Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0189 | 0.9587 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0193 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0193 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0189 | 0.9587 | 0.9587 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Echinococcus granulosus | cysteine protease | 0.0106 | 0.1875 | 0.1875 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0124 | 0.3544 | 0.2164 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0106 | 0.1875 | 0.1697 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0189 | 0.9587 | 0.9587 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0189 | 0.9587 | 0.9587 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0189 | 0.9587 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0189 | 0.9587 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3544 | 0.3544 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0193 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1875 | 0.1772 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0088 | 0.0214 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0189 | 0.9587 | 0.9587 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0106 | 0.1875 | 0.1875 |
Onchocerca volvulus | 0.0189 | 0.9587 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0189 | 0.9587 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0106 | 0.1875 | 0.1875 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.9587 | 0.9587 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0189 | 0.9587 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0189 | 0.9587 | 0.9587 |
Onchocerca volvulus | 0.0189 | 0.9587 | 1 | |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0124 | 0.3544 | 0.3544 |
Leishmania major | cathepsin L-like protease | 0.0189 | 0.9587 | 1 |
Leishmania major | cathepsin L-like protease | 0.0189 | 0.9587 | 1 |
Leishmania major | cathepsin L-like protease | 0.0189 | 0.9587 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0106 | 0.1875 | 0.1875 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0106 | 0.1875 | 0.1875 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0189 | 0.9587 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Echinococcus granulosus | cathepsin L | 0.0106 | 0.1875 | 0.1875 |
Onchocerca volvulus | 0.0189 | 0.9587 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Onchocerca volvulus | 0.0189 | 0.9587 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0189 | 0.9587 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0106 | 0.1875 | 0.1697 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0189 | 0.9587 | 0.9578 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0189 | 0.9587 | 0.9578 |
Onchocerca volvulus | 0.0189 | 0.9587 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1875 | 0.1772 |
Onchocerca volvulus | 0.0189 | 0.9587 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.3544 | 0.3544 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0106 | 0.1875 | 0.1697 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0106 | 0.1875 | 0.1875 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0189 | 0.9587 | 0.9587 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3544 | 0.3544 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0189 | 0.9587 | 0.9578 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0189 | 0.9587 | 0.9587 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0106 | 0.1875 | 0.1697 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0193 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3544 | 0.3553 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0189 | 0.9587 | 0.9587 |
Loa Loa (eye worm) | cathepsin B | 0.0088 | 0.0214 | 0.0214 |
Leishmania major | cysteine peptidase A (CPA) | 0.0189 | 0.9587 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0189 | 0.9587 | 0.9587 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0189 | 0.9587 | 0.9587 |
Echinococcus granulosus | cathepsin b | 0.0193 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0193 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.1875 | 0.1772 |
Brugia malayi | Cathepsin L-like precursor | 0.0189 | 0.9587 | 0.9587 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0193 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0189 | 0.9587 | 0.9587 |
Brugia malayi | Cathepsin L-like precursor | 0.0189 | 0.9587 | 0.9587 |
Leishmania major | cathepsin L-like protease | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0189 | 0.9587 | 0.9578 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0124 | 0.3544 | 0.3544 |
Toxoplasma gondii | cathepsin B | 0.0088 | 0.0214 | 0.0223 |
Brugia malayi | cathepsin L-like precursor | 0.0124 | 0.3544 | 0.3544 |
Brugia malayi | Cathepsin L-like precursor | 0.0189 | 0.9587 | 0.9587 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0088 | 0.0214 | 0.0214 |
Onchocerca volvulus | Cathepsin L homolog | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Leishmania major | cathepsin L-like protease | 0.0189 | 0.9587 | 1 |
Schistosoma mansoni | amine GPCR | 0.0165 | 0.7354 | 0.7354 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0193 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0189 | 0.9587 | 0.9587 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0124 | 0.3544 | 0.3403 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0106 | 0.1875 | 0.1697 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Onchocerca volvulus | 0.0124 | 0.3544 | 0.3697 | |
Giardia lamblia | Cathepsin B precursor | 0.0088 | 0.0214 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0106 | 0.1875 | 0.1772 |
Echinococcus granulosus | cathepsin l1 | 0.0124 | 0.3544 | 0.3544 |
Leishmania major | cathepsin L-like protease | 0.0189 | 0.9587 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3544 | 0.3544 |
Brugia malayi | Cathepsin L-like precursor | 0.0189 | 0.9587 | 0.9587 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0106 | 0.1875 | 0.1875 |
Onchocerca volvulus | Cathepsin F homolog | 0.0189 | 0.9587 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0189 | 0.9587 | 0.9587 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.3544 | 0.3553 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0189 | 0.9587 | 0.9587 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0106 | 0.1875 | 0.1875 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Plasmodium vivax | vivapain-2 | 0.0189 | 0.9587 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.3544 | 0.3544 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0189 | 0.9587 | 1 |
Onchocerca volvulus | 0.0189 | 0.9587 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0189 | 0.9587 | 0.9587 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0189 | 0.9587 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0189 | 0.9587 | 0.9587 |
Leishmania major | cathepsin L-like protease | 0.0189 | 0.9587 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0189 | 0.9587 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0189 | 0.9587 | 0.9587 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0189 | 0.9587 | 0.9578 |
Echinococcus multilocularis | cysteine protease | 0.0189 | 0.9587 | 0.9587 |
Echinococcus multilocularis | cysteine protease | 0.0189 | 0.9587 | 0.9587 |
Giardia lamblia | Cathepsin B precursor | 0.0088 | 0.0214 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0193 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.