Detailed information for compound 865531

Basic information

Technical information
  • TDR Targets ID: 865531
  • Name: N-(2,3-dimethylcyclohexyl)-6-morpholin-4-ylsu lfonyl-4-oxo-1H-quinoline-3-carboxamide
  • MW: 447.548 | Formula: C22H29N3O5S
  • H donors: 2 H acceptors: 5 LogP: 3.12 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCC(C1C)NC(=O)c1cnc2c(c1O)cc(cc2)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C22H29N3O5S/c1-14-4-3-5-19(15(14)2)24-22(27)18-13-23-20-7-6-16(12-17(20)21(18)26)31(28,29)25-8-10-30-11-9-25/h6-7,12-15,19H,3-5,8-11H2,1-2H3,(H,23,26)(H,24,27)
  • InChiKey: LJHFIKNUNWDBPX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,3-dimethylcyclohexyl)-6-morpholinosulfonyl-4-oxo-1H-quinoline-3-carboxamide
  • N-(2,3-dimethylcyclohexyl)-4-keto-6-morpholinosulfonyl-1H-quinoline-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0336 0.0934 0.9889
Entamoeba histolytica hypothetical protein 0.0081 0.0179 0.1895
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 0.013 0.074
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0252 0.2334
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0161 0.0417 0.0417
Echinococcus granulosus NDR protein kinase 0.0287 0.0788 0.448
Brugia malayi Protein kinase domain containing protein 0.034 0.0944 0.537
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0101 0.024 0.2204
Entamoeba histolytica protein kinase, putative 0.034 0.0944 1
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0505 0.2875
Brugia malayi map kinase activated protein kinase protein 2 0.0194 0.0513 0.2917
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0279 0.0764 0.8009
Echinococcus granulosus epidermal growth factor receptor 0.0159 0.0411 0.2337
Schistosoma mansoni diacylglycerol kinase theta 0.0183 0.0482 0.2742
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0191 0.0505 0.2875
Brugia malayi Variant SH3 domain containing protein 0.0028 0.0024 0.0137
Echinococcus multilocularis raf serine:threonine protein kinase 0.0189 0.0499 0.2839
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0123 0.0304 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 0.013 0.074
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0287 0.0788 0.0788
Brugia malayi protein kinase C II. 0.0616 0.1758 1
Loa Loa (eye worm) hypothetical protein 0.3122 0.9153 0.9153
Schistosoma mansoni pyruvate dehydrogenase 0.0123 0.0304 0.1731
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0171 0.0446 0.2538
Trichomonas vaginalis AGC family protein kinase 0.0287 0.0788 0.8267
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0064 0.013 0.074
Echinococcus granulosus tyrosine kinase 0.005 0.0089 0.0507
Echinococcus granulosus Glutaredoxin protein 5 0.005 0.0087 0.0494
Onchocerca volvulus 0.0183 0.0482 0.0527
Echinococcus granulosus protein kinase C gamma type 0.029 0.0795 0.4524
Loa Loa (eye worm) hypothetical protein 0.3122 0.9153 0.9153
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0252 0.2334
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0171 0.0446 0.2538
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0066 0.0135 0.0766
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0287 0.0788 0.0788
Echinococcus multilocularis epidermal growth factor receptor 0.0159 0.0411 0.2337
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0054 0.0101 0.0574
Trypanosoma brucei rac serine-threonine kinase, putative 0.034 0.0944 1
Echinococcus multilocularis N chimaerin 0.0198 0.0524 0.2982
Echinococcus multilocularis NCK adaptor protein 0.0028 0.0024 0.0137
Brugia malayi Protein kinase domain containing protein 0.0054 0.0101 0.0574
Loa Loa (eye worm) hypothetical protein 0.0187 0.0493 0.0493
Trichomonas vaginalis AGC family protein kinase 0.029 0.0798 0.8383
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.0252 0.2666
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0194 0.0513 0.2917
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0287 0.0788 0.448
Echinococcus multilocularis nervana 2 0.005 0.0087 0.0494
Loa Loa (eye worm) hypothetical protein 0.0066 0.0135 0.0135
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0121 0.1278
Entamoeba histolytica protein kinase, putative 0.0022 0.0006 0.0067
Schistosoma mansoni atypical protein kinase C 0.047 0.1329 0.7558
Brugia malayi Variant SH3 domain containing protein 0.0198 0.0524 0.2982
Echinococcus multilocularis rac serine:threonine kinase 0.0061 0.0121 0.0687
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.0499 0.2839
Loa Loa (eye worm) hypothetical protein 0.0183 0.0482 0.0482
Schistosoma mansoni growth factor receptor-bound protein 0.0028 0.0024 0.0137
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0198 0.0524 0.2982
Onchocerca volvulus 0.3122 0.9153 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0041 0.0233
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0142 0.0809
Echinococcus granulosus nervana 2 0.005 0.0087 0.0494
Echinococcus granulosus nervana 2 0.005 0.0087 0.0494
Echinococcus granulosus serine threonine protein kinase nrc 0.0057 0.011 0.0627
Brugia malayi RhoGAP domain containing protein 0.0198 0.0524 0.2982
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.007 0.0146 0.1167
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0252 0.8069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0101 0.024 0.1365
Echinococcus granulosus serine:threonine protein kinase N2 0.0287 0.0788 0.448
Schistosoma mansoni tyrosine kinase 0.0159 0.0411 0.2337
Loa Loa (eye worm) hypothetical protein 0.0183 0.0482 0.0482
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0123 0.0304 0.1731
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0044 0.0072 0.041
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0123 0.0304 0.1731
Echinococcus granulosus myotubularin protein 13 0.0187 0.0493 0.2801
Loa Loa (eye worm) phosphatidylinositol 3 0.017 0.0442 0.0442
Loa Loa (eye worm) TK protein kinase 0.005 0.0089 0.0089
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0057 0.011 0.5
Leishmania major developmentally regulated phosphoprotein-like protein 0.0123 0.0304 1
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0513 0.2917
Echinococcus granulosus tyrosine protein kinase Fyn 0.0064 0.013 0.074
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0123 0.0304 0.1731
Toxoplasma gondii AGC kinase 0.0336 0.0934 1
Giardia lamblia Kinase, PLK 0.0105 0.0252 1
Brugia malayi Protein kinase domain containing protein 0.0287 0.0788 0.448
Echinococcus multilocularis Diacylglycerol kinase theta 0.0183 0.0482 0.2742
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0183 0.0482 0.0482
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0028 0.0024 0.0024
Brugia malayi kinase, mitochondrial precursor 0.0123 0.0304 0.1731
Schistosoma mansoni protein kinase C 0.0186 0.049 0.2786
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0198 0.0524 0.2982
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0089 0.0204 0.1162
Schistosoma mansoni serine/threonine protein kinase 0.0473 0.1337 0.7602
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0047 0.0267
Loa Loa (eye worm) AGC/PKN protein kinase 0.0287 0.0788 0.0788
Schistosoma mansoni diacylglycerol kinase theta 0.0183 0.0482 0.2742
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.007 0.0146 0.1167
Entamoeba histolytica protein kinase 2, putative 0.0057 0.011 0.1168
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0121 0.1278
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0198 0.0524 0.0524
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0064 0.013 0.074
Loa Loa (eye worm) raf kinase 0.0183 0.0482 0.0482
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0089 0.0507
Entamoeba histolytica protein kinase, putative 0.0036 0.0047 0.0497
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0061 0.0121 0.3256
Onchocerca volvulus 0.0143 0.0362 0.0396
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.0252 0.0275
Schistosoma mansoni nck2/grb4 0.0028 0.0024 0.0137
Echinococcus multilocularis protein kinase c iota type 0.047 0.1329 0.7558
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0101 0.024 0.2204
Echinococcus granulosus serine/threonine protein kinase 0.0061 0.0121 0.0687
Brugia malayi SRC-1 0.0064 0.013 0.074
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0252 0.2334
Brugia malayi protein-tyrosine kinase 0.005 0.0089 0.0507
Echinococcus multilocularis insulin receptor 0.0054 0.0101 0.0574
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0047 0.0267
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0057 0.011 0.0627
Schistosoma mansoni protein kinase C mu 0.0183 0.0482 0.2742
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0191 0.0505 0.2875
Brugia malayi Variant SH3 domain containing protein 0.002 0.0001 0.0006
Echinococcus granulosus serine:threonine protein kinase N2 0.0151 0.0386 0.2194
Echinococcus multilocularis myotubularin protein 13 0.0187 0.0493 0.2801
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.0252 0.1432
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0028 0.0024 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0252 0.2334
Schistosoma mansoni tyrosine kinase 0.0082 0.0183 0.1041
Brugia malayi Furin-like cysteine rich region family protein 0.0159 0.0411 0.2337
Loa Loa (eye worm) AGC/NDR protein kinase 0.0287 0.0788 0.0788
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0034 0.0041 0.0433
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0336 0.0934 0.0934
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0106 0.0721
Schistosoma mansoni tyrosine kinase 0.0082 0.0183 0.1041
Echinococcus multilocularis Glutaredoxin protein 5 0.005 0.0087 0.0494
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.0252 0.1432
Echinococcus granulosus Protein kinase C brain isozyme 0.0473 0.1337 0.7602
Schistosoma mansoni growth factor receptor-bound protein 0.0028 0.0024 0.0137
Loa Loa (eye worm) TK/INSR protein kinase 0.0054 0.0101 0.0101
Schistosoma mansoni protein kinase C mu 0.0191 0.0505 0.2875
Echinococcus granulosus tyrosine protein kinase Fyn 0.0064 0.013 0.074
Trichomonas vaginalis AGC family protein kinase 0.034 0.0944 1
Schistosoma mansoni tyrosine kinase 0.0054 0.0101 0.0574
Brugia malayi Protein kinase domain containing protein 0.0287 0.0788 0.448
Schistosoma mansoni unc-13 (munc13) 0.0186 0.049 0.2786
Schistosoma mansoni kinase 0.0057 0.011 0.0625
Entamoeba histolytica diacylglycerol kinase, putative 0.0183 0.0482 0.5106
Echinococcus multilocularis protein kinase c eta type 0.0183 0.0482 0.2742
Brugia malayi Hr1 repeat family protein 0.0287 0.0788 0.448
Echinococcus granulosus tyrosine protein kinase Fyn 0.0064 0.013 0.074
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0101 0.024 0.7637
Loa Loa (eye worm) SRC-1 0.0064 0.013 0.013
Brugia malayi Protein kinase c protein 2 0.0194 0.0513 0.2918
Schistosoma mansoni tyrosine kinase 0.0054 0.0101 0.0574
Loa Loa (eye worm) hypothetical protein 0.0183 0.0482 0.0482
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0022 0.0006 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.0788 0.448
Schistosoma mansoni adapter molecule crk 0.0028 0.0024 0.0137
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0287 0.0788 0.448
Echinococcus granulosus tyrosine protein kinase Lyn 0.0072 0.0154 0.0873
Schistosoma mansoni tyrosine kinase 0.0064 0.013 0.074
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0088 0.02 0.1138
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0252 0.2334
Echinococcus granulosus insulin receptor 0.0054 0.0101 0.0574
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0287 0.0788 0.448
Echinococcus granulosus raf serine:threonine protein kinase 0.0189 0.0499 0.2839
Loa Loa (eye worm) hypothetical protein 0.3122 0.9153 0.9153
Trichomonas vaginalis AGC family protein kinase 0.0287 0.0788 0.8267
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.0788 0.448
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0098 0.0231 0.2448
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.0252 0.7776
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0034 0.0041 0.0433
Trichomonas vaginalis AGC family protein kinase 0.034 0.0944 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0191 0.0504 0.2864
Schistosoma mansoni tyrosine kinase 0.0157 0.0405 0.2305
Echinococcus multilocularis 0.0048 0.0082 0.0466
Loa Loa (eye worm) hypothetical protein 0.0183 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.3305 0.9694 0.9694
Trichomonas vaginalis AGC family protein kinase 0.0287 0.0788 0.8267
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0064 0.013 0.074
Echinococcus granulosus tyrosine protein kinase Blk 0.005 0.0089 0.0507
Schistosoma mansoni tyrosine kinase 0.0034 0.0041 0.0234
Echinococcus granulosus Diacylglycerol kinase theta 0.0183 0.0482 0.2742
Brugia malayi diacylglycerol kinase 0.0183 0.0482 0.2742
Brugia malayi RhoGEF domain containing protein 0.0183 0.0482 0.2742
Onchocerca volvulus Tyrosine kinase homolog 0.0151 0.0387 0.0422
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0106 0.0721
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0287 0.0788 0.448
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0034 0.0041 0.0234
Loa Loa (eye worm) TK/EGFR protein kinase 0.0159 0.0411 0.0411
Schistosoma mansoni tyrosine kinase 0.0064 0.013 0.074
Loa Loa (eye worm) variant SH3 domain-containing protein 0.002 0.0001 0.0001
Entamoeba histolytica diacylglycerol kinase, putative 0.0183 0.0482 0.5106
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.005 0.0087 0.0494
Echinococcus multilocularis tyrosine protein kinase Srms 0.005 0.0089 0.0507
Loa Loa (eye worm) TK protein kinase 0.0036 0.0047 0.0047
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0179 0.1895
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.0417 0.2372
Echinococcus granulosus epidermal growth factor receptor 0.0088 0.02 0.1138
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0101 0.024 0.2204
Loa Loa (eye worm) hypothetical protein 0.0036 0.0046 0.0046
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.0252 0.0252
Loa Loa (eye worm) RasGEF domain-containing protein 0.0183 0.0482 0.0482
Schistosoma mansoni hypothetical protein 0.0183 0.0482 0.2742
Entamoeba histolytica hypothetical protein 0.0183 0.0482 0.5106
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.0788 0.448
Schistosoma mansoni pyruvate dehydrogenase 0.0116 0.0284 0.1616
Trypanosoma brucei polo-like protein kinase 0.0105 0.0252 0.2334
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0186 0.049 0.2786
Echinococcus multilocularis serine:threonine protein kinase N2 0.043 0.1209 0.6878
Entamoeba histolytica protein kinase, putative 0.034 0.0944 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.005 0.0089 0.0507
Brugia malayi C1-like domain containing protein 0.0191 0.0505 0.2875
Brugia malayi p70 ribosomal S6 kinase beta 0.0336 0.0934 0.5311
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0191 0.0505 0.0505
Schistosoma mansoni tyrosine kinase 0.0082 0.0183 0.1041
Brugia malayi Sex muscle abnormal protein 5 0.0028 0.0024 0.0137
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 0.013 0.074
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0064 0.013 0.074
Loa Loa (eye worm) hypothetical protein 0.0187 0.0493 0.0493
Schistosoma mansoni serine/threonine-protein kinase 0.0061 0.0121 0.0687
Schistosoma mansoni tyrosine kinase 0.0088 0.02 0.1138
Echinococcus multilocularis tyrosine protein kinase Abl 0.0034 0.0041 0.0234
Loa Loa (eye worm) hypothetical protein 0.0183 0.0482 0.0482
Brugia malayi RhoGAP domain containing protein 0.0183 0.0482 0.2742
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0191 0.0504 0.2864
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.0788 0.448
Loa Loa (eye worm) hypothetical protein 0.0186 0.049 0.049
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0194 0.0513 0.2917
Echinococcus multilocularis serine threonine protein kinase 0.029 0.0795 0.4524
Schistosoma mansoni tyrosine kinase 0.0088 0.02 0.1138
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0032 0.0032
Echinococcus multilocularis nervana 2 0.005 0.0087 0.0494
Echinococcus multilocularis serine:threonine protein kinase 38 0.0287 0.0788 0.448
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0183 0.0482 0.0482
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.0252 0.1432
Echinococcus granulosus growth factor receptor bound protein 2 0.0028 0.0024 0.0137
Echinococcus multilocularis growth factor receptor bound protein 2 0.0028 0.0024 0.0137
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0028 0.0024 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0473 0.1337 0.7602
Echinococcus granulosus N chimaerin 0.0198 0.0524 0.2982
Echinococcus granulosus tyrosine protein kinase Src64B 0.0064 0.013 0.074
Trichomonas vaginalis AGC family protein kinase 0.034 0.0944 1
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0043 0.0068 0.1317
Trichomonas vaginalis AGC family protein kinase 0.034 0.0944 1
Schistosoma mansoni pyruvate dehydrogenase 0.0116 0.0284 0.1616
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0616 0.1758 0.1758
Schistosoma mansoni tyrosine kinase 0.0034 0.0041 0.0234
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0191 0.0505 0.0505
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0045 0.0073 0.0778
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.005 0.0088 0.0234
Entamoeba histolytica protein kinase, putative 0.0287 0.0788 0.8342
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0101 0.024 0.7637
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0505 0.2875
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0034 0.0041 0.0325
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0252 0.8069
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.005 0.0089 0.0507
Echinococcus multilocularis epidermal growth factor receptor 0.0088 0.02 0.1138
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0054 0.0101 0.0574
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0049 0.0085 0.3088
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0287 0.0788 0.0788
Brugia malayi Tyrosine-protein kinase abl-1 0.0034 0.0041 0.0234
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0198 0.0524 0.2982
Loa Loa (eye worm) hypothetical protein 0.0183 0.0482 0.0482
Trichomonas vaginalis AGC family protein kinase 0.034 0.0944 1
Echinococcus granulosus NCK adaptor protein 0.0028 0.0024 0.0137
Echinococcus granulosus tyrosine protein kinase Src42A 0.0064 0.013 0.074
Brugia malayi Pleckstrin Homology Domain 0.0187 0.0493 0.2801
Brugia malayi Ras association domain family 1 isoform A 0.0183 0.0482 0.2742
Schistosoma mansoni serine/threonine-protein kinase 0.0061 0.0121 0.0687
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Schistosoma mansoni rac gtpase activating protein 0.0183 0.0482 0.2742
Echinococcus multilocularis protein kinase c epsilon type 0.0616 0.1758 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0252 0.2334
Trypanosoma brucei developmentally regulated phosphoprotein 0.0123 0.0304 0.2916
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0198 0.0524 0.2982
Brugia malayi Protein kinase domain containing protein 0.0191 0.0505 0.2875
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0186 0.049 0.2786
Echinococcus granulosus unc 13 munc13 0.0186 0.049 0.2786
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0473 0.1337 0.7602
Schistosoma mansoni vav2 0.0201 0.0535 0.3041
Echinococcus multilocularis serine:threonine protein kinase N2 0.0287 0.0788 0.448
Echinococcus multilocularis unc 13 (munc13) 0.0186 0.049 0.2786
Echinococcus granulosus Rac GTPase activating protein 1 0.0183 0.0482 0.2742
Entamoeba histolytica PH domain containing protein kinase, putative 0.0154 0.0396 0.4196
Echinococcus granulosus protein kinase c epsilon type 0.0616 0.1758 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0287 0.0788 0.448
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0252 0.2334
Trypanosoma cruzi Protein kinase B 0.0061 0.0121 0.3256
Echinococcus granulosus c src tyrosine kinase 0.0034 0.0041 0.0234
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0064 0.013 0.074
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0064 0.013 0.074
Echinococcus multilocularis c src tyrosine kinase 0.0034 0.0041 0.0234
Loa Loa (eye worm) hypothetical protein 0.0183 0.0482 0.0482
Brugia malayi Variant SH3 domain containing protein 0.0028 0.0024 0.0137
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0066 0.0135 0.0766
Brugia malayi diacylglycerol kinase 0.0183 0.0482 0.2742
Echinococcus multilocularis Rac GTPase activating protein 1 0.0183 0.0482 0.2742
Echinococcus granulosus protein kinase c iota type 0.047 0.1329 0.7558
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0194 0.0513 0.0513
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0101 0.024 0.2542
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0287 0.0788 0.448
Onchocerca volvulus 0.0186 0.049 0.0535
Trichomonas vaginalis AGC family protein kinase 0.034 0.0944 1
Trichomonas vaginalis AGC family protein kinase 0.034 0.0944 1
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0043 0.0068 0.0299
Brugia malayi protein kinase C3,putative 0.0191 0.0505 0.2875
Echinococcus granulosus tyrosine protein kinase Src42A 0.0044 0.0072 0.041
Onchocerca volvulus 0.0022 0.0005 0.0006
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0191 0.0504 0.2864
Loa Loa (eye worm) AGC/AKT protein kinase 0.034 0.0944 0.0944
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0057 0.011 0.2872
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0057 0.011 0.0627
Schistosoma mansoni serine/threonine protein kinase 0.0616 0.1758 1
Echinococcus granulosus protein kinase c eta type 0.0183 0.0482 0.2742
Onchocerca volvulus 0.0187 0.0493 0.0538
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0037 0.0049 0.0276
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0191 0.0505 0.2875
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0252 0.1432
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0057 0.011 0.5
Loa Loa (eye worm) hypothetical protein 0.0123 0.0304 0.0304
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.005 0.0087 0.0494
Giardia lamblia Kinase, AGC PKA 0.0057 0.011 0.4127
Loa Loa (eye worm) hypothetical protein 0.0183 0.0482 0.0482
Schistosoma mansoni serine/threonine kinase 0.0287 0.0788 0.448
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0064 0.013 0.074
Schistosoma mansoni unc-13 (munc13) 0.0186 0.049 0.2786
Toxoplasma gondii diacylglycerol kinase, putative 0.0183 0.0482 0.4783
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0064 0.013 0.074

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.