TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 311.118 | Formula: C12H10INO
H donors: 0 H acceptors: 0 LogP: 3.67 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Ic1ccc(cc1)N=Cc1ccc(o1)C
InChi: 1S/C12H10INO/c1-9-2-7-12(15-9)8-14-11-5-3-10(13)4-6-11/h2-8H,1H3/b14-8+
InChiKey: ZIJHUTLPEXVRLA-RIYZIHGNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.4378
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0188	0.0278
Trichomonas vaginalis	abcb9, putative	0.0043	0.0774	0.1145
Echinococcus granulosus	geminin	0.0181	0.4391	0.4391
Trichomonas vaginalis	conserved hypothetical protein	0.0227	0.561	0.8304
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0394	1	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0048	0.0901	0.1334
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0033	0.0509	0.0754
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0043	0.0774	0.1145
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0394	1	1
Mycobacterium tuberculosis	Possible toxin MazF4	0.0142	0.3382	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.4378
Echinococcus granulosus	multidrug resistance protein 1	0.003	0.0434	0.0434
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.1813	0.2684
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0271	0.6756	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0044	0.0794	0.1175
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0794	0.1175
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0044	0.0794	0.1175
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0043	0.0774	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0794	0.0794
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0188	0.0556
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0188	0.0188
Mycobacterium tuberculosis	Possible toxin MazF1	0.0142	0.3382	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0043	0.0774	0.1145
Trichomonas vaginalis	ABC transporter, putative	0.0043	0.0774	0.1145
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0043	0.0774	0.1145
Mycobacterium tuberculosis	Possible toxin MazF5	0.0142	0.3382	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0044	0.0794	0.1175
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0044	0.0794	0.1175
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.1175
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0043	0.0774	0.0774
Mycobacterium tuberculosis	Possible toxin MazF7	0.0142	0.3382	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.0529	0.0942
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0188	0.0188
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0044	0.0794	0.0794
Toxoplasma gondii	hypothetical protein	0.0227	0.561	1
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0085	0.1888	0.1888
Trichomonas vaginalis	ABC transporter, putative	0.0043	0.0774	0.1145
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0774	0.0774
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.0529	0.0782
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0044	0.0794	0.0794
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.002	0.0185	0.102
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Brugia malayi	ABC transporter family protein	0.0043	0.0774	0.0774
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0043	0.0774	0.1145
Loa Loa (eye worm)	multidrug resistance protein 3	0.0043	0.0774	0.0774
Mycobacterium tuberculosis	Toxin MazF6	0.0142	0.3382	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0043	0.0774	0.1145
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Plasmodium falciparum	phosphodiesterase delta, putative	0.0044	0.0794	0.4378
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0044	0.0794	0.4378
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.002	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0227	0.561	0.8304
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0044	0.0794	0.0794
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0188	0.0188
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0271	0.6756	0.6756
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Leishmania major	hypothetical protein, conserved	0.0044	0.0794	0.1175
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0456	0.0456
Leishmania major	p-glycoprotein	0.0043	0.0774	0.1145
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0043	0.0774	0.1145
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0271	0.6756	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0271	0.6756	1
Echinococcus granulosus	multidrug resistance protein 1	0.0043	0.0774	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1813	0.1813
Leishmania major	DNA polymerase eta, putative	0.0034	0.0529	0.0782
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0022	0.0238	0.0353
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0509	0.0754
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0044	0.0794	0.0794
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0043	0.0774	0.1145
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Onchocerca volvulus		0.0043	0.0774	0.5
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0188	0.0188
Trypanosoma brucei	unspecified product	0.0014	0.002	0.003
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0044	0.0794	0.0794
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0179	0.0179
Schistosoma mansoni	smdr2	0.0043	0.0774	0.0774
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0042	0.0761	0.0761
Trypanosoma cruzi	Protein kinase B	0.0022	0.0238	0.0353
Toxoplasma gondii	AGC kinase	0.0031	0.0456	0.0813
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.1175
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.002	0.0185	0.0185
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0043	0.0774	0.0774
Schistosoma mansoni	DNA polymerase eta	0.0048	0.0901	0.0901
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Mycobacterium ulcerans	putative regulatory protein	0.0082	0.1813	0.5362
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0044	0.0794	0.0794
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0043	0.0774	0.1145
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0126	0.296	0.296
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0794	0.1175
Entamoeba histolytica	P-glyco protein 6, putative	0.0043	0.0774	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.0509	0.6583
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0901	0.0901
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0044	0.0794	0.1175
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0044	0.0794	0.0794
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0188	0.0556
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Loa Loa (eye worm)	hypothetical protein	0.0126	0.296	0.296
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0188	0.0188
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0044	0.0794	0.1175
Loa Loa (eye worm)	PDE1B protein	0.0044	0.0794	0.0794
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0044	0.0794	0.1175
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Mycobacterium tuberculosis	Conserved protein	0.0142	0.3382	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0043	0.0774	0.0774
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0043	0.0774	0.0774
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0044	0.0794	0.0794
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0238	0.3079
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0271	0.6756	1
Trichomonas vaginalis	abcb9, putative	0.0043	0.0774	0.1145
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0271	0.6756	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0043	0.0774	0.1145
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.002	0.003
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0774	0.0774
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0129	0.3034	0.3034
Schistosoma mansoni	multidrug resistance protein	0.0043	0.0774	0.0774
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0048	0.0901	0.1334
Trypanosoma brucei	unspecified product	0.0021	0.0188	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0761	0.0761
Echinococcus granulosus	nervana 2	0.002	0.0179	0.0179
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0271	0.6756	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0126	0.296	0.4381
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0043	0.0774	0.1145
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0043	0.0774	0.1145
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0126	0.296	0.296
Leishmania major	DNA polymerase eta, putative	0.0048	0.0901	0.1334
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0271	0.6756	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0043	0.0774	0.0774
Trichomonas vaginalis	ABC transporter, putative	0.0043	0.0774	0.1145
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0509	0.0754
Mycobacterium ulcerans	hypothetical protein	0.0142	0.3382	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0044	0.0794	0.0794
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0126	0.296	0.296
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0043	0.0774	0.0774
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0129	0.3034	0.3034
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0043	0.0774	0.1379
Entamoeba histolytica	protein kinase, putative	0.0033	0.0509	0.6583
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0774	0.0774
Entamoeba histolytica	protein kinase, putative	0.0031	0.0456	0.5895
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0129	0.3034	0.3034
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0188	0.0278
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0794	0.1175
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0238	0.0238
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0044	0.0794	0.1175
Trypanosoma brucei	hypothetical protein, conserved	0.0044	0.0794	0.1175
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Trichomonas vaginalis	conserved hypothetical protein	0.0227	0.561	0.8304
Brugia malayi	multidrug resistance protein 3	0.0043	0.0774	0.0774
Leishmania major	hypothetical protein, conserved	0.0044	0.0794	0.1175
Plasmodium vivax	phosphodiesterase gamma, putative	0.0044	0.0794	0.4378
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0509	0.0754
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0509	0.0754
Echinococcus multilocularis	nervana 2	0.002	0.0179	0.0179
Echinococcus multilocularis	multidrug resistance protein 1	0.0043	0.0774	0.0774
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0794	0.1175
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0044	0.0794	0.0794
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0394	1	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.002	0.0185	0.0274
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Trichomonas vaginalis	conserved hypothetical protein	0.0271	0.6756	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0043	0.0774	0.0774
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0044	0.0794	0.0794
Echinococcus multilocularis	multidrug resistance protein 1	0.0043	0.0774	0.0774
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.002	0.003
Entamoeba histolytica	P-glycoprotein-5	0.0043	0.0774	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0774	0.0774
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0271	0.6756	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0794	0.1175
Toxoplasma gondii	GAF domain-containing protein	0.0082	0.1813	0.3233
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0085	0.1888	0.1888
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0129	0.3034	0.3034
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0082	0.1813	0.5362
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0043	0.0774	0.2287
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0271	0.6756	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0013	0	0.5
Mycobacterium tuberculosis	Toxin MazF9	0.0142	0.3382	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0188	0.4591	0.6795
Entamoeba histolytica	P-glycoprotein-2, putative	0.0043	0.0774	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Mycobacterium ulcerans	putative regulatory protein	0.0082	0.1813	0.5362
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0179	0.0179
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0188	0.062
Schistosoma mansoni	hypothetical protein	0.0181	0.4391	0.4391
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0044	0.0794	0.0794
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0394	1	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0044	0.0794	0.0794
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Plasmodium vivax	hypothetical protein, conserved	0.0082	0.1813	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0238	0.3079
Echinococcus granulosus	dna polymerase eta	0.0048	0.0901	0.0901
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0271	0.6756	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0044	0.0794	0.1175
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0043	0.0774	0.0774
Entamoeba histolytica	P-glycoprotein 5, putative	0.0043	0.0774	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.0509	0.0509
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0043	0.0774	0.1379
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0044	0.0794	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0129	0.3034	0.3034
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0044	0.0794	0.0794
Trichomonas vaginalis	taga, putative	0.0043	0.0774	0.1145
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.1175
Giardia lamblia	hypothetical protein	0.0044	0.0794	0.2617
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0043	0.0774	0.1145
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0043	0.0774	0.0774
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0188	0.0556
Echinococcus granulosus	multidrug resistance protein 1	0.0043	0.0774	0.0774
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0188	0.0188
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0794	0.1175
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0043	0.0774	0.1145
Echinococcus granulosus	nervana 2	0.002	0.0179	0.0179
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.4378
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0022	0.0238	0.0238
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0271	0.6756	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0044	0.0794	0.0794
Plasmodium falciparum	multidrug resistance protein 1	0.0043	0.0774	0.4265
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0188	0.4591	0.6795
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0126	0.296	0.296
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0044	0.0794	0.1175
Entamoeba histolytica	P-glycoprotein-2	0.0043	0.0774	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0085	0.1888	0.1888
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0238	0.0238
Plasmodium falciparum	GAF domain-related protein, putative	0.0082	0.1813	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.1175
Mycobacterium tuberculosis	Toxin MazF2	0.0142	0.3382	1
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0129	0.3034	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0044	0.0794	0.0794
Plasmodium vivax	multidrug resistance protein 1, putative	0.0043	0.0774	0.4265
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.1175
Mycobacterium tuberculosis	Toxin MazF3	0.0142	0.3382	1
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.002	0.0185	0.0185
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Trypanosoma brucei	unspecified product	0.0014	0.002	0.003
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.1175
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0188	0.4591	0.6795
Echinococcus multilocularis	multidrug resistance protein 1	0.003	0.0434	0.0434
Echinococcus multilocularis	ATP binding cassette sub family B	0.0042	0.0761	0.0761
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0188	0.0556
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0043	0.0774	0.1145
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.4378
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0129	0.3034	0.5409
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Echinococcus granulosus	multidrug resistance protein 1	0.0043	0.0774	0.0774
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0044	0.0794	0.0794
Brugia malayi	ImpB/MucB/SamB family protein	0.0048	0.0901	0.0901
Giardia lamblia	Hypothetical protein	0.0044	0.0794	0.2617
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0082	0.1813	0.5362
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0126	0.296	0.296
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0044	0.0794	0.4378
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0044	0.0794	0.1175
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.0188	0.2431
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0271	0.6756	1
Echinococcus granulosus	serine/threonine protein kinase	0.0022	0.0238	0.0238
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0271	0.6756	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0126	0.296	0.4381
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0043	0.0774	0.1145
Echinococcus granulosus	multidrug resistance protein 1	0.003	0.0434	0.0434
Mycobacterium leprae	conserved hypothetical protein	0.0082	0.1813	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0188	0.0188
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0044	0.0794	0.1175
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0271	0.6756	1
Giardia lamblia	Kinase, AGC PKA	0.002	0.0185	0.061
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0043	0.0774	0.1145
Schistosoma mansoni	hypothetical protein	0.0181	0.4391	0.4391
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0456	0.0456
Entamoeba histolytica	protein kinase 2, putative	0.002	0.0185	0.2392
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0043	0.0774	0.1145
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.003	0.0434	0.0642
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0044	0.0794	0.0794
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0082	0.1813	0.5362
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0043	0.0774	0.5
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0126	0.296	0.4381
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0271	0.6756	1
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0044	0.0794	0.0794
Echinococcus multilocularis	geminin	0.0181	0.4391	0.4391
Toxoplasma gondii	hypothetical protein	0.0082	0.1813	0.3233
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0044	0.0794	0.4378
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0129	0.3034	0.3034
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0509	0.0509
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0188	0.0278
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0043	0.0774	0.1145
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.002	0.0185	0.102
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0044	0.0794	0.1175
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0179	0.0179
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0013	0	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0188	0.0278
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0085	0.1888	0.1888
Echinococcus multilocularis	nervana 2	0.002	0.0179	0.0179
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0271	0.6756	0.6756
Toxoplasma gondii	hypothetical protein	0.0082	0.1813	0.3233
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0509	0.0754
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0271	0.6756	0.6756
Entamoeba histolytica	P-glycoprotein-2	0.0043	0.0774	1
Trichomonas vaginalis	abcb9, putative	0.0043	0.0774	0.1145
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0179	0.0179
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0188	0.0278
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0043	0.0774	0.1145
Echinococcus multilocularis	dna polymerase eta	0.0048	0.0901	0.0901
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0794	0.1175
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0188	0.0188
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0043	0.0774	0.1145
Entamoeba histolytica	P-glycoprotein-1	0.0043	0.0774	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0043	0.0774	0.1145
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0188	0.0278
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0509	0.0754
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0509	0.0754
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0044	0.0794	0.1415
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0188	0.0278
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0044	0.0794	0.4378
Trichomonas vaginalis	ABC transporter, putative	0.0043	0.0774	0.1145
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0043	0.0774	0.1145
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0044	0.0794	0.0794
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0043	0.0774	0.1145
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0044	0.0794	0.0794
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0271	0.6756	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0794	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0794	0.0794
Echinococcus granulosus	serine threonine protein kinase nrc	0.002	0.0185	0.0185
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0271	0.6756	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 841019