0397
Toxoplasma gondii PAN domain-containing protein 0.2181 0.3438 1
Loa Loa (eye worm) hypothetical protein 0.0202 0.0245 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0252 0.0325 0.0398
Echinococcus granulosus rhodopsin orphan GPCR 0.0252 0.0325 0.041
Brugia malayi hypothetical protein 0.0252 0.0325 0.0317
Schistosoma mansoni voltage-gated potassium channel 0.0521 0.076 0.0935
Echinococcus multilocularis glycoprotein Antigen 5 0.0202 0.0245 0.0306
Echinococcus granulosus epidermal growth factor receptor 0.0088 0.006 0.0067
Echinococcus granulosus tm gpcr rhodopsin 0.0252 0.0325 0.041
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0245 0.0299
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0079 0.0046 0.0048
Leishmania major hypothetical protein, conserved 0.0321 0.0437 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0126 0.0122 0.0114
Loa Loa (eye worm) hypothetical protein 0.1389 0.2161 0.2161
Echinococcus granulosus neuropeptide receptor 0.0252 0.0325 0.041
Schistosoma mansoni hypothetical protein 0.0252 0.0325 0.0398
Schistosoma mansoni nAChR subunit 0.0113 0.0101 0.0122
Onchocerca volvulus 0.0197 0.0237 0.0979
Schistosoma mansoni nAChR subunit 0.0246 0.0315 0.0386
Brugia malayi Metabotropic glutamate receptor precursor. 0.0079 0.0046 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0252 0.0325 0.0398
Schistosoma mansoni nAChR subunit 0.0246 0.0315 0.0386
Toxoplasma gondii PAN domain-containing protein 0.0197 0.0237 0.0104
Echinococcus granulosus Mastin 0.0202 0.0245 0.0306
Schistosoma mansoni integrin alpha-4 0.0389 0.0546 0.0671
Toxoplasma gondii microneme protein MIC17C 0.0197 0.0237 0.0104
Brugia malayi hypothetical protein 0.0252 0.0325 0.0317
Echinococcus granulosus tm gpcr rhodopsin 0.0252 0.0325 0.041
Onchocerca volvulus 0.0835 0.1266 0.6249
Brugia malayi hypothetical protein 0.0252 0.0325 0.0317
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0133 0.0132 0.016
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0202 0.0245 0.0306
Echinococcus multilocularis neuropeptide receptor 0.0406 0.0574 0.0733
Echinococcus granulosus kelch ECH associated protein 1 0.0096 0.0073 0.0083
Brugia malayi G-protein coupled receptor 0.0252 0.0325 0.0317
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0246 0.0315 0.0397
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0246 0.0315 0.0307
Schistosoma mansoni serine-type protease inhibitor 0.5074 0.8106 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0246 0.0315 0.0397
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0017 0.0017
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0126 0.0122 0.0147
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0009 0.0000013485
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0252 0.0325 0.0317
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0126 0.0122 0.0147
Onchocerca volvulus 0.0215 0.0265 0.1125
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0252 0.0325 0.041
Echinococcus granulosus tyrosine kinase 0.0089 0.0061 0.0068
Echinococcus granulosus potassium voltage gated channel protein 0.0521 0.076 0.0974
Loa Loa (eye worm) ACC-1 protein 0.0246 0.0315 0.0315
Echinococcus granulosus biogenic amine 5HT receptor 0.0252 0.0325 0.041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0252 0.0325 0.0398
Echinococcus granulosus hypothetical protein 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0176 0.0203 0.0203
Echinococcus granulosus rhodopsin orphan GPCR 0.0252 0.0325 0.041
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0314 0.0426 0.054
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0521 0.076 0.0974
Brugia malayi putative neuropeptide receptor 0.0252 0.0325 0.0317
Loa Loa (eye worm) hypothetical protein 0.0314 0.0426 0.0426
Echinococcus multilocularis G-protein coupled receptor, putative 0.0252 0.0325 0.041
Loa Loa (eye worm) RGC/RGC protein kinase 0.0257 0.0333 0.0333
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0314 0.0426 0.054
Echinococcus granulosus neuropeptide Y receptor 0.0252 0.0325 0.041
Brugia malayi AKH receptor 0.0252 0.0325 0.0317
Brugia malayi metabotropic glutamate receptor type 2 0.0079 0.0046 0.0037
Brugia malayi RE15519p 0.0252 0.0325 0.0317
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0252 0.0325 0.041
Echinococcus multilocularis adam 0.0176 0.0203 0.0252
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0056 0.0047
Brugia malayi hypothetical protein 0.0252 0.0325 0.0317
Brugia malayi EGF-like domain containing protein 0.0176 0.0203 0.0195
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0252 0.0325 0.041
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0246 0.0315 0.0397
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Brugia malayi Trypsin family protein 0.1289 0.1998 0.1991
Brugia malayi PAN domain containing protein 0.0197 0.0237 0.0228
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0252 0.0325 0.0325
Echinococcus multilocularis serotonin receptor 0.0252 0.0325 0.041
Echinococcus granulosus glycine receptor subunit alpha 1 0.0246 0.0315 0.0397
Schistosoma mansoni tyrosine kinase 0.0078 0.0045 0.0052
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0079 0.0046 0.0048
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Schistosoma mansoni nAChR subunit 0.0246 0.0315 0.0386
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0056 0.0061
Onchocerca volvulus 0.0202 0.0245 0.1019
Schistosoma mansoni opsin-like receptor 0.0252 0.0325 0.0398
Onchocerca volvulus 0.0252 0.0325 0.1431
Toxoplasma gondii PAN/Apple domain-containing protein 0.0197 0.0237 0.0104
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Echinococcus granulosus integrin alpha ps 0.0441 0.0631 0.0806
Loa Loa (eye worm) hypothetical protein 0.0126 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0074 0.0037 0.0037
Brugia malayi PAN domain containing protein 0.0197 0.0237 0.0228
Schistosoma mansoni hypothetical protein 0.0321 0.0437 0.0536
Loa Loa (eye worm) hypothetical protein 0.0133 0.0132 0.0132
Toxoplasma gondii hypothetical protein 0.0197 0.0237 0.0104
Brugia malayi hypothetical protein 0.0113 0.0101 0.0092
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1034 0.1587 0.1587
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0133 0.0132 0.0124
Schistosoma mansoni nAChR subunit 0.0113 0.0101 0.0122
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0499 0.0723 0.0926
Onchocerca volvulus 0.0197 0.0237 0.0979
Echinococcus granulosus biogenic amine 5HT receptor 0.0252 0.0325 0.041
Echinococcus multilocularis integrin alpha ps 0.0441 0.0631 0.0806
Onchocerca volvulus 0.0252 0.0325 0.1431
Echinococcus multilocularis neuropeptide Y receptor 0.0252 0.0325 0.041
Giardia lamblia Neurogenic locus Notch protein precursor 0.0176 0.0203 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.091 0.1387 0.1387
Echinococcus granulosus fmrfamide receptor 0.0252 0.0325 0.041
Brugia malayi hypothetical protein 0.0252 0.0325 0.0317
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0079 0.0046 0.0048
Echinococcus multilocularis voltage dependent calcium channel 0.0126 0.0122 0.0147
Loa Loa (eye worm) hypothetical protein 0.0202 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.1 0.1532 0.1532
Echinococcus granulosus neuropeptide Y receptor 0.0252 0.0325 0.041
Echinococcus granulosus dro:myosuppressin receptor 0.0252 0.0325 0.041
Echinococcus multilocularis serotonin receptor 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0197 0.0237 0.0237
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0202 0.0245 0.0299
Brugia malayi Cation transporter family protein 0.0246 0.0315 0.0307
Brugia malayi hypothetical protein 0.0252 0.0325 0.0317
Onchocerca volvulus 0.0252 0.0325 0.1431
Loa Loa (eye worm) neuropeptide F receptor 0.0252 0.0325 0.0325
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Echinococcus granulosus tachykinin peptides receptor 99D 0.0252 0.0325 0.041
Brugia malayi G-protein coupled receptor 0.0252 0.0325 0.0317
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0126 0.0122 0.0147
Loa Loa (eye worm) hypothetical protein 0.0197 0.0237 0.0237
Toxoplasma gondii kringle domain-containing protein 0.0321 0.0437 0.0724
Loa Loa (eye worm) hypothetical protein 0.0079 0.0046 0.0046
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0056 0.0061
Onchocerca volvulus 0.0246 0.0315 0.1379
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0246 0.0315 0.0397
Loa Loa (eye worm) hypothetical protein 0.0079 0.0046 0.0046
Brugia malayi GnHR receptor homolog 0.0252 0.0325 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0252 0.0325 0.0398
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0079 0.0046 0.0046
Loa Loa (eye worm) PAN domain-containing protein 0.0197 0.0237 0.0237
Echinococcus granulosus g-protein coupled receptor 0.0252 0.0325 0.041
Plasmodium falciparum cysteine repeat modular protein 1 0.0321 0.0437 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0252 0.0325 0.0398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0252 0.0325 0.041
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0321 0.0437 0.5
Giardia lamblia Tenascin-X 0.0176 0.0203 0.5
Toxoplasma gondii PAN domain-containing protein 0.0197 0.0237 0.0104
Schistosoma mansoni histamine h1 receptor 0.0252 0.0325 0.0398
Schistosoma mansoni integrin alpha 0.1831 0.2873 0.3542
Schistosoma mansoni tyrosine kinase 0.0078 0.0045 0.0052
Loa Loa (eye worm) hypothetical protein 0.0133 0.0132 0.0132
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0202 0.0245 0.0236
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Echinococcus granulosus g protein coupled receptor 0.0252 0.0325 0.041
Brugia malayi Cation transporter family protein 0.0835 0.1266 0.1258
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0835 0.1266 0.1559
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Onchocerca volvulus 0.0252 0.0325 0.1431
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0252 0.0325 0.0317
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0252 0.0325 0.0398
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0133 0.0132 0.016
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0314 0.0426 0.0426
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0113 0.0101 0.012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0252 0.0325 0.0398
Schistosoma mansoni amine GPCR 0.0252 0.0325 0.0398
Echinococcus granulosus allatostatin A receptor 0.0252 0.0325 0.041
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0079 0.0046 0.0048
Schistosoma mansoni protein kinase 0.0257 0.0333 0.0408
Schistosoma mansoni neuropeptide F-like receptor 0.0252 0.0325 0.0398
Loa Loa (eye worm) calcium channel 0.0126 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0085 0.0056 0.0066
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Brugia malayi Kelch motif family protein 0.1034 0.1587 0.158
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Schistosoma mansoni hypothetical protein 0.0215 0.0265 0.0324
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0065 0.0023 0.0019
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0246 0.0315 0.0315
Echinococcus multilocularis neuropeptide s receptor 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0126 0.0122 0.0148
Echinococcus multilocularis dro:myosuppressin receptor 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0133 0.0132 0.0132
Onchocerca volvulus 0.0246 0.0315 0.1379
Onchocerca volvulus 0.0202 0.0245 0.1019
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0079 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Onchocerca volvulus Neuropeptide F receptor homolog 0.0252 0.0325 0.1431
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Echinococcus granulosus nAChR subunit 0.0133 0.0132 0.016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0113 0.0101 0.0092
Giardia lamblia High cysteine protein 0.0176 0.0203 0.5
Schistosoma mansoni neuropeptide receptor 0.0252 0.0325 0.0398
Schistosoma mansoni glutamate receptor NMDA 0.0079 0.0046 0.0053
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0252 0.0325 0.0325
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0079 0.0046 0.0048
Giardia lamblia High cysteine protein 0.0176 0.0203 0.5
Giardia lamblia Tenascin precursor 0.0176 0.0203 0.5
Loa Loa (eye worm) hypothetical protein 0.0176 0.0203 0.0203
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Echinococcus multilocularis Kelch repeat type 1 0.0096 0.0073 0.0083
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0252 0.0325 0.0325
Echinococcus multilocularis tissue type plasminogen activator 0.0321 0.0437 0.0555
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0315 0.0307
Toxoplasma gondii subtilisin SUB12 0.0197 0.0237 0.0104
Loa Loa (eye worm) hypothetical protein 0.0835 0.1266 0.1266
Entamoeba histolytica hypothetical protein 0.0133 0.0132 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0088 0.006 0.0067
Schistosoma mansoni nAChR subunit 0.0246 0.0315 0.0386
Onchocerca volvulus 0.0252 0.0325 0.1431
Schistosoma mansoni alpha-1 adrenergic receptor 0.0252 0.0325 0.0398
Schistosoma mansoni acetylcholine receptor subunit beta 0.0113 0.0101 0.0122
Schistosoma mansoni biogenic amine (5HT) receptor 0.0252 0.0325 0.0398
Loa Loa (eye worm) trypsin family protein 0.0202 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0197 0.0237 0.0237
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0236 0.03 0.0367
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0246 0.0315 0.0307
Loa Loa (eye worm) hypothetical protein 0.0062 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Echinococcus granulosus atrial natriuretic peptide receptor 0.0226 0.0284 0.0357
Onchocerca volvulus 0.0113 0.0101 0.0283
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0113 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0246 0.0315 0.0386
Brugia malayi CUB domain containing protein 0.0074 0.0037 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0252 0.0325 0.041
Echinococcus multilocularis g protein coupled receptor 0.0252 0.0325 0.041
Schistosoma mansoni integrin beta subunit 0.3839 0.6113 0.7541
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0074 0.0085
Schistosoma mansoni neuropeptide receptor 0.0406 0.0574 0.0705
Echinococcus granulosus somatostatin receptor 0.0252 0.0325 0.041
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0246 0.0315 0.0307
Loa Loa (eye worm) hypothetical protein 0.0079 0.0046 0.0046
Echinococcus multilocularis protein jagged 2 0.0176 0.0203 0.0252
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0245 0.0299
Echinococcus multilocularis tyrosine kinase 0.0089 0.0061 0.0068
Loa Loa (eye worm) TK/INSR protein kinase 0.0056 0.0009 0.0009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0315 0.0307
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0113 0.0101 0.0092
Schistosoma mansoni hypothetical protein 0.0252 0.0325 0.0398
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0246 0.0315 0.0315
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0257 0.0333 0.1472
Brugia malayi hypothetical protein 0.0113 0.0101 0.0092
Trichomonas vaginalis hypothetical protein 0.0176 0.0203 0.5
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Schistosoma mansoni metabotropic glutamate receptor 0.0079 0.0046 0.0053
Schistosoma mansoni neuropeptide receptor 0.0252 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0245 0.0299
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0252 0.0325 0.041
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0252 0.0325 0.041
Brugia malayi PAN domain containing protein 0.0197 0.0237 0.0228
Loa Loa (eye worm) hypothetical protein 0.0089 0.0061 0.0061
Echinococcus granulosus integrin alpha ps 0.0983 0.1505 0.1938
Schistosoma mansoni integrin alpha-ps 0.0542 0.0793 0.0975
Loa Loa (eye worm) glutamate receptor 0.0079 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0521 0.076 0.076
Brugia malayi hypothetical protein 0.0252 0.0325 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0252 0.0325 0.041
Onchocerca volvulus 0.0197 0.0237 0.0979
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0252 0.0325 0.041
Echinococcus multilocularis neuropeptide receptor 0.0252 0.0325 0.041
Echinococcus granulosus kelch ECH associated protein 1 like 0.0096 0.0073 0.0083
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0252 0.0325 0.041
Schistosoma mansoni metabotropic glutamate receptor 0.0079 0.0046 0.0053
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0246 0.0315 0.0307
Loa Loa (eye worm) ACC-1 protein 0.0246 0.0315 0.0315
Schistosoma mansoni acetylcholine receptor-related 0.0113 0.0101 0.0122
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0133 0.0132 0.0124
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0252 0.0325 0.0317
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0314 0.0426 0.054
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0079 0.0046 0.0048
Loa Loa (eye worm) hypothetical protein 0.0504 0.0731 0.0731
Loa Loa (eye worm) TK/EGFR protein kinase 0.0156 0.017 0.017
Brugia malayi PAN domain containing protein 0.0197 0.0237 0.0228
Schistosoma mansoni tyrosine kinase 0.0089 0.0061 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.0252 0.0325 0.041
Echinococcus multilocularis neuropeptides capa receptor 0.0252 0.0325 0.041
Echinococcus multilocularis glutamate receptor 2 0.0079 0.0046 0.0048
Loa Loa (eye worm) hypothetical protein 0.0133 0.0132 0.0132
Echinococcus granulosus enteropeptidase 0.0202 0.0245 0.0306
Brugia malayi Dopamine receptor 0.0252 0.0325 0.0317
Loa Loa (eye worm) RGC/RGC protein kinase 0.0109 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0246 0.0315 0.0386
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0056 0.0066
Toxoplasma gondii PAN domain-containing protein 0.0197 0.0237 0.0104
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0252 0.0325 0.041
Brugia malayi PAN domain containing protein 0.0197 0.0237 0.0228
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Echinococcus multilocularis integrin alpha 3 0.1351 0.2099 0.2709
Echinococcus granulosus neuropeptide FF receptor 2 0.0252 0.0325 0.041
Echinococcus granulosus rhodopsin orphan GPCR 0.0252 0.0325 0.041
Onchocerca volvulus 0.0197 0.0237 0.0979
Schistosoma mansoni biogenic amine receptor 0.0252 0.0325 0.0398
Loa Loa (eye worm) RGC/RGC protein kinase 0.0257 0.0333 0.0333
Schistosoma mansoni tyrosine kinase 0.0156 0.017 0.0207
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0079 0.0046 0.0048
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) DOMON domain-containing protein 0.0215 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0085 0.0056 0.0056
Echinococcus multilocularis orexin receptor type 2 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0202 0.0245 0.0245
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0246 0.0315 0.0397
Loa Loa (eye worm) hypothetical protein 0.1289 0.1998 0.1998
Brugia malayi EGF-like domain containing protein 0.0176 0.0203 0.0195
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0126 0.0122 0.0147
Brugia malayi Dopamine receptor protein 2 0.0252 0.0325 0.0317
Onchocerca volvulus 0.0197 0.0237 0.0979
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0079 0.0046 0.0048
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0113 0.0101 0.012
Toxoplasma gondii PAN domain-containing protein 0.2181 0.3438 1
Onchocerca volvulus 0.0133 0.0132 0.0444
Onchocerca volvulus 0.0252 0.0325 0.1431
Echinococcus multilocularis rhodopsin orphan GPCR 0.0252 0.0325 0.041
Echinococcus granulosus g protein coupled receptor 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0079 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0252 0.0325 0.0398
Echinococcus multilocularis g-protein coupled receptor 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Echinococcus granulosus neuropeptides capa receptor 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0246 0.0315 0.0315
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0246 0.0315 0.0386
Echinococcus multilocularis nAChR subunit 0.0133 0.0132 0.016
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0246 0.0315 0.0307
Schistosoma mansoni growth hormone secretagogue receptor 0.0252 0.0325 0.0398
Brugia malayi SEA domain containing protein 0.0215 0.0265 0.0257
Brugia malayi Receptor family ligand binding region containing protein 0.0257 0.0333 0.0325
Brugia malayi hypothetical protein 0.0252 0.0325 0.0317
Loa Loa (eye worm) hypothetical protein 0.1289 0.1998 0.1998
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0113 0.0101 0.0101
Brugia malayi hypothetical protein 0.0079 0.0046 0.0037
Brugia malayi Muscle positioning protein 4 0.0219 0.0272 0.0264
Echinococcus multilocularis fmrfamide receptor 0.0252 0.0325 0.041
Schistosoma mansoni amine GPCR 0.0252 0.0325 0.0398
Echinococcus multilocularis enteropeptidase 0.0202 0.0245 0.0306
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0246 0.0315 0.0386
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0126 0.0122 0.0148
Echinococcus multilocularis fibrillin 2 0.0176 0.0203 0.0252
Brugia malayi hypothetical protein 0.0113 0.0101 0.0092
Brugia malayi hypothetical protein 0.0252 0.0325 0.0317
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus granulosus glycoprotein Antigen 5 0.0202 0.0245 0.0306
Echinococcus granulosus metabotropic glutamate receptor 2 0.0079 0.0046 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0252 0.0325 0.041
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0314 0.0426 0.054
Echinococcus granulosus serotonin receptor 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0133 0.0132 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0252 0.0325 0.041
Brugia malayi Kringle domain containing protein 0.0321 0.0437 0.0429
Schistosoma mansoni hypothetical protein 0.0202 0.0245 0.0299
Schistosoma mansoni adenoreceptor 0.0252 0.0325 0.0398
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0252 0.0325 0.0317
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0009 0.0009
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0133 0.0132 0.0124
Loa Loa (eye worm) PAN domain-containing protein 0.0197 0.0237 0.0237
Loa Loa (eye worm) TK/ROR protein kinase 0.0331 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Schistosoma mansoni neurotransmitter gated ion channel 0.0113 0.0101 0.0122
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0252 0.0325 0.041
Schistosoma mansoni serine-type protease inhibitor 0.5074 0.8106 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0252 0.0325 0.0398
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0252 0.0325 0.041
Loa Loa (eye worm) hypothetical protein 0.0113 0.0101 0.0101
Onchocerca volvulus 0.0252 0.0325 0.1431
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0315 0.0307
Loa Loa (eye worm) hypothetical protein 0.0133 0.0132 0.0132
Brugia malayi G protein-coupled receptor F59B2.13 0.0252 0.0325 0.0317
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0252 0.0325 0.0398
Loa Loa (eye worm) hypothetical protein 0.0252 0.0325 0.0325
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0079 0.0046 0.0048
Brugia malayi excitatory GABA receptor EXP-1A 0.0246 0.0315 0.0307
Onchocerca volvulus 0.0252 0.0325 0.1431
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0252 0.0325 0.041
Brugia malayi putative neuropeptide receptor NPR1 0.0252 0.0325 0.0317
Onchocerca volvulus 0.0215 0.0265 0.1125
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0252 0.0325 0.0398
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0252 0.0325 0.0398
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0202 0.0245 0.0306

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 4.1 % Inhibition of histamine -induced dermal vascular permeability in rats at a peroral dose of 100 mg/kg 1 hr prior to challenge ChEMBL. 3172125
Inhibition (functional) = 9.7 % Inhibition of serotonin -induced dermal vascular permeability in rats at a peroral dose of 100 mg/kg 1 hr prior to challenge ChEMBL. 3172125
Inhibition (functional) = 40 % Inhibition of bradykinin-induced dermal vascular permeability in rats at a peroral dose of 100 mg/kg 1 hr prior to challenge ChEMBL. 3172125

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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