Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.067 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.067 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.067 | 1 | 1 |
Trypanosoma cruzi | Na/H antiporter-like protein, putative | 0.0128 | 0 | 0.5 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.067 | 1 | 0.5 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.067 | 1 | 1 |
Schistosoma mansoni | sodium/hydrogen exchanger 2 (nhe2) | 0.067 | 1 | 1 |
Mycobacterium ulcerans | membrane transporter | 0.0128 | 0 | 0.5 |
Mycobacterium ulcerans | ion antiporter, NhaP | 0.0128 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved integral membrane transport protein | 0.0128 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved integral membrane transport protein YjcE | 0.0128 | 0 | 0.5 |
Toxoplasma gondii | Na+/H+ exchanger NHE1 | 0.0128 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0128 | 0 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.067 | 1 | 1 |
Loa Loa (eye worm) | NHE-3 | 0.067 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.1253 | 0.1253 |
Entamoeba histolytica | sodium/proton antiporter, putative | 0.0128 | 0 | 0.5 |
Entamoeba histolytica | sodium/proton antiporter, putative | 0.0128 | 0 | 0.5 |
Loa Loa (eye worm) | sodium/hydrogen exchanger | 0.067 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | Kef-type K+ transport system, membrane component | 0.0128 | 0 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.067 | 1 | 1 |
Mycobacterium leprae | probable conserved integral membrane transport protein | 0.0128 | 0 | 0.5 |
Trypanosoma cruzi | Na/H antiporter-like protein, putative | 0.0128 | 0 | 0.5 |
Toxoplasma gondii | sodium/hydrogen exchanger NHE2 | 0.0128 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.067 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.067 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.067 | 1 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.067 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.067 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 (nhe2) | 0.0542 | 0.7643 | 0.7643 |
Echinococcus multilocularis | geminin | 0.0196 | 0.1253 | 0.1253 |
Echinococcus granulosus | geminin | 0.0196 | 0.1253 | 0.1253 |
Trypanosoma cruzi | sodium/hydrogen exchanger, putative | 0.0128 | 0 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.067 | 1 | 1 |
Mycobacterium ulcerans | potassium/proton antiporter | 0.0128 | 0 | 0.5 |
Plasmodium vivax | sodium/hydrogen exchanger 1, putative | 0.0128 | 0 | 0.5 |
Loa Loa (eye worm) | sodium/hydrogen exchanger 3 family protein | 0.067 | 1 | 1 |
Toxoplasma gondii | Na+/H+ exchanger NHE3 | 0.0128 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.1253 | 0.1253 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.067 | 1 | 1 |
Leishmania major | Na/H antiporter-like protein | 0.0128 | 0 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.067 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.067 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0542 | 0.7643 | 0.7643 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.067 | 1 | 1 |
Toxoplasma gondii | sodium/hydrogen exchanger 3 protein | 0.0128 | 0 | 0.5 |
Plasmodium falciparum | sodium/hydrogen exchanger, Na+, H+ antiporter | 0.0128 | 0 | 0.5 |
Trypanosoma cruzi | sodium/hydrogen exchanger, putative | 0.0128 | 0 | 0.5 |
Schistosoma mansoni | sodium/hydrogen exchanger | 0.067 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.