Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Cathepsin F homolog | 0.0121 | 0.6833 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0121 | 0.6833 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Onchocerca volvulus | 0.0121 | 0.6833 | 1 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0121 | 0.6833 | 0.6833 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0121 | 0.6833 | 0.6833 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0039 | 0.0915 | 0.0915 |
Onchocerca volvulus | 0.0121 | 0.6833 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0069 | 0.3093 | 0.0794 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0121 | 0.6833 | 0.6833 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0065 | 0.277 | 0.277 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.6833 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0069 | 0.3093 | 0.5778 |
Echinococcus multilocularis | cysteine protease | 0.0121 | 0.6833 | 0.6833 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.277 | 0.4054 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0101 | 0.5353 | 0.5353 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.6833 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1688 | 0.1688 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0065 | 0.277 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0065 | 0.277 | 0.277 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0915 | 0.0915 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0121 | 0.6833 | 0.6833 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0101 | 0.5353 | 0.7834 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0069 | 0.3093 | 0.3093 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.6833 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0083 | 0.4063 | 0.4063 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.6833 | 0.6833 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0065 | 0.277 | 0.277 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Echinococcus granulosus | cysteine protease | 0.0065 | 0.277 | 0.277 |
Plasmodium vivax | unspecified product | 0.0039 | 0.0915 | 0.1338 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0101 | 0.5353 | 0.5353 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.277 | 0.277 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0121 | 0.6833 | 0.6833 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Toxoplasma gondii | cathepsin B | 0.0069 | 0.3093 | 0.4526 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0121 | 0.6833 | 0.6833 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0083 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0121 | 0.6833 | 0.6833 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0069 | 0.3093 | 0.5778 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0065 | 0.277 | 0.277 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.6833 | 0.6833 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Toxoplasma gondii | cathepsin CPL | 0.0121 | 0.6833 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0083 | 0.4063 | 0.5946 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0039 | 0.0915 | 0.0915 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0101 | 0.5353 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0121 | 0.6833 | 0.6833 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0065 | 0.277 | 0.277 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1688 | 0.1688 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0083 | 0.4063 | 0.5946 |
Onchocerca volvulus | 0.0121 | 0.6833 | 1 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0039 | 0.0915 | 0.0915 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.1688 | 0.1688 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0101 | 0.5353 | 0.5353 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0101 | 0.5353 | 0.7834 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0065 | 0.277 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0121 | 0.6833 | 0.6833 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0121 | 0.6833 | 0.6833 |
Echinococcus granulosus | cathepsin l1 | 0.0121 | 0.6833 | 0.6833 |
Brugia malayi | Cathepsin L-like precursor | 0.0083 | 0.4063 | 0.4063 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0083 | 0.4063 | 0.4063 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.6833 | 0.6833 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.4063 | 0.4063 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0083 | 0.4063 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5353 | 0.5353 |
Echinococcus granulosus | cathepsin b | 0.0166 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0121 | 0.6833 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 1 | 1 |
Plasmodium vivax | vivapain-3 | 0.0065 | 0.277 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Onchocerca volvulus | 0.0121 | 0.6833 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0166 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0101 | 0.5353 | 0.7834 |
Plasmodium vivax | vivapain-2 | 0.0121 | 0.6833 | 1 |
Onchocerca volvulus | 0.0083 | 0.4063 | 0.5946 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0101 | 0.5353 | 0.6043 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0065 | 0.277 | 0.277 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0915 | 0.0915 |
Giardia lamblia | Cathepsin B precursor | 0.0069 | 0.3093 | 0.5778 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0101 | 0.5353 | 0.5353 |
Echinococcus granulosus | cathepsin l1 | 0.0083 | 0.4063 | 0.4063 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0069 | 0.3093 | 0.3093 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.6833 | 0.6833 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0101 | 0.5353 | 0.7834 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.6833 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0065 | 0.277 | 0.4054 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0101 | 0.5353 | 0.7834 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0121 | 0.6833 | 0.6833 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0121 | 0.6833 | 1 |
Onchocerca volvulus | 0.0121 | 0.6833 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0069 | 0.3093 | 0.4526 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0101 | 0.5353 | 0.5353 |
Plasmodium vivax | unspecified product | 0.0065 | 0.277 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.6833 | 0.6833 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1688 | 0.1688 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0039 | 0.0915 | 0.0915 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0121 | 0.6833 | 0.6833 |
Loa Loa (eye worm) | cysteine protease | 0.0121 | 0.6833 | 0.6833 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0065 | 0.277 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Echinococcus granulosus | cathepsin L | 0.0065 | 0.277 | 0.277 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.6833 | 0.6833 |
Echinococcus multilocularis | cathepsin L | 0.0065 | 0.277 | 0.277 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0065 | 0.277 | 0.277 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0121 | 0.6833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.6833 | 0.6833 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0101 | 0.5353 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0039 | 0.0915 | 0.0915 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.1688 | 0.1688 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0121 | 0.6833 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Onchocerca volvulus | 0.0121 | 0.6833 | 1 | |
Schistosoma mansoni | cathepsin s | 0.0039 | 0.0915 | 0.0915 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0039 | 0.0915 | 0.0915 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0121 | 0.6833 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0083 | 0.4063 | 0.4063 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0101 | 0.5353 | 0.5353 |
Plasmodium vivax | vivapain-1 | 0.0065 | 0.277 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0065 | 0.277 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0065 | 0.277 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0101 | 0.5353 | 0.6043 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1688 | 0.1688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0083 | 0.4063 | 0.4063 |
Onchocerca volvulus | 0.0121 | 0.6833 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.6833 | 0.6833 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.4063 | 0.4063 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0101 | 0.5353 | 0.6357 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0101 | 0.5353 | 0.5353 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.4063 | 0.4063 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.6833 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0065 | 0.277 | 0.277 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0065 | 0.277 | 0.4054 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1688 | 0.1688 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0101 | 0.5353 | 0.5353 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0101 | 0.5353 | 0.5 |
Loa Loa (eye worm) | fibroinase | 0.0121 | 0.6833 | 0.6833 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.6833 | 0.6833 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0121 | 0.6833 | 0.6833 |
Brugia malayi | Cathepsin L-like precursor | 0.0121 | 0.6833 | 0.6833 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0121 | 0.6833 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0101 | 0.5353 | 0.7834 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0065 | 0.277 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0915 | 0.0915 |
Onchocerca volvulus | Cathepsin L homolog | 0.0121 | 0.6833 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0101 | 0.5353 | 0.5353 |
Plasmodium vivax | vivapain-2 | 0.0121 | 0.6833 | 1 |
Echinococcus granulosus | cathepsin b | 0.0166 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.6833 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0121 | 0.6833 | 0.6833 |
Leishmania major | cysteine peptidase A (CPA) | 0.0121 | 0.6833 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0166 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.6833 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0101 | 0.5353 | 0.7834 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0121 | 0.6833 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1688 | 0.1688 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0101 | 0.5353 | 0.7834 |
Loa Loa (eye worm) | ctsf protein | 0.0121 | 0.6833 | 0.6833 |
Trypanosoma cruzi | cysteine protease, putative | 0.0065 | 0.277 | 0.277 |
Leishmania major | cathepsin L-like protease | 0.0121 | 0.6833 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0069 | 0.3093 | 0.3093 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0065 | 0.277 | 0.277 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0121 | 0.6833 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0065 | 0.277 | 0.4054 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.