TDR Targets

Basic information

Technical information

TDR Targets ID: 845146
Name: 5-chloro-N-(2,4-dimethoxyphenyl)-2-ethylsulfo nylpyrimidine-4-carboxamide
MW: 385.823 | Formula: C15H16ClN3O5S
H donors: 1 H acceptors: 5 LogP: 1.88 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(OC)ccc1NC(=O)c1nc(ncc1Cl)S(=O)(=O)CC
InChi: 1S/C15H16ClN3O5S/c1-4-25(21,22)15-17-8-10(16)13(19-15)14(20)18-11-6-5-9(23-2)7-12(11)24-3/h5-8H,4H2,1-3H3,(H,18,20)
InChiKey: XQSKNQBFYJUIIX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-chloro-N-(2,4-dimethoxyphenyl)-2-ethylsulfonyl-pyrimidine-4-carboxamide
5-chloro-N-(2,4-dimethoxyphenyl)-2-ethylsulfonyl-4-pyrimidinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	DNA polymerase delta catalytic subunit	0.0074	0.5359	0.6412
Trichomonas vaginalis	DNA polymerase alpha catalytic subunit, putative	0.0014	0.0228	0.0426
Brugia malayi	hypothetical protein	0.0102	0.7714	0.7417
Schistosoma mansoni	myosin xvIII	0.0102	0.7714	1
Plasmodium falciparum	DNA polymerase epsilon catalytic subunit A, putative	0.0014	0.0228	0.0426
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0102	0.7714	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0102	0.7714	1
Onchocerca volvulus		0.0102	0.7714	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.7714	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0102	0.7714	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0102	0.7714	1
Schistosoma mansoni	amine GPCR	0.0102	0.7714	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.7714	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0102	0.7714	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.7714	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0102	0.7714	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0102	0.7714	1
Brugia malayi	hypothetical protein	0.0102	0.7714	0.7417
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Plasmodium vivax	DNA polymerase epsilon, catalytic subunit a, putative	0.0024	0.1151	0.097
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0102	0.7714	1
Onchocerca volvulus		0.0102	0.7714	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0102	0.7714	1
Echinococcus multilocularis	DNA polymerase delta catalytic subunit	0.0074	0.5359	0.6412
Onchocerca volvulus		0.0102	0.7714	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0102	0.7714	1
Echinococcus multilocularis	sex peptide receptor	0.0102	0.7714	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0102	0.7714	1
Echinococcus granulosus	sex peptide receptor	0.0102	0.7714	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.7714	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0102	0.7714	1
Brugia malayi	hypothetical protein	0.0102	0.7714	0.7417
Brugia malayi	neuropeptide F receptor	0.0102	0.7714	0.7417
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0102	0.7714	0.7417
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0102	0.7714	1
Echinococcus multilocularis	neuropeptide receptor	0.0102	0.7714	1
Schistosoma mansoni	amine GPCR	0.0102	0.7714	1
Echinococcus multilocularis	serotonin receptor	0.0102	0.7714	1
Brugia malayi	hypothetical protein	0.0102	0.7714	0.7417
Loa Loa (eye worm)	DNA-directed DNA polymerase III	0.0074	0.5359	0.5359
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus multilocularis	neuropeptide s receptor	0.0102	0.7714	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.7714	1
Schistosoma mansoni	amine GPCR	0.0102	0.7714	1
Echinococcus multilocularis	g protein coupled receptor	0.0102	0.7714	1
Echinococcus granulosus	neuropeptide Y receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.7714	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.1247	1
Schistosoma mansoni	neuropeptide receptor	0.0102	0.7714	1
Echinococcus multilocularis	fmrfamide receptor	0.0102	0.7714	1
Mycobacterium ulcerans	hypothetical protein	0.0026	0.1247	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0102	0.7714	0.7417
Schistosoma mansoni	hypothetical protein	0.0102	0.7714	1
Toxoplasma gondii	DNA polymerase (pol2) superfamily protein	0.0024	0.1151	0.2147
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0102	0.7714	1
Schistosoma mansoni	hypothetical protein	0.0102	0.7714	1
Echinococcus granulosus	hypothetical protein	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Onchocerca volvulus		0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.1247	0.0109
Trichomonas vaginalis	DNA polymerase alpha catalytic subunit, putative	0.0024	0.1151	0.2147
Onchocerca volvulus		0.0102	0.7714	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0102	0.7714	0.7417
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0699	0.0699
Onchocerca volvulus	DNA polymerase delta catalytic subunit homolog	0.0074	0.5359	0.6412
Loa Loa (eye worm)	DNA polymerase epsilon catalytic subunit	0.0014	0.0228	0.0228
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0102	0.7714	1
Brugia malayi	G-protein coupled receptor	0.0102	0.7714	0.7417
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.1247	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.7714	1
Brugia malayi	putative neuropeptide receptor	0.0102	0.7714	0.7417
Brugia malayi	Melatonin receptor type 1A	0.0102	0.7714	0.7417
Brugia malayi	Dopamine receptor protein 2	0.0102	0.7714	0.7417
Leishmania major	DNA polymerase I alpha catalytic subunit, putative	0.0024	0.1151	0.2147
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.1247	0.2327
Brugia malayi	hypothetical protein	0.0102	0.7714	0.7417
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0102	0.7714	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0102	0.7714	0.7714
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0102	0.7714	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0102	0.7714	1
Echinococcus multilocularis	serotonin receptor	0.0102	0.7714	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0102	0.7714	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0102	0.7714	0.7417
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0102	0.7714	1
Trichomonas vaginalis	DNA polymerase II, putative	0.0024	0.1151	0.2147
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.1247	0.2327
Schistosoma mansoni	opsin-like receptor	0.0102	0.7714	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0102	0.7714	1
Echinococcus multilocularis	fmrfamide receptor	0.0102	0.7714	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.1247	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0102	0.7714	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.1247	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.1247	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0102	0.7714	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0102	0.7714	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0102	0.7714	1
Echinococcus granulosus	allatostatin A receptor	0.0102	0.7714	1
Brugia malayi	ORL1-like opioid receptor	0.0102	0.7714	0.7417
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Onchocerca volvulus		0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1247	0.1247
Echinococcus granulosus	neuropeptide s receptor	0.0102	0.7714	1
Brugia malayi	G protein-coupled receptor	0.0102	0.7714	0.7417
Brugia malayi	neuropeptide F receptor	0.0102	0.7714	0.7417
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Leishmania major	DNA polymerase delta catalytic subunit, putative	0.0074	0.5359	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.7714	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0699	0.5
Echinococcus granulosus	somatostatin receptor	0.0102	0.7714	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0102	0.7714	0.7417
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.7714	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0102	0.7714	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.1247	0.2327
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0102	0.7714	0.7714
Echinococcus granulosus	neuropeptide receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.7714	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	1	1
Schistosoma mansoni	amine GPCR	0.0102	0.7714	1
Entamoeba histolytica	DNA polymerase delta catalytic subunit, putative	0.0074	0.5359	1
Schistosoma mansoni	hypothetical protein	0.0102	0.7714	1
Toxoplasma gondii	DNA polymerase family B protein	0.0024	0.1151	0.2147
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus multilocularis	somatostatin receptor	0.0102	0.7714	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.7714	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.7714	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.1247	1
Brugia malayi	AKH receptor	0.0102	0.7714	0.7417
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.1247	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Giardia lamblia	DNA polymerase epsilon, catalytic subunit	0.0024	0.1151	0.2147
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0102	0.7714	1
Echinococcus granulosus	g protein coupled receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0102	0.7714	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.7714	1
Brugia malayi	Serotonin receptor	0.0102	0.7714	0.7417
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0102	0.7714	0.7714
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0102	0.7714	1
Brugia malayi	GnHR receptor homolog	0.0102	0.7714	0.7417
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.7714	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.1247	0.2327
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus multilocularis	allatostatin A receptor	0.0102	0.7714	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0102	0.7714	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0102	0.7714	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0699	0.0699
Echinococcus granulosus	g protein coupled receptor	0.0102	0.7714	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.1247	0.0109
Brugia malayi	follicle stimulating hormone receptor	0.0102	0.7714	0.7417
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.1247	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0102	0.7714	1
Onchocerca volvulus		0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.7714	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0102	0.7714	1
Schistosoma mansoni	adenoreceptor	0.0102	0.7714	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0102	0.7714	1
Brugia malayi	hypothetical protein	0.0102	0.7714	0.7417
Schistosoma mansoni	biogenic amine receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0699	0.0699
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.1247	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus multilocularis	g protein coupled receptor	0.0102	0.7714	1
Brugia malayi	G-protein coupled receptor	0.0102	0.7714	0.7417
Brugia malayi	Dopamine receptor	0.0102	0.7714	0.7417
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Brugia malayi	sulfakinin receptor protein	0.0102	0.7714	0.7417
Echinococcus granulosus	neuropeptide receptor	0.0102	0.7714	1
Schistosoma mansoni	histamine h1 receptor	0.0102	0.7714	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0102	0.7714	1
Brugia malayi	hypothetical protein	0.0102	0.7714	0.7417
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Onchocerca volvulus		0.0102	0.7714	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0102	0.7714	1
Trypanosoma brucei	DNA polymerase delta catalytic subunit, putative	0.0074	0.5359	1
Echinococcus granulosus	G protein coupled receptor 139	0.0102	0.7714	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.7714	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.7714	1
Trichomonas vaginalis	DNA polymerase delta catalytic subunit, putative	0.0024	0.1151	0.2147
Schistosoma mansoni	DNA polymerase delta catalytic subunit	0.0074	0.5359	0.6412
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0102	0.7714	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.1247	0.0109
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0102	0.7714	1
Plasmodium vivax	DNA polymerase alpha, putative	0.0024	0.1151	0.097
Onchocerca volvulus		0.0102	0.7714	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0102	0.7714	1
Onchocerca volvulus		0.0102	0.7714	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0102	0.7714	0.7417
Onchocerca volvulus		0.0102	0.7714	1
Trypanosoma cruzi	DNA polymerase epsilon catalytic subunit, putative	0.0024	0.1151	0.2147
Loa Loa (eye worm)	neuropeptide F receptor	0.0102	0.7714	0.7714
Schistosoma mansoni	growth hormone secretagogue receptor	0.0102	0.7714	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0102	0.7714	1
Echinococcus granulosus	orexin receptor type 2	0.0102	0.7714	1
Echinococcus multilocularis	g-protein coupled receptor	0.0102	0.7714	1
Echinococcus granulosus	neuropeptide Y receptor	0.0102	0.7714	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0102	0.7714	1
Loa Loa (eye worm)	TYRA-2 protein	0.0102	0.7714	0.7714
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.7714	1
Echinococcus granulosus	serotonin receptor	0.0102	0.7714	1
Onchocerca volvulus		0.0102	0.7714	1
Brugia malayi	hypothetical protein	0.0102	0.7714	0.7417
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0102	0.7714	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0102	0.7714	1
Trichomonas vaginalis	DNA polymerase alpha catalytic subunit, putative	0.0024	0.1151	0.2147
Onchocerca volvulus		0.0102	0.7714	1
Schistosoma mansoni	neuropeptide receptor	0.0102	0.7714	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.7714	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0102	0.7714	0.7714
Brugia malayi	larval opioid receptor	0.0102	0.7714	0.7417
Brugia malayi	RE15519p	0.0102	0.7714	0.7417
Trypanosoma cruzi	DNA polymerase delta catalytic subunit, putative	0.0074	0.5359	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0102	0.7714	1
Plasmodium vivax	DNA polymerase zeta catalytic subunit, putative	0.0024	0.1151	0.097
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1151	0.1151
Echinococcus multilocularis	neuropeptide receptor	0.0102	0.7714	1
Schistosoma mansoni	neuropeptide receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus granulosus	tm gpcr rhodopsin	0.0102	0.7714	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0102	0.7714	0.7714
Echinococcus multilocularis	neuropeptides capa receptor	0.0102	0.7714	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.7714	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0102	0.7714	0.7417
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Loa Loa (eye worm)	neuropeptide F receptor	0.0102	0.7714	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0102	0.7714	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Plasmodium falciparum	DNA polymerase delta catalytic subunit	0.0074	0.5359	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Brugia malayi	hypothetical protein	0.0102	0.7714	0.7417
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0699	0.0699
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.1247	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0102	0.7714	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.1247	0.2327
Leishmania major	DNA polymerase epsilon catalytic subunit, putative	0.0024	0.1151	0.2147
Onchocerca volvulus		0.0102	0.7714	1
Schistosoma mansoni	hypothetical protein	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0102	0.7714	1
Schistosoma mansoni	neuropeptide receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0228	0.0228
Schistosoma mansoni	opsin-like receptor	0.0102	0.7714	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0102	0.7714	1
Brugia malayi	Dopamine receptor protein 1	0.0102	0.7714	0.7417
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0102	0.7714	1
Brugia malayi	hypothetical protein	0.0102	0.7714	0.7417
Plasmodium vivax	DNA polymerase delta catalytic subunit, putative	0.0074	0.5359	1
Trypanosoma cruzi	DNA polymerase delta catalytic subunit, putative	0.006	0.4208	0.7853
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0102	0.7714	1
Schistosoma mansoni	biogenic amine receptor	0.0102	0.7714	1
Echinococcus granulosus	g-protein coupled receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0699	0.0699
Trypanosoma cruzi	DNA polymerase I alpha catalytic subunit, putative	0.0024	0.1151	0.2147
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.1247	0.2327
Onchocerca volvulus		0.0102	0.7714	1
Brugia malayi	Serotonin receptor	0.0102	0.7714	0.7417
Trichomonas vaginalis	DNA polymerase zeta catalytic subunit, putative	0.0074	0.5359	1
Echinococcus multilocularis	orexin receptor type 2	0.0102	0.7714	1
Giardia lamblia	DNA polymerase delta, catalytic subunit	0.0074	0.5359	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0102	0.7714	1
Schistosoma mansoni	opsin-like receptor	0.0102	0.7714	1
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0699	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Schistosoma mansoni	neuropeptide F-like receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus granulosus	neuropeptides capa receptor	0.0102	0.7714	1
Echinococcus granulosus	neuropeptides capa receptor	0.0102	0.7714	1
Schistosoma mansoni	biogenic amine receptor	0.0102	0.7714	1
Toxoplasma gondii	DNA polymerase	0.0074	0.5359	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Trypanosoma cruzi	DNA polymerase epsilon catalytic subunit, putative	0.0024	0.1151	0.2147
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Echinococcus granulosus	neuropeptide receptor A26	0.0102	0.7714	1
Echinococcus granulosus	g protein coupled receptor	0.0102	0.7714	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0102	0.7714	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0102	0.7714	0.7714
Echinococcus multilocularis	dro:myosuppressin receptor	0.0102	0.7714	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.1247	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0228	0.0228
Loa Loa (eye worm)	G-protein coupled receptor	0.0102	0.7714	0.7714
Echinococcus granulosus	fmrfamide receptor	0.0102	0.7714	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0102	0.7714	1
Echinococcus multilocularis	g protein coupled receptor	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0102	0.7714	0.7714
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Schistosoma mansoni	amine GPCR	0.0102	0.7714	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0102	0.7714	1
Onchocerca volvulus		0.0102	0.7714	1
Onchocerca volvulus		0.0026	0.1247	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Brugia malayi	DNA polymerase delta catalytic subunit	0.0074	0.5359	0.4755
Echinococcus granulosus	7TM GPCR rhodopsin	0.0102	0.7714	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0102	0.7714	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.7714	0.7714
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0699	0.139
Onchocerca volvulus		0.0102	0.7714	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0102	0.7714	0.7417

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 845146