Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Plasmodium falciparum | potassium channel | 0.009 | 0.0271 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog | 0.009 | 0.0271 | 0.7358 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.0114 | 0.0114 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0084 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Schistosoma mansoni | twik family of potassium channels-related | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Plasmodium vivax | potassium channel, putative | 0.009 | 0.0271 | 1 |
Leishmania major | ion transport protein-like protein | 0.009 | 0.0271 | 1 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.009 | 0.0271 | 0.0271 |
Echinococcus multilocularis | twik family of potassium channels | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.0352 | 0.8342 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 45 | 0.009 | 0.0271 | 0.7358 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.009 | 0.0271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0877 | 0.327 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Schistosoma mansoni | twik family of potassium channels-related | 0.009 | 0.0271 | 0.0271 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.009 | 0.0271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0368 | 1 |
Schistosoma mansoni | twik family of potassium channels-related | 0.009 | 0.0271 | 0.0271 |
Leishmania major | hypothetical protein, conserved | 0.009 | 0.0271 | 1 |
Loa Loa (eye worm) | S-phase kinase-associated protein 1A | 0.009 | 0.0271 | 0.0271 |
Echinococcus multilocularis | potassium channel subfamily K | 0.009 | 0.0271 | 0.0271 |
Plasmodium vivax | potassium channel, putative | 0.009 | 0.0271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Giardia lamblia | Hypothetical protein | 0.009 | 0.0271 | 0.5 |
Echinococcus granulosus | TWiK family of potassium channels protein 7 | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Trypanosoma cruzi | ion transport protein, putative | 0.009 | 0.0271 | 1 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.009 | 0.0271 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 21 | 0.009 | 0.0271 | 0.7358 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.0114 | 0.0114 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.009 | 0.0271 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0084 | 0.0246 | 0.6688 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 0.009 | 0.0271 | 0.0271 |
Leishmania major | hypothetical protein, conserved | 0.009 | 0.0271 | 1 |
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | uncoordinated protein 58 | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 39A | 0.009 | 0.0271 | 0.7358 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0124 | 0.04 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog | 0.009 | 0.0271 | 0.7358 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.009 | 0.0271 | 0.5498 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Leishmania major | potassium channel subunit-like protein | 0.009 | 0.0271 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 13 | 0.009 | 0.0271 | 0.7358 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Echinococcus granulosus | calcium activated potassium channel variant | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 28 | 0.009 | 0.0271 | 0.7358 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0124 | 0.04 | 1 |
Schistosoma mansoni | twik family of potassium channels-related | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 7 | 0.009 | 0.0271 | 0.7358 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.009 | 0.0271 | 1 |
Onchocerca volvulus | 0.009 | 0.0271 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0246 | 0.0246 |
Schistosoma mansoni | twik family of potassium channels-related | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Toxoplasma gondii | ion channel protein | 0.009 | 0.0271 | 1 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.009 | 0.0271 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.009 | 0.0271 | 0.5 |
Echinococcus multilocularis | twik family of potassium channels | 0.009 | 0.0271 | 0.0271 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0084 | 0.0246 | 0.0246 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.009 | 0.0271 | 1 |
Echinococcus granulosus | potassium channel subfamily K | 0.009 | 0.0271 | 0.0271 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0124 | 0.04 | 1 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.009 | 0.0271 | 1 |
Toxoplasma gondii | ion channel protein | 0.009 | 0.0271 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.008 | 0.0232 | 0.0232 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 5 | 0.009 | 0.0271 | 0.7358 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0124 | 0.04 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0084 | 0.0084 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.0352 | 0.8342 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 17 | 0.009 | 0.0271 | 0.7358 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0157 | 0.4261 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.0352 | 0.8342 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.009 | 0.0271 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Echinococcus granulosus | potassium channel subfamily K 8 | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | hypothetical protein | 0.009 | 0.0271 | 0.7358 |
Schistosoma mansoni | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.009 | 0.0271 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.0114 | 0.3087 |
Brugia malayi | glutathione reductase | 0.0049 | 0.0114 | 0.3087 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 30. | 0.009 | 0.0271 | 0.7358 |
Echinococcus granulosus | potassium channel subfamily K 8 | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 35 | 0.009 | 0.0271 | 0.7358 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 32 | 0.009 | 0.0271 | 0.7358 |
Loa Loa (eye worm) | hypothetical protein | 0.0748 | 0.2779 | 0.2779 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0368 | 0.0368 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0084 | 0.0084 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0838 | 0.3123 | 0.3123 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.2641 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0084 | 0.2289 |
Onchocerca volvulus | 0.009 | 0.0271 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.2641 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0084 | 0.0246 | 0.0246 |
Trypanosoma cruzi | ion transport protein, putative | 0.009 | 0.0271 | 1 |
Echinococcus multilocularis | calcium activated potassium channel variant | 0.009 | 0.0271 | 0.0271 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Plasmodium falciparum | potassium channel | 0.009 | 0.0271 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.2641 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 39B | 0.009 | 0.0271 | 0.7358 |
Loa Loa (eye worm) | TWK-7 protein | 0.009 | 0.0271 | 0.0271 |
Schistosoma mansoni | calcium-activated potassium channel | 0.1674 | 0.6313 | 0.6313 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.009 | 0.0271 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | Twik (KCNK-like) family of potasium channels, alpha subunit 40 | 0.009 | 0.0271 | 0.7358 |
Brugia malayi | hypothetical protein | 0.009 | 0.0271 | 0.7358 |
Onchocerca volvulus | 0.009 | 0.0271 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 24 | 0.009 | 0.0271 | 0.7358 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.009 | 0.0271 | 1 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.009 | 0.0271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Mycobacterium ulcerans | ion transport protein | 0.009 | 0.0271 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 12 | 0.009 | 0.0271 | 0.7358 |
Schistosoma mansoni | twik family of potassium channels-related | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.009 | 0.0271 | 0.5 |
Schistosoma mansoni | twik family of potassium channels-related | 0.009 | 0.0271 | 0.0271 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0157 | 0.4261 |
Echinococcus granulosus | twik family of potassium channels | 0.009 | 0.0271 | 0.0271 |
Echinococcus granulosus | twik family of potassium channels | 0.009 | 0.0271 | 0.0271 |
Onchocerca volvulus | 0.009 | 0.0271 | 0.5 | |
Onchocerca volvulus | 0.009 | 0.0271 | 0.5 | |
Onchocerca volvulus | 0.009 | 0.0271 | 0.5 | |
Echinococcus multilocularis | potassium channel subfamily K 8 | 0.009 | 0.0271 | 0.0271 |
Schistosoma mansoni | calcium-activated potassium channel | 0.009 | 0.0271 | 0.0271 |
Schistosoma mansoni | calcium-activated potassium channel | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0927 | 0.3461 | 0.3461 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0157 | 0.0157 |
Schistosoma mansoni | twik family of potassium channels-related | 0.009 | 0.0271 | 0.0271 |
Onchocerca volvulus | 0.009 | 0.0271 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0157 | 0.0157 |
Schistosoma mansoni | hypothetical protein | 0.2641 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Echinococcus multilocularis | potassium channel subfamily K 8 | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.0352 | 0.8342 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.0352 | 0.8342 |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.009 | 0.0271 | 0.5 |
Onchocerca volvulus | 0.009 | 0.0271 | 0.5 | |
Echinococcus multilocularis | TWiK family of potassium channels protein 7 | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | TWK-28 protein | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0271 | 0.0271 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.0352 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0246 | 0.0246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.