Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0388 | 0.074 |
Brugia malayi | Plexin repeat family protein | 0.0034 | 0.1281 | 0.2441 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0121 | 0.5247 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0121 | 0.5247 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0121 | 0.5247 | 1 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0015 | 0.0382 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0626 | 0.1193 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1388 | 0.1826 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0226 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0449 | 0.0449 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1388 | 0.1826 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0121 | 0.5247 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0121 | 0.5247 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0121 | 0.5247 | 1 |
Schistosoma mansoni | netrin receptor unc5 | 0.0015 | 0.0382 | 0.0503 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1388 | 0.1388 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0368 | 0.0702 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0015 | 0.0382 | 0.0503 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0449 | 0.0855 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0121 | 0.5247 | 1 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0368 | 0.0702 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0015 | 0.0382 | 0.0729 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0121 | 0.5247 | 0.5247 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0449 | 0.0855 |
Echinococcus granulosus | semaphorin 1A | 0.0014 | 0.0368 | 0.0368 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1388 | 0.2646 |
Onchocerca volvulus | Netrin receptor homolog | 0.0015 | 0.0382 | 0.0029 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0015 | 0.0382 | 0.0382 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0015 | 0.0388 | 0.051 |
Brugia malayi | Death domain containing protein | 0.0015 | 0.0382 | 0.0729 |
Echinococcus multilocularis | plexin a4 | 0.0041 | 0.1568 | 0.1568 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0008 | 0.0077 | 0.0146 |
Echinococcus multilocularis | hypothetical protein | 0.0014 | 0.0368 | 0.0368 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0121 | 0.5247 | 0.5247 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.5247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0368 | 0.0702 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0121 | 0.5247 | 0.69 |
Echinococcus granulosus | semaphorin 5B | 0.0014 | 0.0368 | 0.0368 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0368 | 0.0702 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1388 | 0.2646 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0382 | 0.0729 |
Schistosoma mansoni | semaphorin 5-related | 0.0014 | 0.0368 | 0.0484 |
Echinococcus granulosus | plexin a4 | 0.0041 | 0.1568 | 0.1568 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.0382 | 0.0729 |
Schistosoma mansoni | plexin | 0.0034 | 0.1281 | 0.1685 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0449 | 0.0449 |
Echinococcus granulosus | Ankyrin | 0.0015 | 0.0388 | 0.0388 |
Echinococcus multilocularis | semaphorin 5B | 0.0014 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0014 | 0.0368 | 0.0702 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.7603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0368 | 0.0702 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1281 | 0.2441 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1388 | 0.2646 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1388 | 0.1388 |
Echinococcus multilocularis | Ankyrin | 0.0015 | 0.0388 | 0.0388 |
Loa Loa (eye worm) | plexin A | 0.0041 | 0.1568 | 0.2989 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0368 | 0.0484 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0449 | 0.0449 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0382 | 0.0503 |
Brugia malayi | Uncoordinated protein 44 | 0.0015 | 0.0382 | 0.0729 |
Onchocerca volvulus | 0.0034 | 0.1281 | 0.1871 | |
Echinococcus multilocularis | geminin | 0.0173 | 0.7603 | 0.7603 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0121 | 0.5247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0368 | 0.0702 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1388 | 0.2646 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.7603 | 1 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0015 | 0.0382 | 0.0382 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0449 | 0.0449 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0121 | 0.5247 | 1 |
Echinococcus granulosus | geminin | 0.0173 | 0.7603 | 0.7603 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0382 | 0.0729 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0449 | 0.0449 |
Plasmodium vivax | RNA helicase-1, putative | 0.0121 | 0.5247 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0121 | 0.5247 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0121 | 0.5247 | 0.5247 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0121 | 0.5247 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0121 | 0.5247 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0121 | 0.5247 | 0.5247 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0121 | 0.5247 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0449 | 0.059 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0008 | 0.0077 | 0.0146 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0449 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0368 | 0.0702 |
Brugia malayi | plexin A | 0.0041 | 0.1568 | 0.2989 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0368 | 0.0484 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0015 | 0.0382 | 0.0382 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0449 | 0.0449 |
Schistosoma mansoni | plexin | 0.002 | 0.0626 | 0.0823 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1388 | 0.2646 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0368 | 0.0702 |
Echinococcus granulosus | death domain containing protein | 0.0015 | 0.0382 | 0.0382 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0121 | 0.5247 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0626 | 0.0823 |
Brugia malayi | Sema domain containing protein | 0.0014 | 0.0368 | 0.0702 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0121 | 0.5247 | 0.69 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0121 | 0.5247 | 0.5 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0014 | 0.0368 | 0.0702 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0121 | 0.5247 | 1 |
Brugia malayi | Sema domain containing protein | 0.0014 | 0.0368 | 0.0702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.