Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0175 | 0.0175 |
Echinococcus granulosus | FTZ F1 alpha | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0152 | 0.444 | 0.444 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0287 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0152 | 0.444 | 0.444 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0287 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0072 | 0.1185 | 0.1185 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0257 | 0.8744 | 0.8744 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0135 | 0.3773 | 0.3773 |
Echinococcus granulosus | jun protein | 0.0089 | 0.187 | 0.187 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.093 | 0.093 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0175 | 0.0175 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0135 | 0.3773 | 0.3773 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0287 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0135 | 0.3773 | 0.3773 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0287 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0135 | 0.3773 | 0.3773 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0122 | 0.3212 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0287 | 1 | 1 |
Echinococcus multilocularis | jun protein | 0.0089 | 0.187 | 0.187 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0152 | 0.444 | 0.444 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0287 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | conserved hypotetical protein | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0257 | 0.8744 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.444 | 0.444 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0287 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0135 | 0.3773 | 0.3773 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0287 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.093 | 0.093 |
Schistosoma mansoni | lipoxygenase | 0.0059 | 0.0617 | 0.0617 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0076 | 0.1319 | 0.1319 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.444 | 0.444 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0257 | 0.8744 | 0.8744 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0175 | 0.0175 |
Schistosoma mansoni | nuclear receptor | 0.0135 | 0.3773 | 0.3773 |
Plasmodium vivax | amine transporter, putative | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | DR-78 | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | Ets-domain containing protein | 0.0076 | 0.1319 | 0.1319 |
Brugia malayi | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Onchocerca volvulus | 0.007 | 0.1084 | 0.1084 | |
Schistosoma mansoni | zinc finger protein | 0.0135 | 0.3773 | 0.3773 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0087 | 0.1771 | 0.4783 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0135 | 0.3773 | 0.3773 |
Schistosoma mansoni | thyroid hormone receptor | 0.0287 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0287 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | serotonin transporter b | 0.0257 | 0.8744 | 0.8744 |
Loa Loa (eye worm) | fli-1 protein | 0.023 | 0.7645 | 0.7645 |
Echinococcus granulosus | serotonin transporter | 0.0257 | 0.8744 | 0.8744 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0287 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0135 | 0.3773 | 0.3773 |
Schistosoma mansoni | nuclear receptor | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | hypothetical protein | 0.0284 | 0.9873 | 0.9873 |
Onchocerca volvulus | 0.0257 | 0.8744 | 0.8744 | |
Brugia malayi | bZIP transcription factor family protein | 0.0089 | 0.187 | 0.187 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0287 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0152 | 0.444 | 0.444 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0287 | 1 | 1 |
Schistosoma mansoni | ets-related | 0.023 | 0.7645 | 0.7645 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0044 | 0 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0135 | 0.3773 | 0.3773 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0135 | 0.3773 | 0.3773 |
Onchocerca volvulus | 0.0287 | 1 | 1 | |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.093 | 0.093 |
Brugia malayi | nuclear hormone receptor | 0.0287 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0287 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0152 | 0.444 | 0.444 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.093 | 0.093 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.177 | 0.177 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0184 | 0.576 | 0.5 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0076 | 0.1319 | 0.1319 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0076 | 0.1319 | 0.1319 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0287 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0152 | 0.444 | 0.444 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0287 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.093 | 0.093 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0287 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0175 | 0.0175 |
Brugia malayi | nuclear receptor RXR | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0287 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.093 | 0.093 |
Brugia malayi | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0135 | 0.3773 | 0.3773 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Schistosoma mansoni | nuclear hormone receptor | 0.0135 | 0.3773 | 0.3773 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.8744 | 0.8744 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0089 | 0.187 | 0.187 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0257 | 0.8744 | 0.8744 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.0337 | 0.0337 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0184 | 0.576 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0257 | 0.8744 | 0.8744 |
Brugia malayi | tailless protein | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.8744 | 0.8744 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0287 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0287 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0287 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.093 | 0.093 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0287 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0287 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0287 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.093 | 0.093 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0287 | 1 | 1 |
Plasmodium falciparum | transporter, putative | 0.0044 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0287 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0059 | 0.0617 | 0.0617 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0135 | 0.3773 | 0.3773 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0152 | 0.444 | 0.444 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.093 | 0.093 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0287 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0287 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0152 | 0.444 | 0.444 |
Echinococcus multilocularis | serotonin transporter | 0.0257 | 0.8744 | 0.8744 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0184 | 0.576 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0175 | 0.0175 |
Schistosoma mansoni | gabp alpha | 0.0076 | 0.1319 | 0.1319 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0287 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0287 | 1 | 1 |
Onchocerca volvulus | 0.0135 | 0.3773 | 0.3773 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0287 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0175 | 0.0175 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0287 | 1 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0062 | 0.076 | 0.1125 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0287 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0135 | 0.3773 | 0.3773 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.093 | 0.093 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0287 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0066 | 0.093 | 0.093 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0287 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0287 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0135 | 0.3773 | 0.3773 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0062 | 0.076 | 0.1125 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.444 | 0.444 |
Schistosoma mansoni | nuclear hormone receptor | 0.0135 | 0.3773 | 0.3773 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0135 | 0.3773 | 0.3773 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0287 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0152 | 0.444 | 0.444 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0257 | 0.8744 | 0.8744 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0287 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0089 | 0.187 | 0.187 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0287 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.3148 | 0.3148 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0287 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0135 | 0.3773 | 0.3773 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.093 | 0.093 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0059 | 0.0617 | 0.0617 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0175 | 0.0175 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0287 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0287 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.1185 | 0.1185 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0087 | 0.1771 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.8744 | 0.8744 |
Brugia malayi | hypothetical protein | 0.007 | 0.1084 | 0.1084 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0287 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0287 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0152 | 0.444 | 0.444 |
Brugia malayi | Ets-domain containing protein | 0.0076 | 0.1319 | 0.1319 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0175 | 0.0175 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0135 | 0.3773 | 0.3773 |
Onchocerca volvulus | 0.0135 | 0.3773 | 0.3773 | |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.444 | 0.444 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.444 | 0.444 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0044 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Plasmodium vivax | hypothetical protein, conserved | 0.0044 | 0 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0287 | 1 | 1 |
Brugia malayi | Fli-1 protein | 0.023 | 0.7645 | 0.7645 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3773 | 0.3773 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0869 | 0.0869 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0135 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.0337 | 0.0337 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0135 | 0.3773 | 0.3773 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0087 | 0.1771 | 0.4783 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0287 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0287 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.093 | 0.093 |
Plasmodium falciparum | amino acid transporter, putative | 0.0044 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.