Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | galactosylceramidase | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | methyltransferase protein 5 | 0.0097 | 0.0372 | 0.0372 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.1084 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0222 | 0.1583 | 0.1583 |
Echinococcus granulosus | protein arginine N methyltransferase 7 | 0.0097 | 0.0372 | 0.0372 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0097 | 0.0372 | 0.5 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0097 | 0.0372 | 0.5 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.1084 | 1 | 1 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0097 | 0.0372 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0372 | 0.0372 |
Trypanosoma brucei | protein arginine n-methyltransferase 7 | 0.0097 | 0.0372 | 0.5 |
Loa Loa (eye worm) | Carm1-pending protein | 0.1084 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0097 | 0.0372 | 0.5 |
Entamoeba histolytica | arginine N-methyltransferase 1, putative | 0.0097 | 0.0372 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0097 | 0.0372 | 0.5 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.1084 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0222 | 0.1583 | 0.1583 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.1084 | 1 | 1 |
Onchocerca volvulus | 0.0987 | 0.9049 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0372 | 0.0372 |
Brugia malayi | hypothetical protein | 0.0222 | 0.1583 | 0.1583 |
Brugia malayi | hypothetical protein | 0.0182 | 0.1201 | 0.1201 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0097 | 0.0372 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0097 | 0.0372 | 0.5 |
Trypanosoma cruzi | protein arginine n-methyltransferase 7 | 0.0097 | 0.0372 | 0.5 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0097 | 0.0372 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.076 | 0.6835 | 0.6835 |
Leishmania major | arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 | 0.0097 | 0.0372 | 0.5 |
Leishmania major | arginine N-methyltransferase, type I | 0.0097 | 0.0372 | 0.5 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0097 | 0.0372 | 0.5 |
Brugia malayi | hypothetical protein | 0.0097 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1201 | 0.1201 |
Brugia malayi | Protein arginine N-methyltransferase | 0.0097 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | protein arginine N-methyltransferase | 0.0097 | 0.0372 | 0.0372 |
Trypanosoma cruzi | arginine N-methyltransferase, type III | 0.0097 | 0.0372 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1583 | 0.1583 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0097 | 0.0372 | 0.5 |
Echinococcus multilocularis | protein arginine N methyltransferase 7 | 0.0097 | 0.0372 | 0.0372 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.