Detailed information for compound 848300

Basic information

Technical information
  • TDR Targets ID: 848300
  • Name: N-(pyridin-3-ylmethylideneamino)hexanamide
  • MW: 219.283 | Formula: C12H17N3O
  • H donors: 1 H acceptors: 2 LogP: 2.01 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC(=O)N/N=C/c1cccnc1
  • InChi: 1S/C12H17N3O/c1-2-3-4-7-12(16)15-14-10-11-6-5-8-13-9-11/h5-6,8-10H,2-4,7H2,1H3,(H,15,16)/b14-10+
  • InChiKey: JHKOORSAARYROG-GXDHUFHOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-pyridylmethyleneamino)hexanamide
  • CBMicro_017855
  • IVK/8179016
  • BIM-0017676.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0165 0.0342 0.0336
Schistosoma mansoni histone deacetylase 1 2 3 0.0531 0.258 0.2576
Echinococcus granulosus histone deacetylase 6 0.0646 0.3285 0.3281
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0165 0.0342 0.0336
Trichomonas vaginalis histone deacetylase, putative 0.1743 1 1
Trypanosoma brucei histone deacetylase 2 0.0531 0.258 0.2576
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0137 0.0131
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0834 0.4436 0.4436
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0165 0.0342 0.0342
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.011 0.0006 0.5
Loa Loa (eye worm) hypothetical protein 0.011 0.0006 0.0006
Trypanosoma cruzi histone deacetylase, putative 0.064 0.3248 0.3244
Plasmodium vivax histone deacetylase, putative 0.0531 0.258 0.2576
Treponema pallidum catabolite gene activator (Crp) 0.011 0.0006 0.5
Toxoplasma gondii histone deacetylase HDAC1 0.064 0.3248 0.3244
Trypanosoma brucei histone deacetylase, putative 0.064 0.3248 0.3244
Schistosoma mansoni histone deacetylase 4 5 0.064 0.3248 0.3244
Treponema pallidum cyclic nucleotide binding protein 0.011 0.0006 0.5
Brugia malayi Histone deacetylase family protein 0.064 0.3248 0.3244
Mycobacterium ulcerans transcriptional regulatory protein 0.011 0.0006 0.5
Loa Loa (eye worm) AGC/PKG protein kinase 0.011 0.0006 0.0006
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.011 0.0006 0.5
Trichomonas vaginalis histone deacetylase, putative 0.1743 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0779 0.41 0.4096
Trypanosoma brucei histone deacetylase 3 0.064 0.3248 0.3244
Schistosoma mansoni histone deacetylase hda2 0.0646 0.3285 0.3281
Mycobacterium tuberculosis Conserved protein 0.011 0.0006 0.5
Giardia lamblia Histone deacetylase 0.1743 1 1
Echinococcus multilocularis histone deacetylase 1 0.1743 1 1
Loa Loa (eye worm) histone deacetylase 7A 0.064 0.3248 0.3248
Trypanosoma brucei histone deacetylase 1 0.1743 1 1
Trypanosoma cruzi histone deacetylase, putative 0.064 0.3248 0.3244
Echinococcus granulosus histone deacetylase 0.064 0.3248 0.3244
Echinococcus granulosus histone deacetylase 3 0.1743 1 1
Leishmania major histone deacetylase, putative 0.064 0.3248 0.3244
Echinococcus multilocularis histone deacetylase 3 0.1743 1 1
Plasmodium vivax histone deacetylase 2, putative 0.064 0.3248 0.3244
Plasmodium falciparum histone deacetylase 1 0.1743 1 1
Mycobacterium ulcerans transmembrane transport protein 0.011 0.0006 0.5
Loa Loa (eye worm) histone deacetylase 3 0.1743 1 1
Leishmania major histone deacetylase, putative 0.1743 1 1
Toxoplasma gondii histone deacetylase HDAC5 0.0531 0.258 0.2576
Echinococcus multilocularis histone deacetylase 6 0.064 0.3248 0.3244
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.011 0.0006 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0242 0.0811 0.0805
Entamoeba histolytica histone deacetylase, putative 0.1743 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0115 0.0037 0.0037
Treponema pallidum cyclic nucleotide binding protein 0.011 0.0006 0.5
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0165 0.0342 0.0342
Trypanosoma brucei histone deacetylase 4 0.064 0.3248 0.3244
Echinococcus granulosus histone deacetylase 1 0.1743 1 1
Trichomonas vaginalis histone deacetylase, putative 0.1743 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.011 0.0006 0.5
Loa Loa (eye worm) hypothetical protein 0.011 0.0006 0.0006
Brugia malayi Histone deacetylase 1 0.1743 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0165 0.0342 0.0336
Schistosoma mansoni 60S ribosomal protein L21 0.0131 0.0137 0.0131
Schistosoma mansoni histone deacetylase 0.1743 1 1
Loa Loa (eye worm) histone deacetylase 1 0.1743 1 1
Schistosoma mansoni histone deacetylase 0.1743 1 1
Loa Loa (eye worm) histone deacetylase 0.064 0.3248 0.3248
Trichomonas vaginalis histone deacetylase, putative 0.1743 1 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1743 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0834 0.4436 0.4432
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0242 0.0811 0.0805
Leishmania major histone deacetylase, putative 0.064 0.3248 0.3244
Plasmodium vivax histone deacetylase, putative 0.064 0.3248 0.3244
Trypanosoma cruzi histone deacetylase 1, putative 0.1743 1 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.0811 0.0811
Brugia malayi Cyclic-nucleotide gated cation channel 0.0165 0.0342 0.0336
Brugia malayi Histone deacetylase family protein 0.064 0.3248 0.3244
Trypanosoma cruzi histone deacetylase 1, putative 0.1743 1 1
Echinococcus granulosus histone deacetylase 6 0.064 0.3248 0.3244
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0834 0.4436 0.4432
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.0811 0.0805
Echinococcus granulosus histone deacetylase 6 0.064 0.3248 0.3244
Echinococcus multilocularis histone deacetylase 8 0.0531 0.258 0.2576
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0165 0.0342 0.0336
Echinococcus multilocularis histone deacetylase 6 0.064 0.3248 0.3244
Trypanosoma cruzi histone deacetylase, putative 0.0531 0.258 0.2576
Schistosoma mansoni voltage-gated potassium channel 0.0242 0.0811 0.0805
Brugia malayi histone deacetylase 1 (HD1) 0.1743 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0165 0.0342 0.0336
Toxoplasma gondii histone deacetylase HDAC2 0.1743 1 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.0342 0.0342
Trichomonas vaginalis histone deacetylase, putative 0.1743 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0165 0.0342 0.0336
Mycobacterium leprae Conserved hypothetical protein 0.011 0.0006 0.5
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0165 0.0342 0.0336
Schistosoma mansoni voltage-gated potassium channel 0.0911 0.4905 0.4902
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0165 0.0342 0.0336
Echinococcus multilocularis histone deacetylase 6 0.0646 0.3285 0.3281
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.011 0.0006 0.5
Plasmodium vivax histone deacetylase 1, putative 0.1743 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0165 0.0342 0.0336
Trypanosoma cruzi histone deacetylase, putative 0.0531 0.258 0.2576
Echinococcus granulosus voltage gated potassium channel 0.0242 0.0811 0.0805
Plasmodium falciparum histone deacetylase, putative 0.064 0.3248 0.3244
Leishmania major histone deacetylase, putative 0.1743 1 1
Toxoplasma gondii histone deacetylase HDAC4 0.0531 0.258 0.2576
Treponema pallidum catabolite gene activator 0.011 0.0006 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0165 0.0342 0.0336
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0779 0.41 0.4096
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.1743 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0165 0.0342 0.0336
Mycobacterium tuberculosis Conserved hypothetical protein 0.011 0.0006 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0165 0.0342 0.0336
Brugia malayi histone deacetylase 11 0.0531 0.258 0.2576
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0165 0.0342 0.0336
Echinococcus multilocularis voltage gated potassium channel 0.0242 0.0811 0.0805
Mycobacterium ulcerans hypothetical protein 0.011 0.0006 0.5
Onchocerca volvulus Histone deacetylase 10 homolog 0.0531 0.258 1
Loa Loa (eye worm) hypothetical protein 0.0724 0.3762 0.3762
Echinococcus multilocularis histone deacetylase 0.064 0.3248 0.3244
Loa Loa (eye worm) hypothetical protein 0.0531 0.258 0.258
Plasmodium falciparum histone deacetylase 2 0.064 0.3248 0.3244
Schistosoma mansoni voltage-gated potassium channel 0.0911 0.4905 0.4902
Echinococcus granulosus histone deacetylase 8 0.0531 0.258 0.2576
Mycobacterium ulcerans regulatory protein 0.011 0.0006 0.5
Echinococcus granulosus hyperpolarization activated cyclic 0.0165 0.0342 0.0336
Echinococcus multilocularis histone deacetylase 7 0.064 0.3248 0.3244
Trichomonas vaginalis histone deacetylase, putative 0.1743 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0165 0.0342 0.0336
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0165 0.0342 0.0336
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1743 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0165 0.0342 0.0336
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1743 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0165 0.0342 0.0336
Echinococcus granulosus histone deacetylase 7 0.064 0.3248 0.3244
Toxoplasma gondii histone deacetylase HDAC3 0.1743 1 1
Mycobacterium ulcerans hypothetical protein 0.011 0.0006 0.5
Loa Loa (eye worm) histone deacetylase 11 0.0531 0.258 0.258
Trypanosoma cruzi histone deacetylase, putative 0.064 0.3248 0.3244
Schistosoma mansoni histone deacetylase hda2 0.0531 0.258 0.2576
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0165 0.0342 0.0336
Mycobacterium ulcerans hypothetical protein 0.011 0.0006 0.5
Schistosoma mansoni histone deacetylase 4 5 0.064 0.3248 0.3244
Mycobacterium ulcerans hypothetical protein 0.011 0.0006 0.5
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.011 0.0006 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0834 0.4436 0.4432
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0242 0.0811 0.0805

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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