Detailed information for compound 834145

Basic information

Technical information
  • TDR Targets ID: 834145
  • Name: 2-(2-methoxyphenyl)-N-[[3-(4-methylphenyl)-1, 2,4-oxadiazol-5-yl]methyl]-N-propan-2-ylaceta mide
  • MW: 379.452 | Formula: C22H25N3O3
  • H donors: 0 H acceptors: 3 LogP: 3.86 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CC(=O)N(C(C)C)Cc1onc(n1)c1ccc(cc1)C
  • InChi: 1S/C22H25N3O3/c1-15(2)25(21(26)13-18-7-5-6-8-19(18)27-4)14-20-23-22(24-28-20)17-11-9-16(3)10-12-17/h5-12,15H,13-14H2,1-4H3
  • InChiKey: WLMCXRXJHDTEGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-isopropyl-2-(2-methoxyphenyl)-N-[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]acetamide
  • 2-(2-methoxyphenyl)-N-[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-propan-2-yl-ethanamide
  • ZINC04850514
  • STK300666

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0065 0.1781 1
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0139 0.4334 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0165 0.0165
Leishmania major GTP-binding protein, putative 0.0021 0.0247 0.0197
Echinococcus multilocularis Niemann Pick C1 protein 0.0057 0.1505 0.1505
Trichomonas vaginalis ran, putative 0.0021 0.0247 0.0508
Schistosoma mansoni tar DNA-binding protein 0.0063 0.17 0.1637
Echinococcus granulosus sterol regulatory element binding protein 0.0057 0.1505 0.1505
Echinococcus multilocularis musashi 0.0028 0.0509 0.0509
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0139 0.4334 0.4334
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0139 0.4334 1
Schistosoma mansoni ran 0.0021 0.0247 0.0174
Schistosoma mansoni hypothetical protein 0.0302 1 1
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0139 0.4334 1
Brugia malayi RNA binding protein 0.0063 0.17 0.3848
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0139 0.4334 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 1 1
Schistosoma mansoni lamin 0.0028 0.0509 0.0437
Brugia malayi intermediate filament protein 0.0028 0.0509 0.1067
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0321 0.0963
Echinococcus multilocularis snurportin 1 0.0302 1 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0509 0.0509
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0075 0.0054
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0065 0.1781 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.17 0.1637
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0075 0.0075
Brugia malayi hypothetical protein 0.0129 0.3994 0.9205
Echinococcus multilocularis protein dispatched 1 0.0057 0.1505 0.1505
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0139 0.4334 0.4291
Brugia malayi Importin beta-1 subunit 0.0028 0.0507 0.1061
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0165 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0713 0.0713
Loa Loa (eye worm) RNA binding protein 0.0063 0.17 0.17
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0247 0.0508
Entamoeba histolytica hypothetical protein 0.0023 0.0321 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.17 0.1637
Loa Loa (eye worm) hypothetical protein 0.0028 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0034 0.0713 0.0643
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0165 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0075
Brugia malayi RNA, U transporter 1 0.0081 0.2316 0.5286
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1263 0.1263
Echinococcus granulosus lamin 0.0028 0.0509 0.0509
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0321 0.0373
Plasmodium vivax importin-beta 2, putative 0.0028 0.0507 1
Brugia malayi CHE-14 protein 0.0057 0.1505 0.3393
Echinococcus multilocularis lamin dm0 0.0028 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0129 0.3994 0.3994
Echinococcus multilocularis sterol regulatory element binding protein 0.0057 0.1505 0.1505
Schistosoma mansoni lamin 0.0028 0.0509 0.0437
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0165 0.0264
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0247 0.2408
Loa Loa (eye worm) hypothetical protein 0.0057 0.1505 0.1505
Schistosoma mansoni ap endonuclease 0.0018 0.0165 0.0091
Loa Loa (eye worm) hypothetical protein 0.0028 0.0491 0.0491
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0247 0.2408
Echinococcus granulosus lamin dm0 0.0028 0.0509 0.0509
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0075 0.0075
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0507 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.1505 0.8291
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0165 0.0165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1263 0.2828
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0139 0.4334 0.4334
Echinococcus granulosus Niemann Pick C1 protein 0.0057 0.1505 0.1505
Schistosoma mansoni intermediate filament proteins 0.0028 0.0509 0.0437
Echinococcus granulosus Protein patched homolog 1 0.0057 0.1505 0.1505
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0247 0.0197
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0028 0.0509 0.0509
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0507 0.0819
Schistosoma mansoni ap endonuclease 0.0018 0.0165 0.0091
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0247 0.0197
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0509 0.1067
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0321 0.0963
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0052 0.0052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0075 0.0054
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0065 0.1781 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.17 0.17
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0247 0.0247
Echinococcus granulosus importin subunit beta 1 0.0028 0.0507 0.0507
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0247 0.0197
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0139 0.4334 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0075 0.0075
Plasmodium falciparum importin beta, putative 0.0028 0.0507 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.17 0.17
Echinococcus granulosus tar DNA binding protein 0.0063 0.17 0.17
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0057 0.1505 0.1505
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0507 0.0819
Schistosoma mansoni ran 0.0021 0.0247 0.0174
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0321 0.0963
Leishmania major importin beta-1 subunit, putative 0.0023 0.0321 0.0373
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0057 0.1505 0.1441
Echinococcus multilocularis lamin 0.0028 0.0509 0.0509
Schistosoma mansoni patched 1 0.0057 0.1505 0.1441
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0247 0.0456
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0507 0.0507
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0075 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0063 0.17 0.1637
Echinococcus granulosus intermediate filament protein 0.0028 0.0509 0.0509
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0165 0.0165
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0139 0.4334 1
Schistosoma mansoni importin beta-1 0.0028 0.0507 0.0435
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0713 0.1544
Schistosoma mansoni tar DNA-binding protein 0.0063 0.17 0.1637
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.17 0.3848
Brugia malayi TAR-binding protein 0.0063 0.17 0.3848
Entamoeba histolytica Ran family GTPase 0.0021 0.0247 0.5279
Loa Loa (eye worm) hypothetical protein 0.0129 0.3994 0.3994
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0247 0.0247
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0065 0.1781 1
Onchocerca volvulus Huntingtin homolog 0.0129 0.3994 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0509 0.0509
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0075 0.0075
Echinococcus multilocularis protein patched 0.0057 0.1505 0.1505
Loa Loa (eye worm) hypothetical protein 0.005 0.1263 0.1263
Onchocerca volvulus Huntingtin homolog 0.0129 0.3994 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1263 0.2828
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0165 0.5
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0139 0.4334 0.4334
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0247 0.2408
Echinococcus granulosus GPCR family 2 0.0016 0.0075 0.0075
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.17 0.17

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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