Detailed information for compound 833912

Basic information

Technical information
  • TDR Targets ID: 833912
  • Name: N-(4-methoxyphenyl)-3-(1,3,4,6-tetramethylpyr azolo[4,5-e]pyridin-5-yl)propanamide
  • MW: 352.43 | Formula: C20H24N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)CCc1c(C)nc2c(c1C)c(C)nn2C
  • InChi: 1S/C20H24N4O2/c1-12-17(13(2)21-20-19(12)14(3)23-24(20)4)10-11-18(25)22-15-6-8-16(26-5)9-7-15/h6-9H,10-11H2,1-5H3,(H,22,25)
  • InChiKey: FCVFEZAIIOZGSO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-methoxyphenyl)-3-(1,3,4,6-tetramethyl-5-pyrazolo[4,5-e]pyridinyl)propanamide
  • N-(4-methoxyphenyl)-3-(1,3,4,6-tetramethylpyrazolo[4,5-e]pyridin-5-yl)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0048 0.046 0.5
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0048 0.046 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0024 0.0067 0.0143
Echinococcus granulosus semaphorin 5B 0.0074 0.088 0.088
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0048 0.0455 0.0455
Brugia malayi hypothetical protein 0.0074 0.088 0.1885
Loa Loa (eye worm) SRC-1 0.0024 0.0067 0.0143
Entamoeba histolytica cell surface protease gp63, putative 0.0032 0.0197 0.4246
Loa Loa (eye worm) sema domain-containing protein 0.0074 0.088 0.1885
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0048 0.046 0.0984
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.2066 0.2066
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0304 0.467 0.467
Echinococcus multilocularis transcription factor collier 0.0032 0.0197 0.0422
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0024 0.0067 0.0067
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.046 0.5
Onchocerca volvulus 0.0153 0.2181 0.8473
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0048 0.046 0.046
Echinococcus multilocularis 0.0038 0.0288 0.0618
Schistosoma mansoni tyrosine kinase 0.0024 0.0067 0.0143
Brugia malayi Fibronectin type III domain containing protein 0.0045 0.04 0.0856
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0067 0.0067
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.046 1
Onchocerca volvulus 0.0177 0.2575 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0498 0.1067
Schistosoma mansoni tyrosine kinase 0.0129 0.1799 0.3852
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0024 0.0067 0.0143
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0024 0.0067 0.0067
Brugia malayi Plexin repeat family protein 0.0177 0.2575 0.5513
Loa Loa (eye worm) hypothetical protein 0.0048 0.0455 0.0974
Loa Loa (eye worm) hypothetical protein 0.0032 0.0197 0.0422
Echinococcus multilocularis tyrosine protein kinase Abl 0.0024 0.0067 0.0143
Onchocerca volvulus 0.0074 0.088 0.3419
Schistosoma mansoni hypothetical protein 0.0032 0.0197 0.0422
Loa Loa (eye worm) TK/INSR protein kinase 0.0304 0.467 1
Schistosoma mansoni plexin 0.0177 0.2575 0.5513
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0024 0.0067 0.0143
Loa Loa (eye worm) hypothetical protein 0.0074 0.088 0.1885
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.046 0.0984
Brugia malayi DNA-binding protein LAG-1 0.0032 0.0197 0.0422
Brugia malayi Probable exocyst complex component Sec5 0.0032 0.0197 0.0422
Loa Loa (eye worm) hypothetical protein 0.0045 0.04 0.0856
Loa Loa (eye worm) hypothetical protein 0.0045 0.04 0.0856
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0024 0.0067 0.0067
Brugia malayi Immunoglobulin I-set domain containing protein 0.0217 0.3239 0.6937
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.04 0.0856
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0146 0.2066 0.2066
Brugia malayi Protein kinase domain containing protein 0.0304 0.467 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0024 0.0067 0.0143
Echinococcus multilocularis exocyst complex component 2 0.0032 0.0197 0.0422
Schistosoma mansoni tyrosine kinase 0.0304 0.467 1
Brugia malayi plexin A 0.0209 0.3107 0.6654
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0024 0.0067 0.0143
Echinococcus multilocularis semaphorin 5B 0.0074 0.088 0.1885
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.046 0.0984
Echinococcus granulosus cyclin dependent kinase 1 0.0048 0.046 0.046
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0024 0.0067 0.0143
Schistosoma mansoni plexin 0.0103 0.1359 0.2909
Schistosoma mansoni hypothetical protein 0.0074 0.088 0.1885
Schistosoma mansoni serine/threonine protein kinase 0.02 0.2957 0.6332
Echinococcus granulosus defective proboscis extension response 0.0045 0.04 0.04
Brugia malayi hypothetical protein 0.0074 0.088 0.1885
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.046 0.5
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.4246
Giardia lamblia Kinase, CMGC CDK 0.0048 0.046 0.5
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.046 0.0984
Schistosoma mansoni cell adhesion molecule 0.0048 0.0455 0.0974
Brugia malayi Sema domain containing protein 0.0074 0.088 0.1885
Loa Loa (eye worm) hypothetical protein 0.0045 0.04 0.0856
Brugia malayi Sema domain containing protein 0.0074 0.088 0.1885
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0217 0.3239 0.6937
Schistosoma mansoni tyrosine kinase 0.0024 0.0067 0.0143
Brugia malayi hypothetical protein 0.0045 0.04 0.0856
Schistosoma mansoni tyrosine kinase 0.0024 0.0067 0.0143
Echinococcus granulosus roundabout 2 0.0051 0.0498 0.0498
Echinococcus granulosus tyrosine protein kinase Src42A 0.0024 0.0067 0.0067
Schistosoma mansoni fibrocystin l 0.0032 0.0197 0.0422
Echinococcus multilocularis Immunoglobulin 0.0045 0.04 0.0856
Loa Loa (eye worm) hypothetical protein 0.0103 0.1359 0.2909
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.046 0.9902
Giardia lamblia Kinase, CMGC CDK 0.0048 0.046 0.5
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.02 0.2957 0.6332
Brugia malayi map kinase activated protein kinase protein 2 0.02 0.2957 0.6332
Echinococcus multilocularis neuroglian 0.0047 0.0443 0.0949
Schistosoma mansoni hypothetical protein 0.0103 0.1359 0.2909
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0024 0.0067 0.0143
Schistosoma mansoni tyrosine kinase 0.0304 0.467 1
Echinococcus multilocularis cyclin dependent kinase 0.0048 0.046 0.0984
Schistosoma mansoni tyrosine kinase 0.0129 0.1799 0.3852
Echinococcus multilocularis plexin a4 0.0209 0.3107 0.6654
Echinococcus granulosus insulin receptor 0.0304 0.467 0.467
Echinococcus granulosus neuroglian 0.0047 0.0443 0.0443
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.4246
Loa Loa (eye worm) hypothetical protein 0.0051 0.0498 0.1067
Schistosoma mansoni tyrosine kinase 0.0022 0.003 0.0064
Schistosoma mansoni tyrosine kinase 0.0146 0.2066 0.4424
Brugia malayi SRC-1 0.0024 0.0067 0.0143
Schistosoma mansoni tyrosine kinase 0.0146 0.2066 0.4424
Entamoeba histolytica tyrosin kinase, putative 0.0049 0.0464 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.04 0.0856
Brugia malayi IPT/TIG domain containing protein 0.0032 0.0197 0.0422
Schistosoma mansoni hypothetical protein 0.0074 0.088 0.1885
Echinococcus multilocularis cyclin dependent kinase 5 0.0048 0.046 0.0984
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.046 0.0984
Plasmodium vivax protein kinase Crk2 0.0048 0.046 0.5
Schistosoma mansoni hypothetical protein 0.0032 0.0197 0.0422
Schistosoma mansoni semaphorin 5-related 0.0074 0.088 0.1885
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0045 0.04 0.0856
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0048 0.046 0.5
Plasmodium falciparum protein kinase 5 0.0048 0.046 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.046 1
Echinococcus multilocularis insulin receptor 0.0304 0.467 1
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.046 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0067 0.0143
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.2066 0.4424
Echinococcus granulosus c src tyrosine kinase 0.0024 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0074 0.088 0.1885
Loa Loa (eye worm) hypothetical protein 0.0045 0.04 0.0856
Loa Loa (eye worm) hypothetical protein 0.0032 0.0197 0.0422
Loa Loa (eye worm) hypothetical protein 0.0158 0.2268 0.4857
Brugia malayi Protein kinase domain containing protein 0.0048 0.046 0.0984
Loa Loa (eye worm) hypothetical protein 0.0074 0.088 0.1885
Schistosoma mansoni nephrin 0.0047 0.0443 0.0949
Echinococcus multilocularis hypothetical protein 0.0074 0.088 0.1885
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.4246
Echinococcus granulosus cyclin dependent kinase 5 0.0048 0.046 0.046
Schistosoma mansoni tyrosine kinase 0.0024 0.0067 0.0143
Trypanosoma brucei cdc2-related kinase 3 0.0048 0.046 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.2066 0.4424
Echinococcus granulosus Immunoglobulin 0.0045 0.04 0.04
Echinococcus granulosus transcription factor collier 0.0032 0.0197 0.0197
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0067 0.0067
Echinococcus multilocularis c src tyrosine kinase 0.0024 0.0067 0.0143
Echinococcus granulosus tyrosine protein kinase Lyn 0.0025 0.0084 0.0084
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0024 0.0067 0.0143
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.046 0.5
Loa Loa (eye worm) hypothetical protein 0.0177 0.2575 0.5513
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.2066 0.4424
Schistosoma mansoni tyrosine kinase 0.0146 0.2066 0.4424
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.046 0.0984
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0067 0.0067
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0045 0.04 0.0856
Loa Loa (eye worm) sema domain-containing protein 0.0074 0.088 0.1885
Loa Loa (eye worm) hypothetical protein 0.0032 0.0197 0.0422
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0024 0.0067 0.0143
Schistosoma mansoni vesicular amine transporter 0.0045 0.04 0.0856
Schistosoma mansoni tyrosine kinase 0.0129 0.1799 0.3852
Loa Loa (eye worm) hypothetical protein 0.0074 0.088 0.1885
Echinococcus multilocularis roundabout 2 0.0051 0.0498 0.1067
Loa Loa (eye worm) hypothetical protein 0.0074 0.088 0.1885
Loa Loa (eye worm) hypothetical protein 0.0045 0.04 0.0856
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0067 0.0143
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0045 0.04 0.0856
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.046 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.046 0.0984
Brugia malayi cell division control protein 2 homolog 0.0048 0.046 0.0984
Loa Loa (eye worm) plexin A 0.0209 0.3107 0.6654
Echinococcus granulosus tyrosine protein kinase Src64B 0.0024 0.0067 0.0067
Trypanosoma brucei cdc2-related kinase 1 0.0048 0.046 0.5
Echinococcus granulosus MAP kinase activated protein kinase 2 0.02 0.2957 0.2957
Echinococcus granulosus cyclin dependent kinase 0.0048 0.046 0.046
Echinococcus granulosus semaphorin 1A 0.0074 0.088 0.088
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.02 0.2957 0.6332
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.4246
Loa Loa (eye worm) hypothetical protein 0.0032 0.0197 0.0422
Loa Loa (eye worm) hypothetical protein 0.0074 0.088 0.1885
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.2066 0.2066
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0464 1
Echinococcus granulosus exocyst complex component 2 0.0032 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0047 0.0443 0.0948
Brugia malayi Protein kinase domain containing protein 0.0174 0.2535 0.5429
Echinococcus granulosus plexin a4 0.0209 0.3107 0.3107
Echinococcus granulosus twitchin 0.0048 0.046 0.046
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.046 0.9902
Echinococcus multilocularis Immunoglobulin 0.0045 0.04 0.0856
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0304 0.467 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0067 0.0143
Onchocerca volvulus Tyrosine kinase homolog 0.0172 0.2492 0.9679
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.2066 0.4424

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.