Detailed information for compound 85906

Basic information

Technical information
  • TDR Targets ID: 85906
  • Name: (5Z)-5-[[4-[(2,2,4,6,7-pentamethyl-5-phenylme thoxy-3H-1-benzofuran-3-yl)methoxy]phenyl]met hylidene]-1,3-thiazolidine-2,4-dione
  • MW: 529.647 | Formula: C31H31NO5S
  • H donors: 1 H acceptors: 2 LogP: 6.84 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1NC(=O)/C(=C/c2ccc(cc2)OCC2c3c(OC2(C)C)c(C)c(c(c3C)OCc2ccccc2)C)/S1
  • InChi: 1S/C31H31NO5S/c1-18-19(2)28-26(20(3)27(18)36-16-22-9-7-6-8-10-22)24(31(4,5)37-28)17-35-23-13-11-21(12-14-23)15-25-29(33)32-30(34)38-25/h6-15,24H,16-17H2,1-5H3,(H,32,33,34)/b25-15-
  • InChiKey: KULVWOKZVOLTQA-MYYYXRDXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z)-5-[[4-[(5-benzyloxy-2,2,4,6,7-pentamethyl-3H-benzofuran-3-yl)methoxy]phenyl]methylene]thiazolidine-2,4-dione
  • (5Z)-5-[4-[(5-benzoxy-2,2,4,6,7-pentamethyl-coumaran-3-yl)methoxy]benzylidene]thiazolidine-2,4-quinone
  • (5Z)-5-[[4-[[2,2,4,6,7-pentamethyl-5-(phenylmethoxy)-3H-1-benzofuran-3-yl]methoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione
  • (5Z)-5-[[4-[[2,2,4,6,7-pentamethyl-5-(phenylmethoxy)-3H-benzofuran-3-yl]methoxy]phenyl]methylene]thiazolidine-2,4-dione
  • (5Z)-5-[4-[[5-(benzyloxy)-2,2,4,6,7-pentamethyl-3H-benzofuran-3-yl]methoxy]benzylidene]thiazolidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase kappa, putative 0.0019 0.0044 0.0073
Onchocerca volvulus 0.0048 0.0416 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.001
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0163 0.1874 0.1874
Echinococcus granulosus carbonic anhydrase 0.022 0.2588 0.3456
Leishmania major hypothetical protein, conserved 0.0016 0.001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Loa Loa (eye worm) hypothetical protein 0.0034 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0261
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.001 0.0001
Echinococcus granulosus muscleblind protein 0.0606 0.7489 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0421 0.0421
Schistosoma mansoni ets-related 0.0217 0.2557 0.4063
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.001 0.0001
Echinococcus multilocularis muscleblind protein 0.0606 0.7489 0.7576
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.001 0.001
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.044 0.4018
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.001 0.001
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0013
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0313 0.3767 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0416 0.3451
Loa Loa (eye worm) hypothetical protein 0.022 0.2588 0.2588
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0229 0.0306
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0416 0.3794
Loa Loa (eye worm) hypothetical protein 0.0606 0.7489 0.7489
Loa Loa (eye worm) hypothetical protein 0.0048 0.0416 0.0416
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0775 0.1034
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0261 0.0539
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0118 0.0288
Schistosoma mansoni carbonic anhydrase-related 0.022 0.2588 0.4112
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0416 0.0812
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0041 0.0082
Brugia malayi jmjC domain containing protein 0.0016 0.001 0.0014
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0775 0.1645
Brugia malayi Isocitrate dehydrogenase 0.0016 0.001 0.0013
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0163 0.1874 0.1874
Brugia malayi hypothetical protein 0.0025 0.0118 0.0158
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0383 0.4658 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0775 0.1645
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0118 0.0233
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0775 1
Schistosoma mansoni ap endonuclease 0.0019 0.0041 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0573 0.4894
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0416 0.3451
Leishmania major DNA polymerase eta, putative 0.0019 0.0044 0.0073
Brugia malayi isocitrate dehydrogenase 0.0016 0.001 0.0013
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0041 0.0288
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0044 0.0073
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.001 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0383 0.4658 1
Brugia malayi jmjC domain containing protein 0.0016 0.001 0.0014
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0416 0.4369
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.9885 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Schistosoma mansoni ap endonuclease 0.0019 0.0041 0.0065
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.001 0.0001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.044 0.4744
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0383 0.4658 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0416 0.0812
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0427 0.057
Echinococcus multilocularis carbonic anhydrase 0.022 0.2588 0.2618
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.022 0.2588 0.3456
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0313 0.3767 0.503
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0261
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0101 0.1079 0.9559
Schistosoma mansoni jumonji domain containing protein 0.0016 0.001 0.0016
Echinococcus multilocularis carbonic anhydrase 0.022 0.2588 0.2618
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.044 0.4018
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0041 0.0055
Echinococcus multilocularis carbonic anhydrase 0.022 0.2588 0.2618
Plasmodium vivax JmjC domain containing protein 0.0016 0.001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0416 0.3451
Echinococcus granulosus carbonic anhydrase II 0.0313 0.3767 0.503
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0118 0.0233
Brugia malayi jmjC domain containing protein 0.0016 0.001 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0091
Echinococcus multilocularis carbonic anhydrase II 0.0313 0.3767 0.3811
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0261 0.2344
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0313 0.3767 0.503
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0416 0.0873
Mycobacterium ulcerans hypothetical protein 0.0048 0.0416 0.3451
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0044 0.0007
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0044 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0573 0.4894
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.001 0.001
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0059
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0573 0.091
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0973 0.1545
Schistosoma mansoni hypothetical protein 0.0512 0.6294 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0041 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0973 0.1545
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0573 0.4894
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0137 0.1314
Schistosoma mansoni gabp alpha 0.0072 0.071 0.1128
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0041 0.0082
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.001 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0973 0.0984
Schistosoma mansoni hypothetical protein 0.0512 0.6294 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0044 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0044 0.003
Echinococcus multilocularis dna polymerase eta 0.0019 0.0044 0.0045
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0313 0.3767 0.5986
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0041 0.0041
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0313 0.3767 0.5986
Brugia malayi Ets-domain containing protein 0.0072 0.071 0.0948
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.001 0.0011
Brugia malayi Cytochrome P450 family protein 0.0049 0.0421 0.0562
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0044 0.007
Echinococcus granulosus peptidase Clp S14 family 0.005 0.044 0.0587
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0775 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0416 0.0555
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0582 0.0778
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0313 0.3767 0.3767
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0775 0.0784
Brugia malayi Fli-1 protein 0.0217 0.2557 0.3415
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0775 1
Loa Loa (eye worm) hypothetical protein 0.022 0.2588 0.2588
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0044 0.003
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0313 0.3767 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.022 0.2588 0.3456
Loa Loa (eye worm) hypothetical protein 0.0025 0.0118 0.0118
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.071 0.0718
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0973 0.0984
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0573 0.5261
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0091
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.001 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0261 0.2023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0236 0.211
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.001 0.0014
Schistosoma mansoni DNA polymerase eta 0.0019 0.0044 0.007
Schistosoma mansoni phd/f-box containing protein 0.0016 0.001 0.0016
Trypanosoma brucei unspecified product 0.0019 0.0044 0.0091
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.001
Schistosoma mansoni carbonic anhydrase 0.022 0.2588 0.4112
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0973 0.0973
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0573 0.121
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0041 0.0082
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0582 0.0589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0973 0.1299
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0582 0.0778
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.001 0.0014
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0775 0.1231
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.001 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0416 0.3451
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0261
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0416 0.4369
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0044 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Giardia lamblia Macrophage migration inhibitory factor 0.0383 0.4658 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0416 0.3451
Loa Loa (eye worm) fli-1 protein 0.0217 0.2557 0.2557
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0416 0.0873
Echinococcus multilocularis muscleblind protein 1 0.0606 0.7489 0.7576
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0236 0.211
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0573 0.121
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0261
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.022 0.2588 0.3456
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0582 0.0589
Leishmania major carbonic anhydrase-like protein 0.0313 0.3767 0.8084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0973 0.1299
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0416 0.3451
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.071 0.0948
Leishmania major macrophage migration inhibitory factor-like protein 0.0383 0.4658 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0044 0.0007
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0041 0.0066
Brugia malayi hypothetical protein 0.0016 0.0006 0.0008
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.001 0.0014
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0573 0.091
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0427 0.057
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0118 0.0233
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0383 0.4658 1
Echinococcus multilocularis phd:f box containing protein 0.0016 0.001 0.0011
Trypanosoma brucei carbonic anhydrase-like protein 0.0313 0.3767 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Brugia malayi jmjC domain containing protein 0.0062 0.0582 0.0778
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.022 0.2588 0.3456
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0775 0.1645
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0041 0.0055
Brugia malayi jmjC domain containing protein 0.0062 0.0582 0.0778
Loa Loa (eye worm) hypothetical protein 0.0061 0.0578 0.0578
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.022 0.2588 0.2588
Leishmania major hypothetical protein, conserved 0.0025 0.0118 0.0233
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0041 0.0041
Schistosoma mansoni carbonic anhydrase-related 0.022 0.2588 0.4112
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0416 0.0812
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0573 0.0579
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0261
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0582 0.0925
Echinococcus granulosus carbonic anhydrase 0.022 0.2588 0.3456
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.071 0.071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0973 0.1545
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.001 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0236 0.211
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0427 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.001 0.0016
Echinococcus granulosus phd:f box containing protein 0.0016 0.001 0.0014
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0059
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0775 1
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.001 0.0014
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0104 0.1127 1
Toxoplasma gondii hypothetical protein 0.022 0.2588 0.5547
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0044 0.0007
Brugia malayi Probable ClpP-like protease 0.0077 0.0775 0.1034
Plasmodium falciparum carbonic anhydrase 0.022 0.2588 0.5547
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0775 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0044 0.0059
Loa Loa (eye worm) hypothetical protein 0.0606 0.7489 0.7489
Brugia malayi Ets-domain containing protein 0.0072 0.071 0.0948
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0118 0.0233
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.022 0.2588 0.3456
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0236 0.211
Echinococcus granulosus carbonic anhydrase 0.022 0.2588 0.3456
Schistosoma mansoni carbonic anhydrase-related 0.022 0.2588 0.4112
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0416 0.0555
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0775 0.6755
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0416 0.0873
Toxoplasma gondii hypothetical protein 0.0026 0.0137 0.0274
Leishmania major macrophage migration inhibitory factor-like protein 0.0383 0.4658 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0775 0.0775
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0118 0.0288
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0582 0.0925
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0383 0.4658 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0044 0.0007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.001 0.0011
Echinococcus multilocularis geminin 0.0512 0.6294 0.6367
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0059
Brugia malayi Bm-MIF-1, identical 0.0383 0.4658 0.6219
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.044 0.0445
Loa Loa (eye worm) hypothetical protein 0.0049 0.0427 0.0427
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0261 0.0539
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0118 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Loa Loa (eye worm) carbonic anhydrase 3 0.0313 0.3767 0.3767
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0775 0.6755
Brugia malayi jmjC domain containing protein 0.0016 0.001 0.0014
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.001 0.0001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0041 0.0066
Plasmodium falciparum macrophage migration inhibitory factor 0.0383 0.4658 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0044 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0573 0.0765
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0044
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0041 0.0066
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0044 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.0416 0.0416
Schistosoma mansoni protein phosphatase 2C 0.0016 0.001 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0091
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0044 0.0319
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0775 0.1645
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0973 0.1299
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0044 0.0319
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0582 0.0925
Schistosoma mansoni hypothetical protein 0.0034 0.0229 0.0364
Echinococcus granulosus geminin 0.0512 0.6294 0.8404
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.001 0.001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0416 0.3451
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0101 0.1079 0.9559
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0137 0.0274
Schistosoma mansoni hypothetical protein 0.022 0.2588 0.4112
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0416 0.0416
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.001 0.0016
Brugia malayi Muscleblind-like protein 0.0606 0.7489 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0416 0.3794
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0416 0.0555
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0383 0.4658 0.4658
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0101 0.1079 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.001 0.0011
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0582 0.0582
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0137 0.0274
Echinococcus granulosus dna polymerase eta 0.0019 0.0044 0.0059

Activities

Activity type Activity value Assay description Source Reference
PG (functional) = 10 % Percent reduction of plasma glucose (PG) after 6 days of treatment. It is the mean of standard deviation observed in plasma glucose (PG) in db/db mice at dose of 200 mg/kg/day ChEMBL. 10354401
PG (functional) = 10 % Percent reduction of plasma glucose (PG) after 6 days of treatment. It is the mean of standard deviation observed in plasma glucose (PG) in db/db mice at dose of 200 mg/kg/day ChEMBL. 10354401
Reduction (functional) 0 % The compound was tested for percent reduction of plasma triglyceride after 6 days of treatment; not active ChEMBL. 10354401
Reduction (functional) = 10 % Percent reduction of plasma glucose after 6 days of treatment (various doses). ChEMBL. 10354401
Reduction (functional) = 10 % Percent reduction of plasma glucose after 6 days of treatment (various doses). ChEMBL. 10354401
TG (functional) 0 % Percent reduction in plasma triglyceride (TG) after 6 days of treatment. It is the mean of standard deviation observed in plasma triglyceride (TG) in db/db mice at dose of 200 mg/kg/day; NA = Not Active ChEMBL. 10354401

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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