Detailed information for compound 839154

Basic information

Technical information
  • TDR Targets ID: 839154
  • Name: 2-[2-[(E)-[[2-(2,4,6-tribromophenoxy)acetyl]h ydrazinylidene]methyl]phenoxy]acetic acid
  • MW: 565.008 | Formula: C17H13Br3N2O5
  • H donors: 2 H acceptors: 3 LogP: 4.51 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(COc1c(Br)cc(cc1Br)Br)N/N=C/c1ccccc1OCC(=O)O
  • InChi: 1S/C17H13Br3N2O5/c18-11-5-12(19)17(13(20)6-11)27-8-15(23)22-21-7-10-3-1-2-4-14(10)26-9-16(24)25/h1-7H,8-9H2,(H,22,23)(H,24,25)/b21-7+
  • InChiKey: FQCOGROKWDWJEL-QPSGOUHRSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[2-[[[2-(2,4,6-tribromophenoxy)acetyl]hydrazinylidene]methyl]phenoxy]acetic acid
  • 2-[2-[(E)-[[2-(2,4,6-tribromophenoxy)acetyl]hydrazono]methyl]phenoxy]acetic acid
  • 2-[2-[[[2-(2,4,6-tribromophenoxy)acetyl]hydrazono]methyl]phenoxy]acetic acid
  • 2-[2-[(E)-[[1-oxo-2-(2,4,6-tribromophenoxy)ethyl]hydrazono]methyl]phenoxy]acetic acid
  • 2-[2-[[[1-oxo-2-(2,4,6-tribromophenoxy)ethyl]hydrazono]methyl]phenoxy]acetic acid
  • 2-[2-[(E)-[2-(2,4,6-tribromophenoxy)ethanoylhydrazinylidene]methyl]phenoxy]ethanoic acid
  • 2-[2-[[2-(2,4,6-tribromophenoxy)ethanoylhydrazinylidene]methyl]phenoxy]ethanoic acid
  • CBMicro_020971
  • BIM-0020823.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0065 0.0869 0.0869
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0287 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0287 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0287 1 1
Loa Loa (eye worm) hypothetical protein 0.0287 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0152 0.444 0.444
Brugia malayi nuclear hormone receptor family member odr-7 0.0135 0.3773 0.3773
Loa Loa (eye worm) norepinephrine transporter 0.0257 0.8744 0.8744
Brugia malayi TAR-binding protein 0.0066 0.093 0.093
Echinococcus granulosus tar DNA binding protein 0.0066 0.093 0.093
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0287 1 1
Onchocerca volvulus 0.0287 1 1
Plasmodium vivax amine transporter, putative 0.0044 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0287 1 1
Schistosoma mansoni lipoxygenase 0.0059 0.0617 0.0617
Brugia malayi Fli-1 protein 0.023 0.7645 0.7645
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0257 0.8744 0.8744
Schistosoma mansoni thyroid hormone receptor 0.0287 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0135 0.3773 0.3773
Echinococcus multilocularis tar DNA binding protein 0.0066 0.093 0.093
Loa Loa (eye worm) hypothetical protein 0.0152 0.444 0.444
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0135 0.3773 0.3773
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0152 0.444 0.444
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.187 0.187
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.093 0.093
Brugia malayi nuclear receptor RXR 0.0135 0.3773 0.3773
Echinococcus granulosus Nuclear hormone receptor HR96 0.0135 0.3773 0.3773
Schistosoma mansoni tar DNA-binding protein 0.0066 0.093 0.093
Echinococcus granulosus ecdysone induced protein 78C 0.0287 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0135 0.3773 0.3773
Toxoplasma gondii hypothetical protein 0.0044 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0175 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0287 1 1
Loa Loa (eye worm) hypothetical protein 0.0287 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0287 1 1
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0062 0.076 0.1125
Schistosoma mansoni steroid hormone receptor ad4bp 0.0287 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0287 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0135 0.3773 0.3773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0287 1 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Plasmodium vivax hypothetical protein, conserved 0.0044 0 0.5
Loa Loa (eye worm) solute carrier family 6 member 4 0.0257 0.8744 0.8744
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0287 1 1
Echinococcus multilocularis serotonin transporter 0.0257 0.8744 0.8744
Loa Loa (eye worm) serotonin transporter b 0.0257 0.8744 0.8744
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0287 1 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Brugia malayi hypothetical protein 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0287 1 1
Echinococcus granulosus FTZ F1 alpha 0.0287 1 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.093 0.093
Loa Loa (eye worm) hypothetical protein 0.0287 1 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.1319 0.1319
Echinococcus multilocularis jun protein 0.0089 0.187 0.187
Echinococcus granulosus jun protein 0.0089 0.187 0.187
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.1319 0.1319
Loa Loa (eye worm) hypothetical protein 0.0152 0.444 0.444
Brugia malayi hypothetical protein 0.0152 0.444 0.444
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0287 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0287 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0287 1 1
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0087 0.1771 0.4783
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0135 0.3773 0.3773
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0135 0.3773 0.3773
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0287 1 1
Brugia malayi Ets-domain containing protein 0.0076 0.1319 0.1319
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0087 0.1771 0.4783
Plasmodium falciparum amino acid transporter, putative 0.0044 0 0.5
Brugia malayi hypothetical protein 0.0284 0.9873 0.9873
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0184 0.576 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0287 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.093 0.093
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0152 0.444 0.444
Schistosoma mansoni jun-related protein 0.0072 0.1185 0.1185
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0287 1 1
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.1319 0.1319
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0135 0.3773 0.3773
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0087 0.177 0.177
Brugia malayi nuclear hormone receptor 0.0135 0.3773 0.3773
Schistosoma mansoni tar DNA-binding protein 0.0066 0.093 0.093
Brugia malayi ecdysone receptor 0.0135 0.3773 0.3773
Schistosoma mansoni nuclear receptor 0.0135 0.3773 0.3773
Schistosoma mansoni nuclear receptor nhr-48 0.0135 0.3773 0.3773
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0287 1 1
Onchocerca volvulus 0.0257 0.8744 0.8744
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0175 0.0175
Onchocerca volvulus Protein ultraspiracle homolog 0.0287 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0287 1 1
Brugia malayi Nuclear hormone receptor E75 0.0135 0.3773 0.3773
Loa Loa (eye worm) nuclear hormone receptor 0.0135 0.3773 0.3773
Schistosoma mansoni hypothetical protein 0.0072 0.1185 0.1185
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0287 1 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Loa Loa (eye worm) TAR-binding protein 0.0066 0.093 0.093
Schistosoma mansoni nuclear hormone receptor 0.0287 1 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0044 0 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0135 0.3773 0.3773
Brugia malayi orphan nuclear receptor NR2E1 0.0135 0.3773 0.3773
Brugia malayi nuclear hormone receptor 0.0287 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0135 0.3773 0.3773
Brugia malayi RNA binding protein 0.0066 0.093 0.093
Onchocerca volvulus 0.0135 0.3773 0.3773
Schistosoma mansoni nuclear hormone receptor 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0287 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0287 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0287 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0287 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0287 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0287 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0175 0.0175
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0287 1 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0287 1 1
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0122 0.3212 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0175 0.0175
Trichomonas vaginalis aldehyde oxidase, putative 0.0184 0.576 0.5
Brugia malayi nuclear receptor NHR-88 0.0287 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0135 0.3773 0.3773
Schistosoma mansoni tar DNA-binding protein 0.0066 0.093 0.093
Schistosoma mansoni nuclear hormone receptor 0.0135 0.3773 0.3773
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0337 0.0337
Brugia malayi photoreceptor-specific nuclear receptor 0.0287 1 1
Brugia malayi hypothetical protein 0.0135 0.3773 0.3773
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0287 1 1
Brugia malayi nuclear receptor NHR-67 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0287 1 1
Onchocerca volvulus 0.007 0.1084 0.1084
Brugia malayi Nuclear hormone receptor-like 1 0.0152 0.444 0.444
Brugia malayi bZIP transcription factor family protein 0.0089 0.187 0.187
Brugia malayi Steroid receptor seven-up type 2 0.0287 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0257 0.8744 0.8744
Brugia malayi Nuclear hormone receptor-like 1 0.0152 0.444 0.444
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.187 0.187
Loa Loa (eye worm) steroid hormone receptor 0.0287 1 1
Loa Loa (eye worm) hypothetical protein 0.0287 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0135 0.3773 0.3773
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0287 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0175 0.0175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0175 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0287 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0135 0.3773 0.3773
Loa Loa (eye worm) DR-78 0.0135 0.3773 0.3773
Schistosoma mansoni thyroid hormone receptor 0.0287 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0135 0.3773 0.3773
Schistosoma mansoni sodium/chloride dependent transporter 0.0257 0.8744 0.8744
Brugia malayi nuclear receptor NHR-88 0.0135 0.3773 0.3773
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0617 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0287 1 1
Brugia malayi Nuclear hormone receptor E75 0.0135 0.3773 0.3773
Onchocerca volvulus Bile acid receptor homolog 0.0287 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0175 0.0175
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0287 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0287 1 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0257 0.8744 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0287 1 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.093 0.093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0287 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0287 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.444 0.444
Loa Loa (eye worm) hypothetical protein 0.0257 0.8744 0.8744
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0257 0.8744 0.8744
Loa Loa (eye worm) hypothetical protein 0.0287 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0287 1 1
Brugia malayi hypothetical protein 0.0152 0.444 0.444
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0184 0.576 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0287 1 1
Plasmodium falciparum transporter, putative 0.0044 0 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0287 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0287 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0135 0.3773 0.3773
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0287 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.444 0.444
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0287 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0287 1 1
Brugia malayi Cytochrome P450 family protein 0.0052 0.0337 0.0337
Brugia malayi hypothetical protein 0.007 0.1084 0.1084
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0135 0.3773 0.3773
Loa Loa (eye worm) RNA binding protein 0.0066 0.093 0.093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0152 0.444 0.444
Onchocerca volvulus 0.0135 0.3773 0.3773
Schistosoma mansoni gabp alpha 0.0076 0.1319 0.1319
Echinococcus granulosus serotonin transporter 0.0257 0.8744 0.8744
Toxoplasma gondii hypothetical protein 0.0044 0 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0152 0.444 0.444
Brugia malayi tailless protein 0.0135 0.3773 0.3773
Schistosoma mansoni nuclear receptor 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0135 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.012 0.3148 0.3148
Loa Loa (eye worm) fli-1 protein 0.023 0.7645 0.7645
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0087 0.1771 1
Brugia malayi steroid hormone receptor 0.0287 1 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.8744 0.8744
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0287 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0135 0.3773 0.3773
Brugia malayi conserved hypotetical protein 0.0135 0.3773 0.3773
Schistosoma mansoni coup transcription factor 0.0287 1 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0152 0.444 0.444
Schistosoma mansoni ets-related 0.023 0.7645 0.7645
Brugia malayi nuclear receptor RXR 0.0152 0.444 0.444
Schistosoma mansoni zinc finger protein 0.0135 0.3773 0.3773
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0287 1 1
Brugia malayi Ets-domain containing protein 0.0076 0.1319 0.1319
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0062 0.076 0.1125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0287 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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