TDR Targets

Basic information

Technical information

TDR Targets ID: 863336
Name: N-butyl-N,2,3-trimethyl-4H-thieno[2,3-d]thiop yran-6-carboxamide
MW: 295.463 | Formula: C15H21NOS2
H donors: 0 H acceptors: 1 LogP: 3.91 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(C(=O)C1=Cc2c(CS1)c(c(s2)C)C)C
InChi: 1S/C15H21NOS2/c1-5-6-7-16(4)15(17)14-8-13-12(9-18-14)10(2)11(3)19-13/h8H,5-7,9H2,1-4H3
InChiKey: LBVLFVNZENZKNJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0121	0.5247	0.5247
Brugia malayi	hypothetical protein	0.0014	0.0368	0.0702
Schistosoma mansoni	plexin	0.0034	0.1281	0.1685
Schistosoma mansoni	semaphorin 5-related	0.0014	0.0368	0.0484
Brugia malayi	eukaryotic initiation factor 4A	0.0121	0.5247	1
Entamoeba histolytica	hypothetical protein	0.0037	0.1388	0.2646
Loa Loa (eye worm)	sema domain-containing protein	0.0014	0.0368	0.0702
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0449	0.0855
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0368	0.0702
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0121	0.5247	0.5247
Brugia malayi	Uncoordinated protein 44	0.0015	0.0382	0.0729
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0449	0.0855
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0121	0.5247	0.69
Entamoeba histolytica	hypothetical protein	0.0037	0.1388	0.2646
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0121	0.5247	0.69
Schistosoma mansoni	hypothetical protein	0.0015	0.0382	0.0503
Schistosoma mansoni	plexin	0.002	0.0626	0.0823
Brugia malayi	Death domain containing protein	0.0015	0.0382	0.0729
Echinococcus granulosus	Ankyrin	0.0015	0.0388	0.0388
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0226	1	1
Echinococcus granulosus	death domain containing protein	0.0015	0.0382	0.0382
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.1388	0.1388
Schistosoma mansoni	hypothetical protein	0.0173	0.7603	1
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0382	0.0729
Loa Loa (eye worm)	hypothetical protein	0.002	0.0626	0.1193
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0449	0.0449
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0121	0.5247	1
Echinococcus granulosus	geminin	0.0173	0.7603	0.7603
Schistosoma mansoni	hypothetical protein	0.0014	0.0368	0.0484
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0121	0.5247	1
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0121	0.5247	1
Schistosoma mansoni	hypothetical protein	0.0037	0.1388	0.1826
Loa Loa (eye worm)	sema domain-containing protein	0.0014	0.0368	0.0702
Brugia malayi	hypothetical protein	0.0014	0.0368	0.0702
Onchocerca volvulus	Netrin receptor homolog	0.0015	0.0382	0.0029
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0121	0.5247	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.1388	0.1388
Leishmania major	eukaryotic initiation factor 4a, putative	0.0121	0.5247	1
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0121	0.5247	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0449	0.0449
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0449	0.0855
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0449	0.0449
Treponema pallidum	ATP-dependent RNA helicase	0.0121	0.5247	0.5
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0121	0.5247	1
Schistosoma mansoni	ankyrin 23/unc44	0.0015	0.0382	0.0503
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0121	0.5247	1
Brugia malayi	Plexin repeat family protein	0.0034	0.1281	0.2441
Loa Loa (eye worm)	hypothetical protein	0.0121	0.5247	1
Schistosoma mansoni	hypothetical protein	0.002	0.0626	0.0823
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.0382	0.0729
Entamoeba histolytica	hypothetical protein	0.0037	0.1388	0.2646
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0015	0.0382	0.0382
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0121	0.5247	1
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0388	0.051
Brugia malayi	hypothetical protein	0.0037	0.1388	0.2646
Echinococcus multilocularis	Ankyrin	0.0015	0.0388	0.0388
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0121	0.5247	1
Brugia malayi	plexin A	0.0041	0.1568	0.2989
Echinococcus multilocularis	geminin	0.0173	0.7603	0.7603
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.0382	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0382	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0368	0.0702
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0121	0.5247	0.5247
Echinococcus granulosus	semaphorin 1A	0.0014	0.0368	0.0368
Brugia malayi	Sema domain containing protein	0.0014	0.0368	0.0702
Loa Loa (eye worm)	plexin A	0.0041	0.1568	0.2989
Brugia malayi	Sema domain containing protein	0.0014	0.0368	0.0702
Schistosoma mansoni	hypothetical protein	0.0173	0.7603	1
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0121	0.5247	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0368	0.0702
Entamoeba histolytica	hypothetical protein	0.0037	0.1388	0.2646
Echinococcus multilocularis	semaphorin 5B	0.0014	0.0368	0.0368
Echinococcus multilocularis	hypothetical protein	0.0014	0.0368	0.0368
Echinococcus granulosus	netrin receptor unc 5	0.0015	0.0382	0.0382
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0121	0.5247	0.5247
Echinococcus multilocularis	netrin receptor unc 5	0.0015	0.0382	0.0382
Leishmania major	eukaryotic initiation factor 4a, putative	0.0121	0.5247	1
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.1388	0.1826
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0368	0.0702
Echinococcus granulosus	semaphorin 5B	0.0014	0.0368	0.0368
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0449	0.059
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0368	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0368	0.0702
Plasmodium vivax	RNA helicase-1, putative	0.0121	0.5247	1
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0121	0.5247	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0449	0.0449
Schistosoma mansoni	hypothetical protein	0.0014	0.0368	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1281	0.2441
Entamoeba histolytica	tyrosin kinase, putative	0.0008	0.0077	0.0146
Echinococcus granulosus	plexin a4	0.0041	0.1568	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0388	0.074
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0015	0.0382	0.0382
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0077	0.0146
Echinococcus multilocularis	plexin a4	0.0041	0.1568	0.1568
Schistosoma mansoni	netrin receptor unc5	0.0015	0.0382	0.0503
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0121	0.5247	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0449	0.0449
Onchocerca volvulus		0.0034	0.1281	0.1871

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 863336