TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 168.193 | Formula: C8H12N2O2
H donors: 1 H acceptors: 2 LogP: 0.87 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1n[nH]c(c1)C(C)C
InChi: 1S/C8H12N2O2/c1-5(2)6-4-7(10-9-6)8(11)12-3/h4-5H,1-3H3,(H,9,10)
InChiKey: CWOFANOGQNEOTQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	neuropeptide f receptor 76f	0.0165	0.3225	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0056	0.0842	0.083
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0318	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0165	0.3225	0.3547
Brugia malayi	Pre-SET motif family protein	0.0071	0.1175	0.1164
Onchocerca volvulus		0.0165	0.3225	0.2322
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Onchocerca volvulus		0.0165	0.3225	0.2322
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0165	0.3225	0.3547
Schistosoma mansoni	glucose transport protein	0.0104	0.1881	0.2174
Onchocerca volvulus		0.0165	0.3225	0.2322
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Brugia malayi	RE15519p	0.0165	0.3225	0.3547
Brugia malayi	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	neuropeptide receptor	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Schistosoma mansoni	adenoreceptor	0.0165	0.3225	0.3835
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0165	0.3225	0.3547
Echinococcus multilocularis	neuropeptide Y receptor	0.0165	0.3225	0.3794
Onchocerca volvulus		0.0165	0.3225	0.2322
Brugia malayi	G-protein coupled receptor	0.0165	0.3225	0.3547
Leishmania major	glucose transporter, lmgt3	0.0032	0.0318	1
Echinococcus granulosus	orexin receptor type 2	0.0165	0.3225	0.3794
Echinococcus multilocularis	neuropeptides capa receptor	0.0165	0.3225	0.3794
Brugia malayi	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.1881	0.2122
Echinococcus granulosus	General substrate transporter	0.0089	0.1562	0.1726
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0165	0.3225	0.3794
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0165	0.3225	0.3547
Brugia malayi	Sugar transporter family protein	0.0104	0.1881	0.1984
Brugia malayi	hypothetical protein	0.0165	0.3225	0.3547
Leishmania major	glucose transporter, lmgt2	0.0032	0.0318	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.3225	0.3835
Trichomonas vaginalis	set domain proteins, putative	0.0475	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0165	0.3225	0.3794
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Brugia malayi	sulfakinin receptor protein	0.0165	0.3225	0.3547
Schistosoma mansoni	glucose transport protein	0.0104	0.1881	0.2174
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Brugia malayi	neuropeptide F receptor	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	fmrfamide receptor	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0394	0.8214	0.9349
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0318	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0165	0.3225	0.3547
Echinococcus granulosus	allatostatin A receptor	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Plasmodium vivax	hexose transporter	0.0104	0.1881	0.2122
Brugia malayi	Isocitrate dehydrogenase	0.0031	0.029	0.0134
Schistosoma mansoni	neuropeptide receptor	0.0165	0.3225	0.3835
Brugia malayi	follicle stimulating hormone receptor	0.0165	0.3225	0.3547
Brugia malayi	AKH receptor	0.0165	0.3225	0.3547
Schistosoma mansoni	hypothetical protein	0.0104	0.1881	0.2174
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0165	0.3225	0.3794
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0031	0.029	0.0143
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0165	0.3225	0.3794
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0165	0.3225	0.3794
Echinococcus granulosus	somatostatin receptor	0.0165	0.3225	0.3794
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0165	0.3225	0.3835
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0031	0.029	0.0143
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.029	0.9096
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.1881	0.2122
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.1881	0.2122
Brugia malayi	Dopamine receptor	0.0165	0.3225	0.3547
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0071	0.1175	0.1245
Onchocerca volvulus		0.0165	0.3225	0.2322
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0165	0.3225	0.3794
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0165	0.3225	0.2322
Trypanosoma cruzi	hexose transporter	0.0032	0.0318	1
Brugia malayi	ORL1-like opioid receptor	0.0165	0.3225	0.3547
Schistosoma mansoni	neuropeptide receptor	0.0165	0.3225	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1175	0.1164
Echinococcus multilocularis	neuropeptide receptor A26	0.0165	0.3225	0.3794
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.3225	0.3835
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0031	0.029	0.0134
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0165	0.3225	0.3794
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Schistosoma mansoni	growth hormone secretagogue receptor	0.0165	0.3225	0.3835
Schistosoma mansoni	hypothetical protein	0.0165	0.3225	0.3835
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0165	0.3225	0.3794
Echinococcus multilocularis	neuropeptides capa receptor	0.0165	0.3225	0.3794
Brugia malayi	putative neuropeptide receptor NPR1	0.0165	0.3225	0.3547
Schistosoma mansoni	amine GPCR	0.0165	0.3225	0.3835
Brugia malayi	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0165	0.3225	0.3794
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0318	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0071	0.1175	0.1245
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0165	0.3225	0.3835
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0071	0.1175	0.1303
Onchocerca volvulus		0.0165	0.3225	0.2322
Schistosoma mansoni	neuropeptide F-like receptor	0.0165	0.3225	0.3835
Echinococcus granulosus	tm gpcr rhodopsin	0.0165	0.3225	0.3794
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0318	1
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0318	0.0147
Schistosoma mansoni	hypothetical protein	0.0165	0.3225	0.3835
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0165	0.3225	0.3835
Brugia malayi	Serotonin receptor	0.0165	0.3225	0.3547
Echinococcus granulosus	biogenic amine 5HT receptor	0.0289	0.5936	0.7166
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus multilocularis	sex peptide receptor	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0289	0.5936	0.6699
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0071	0.1175	0.1245
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0318	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Onchocerca volvulus		0.0165	0.3225	0.2322
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0165	0.3225	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Schistosoma mansoni	biogenic amine receptor	0.0165	0.3225	0.3835
Brugia malayi	Serotonin receptor	0.0165	0.3225	0.3547
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0318	1
Echinococcus multilocularis	serotonin receptor	0.0289	0.5936	0.7166
Echinococcus multilocularis	allatostatin A receptor	0.0165	0.3225	0.3794
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0174	0.5
Onchocerca volvulus		0.0165	0.3225	0.2322
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0031	0.029	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.1881	0.1737
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0071	0.1175	0.1303
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0165	0.3225	0.3794
Loa Loa (eye worm)	neuropeptide F receptor	0.0165	0.3225	0.3547
Onchocerca volvulus		0.0165	0.3225	0.2322
Onchocerca volvulus		0.0165	0.3225	0.2322
Echinococcus granulosus	g protein coupled receptor	0.0165	0.3225	0.3794
Plasmodium falciparum	SET domain protein, putative	0.0394	0.8214	1
Echinococcus multilocularis	fmrfamide receptor	0.0165	0.3225	0.3794
Echinococcus multilocularis	g protein coupled receptor	0.0165	0.3225	0.3794
Echinococcus granulosus	sex peptide receptor	0.0165	0.3225	0.3794
Onchocerca volvulus		0.0165	0.3225	0.2322
Schistosoma mansoni	neuropeptide receptor	0.0165	0.3225	0.3835
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0031	0.029	0.9096
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Schistosoma mansoni	biogenic amine receptor	0.0165	0.3225	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Brugia malayi	Melatonin receptor type 1A	0.0165	0.3225	0.3547
Loa Loa (eye worm)	melatonin receptor type 1A	0.0165	0.3225	0.3547
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0165	0.3225	0.3547
Brugia malayi	hypothetical protein	0.0165	0.3225	0.3547
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0165	0.3225	0.3547
Echinococcus granulosus	neuropeptide Y receptor	0.0165	0.3225	0.3794
Echinococcus multilocularis	g protein coupled receptor	0.0165	0.3225	0.3794
Echinococcus multilocularis	fmrfamide receptor	0.0165	0.3225	0.3794
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.029	0.8003
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0165	0.3225	0.3835
Echinococcus multilocularis	g-protein coupled receptor	0.0165	0.3225	0.3794
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.1881	0.2122
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0165	0.3225	0.3794
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0031	0.029	0.0143
Onchocerca volvulus		0.0165	0.3225	0.2322
Schistosoma mansoni	neuropeptide F-like receptor	0.0165	0.3225	0.3835
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0318	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Brugia malayi	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Onchocerca volvulus		0.0165	0.3225	0.2322
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.3225	0.3835
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0165	0.3225	0.3547
Echinococcus multilocularis	isocitrate dehydrogenase	0.0031	0.029	0.0143
Echinococcus granulosus	tm gpcr rhodopsin	0.0165	0.3225	0.3794
Brugia malayi	G protein-coupled receptor	0.0165	0.3225	0.3547
Echinococcus multilocularis	neuropeptide receptor	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.3225	0.3835
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0318	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.1881	0.2122
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0165	0.3225	0.3794
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0318	0.0147
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0165	0.3225	0.3835
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.029	0.0143
Schistosoma mansoni	amine GPCR	0.0165	0.3225	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0318	0.0147
Brugia malayi	larval opioid receptor	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Schistosoma mansoni	opsin-like receptor	0.0165	0.3225	0.3835
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0165	0.3225	0.3794
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.1881	0.2122
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0165	0.3225	0.3835
Brugia malayi	neuropeptide F receptor	0.0165	0.3225	0.3547
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0165	0.3225	0.3794
Echinococcus granulosus	serotonin receptor	0.0165	0.3225	0.3794
Echinococcus granulosus	neuropeptide Y receptor	0.0165	0.3225	0.3794
Onchocerca volvulus		0.0165	0.3225	0.2322
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0071	0.1175	0.1245
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.029	0.8003
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0394	0.8214	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0165	0.3225	0.3835
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0318	1
Echinococcus granulosus	g protein coupled receptor	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Brugia malayi	G protein-coupled receptor F59B2.13	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Plasmodium falciparum	hexose transporter	0.0104	0.1881	0.2122
Echinococcus granulosus	dro:myosuppressin receptor	0.0165	0.3225	0.3794
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0165	0.3225	0.3794
Brugia malayi	GnHR receptor homolog	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0104	0.1881	0.2122
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.3225	0.3835
Echinococcus granulosus	tm gpcr rhodopsin	0.0165	0.3225	0.3794
Echinococcus granulosus	g protein coupled receptor	0.0165	0.3225	0.3794
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.3225	0.3835
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0318	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0165	0.3225	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.3225	0.3835
Echinococcus granulosus	hypothetical protein	0.0165	0.3225	0.3794
Echinococcus multilocularis	dro:myosuppressin receptor	0.0165	0.3225	0.3794
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0165	0.3225	0.3794
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0165	0.3225	0.3794
Schistosoma mansoni	opsin-like receptor	0.0165	0.3225	0.3835
Onchocerca volvulus		0.0165	0.3225	0.2322
Brugia malayi	Dopamine receptor protein 1	0.0165	0.3225	0.3547
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0318	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0318	0.0147
Plasmodium vivax	SET domain protein, putative	0.0071	0.1175	0.1245
Schistosoma mansoni	amine GPCR	0.0165	0.3225	0.3835
Echinococcus multilocularis	General substrate transporter	0.0089	0.1562	0.1726
Schistosoma mansoni	glucose transport protein	0.0104	0.1881	0.2174
Echinococcus granulosus	g-protein coupled receptor	0.0165	0.3225	0.3794
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Schistosoma mansoni	amine GPCR	0.0165	0.3225	0.3835
Brugia malayi	hypothetical protein	0.0165	0.3225	0.3547
Schistosoma mansoni	myosin xvIII	0.0165	0.3225	0.3835
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0318	1
Schistosoma mansoni	biogenic amine receptor	0.0165	0.3225	0.3835
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0289	0.5936	0.7185
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0318	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0071	0.1175	0.1303
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0174	0.5
Plasmodium vivax	SET domain protein, putative	0.0394	0.8214	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Schistosoma mansoni	histamine h1 receptor	0.0165	0.3225	0.3835
Echinococcus granulosus	neuropeptides capa receptor	0.0165	0.3225	0.3794
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0165	0.3225	0.3547
Loa Loa (eye worm)	sugar transporter	0.0104	0.1881	0.1984
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0318	0.0147
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0419	0.8774	1
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0394	0.8214	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0165	0.3225	0.3835
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0394	0.8214	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0104	0.1881	0.2122
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Loa Loa (eye worm)	TYRA-2 protein	0.0165	0.3225	0.3547
Brugia malayi	Pre-SET motif family protein	0.0419	0.8774	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.029	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus multilocularis	somatostatin receptor	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.029	0.0143
Schistosoma mansoni	hypothetical protein	0.0165	0.3225	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0394	0.8214	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus multilocularis	G protein coupled receptor 139	0.0165	0.3225	0.3794
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0318	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0165	0.3225	0.3794
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0165	0.3225	0.3835
Echinococcus granulosus	neuropeptide s receptor	0.0165	0.3225	0.3794
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0165	0.3225	0.3835
Leishmania major	glucose transporter, lmgt1	0.0032	0.0318	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0165	0.3225	0.3794
Brugia malayi	hypothetical protein	0.0165	0.3225	0.3547
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0031	0.029	0.8003
Echinococcus granulosus	neuropeptide receptor A26	0.0165	0.3225	0.3794
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0318	1
Echinococcus multilocularis	orexin receptor type 2	0.0165	0.3225	0.3794
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.3225	0.3835
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0165	0.3225	0.2322
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0165	0.3225	0.3794
Brugia malayi	G-protein coupled receptor	0.0165	0.3225	0.3547
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0031	0.029	0.0143
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0165	0.3225	0.3794
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0174	0.5473
Schistosoma mansoni	amine GPCR	0.0165	0.3225	0.3835
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0165	0.3225	0.3794
Echinococcus granulosus	neuropeptide receptor	0.0165	0.3225	0.3794
Brugia malayi	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	G protein coupled receptor 139	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0165	0.3225	0.3794
Brugia malayi	isocitrate dehydrogenase	0.0031	0.029	0.0134
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0318	1
Onchocerca volvulus		0.0165	0.3225	0.2322
Schistosoma mansoni	hypothetical protein	0.0165	0.3225	0.3835
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0165	0.3225	0.3794
Echinococcus multilocularis	g protein coupled receptor	0.0165	0.3225	0.3794
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0318	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.3225	0.3794
Toxoplasma gondii	isocitrate dehydrogenase	0.0031	0.029	0.0143
Echinococcus multilocularis	neuropeptide Y receptor	0.0165	0.3225	0.3794
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0071	0.1175	0.1303
Schistosoma mansoni	opsin-like receptor	0.0165	0.3225	0.3835
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0031	0.029	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	neuropeptides capa receptor	0.0165	0.3225	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	7TM GPCR rhodopsin	0.0165	0.3225	0.3794
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0318	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus granulosus	7tm_1 domain containing protein	0.0165	0.3225	0.3794
Onchocerca volvulus		0.0165	0.3225	0.2322
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0165	0.3225	0.3547
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0165	0.3225	0.3835
Brugia malayi	hypothetical protein	0.0165	0.3225	0.3547
Brugia malayi	Dopamine receptor protein 2	0.0165	0.3225	0.3547
Echinococcus granulosus	neuropeptide FF receptor 2	0.0165	0.3225	0.3794
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0165	0.3225	0.3835
Brugia malayi	putative neuropeptide receptor	0.0165	0.3225	0.3547
Echinococcus multilocularis	serotonin receptor	0.0289	0.5936	0.7166
Brugia malayi	Protein set-1	0.0394	0.8214	0.9349
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0165	0.3225	0.3547
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.3225	0.3835
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.1881	0.2122
Loa Loa (eye worm)	hypothetical protein	0.0289	0.5936	0.6699
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0318	0.0147
Echinococcus multilocularis	neuropeptide s receptor	0.0165	0.3225	0.3794
Schistosoma mansoni	neuropeptide receptor	0.0165	0.3225	0.3835
Loa Loa (eye worm)	G-protein coupled receptor	0.0165	0.3225	0.3547
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0165	0.3225	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3225	0.3547
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0165	0.3225	0.3794
Toxoplasma gondii	isocitrate dehydrogenase	0.0031	0.029	0.0143
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0165	0.3225	0.3547
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.3225	0.3794

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 844100