TDR Targets

Basic information

Technical information

TDR Targets ID: 838786
Name: [3-bromo-5-phenyl-7-(trifluoromethyl)pyrazolo [1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanon e
MW: 453.256 | Formula: C19H16BrF3N4O
H donors: 0 H acceptors: 3 LogP: 4.24 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1nn2c(c1Br)nc(cc2C(F)(F)F)c1ccccc1)N1CCCCC1
InChi: 1S/C19H16BrF3N4O/c20-15-16(18(28)26-9-5-2-6-10-26)25-27-14(19(21,22)23)11-13(24-17(15)27)12-7-3-1-4-8-12/h1,3-4,7-8,11H,2,5-6,9-10H2
InChiKey: XDTQQYCXNJYNME-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[3-bromo-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(1-piperidyl)methanone
[3-bromo-5-phenyl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]-(1-piperidyl)methanone
[3-bromo-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidino-methanone
[3-bromo-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-yl-methanone
CBMicro_018250
ST5000554
BIM-0018345.P001
BAS 00189415

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable oxidoreductase	0.0012	0.0008	0.0021
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0265	0.0726
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0022	0.0208	0.0341
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Echinococcus granulosus	cyclin G2	0.0022	0.0208	0.0209
Trypanosoma brucei	mitotic cyclin 6	0.0091	0.167	0.2734
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0091	0.167	0.2734
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0012	0.0008	0.0021
Onchocerca volvulus	Cyclin L homolog	0.0022	0.0208	0.0329
Brugia malayi	hypothetical protein	0.0025	0.0265	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0091	0.167	0.2734
Leishmania major	cyclin	0.0091	0.167	0.2734
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0012	0.0008	0.0013
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0299	0.6108	1
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0184	0.3647	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0012	0.0008	0.0013
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0022	0.0208	0.0209
Leishmania major	oxidoreductase-like protein	0.0012	0.0008	0.0013
Trichomonas vaginalis	cyclin B3, putative	0.0091	0.167	0.2478
Loa Loa (eye worm)	cyclin domain-containing protein	0.0022	0.0208	0.0341
Loa Loa (eye worm)	cyclin domain-containing protein	0.0022	0.0208	0.0341
Echinococcus multilocularis	cyclin A3 4	0.0022	0.0208	0.0208
Giardia lamblia	G2/mitotic-specific cyclin B	0.0091	0.167	0.2478
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0022	0.0208	0.0341
Echinococcus granulosus	cyclin y	0.0022	0.0208	0.0209
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0012	0.0008	0.0013
Echinococcus multilocularis	cyclin t1	0.0022	0.0208	0.0208
Schistosoma mansoni	fatty-acid amide hydrolase	0.01	0.1871	0.1913
Toxoplasma gondii	hypothetical protein	0.0069	0.1205	0.329
Brugia malayi	cyclin fold protein 1 variant b	0.0022	0.0208	0.0341
Onchocerca volvulus		0.0022	0.0208	0.0329
Trypanosoma cruzi	mitotic cyclin, putative	0.0022	0.0208	0.0341
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Loa Loa (eye worm)	cyclin domain-containing protein	0.0022	0.0208	0.0341
Plasmodium falciparum	cyclin	0.0091	0.167	0.4579
Toxoplasma gondii	cyclin 4, putative	0.0022	0.0208	0.0551
Trypanosoma brucei	oxidoreductase-like protein	0.0012	0.0008	0.0013
Leishmania major	pteridine reductase 1	0.0012	0.0008	0.0013
Trypanosoma brucei	polo-like protein kinase	0.0299	0.6108	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.01	0.1871	0.1874
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0265	0.0433
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0012	0.0008	0.0021
Schistosoma mansoni	g1/s-specific cyclin C	0.0022	0.0208	0.0213
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0022	0.0208	0.0341
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0022	0.0208	0.0341
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0208	0.0341
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.01	0.1871	0.1871
Entamoeba histolytica	cyclin, putative	0.0091	0.167	0.2725
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0184	0.3647	1
Trypanosoma cruzi	cyclin, putative	0.0091	0.167	0.2734
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0265	0.0706
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0012	0.0008	0.0013
Echinococcus granulosus	cyclins	0.0091	0.167	0.1672
Echinococcus granulosus	cyclin b3	0.0091	0.167	0.1672
Plasmodium vivax	cyclin 4, putative	0.0022	0.0208	0.0571
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0012	0.0008	0.0021
Trichomonas vaginalis	cyclins, putative	0.0091	0.167	0.2478
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0091	0.167	0.2734
Trichomonas vaginalis	cyclins, putative	0.0091	0.167	0.2478
Brugia malayi	amidase	0.01	0.1871	0.3064
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0012	0.0008	0.0021
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0012	0.0008	0.0021
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0012	0	0.5
Echinococcus multilocularis	cyclin B3 1	0.0091	0.167	0.167
Schistosoma mansoni	cyclin B	0.0091	0.167	0.1707
Giardia lamblia	Kinase, PLK	0.0299	0.6108	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0208	0.0341
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0012	0.0008	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.167	0.2478
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0022	0.0208	0.0341
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Echinococcus multilocularis	cyclin G2	0.0022	0.0208	0.0208
Schistosoma mansoni	hypothetical protein	0.0022	0.0208	0.0213
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0184	0.3647	1
Trichomonas vaginalis	CAMK family protein kinase	0.0299	0.6108	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0012	0.0008	0.0021
Trichomonas vaginalis	cyclin B, putative	0.0091	0.167	0.2478
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0022	0.0208	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0008	0.0013
Mycobacterium tuberculosis	Possible oxidoreductase	0.0012	0.0008	0.0021
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Echinococcus granulosus	fatty acid amide hydrolase 1	0.01	0.1871	0.1874
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0299	0.6108	0.6108
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0299	0.6108	0.6117
Entamoeba histolytica	hypothetical protein	0.0022	0.0208	0.0329
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0022	0.0208	0.0341
Toxoplasma gondii	hypothetical protein	0.0022	0.0208	0.0551
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0012	0.0008	0.0021
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0022	0.0208	0.0341
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0012	0.0008	0.0013
Brugia malayi	hypothetical protein	0.0022	0.0208	0.0341
Brugia malayi	hypothetical protein	0.0016	0.008	0.0131
Echinococcus multilocularis	calcium activated potassium channel	0.0013	0.0018	0.0018
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0022	0.0208	0.0551
Entamoeba histolytica	cyclin family protein	0.0091	0.167	0.2725
Entamoeba histolytica	cyclin, putative	0.0091	0.167	0.2725
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0208	0.0571
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0091	0.167	0.2734
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0184	0.3647	1
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0022	0.0208	0.0208
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0091	0.167	0.2734
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0091	0.167	0.2734
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0012	0.0008	0.0008
Entamoeba histolytica	cyclin C, putative	0.0022	0.0208	0.0329
Brugia malayi	serine/threonine-protein kinase plk-2	0.0299	0.6108	1
Echinococcus multilocularis	Cyclin L1	0.0022	0.0208	0.0208
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0299	0.6108	1
Schistosoma mansoni	Cyclin fold protein	0.0022	0.0208	0.0213
Echinococcus multilocularis	ankyrin repeat protein	0.0472	0.978	0.978
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0012	0.0008	0.0021
Trichomonas vaginalis	CAMK family protein kinase	0.0149	0.2919	0.4595
Loa Loa (eye worm)	oxidoreductase	0.0012	0.0008	0.0013
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0012	0.0008	0.0021
Echinococcus multilocularis	cyclin y	0.0022	0.0208	0.0208
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0012	0.0008	0.0021
Leishmania major	mitotic cyclin, putative	0.0022	0.0208	0.0341
Echinococcus granulosus	cyclins	0.0091	0.167	0.1672
Echinococcus multilocularis	cyclin G2	0.0022	0.0208	0.0208
Echinococcus multilocularis	cyclins	0.0091	0.167	0.167
Schistosoma mansoni	cyclin G	0.0022	0.0208	0.0213
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.6108	0.6245
Schistosoma mansoni	amidase	0.01	0.1871	0.1913
Echinococcus multilocularis	cyclins	0.0091	0.167	0.167
Trichomonas vaginalis	CAMK family protein kinase	0.0299	0.6108	1
Echinococcus multilocularis	cyclins	0.0091	0.167	0.167
Echinococcus granulosus	cyclin A3 4	0.0022	0.0208	0.0209
Loa Loa (eye worm)	cyclin C	0.0022	0.0208	0.0341
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0022	0.0208	0.0208
Echinococcus granulosus	transient receptor potential cation channel	0.0482	0.9985	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0265	0.0433
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0022	0.0208	0.0551
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0012	0.0008	0.0013
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Echinococcus multilocularis	cyclin k	0.0022	0.0208	0.0208
Loa Loa (eye worm)	cyclin domain-containing protein	0.0022	0.0208	0.0341
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0012	0.0008	0.0021
Trichomonas vaginalis	CAMK family protein kinase	0.0149	0.2919	0.4595
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0265	0.0433
Brugia malayi	hypothetical protein	0.0022	0.0208	0.0341
Loa Loa (eye worm)	hypothetical protein	0.01	0.1871	0.3064
Echinococcus granulosus	ankyrin repeat protein	0.0472	0.978	0.9795
Schistosoma mansoni	cyclin B3	0.0091	0.167	0.1707
Schistosoma mansoni	dihydropteridine reductase	0.0012	0.0008	0.0008
Echinococcus multilocularis	cyclins	0.0091	0.167	0.167
Trichomonas vaginalis	CAMK family protein kinase	0.0299	0.6108	1
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0184	0.3647	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0012	0.0008	0.0008
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0022	0.0208	0.0213
Echinococcus multilocularis	cyclins	0.0091	0.167	0.167
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0184	0.3647	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0012	0.0008	0.0021
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0022	0.0208	0.0571
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0012	0.0008	0.0021
Echinococcus granulosus	cyclin t1	0.0022	0.0208	0.0209
Trypanosoma brucei	pteridine reductase 1	0.0012	0.0008	0.0013
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0012	0.0008	0.0021
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0022	0.0208	0.0571
Trichomonas vaginalis	cyclin B, putative	0.0091	0.167	0.2478
Trypanosoma cruzi	cyclin, putative	0.0091	0.167	0.2734
Loa Loa (eye worm)	hypothetical protein	0.0091	0.167	0.2734
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Loa Loa (eye worm)	cyclin domain-containing protein	0.0022	0.0208	0.0341
Schistosoma mansoni	kinase	0.0153	0.3003	0.307
Echinococcus multilocularis	cyclin y	0.0022	0.0208	0.0208
Trichomonas vaginalis	cyclin D, putative	0.0091	0.167	0.2478
Trichomonas vaginalis	CAMK family protein kinase	0.0299	0.6108	1
Plasmodium falciparum	cyclin 1	0.0022	0.0208	0.0571
Trichomonas vaginalis	cyclin D, putative	0.0091	0.167	0.2478
Schistosoma mansoni	cyclin l	0.0022	0.0208	0.0213
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0012	0.0008	0.0021
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0022	0.0208	0.0341
Trichomonas vaginalis	cyclins, putative	0.0091	0.167	0.2478
Echinococcus granulosus	Cyclin L1	0.0022	0.0208	0.0209
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0012	0.0008	0.0013
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0012	0.0008	0.0013
Echinococcus multilocularis	G1:S specific cyclin D1	0.0022	0.0208	0.0208
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Trypanosoma brucei	mitotic cyclin	0.0022	0.0208	0.0341
Trichomonas vaginalis	cyclins, putative	0.0091	0.167	0.2478
Giardia lamblia	Hypothetical protein	0.0091	0.167	0.2478
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0299	0.6108	1
Echinococcus granulosus	cyclin G2	0.0022	0.0208	0.0209
Trichomonas vaginalis	cyclin B, putative	0.0091	0.167	0.2478
Echinococcus multilocularis	cyclins	0.0091	0.167	0.167
Loa Loa (eye worm)	CYL-1 protein	0.0022	0.0208	0.0341
Entamoeba histolytica	cyclin, domain containing protein	0.0022	0.0208	0.0329
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0472	0.978	1
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0022	0.0208	0.0571
Entamoeba histolytica	cyclin family protein	0.0091	0.167	0.2725
Trichomonas vaginalis	hypothetical protein	0.0184	0.3647	0.5829
Echinococcus granulosus	G1:S specific cyclin D1	0.0022	0.0208	0.0209
Trypanosoma brucei	cyclin 9	0.0022	0.0208	0.0341
Echinococcus multilocularis	cyclins	0.0091	0.167	0.167
Trypanosoma cruzi	cyclin 6, putative	0.0091	0.167	0.2734
Brugia malayi	Cyclin C	0.0022	0.0208	0.0341
Echinococcus granulosus	calcium activated potassium channel	0.0013	0.0018	0.0018
Schistosoma mansoni	cyclin d	0.0022	0.0208	0.0213
Echinococcus granulosus	cyclins	0.0091	0.167	0.1672
Onchocerca volvulus		0.0091	0.167	0.2725
Trichomonas vaginalis	cyclin B, putative	0.0091	0.167	0.2478
Echinococcus multilocularis	cyclin	0.0022	0.0208	0.0208
Plasmodium vivax	cyclin homologue, putative	0.0022	0.0208	0.0571
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Mycobacterium ulcerans	oxidoreductase	0.0012	0.0008	0.0021
Echinococcus granulosus	cyclin	0.0022	0.0208	0.0209
Mycobacterium ulcerans	short chain dehydrogenase	0.0012	0.0008	0.0021
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Echinococcus multilocularis	cyclin B	0.0091	0.167	0.167
Trypanosoma cruzi	mitotic cyclin, putative	0.0022	0.0208	0.0341
Trichomonas vaginalis	cyclin A, putative	0.0091	0.167	0.2478
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0265	0.0726
Echinococcus granulosus	cyclin y	0.0022	0.0208	0.0209
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0022	0.0208	0.0209
Trypanosoma brucei	cyclin 3	0.0022	0.0208	0.0341
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0184	0.3647	1
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0012	0.0008	0.0021
Leishmania major	hypothetical protein, conserved	0.0025	0.0265	0.0433
Echinococcus granulosus	cyclins	0.0091	0.167	0.1672
Trichomonas vaginalis	CAMK family protein kinase	0.0299	0.6108	1
Echinococcus granulosus	cyclin B	0.0091	0.167	0.1672
Trichomonas vaginalis	CAMK family protein kinase	0.0299	0.6108	1
Echinococcus granulosus	cyclins	0.0091	0.167	0.1672
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0265	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0208	0.0341
Trypanosoma cruzi	polo-like protein kinase, putative	0.0299	0.6108	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0091	0.167	0.2734
Onchocerca volvulus	Cyclin L homolog	0.0022	0.0208	0.0329
Entamoeba histolytica	cyclin, domain containing protein	0.0022	0.0208	0.0329
Leishmania major	mitotic cyclin, putative	0.0022	0.0208	0.0341
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Trichomonas vaginalis	cyclin B, putative	0.0091	0.167	0.2478
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.01	0.1871	0.1871
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0091	0.167	0.167
Trichomonas vaginalis	CAMK family protein kinase	0.0299	0.6108	1
Giardia lamblia	Cyclin A	0.0091	0.167	0.2478
Schistosoma mansoni	cyclins	0.0091	0.167	0.1707
Onchocerca volvulus	Protein CNPPD1 homolog	0.0022	0.0208	0.0329
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0299	0.6108	1
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0184	0.3647	1
Trypanosoma cruzi	cyclin 9, putative	0.0022	0.0208	0.0341
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0012	0.0008	0.0021
Leishmania major	cyclin 9, putative	0.0022	0.0208	0.0341
Chlamydia trachomatis	oxoacy-ACP reductase	0.0012	0.0008	0.0021
Trichomonas vaginalis	cyclins, putative	0.0091	0.167	0.2478
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0012	0.0008	0.0008
Echinococcus granulosus	cyclin B3 1	0.0091	0.167	0.1672
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0012	0.0008	0.0013
Echinococcus multilocularis	cyclin b3	0.0091	0.167	0.167
Schistosoma mansoni	hypothetical protein	0.0022	0.0208	0.0213
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0012	0.0008	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0265	0.0433
Schistosoma mansoni	cyclin G2	0.0022	0.0208	0.0213
Schistosoma mansoni	cyclin k	0.0022	0.0208	0.0213
Trypanosoma cruzi	polo-like protein kinase, putative	0.0299	0.6108	1
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0091	0.167	0.1672
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0012	0.0008	0.0021
Echinococcus granulosus	cyclin k	0.0022	0.0208	0.0209
Loa Loa (eye worm)	cyclin domain-containing protein	0.0022	0.0208	0.0341
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0022	0.0208	0.0551
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0012	0.0008	0.0013
Echinococcus granulosus	cyclins	0.0022	0.0208	0.0209

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 838786