Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.01 | 0.0184 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0057 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.0603 | 0.111 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0259 | 0.0399 |
Onchocerca volvulus | 0.0029 | 0.0189 | 0.1889 | |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0259 | 0.0814 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0144 | 0.1269 | 0.2195 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0411 | 0.379 | 0.6983 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0259 | 0.0814 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0259 | 0.0814 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0103 |
Plasmodium vivax | kinesin-5 | 0.0028 | 0.0185 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0144 | 0.1269 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0259 | 0.0814 |
Loa Loa (eye worm) | DNA-binding protein D-ETS-3 | 0.0011 | 0.0016 | 0.0028 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0275 | 0.2502 | 0.9294 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.01 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.2186 | 0.4026 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0011 | 0.0016 | 0.0028 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0259 | 0.0814 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.01 | 0.0057 |
Echinococcus multilocularis | ETS transcription factor Elf 5 | 0.0011 | 0.0016 | 0.0028 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.01 | 0.0103 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0241 | 0.2186 | 0.4026 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0585 | 0.5427 | 1 |
Echinococcus granulosus | ETS transcription factor Elf 2 | 0.0011 | 0.0016 | 0.0028 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0057 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0014 | 0.0044 | 0.0001 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0259 | 0.0814 |
Loa Loa (eye worm) | fli-1 protein | 0.0221 | 0.1999 | 0.3682 |
Echinococcus multilocularis | ETS transcription factor Elf 2 | 0.0011 | 0.0016 | 0.0028 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.1245 | 0.1231 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.01 | 0.0057 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0057 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0241 | 0.2186 | 0.4026 |
Entamoeba histolytica | kinesin, putative | 0.0028 | 0.0185 | 0.0531 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0294 | 0.2685 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.01 | 0.0182 |
Brugia malayi | Kinesin motor domain containing protein | 0.0028 | 0.0185 | 0.034 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0204 | 0.0188 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0241 | 0.2186 | 0.4026 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.1245 | 0.1231 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.01 | 0.0182 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0204 | 0.0375 |
Echinococcus granulosus | ETS transcription factor Elf 5 | 0.0011 | 0.0016 | 0.0028 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.01 | 0.0083 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0259 | 0.0814 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.01 | 0.0057 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.01 | 0.0182 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0241 | 0.2186 | 0.4026 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0259 | 0.0476 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0259 | 0.0814 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0204 | 0.0188 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0585 | 0.5427 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0275 | 0.2502 | 0.9309 |
Schistosoma mansoni | hypothetical protein | 0.0411 | 0.379 | 0.378 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0585 | 0.5427 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0275 | 0.2502 | 0.9309 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0259 | 0.0476 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0241 | 0.2186 | 0.4026 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0259 | 0.0217 |
Brugia malayi | CHE-14 protein | 0.0241 | 0.2186 | 0.4027 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.01 | 0.0083 |
Echinococcus multilocularis | ETS transcription factor Elf 1 | 0.0011 | 0.0016 | 0.0028 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0103 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0057 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0259 | 0.0399 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.01 | 0.0103 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0189 | 0.0346 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.01 | 0.0182 |
Echinococcus multilocularis | kinesin family 1 | 0.0219 | 0.1978 | 0.3644 |
Echinococcus multilocularis | protein C ets 2 | 0.0011 | 0.0016 | 0.0028 |
Echinococcus multilocularis | ewsr:fli fusion protein type | 0.0011 | 0.0016 | 0.0028 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0057 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.01 | 0.0182 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0164 | 0.146 | 0.2688 |
Schistosoma mansoni | kinesin eg-5 | 0.0028 | 0.0185 | 0.0169 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0585 | 0.5427 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.1071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0044 | 0.008 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0057 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0103 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0294 | 0.2685 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0241 | 0.2186 | 0.4026 |
Echinococcus granulosus | ewsr:fli fusion protein type | 0.0011 | 0.0016 | 0.0028 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0014 | 0.0044 | 0.0082 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.01 | 0.0209 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.146 | 0.2688 |
Brugia malayi | DNA-binding protein D-ETS-3 | 0.0011 | 0.0016 | 0.003 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0259 | 0.0814 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0073 | 0.0603 | 0.1109 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0103 |
Echinococcus granulosus | dnaJ subfamily B | 0.0411 | 0.379 | 0.6983 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0164 | 0.146 | 0.2688 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0073 | 0.0603 | 0.1109 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0189 | 0.0348 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.01 | 0.0209 |
Brugia malayi | transcription factor E74 isoform | 0.0011 | 0.0016 | 0.003 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0241 | 0.2186 | 0.2173 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.01 | 0.0057 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0585 | 0.5427 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0294 | 0.2685 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0028 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0294 | 0.2685 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0585 | 0.5427 | 0.542 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0294 | 0.2685 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0057 |
Schistosoma mansoni | gabp alpha | 0.0073 | 0.0603 | 0.0587 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0057 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.171 | 0.1697 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0259 | 0.0399 |
Echinococcus multilocularis | protein patched | 0.0241 | 0.2186 | 0.4026 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0164 | 0.146 | 0.269 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0294 | 0.2685 | 1 |
Echinococcus granulosus | kinesin family 1 | 0.0219 | 0.1978 | 0.3644 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0057 |
Echinococcus multilocularis | ETS domain containing protein Elk 1 | 0.0011 | 0.0016 | 0.0028 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.01 | 0.0057 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0028 | 0.0185 | 0.0338 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0259 | 0.0478 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0294 | 0.2685 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.01 | 0.0184 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0103 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0204 | 0.0375 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0294 | 0.2685 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0259 | 0.3013 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0259 | 0.0814 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.01 | 0.0103 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.0494 | 0.0478 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0259 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.5427 | 1 |
Echinococcus granulosus | ETS transcription factor Elf 1 | 0.0011 | 0.0016 | 0.0028 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0294 | 0.2685 | 1 |
Loa Loa (eye worm) | ets-domain-containing protein | 0.0011 | 0.0016 | 0.0028 |
Loa Loa (eye worm) | D-ets-2 protein | 0.0011 | 0.0016 | 0.0028 |
Giardia lamblia | Kinesin-5 | 0.0028 | 0.0185 | 0.0329 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0259 | 0.0476 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.01 | 0.0182 |
Echinococcus granulosus | ETS domain containing protein Elk 1 | 0.0011 | 0.0016 | 0.0028 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0275 | 0.2502 | 0.9309 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0294 | 0.2685 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0585 | 0.5427 | 0.5408 |
Brugia malayi | Ets-domain containing protein | 0.0011 | 0.0016 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.01 | 0.0182 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0144 | 0.1269 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.0603 | 0.111 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0241 | 0.2186 | 0.4026 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.01 | 0.0083 |
Echinococcus multilocularis | ets variant gene 4 | 0.0011 | 0.0016 | 0.0028 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0073 | 0.0603 | 0.1109 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0189 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0503 | 0.0925 |
Echinococcus granulosus | ETS transcription factor Elf 2 | 0.0011 | 0.0016 | 0.0028 |
Echinococcus granulosus | protein C ets 2 | 0.0011 | 0.0016 | 0.0028 |
Schistosoma mansoni | patched 1 | 0.0241 | 0.2186 | 0.2173 |
Onchocerca volvulus | 0.0095 | 0.0809 | 1 | |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0585 | 0.5427 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.01 | 0.0057 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0259 | 0.0243 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.01 | 0.0209 |
Brugia malayi | Fli-1 protein | 0.0221 | 0.1999 | 0.3683 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0028 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0294 | 0.2685 | 1 |
Schistosoma mansoni | ets-related | 0.0221 | 0.1999 | 0.1986 |
Echinococcus multilocularis | ETS transcription factor Elf 2 | 0.0011 | 0.0016 | 0.0028 |
Plasmodium falciparum | kinesin-5 | 0.0028 | 0.0185 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.146 | 0.2688 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0294 | 0.2685 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.0432 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0585 | 0.5427 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0241 | 0.2186 | 0.811 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.