Detailed information for compound 840209

Basic information

Technical information
  • TDR Targets ID: 840209
  • Name: 1-[(3-methyl-2-oxo-1,3-benzoxazol-6-yl)sulfon yl]-N-propylpiperidine-3-carboxamide
  • MW: 381.447 | Formula: C17H23N3O5S
  • H donors: 1 H acceptors: 4 LogP: 1.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC(=O)C1CCCN(C1)S(=O)(=O)c1ccc2c(c1)oc(=O)n2C
  • InChi: 1S/C17H23N3O5S/c1-3-8-18-16(21)12-5-4-9-20(11-12)26(23,24)13-6-7-14-15(10-13)25-17(22)19(14)2/h6-7,10,12H,3-5,8-9,11H2,1-2H3,(H,18,21)
  • InChiKey: COIHPECORXMCAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(3-methyl-2-oxo-1,3-benzoxazol-6-yl)sulfonyl]-N-propyl-piperidine-3-carboxamide
  • 1-[(3-methyl-2-oxo-1,3-benzoxazol-6-yl)sulfonyl]-N-propyl-3-piperidinecarboxamide
  • 1-[(2-keto-3-methyl-1,3-benzoxazol-6-yl)sulfonyl]-N-propyl-nipecotamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Excitatory amino acid transporter 0.0263 0.3152 0.3109
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.158 0.3742
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.13 0.1246
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0082 0.0065
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0082 0.0292
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.214 0.2091
Leishmania major GTP-binding protein, putative 0.0024 0.0121 0.0454
Schistosoma mansoni alpha-glucosidase 0.0158 0.1817 0.1766
Echinococcus granulosus snurportin 1 0.0346 0.4205 0.4169
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0219 0.5776
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3801 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0082 0.0292
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0152 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2444 0.642
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0334 0.0853
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0334 0.1328
Echinococcus granulosus lysosomal alpha glucosidase 0.0183 0.214 0.2091
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0082 0.0334
Brugia malayi 6-phosphofructokinase 0.0117 0.13 0.4104
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0062 0.0135
Schistosoma mansoni importin beta-1 0.0032 0.0229 0.0169
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.13 0.3401
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0207 0.2444 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0062 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2444 0.642
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.13 0.1246
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0082 0.0188
Brugia malayi RNA, U transporter 1 0.0092 0.0987 0.3108
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0117 0.1296 0.1242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.047 0.0411
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0219 0.9362
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0671 0.2715
Echinococcus multilocularis snurportin 1 0.0346 0.4205 0.4169
Schistosoma mansoni ran 0.0024 0.0121 0.006
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0219 0.0549
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3801 1
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0334 0.1328
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0219 0.0549
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0229 0.0939
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0082 0.002
Trypanosoma cruzi polo-like protein kinase, putative 0.0207 0.2444 1
Echinococcus granulosus neutral amino acid transporter 0.0263 0.3152 0.3109
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.13 0.1246
Brugia malayi Excitatory amino acid transporter 0.0263 0.3152 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0183 0.214 0.5077
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0062 0.0162
Echinococcus granulosus importin subunit beta 1 0.0032 0.0229 0.0169
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0082 0.0188
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.1764 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.047 0.0411
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0121 0.0159
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2444 0.642
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.2444 0.2397
Schistosoma mansoni hypothetical protein 0.0346 0.4205 0.4169
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.13 0.5298
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0082 0.0188
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0671 0.0613
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0219 0.9362
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0334 0.0853
Brugia malayi serine/threonine-protein kinase plk-2 0.0207 0.2444 0.7746
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0219 0.5776
Echinococcus granulosus excitatory amino acid transporter 2 0.0263 0.3152 0.3109
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0082 0.0118
Treponema pallidum glutamate/aspartate transporter 0.0117 0.1296 0.3301
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0334 0.0853
Schistosoma mansoni alpha-glucosidase 0.0158 0.1817 0.1766
Treponema pallidum fructose-bisphosphate aldolase 0.0314 0.3801 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3801 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0219 0.0549
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.214 0.2091
Entamoeba histolytica serine/threonine protein kinase, putative 0.0207 0.2444 0.642
Giardia lamblia Kinase, PLK 0.0207 0.2444 0.6371
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0334 1
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0312 0.0252
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0334 0.0771
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0062 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0082 0.0334
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.047 0.0411
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3801 1
Onchocerca volvulus 0.0106 0.1161 0.3663
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0121 0.0352
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0219 0.0549
Echinococcus multilocularis excitatory amino acid transporter 2 0.0263 0.3152 0.3109
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.13 0.3401
Chlamydia trachomatis glutamate symporter 0.0263 0.3152 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.13 0.4007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.047 0.0411
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0082 0.0334
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0263 0.3152 0.3109
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0671 0.2103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0082 0.017
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.13 0.3074
Onchocerca volvulus 0.006 0.0575 0.1798
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.1764 1
Schistosoma mansoni ran 0.0024 0.0121 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0334 0.0853
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0062 0.0135
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0219 0.9362
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0229 0.617
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0062 0.0135
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0082 0.002
Trypanosoma brucei unspecified product 0.0021 0.0082 0.0334
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0671 0.2715
Trypanosoma brucei glucosidase, putative 0.0041 0.0334 0.1366
Leishmania major DNA polymerase eta, putative 0.0021 0.0082 0.0292
Schistosoma mansoni microtubule-associated protein tau 0.0804 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.047 0.1097
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0121 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.13 0.3401
Echinococcus granulosus neutral amino acid transporter A 0.0263 0.3152 0.3109
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0219 0.0549
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.13 0.3401
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.1764 0.5509
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0082 0.0334
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0334 0.0853
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0334 0.0853
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0062 0.021
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0219 0.0549
Brugia malayi Glycosyl hydrolases family 31 protein 0.0183 0.214 0.6779
Brugia malayi MH2 domain containing protein 0.0139 0.158 0.4996
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0082 0.0065
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0263 0.3152 1
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.13 0.3401
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0082 0.0334
Schistosoma mansoni kinase 0.0105 0.1153 0.1098
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0671 0.2746
Echinococcus multilocularis neutral amino acid transporter A 0.0263 0.3152 0.3109
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0334 0.0853
Schistosoma mansoni DNA polymerase eta 0.0021 0.0082 0.002
Plasmodium vivax importin-beta 2, putative 0.0032 0.0229 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0334 0.1328
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0263 0.3152 0.3109
Brugia malayi Importin beta-1 subunit 0.0032 0.0229 0.0697
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0082 0.002
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0207 0.2444 0.2397
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0229 0.0169
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0121 0.006
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0082 0.0292
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0334 0.0274
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0207 0.2444 0.5802
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.047 0.0411
Echinococcus multilocularis microtubule associated protein 2 0.0804 1 1
Entamoeba histolytica hypothetical protein 0.0026 0.0152 0.0373
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0121 0.006
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0671 0.2715
Echinococcus granulosus dna polymerase eta 0.0021 0.0082 0.002
Treponema pallidum glutamate transporter 0.0117 0.1296 0.3301
Trypanosoma brucei polo-like protein kinase 0.0207 0.2444 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0334 0.0853
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0575 0.0517
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0082 0.0334
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0082 0.0292
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0219 0.0421
Echinococcus granulosus tumor protein p63 0.0408 0.4987 0.4956
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0117 0.1296 0.1242
Echinococcus multilocularis Excitatory amino acid transporter 0.0263 0.3152 0.3109
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0082 0.0334
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0011 0.0043
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0219 0.9362
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.047 0.0411
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3801 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0082 0.0334
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0121 0.3543
Giardia lamblia DINP protein human, muc B family 0.0021 0.0082 0.0054
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0671 0.0613
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0121 0.0454
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.017
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0121 0.3543
Echinococcus granulosus dna polymerase kappa 0.0021 0.0082 0.002
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0117 0.1296 0.1242
Entamoeba histolytica Ran family GTPase 0.0024 0.0121 0.0292
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0152 0.0373
Leishmania major importin beta-1 subunit, putative 0.0026 0.0152 0.0581
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0334 0.0853
Loa Loa (eye worm) hypothetical protein 0.006 0.0575 0.1346
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0671 0.1575
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3801 1
Echinococcus multilocularis excitatory amino acid transporter 3 0.0263 0.3152 0.3109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.047 0.0411
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2444 0.642
Brugia malayi 6-phosphofructokinase 0.0117 0.13 0.4104
Echinococcus multilocularis dna polymerase eta 0.0021 0.0082 0.002
Loa Loa (eye worm) excitatory amino acid transporter 0.0263 0.3152 0.749
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3801 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.13 0.5318
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0082 0.0334
Loa Loa (eye worm) phosphofructokinase 0.0117 0.13 0.3074
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1118 0.2922
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0082 0.0118
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0671 0.0613
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0334 0.0853
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.158 0.3742
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.13 0.7273
Trichomonas vaginalis ran, putative 0.0024 0.0121 0.0292
Schistosoma mansoni alpha glucosidase 0.0041 0.0334 0.0274
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0062 0.021
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0219 0.0549
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0082 0.0226
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.13 0.3401
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0229 0.0939
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0082 0.002
Echinococcus multilocularis neutral amino acid transporter A 0.0263 0.3152 0.3109
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2444 0.642
Leishmania major DNA polymerase kappa, putative 0.0021 0.0082 0.0292
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0219 0.5776
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0312 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1118 0.2922
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0082 0.0292
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.4205 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0334 0.0853
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.047 0.1464
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0671 0.1743
Giardia lamblia Fructose-bisphosphate aldolase 0.0314 0.3801 1
Echinococcus granulosus Excitatory amino acid transporter 0.0263 0.3152 0.3109
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.13 0.3074
Echinococcus multilocularis tumor protein p63 0.0408 0.4987 0.4956
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0152 0.0581
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0082 0.002
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0314 0.3801 1
Echinococcus granulosus sodium:dicarboxylate symporter 0.0263 0.3152 0.3109
Loa Loa (eye worm) hypothetical protein 0.0032 0.0229 0.0522
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0062 0.0122
Chlamydia trachomatis neutral amino acid transporter 0.0117 0.1296 0.3673
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.13 0.3311
Plasmodium falciparum importin beta, putative 0.0032 0.0229 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.0263 0.3152 0.3109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3801 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0314 0.3801 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0121 0.2186
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.13 0.3401
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2444 0.642
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0263 0.3152 1
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.2444 0.642
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0117 0.1296 0.1242
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0082 0.0334
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0207 0.2444 0.2397
Echinococcus granulosus Excitatory amino acid transporter 0.0263 0.3152 0.3109
Echinococcus granulosus neutral amino acid transporter A 0.0263 0.3152 0.3109
Echinococcus granulosus excitatory amino acid transporter 2 0.0263 0.3152 0.3109
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0082 0.0334
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0121 0.0495
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0263 0.3152 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0082 0.0334
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0219 0.0421
Onchocerca volvulus Serine\/threonine kinase homolog 0.0207 0.2444 0.7746
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0082 0.0226
Trypanosoma cruzi polo-like protein kinase, putative 0.0207 0.2444 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0334 0.0274
Brugia malayi phosphofructokinase 0.0117 0.13 0.4104
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0219 0.0549
Echinococcus multilocularis neutral amino acid transporter A 0.0263 0.3152 0.3109
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0121 0.0454
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0334 0.1029
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0152 0.0373
Echinococcus granulosus excitatory amino acid transporter 3 0.0263 0.3152 0.3109
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.13 0.5298
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0082 0.0292
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.13 0.1246
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0082 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0082 0.0334
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0263 0.3152 0.3109

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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