TDR Targets

Basic information

Technical information

TDR Targets ID: 867783
Name: N-cyclohexyl-3-formyl-N-methyl-1H-indole-5-su lfonamide
MW: 320.407 | Formula: C16H20N2O3S
H donors: 1 H acceptors: 3 LogP: 2.29 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=Cc1c[nH]c2c1cc(cc2)S(=O)(=O)N(C1CCCCC1)C
InChi: 1S/C16H20N2O3S/c1-18(13-5-3-2-4-6-13)22(20,21)14-7-8-16-15(9-14)12(11-19)10-17-16/h7-11,13,17H,2-6H2,1H3
InChiKey: JPJXVFRPTFNWNU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cyclohexyl-3-methanoyl-N-methyl-1H-indole-5-sulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0431	0.1213
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0057	0.0979	0.2071
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.015	0.3077	1
Trypanosoma cruzi	p450 reductase, putative	0.015	0.3077	1
Giardia lamblia	Hypothetical protein	0.0133	0.269	1
Echinococcus multilocularis	musashi	0.0026	0.0278	0.0214
Trypanosoma brucei	protein kinase, putative	0.0051	0.0827	0.253
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0431	0.0368
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0827	0.1498
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0431	0.5018
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0827	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0203	0.0661
Schistosoma mansoni	diflavin oxidoreductase	0.0074	0.1365	0.4317
Entamoeba histolytica	type A flavoprotein, putative	0.0057	0.0979	1
Leishmania major	hypothetical protein, conserved	0.0057	0.0979	0.3033
Onchocerca volvulus		0.0026	0.0278	0.2919
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0431	0.14
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0431	0.14
Echinococcus multilocularis	tumor protein p63	0.0336	0.7292	0.7274
Loa Loa (eye worm)	flavodoxin family protein	0.0057	0.0979	0.3181
Leishmania major	cytochrome P450 reductase, putative	0.0133	0.269	0.8717
Plasmodium vivax	ferredoxin--NADP reductase, putative	0.0017	0.0065	0.0002
Schistosoma mansoni	NADH-cytochrome B5 reductase	0.0017	0.0065	0.0002
Echinococcus granulosus	tumor protein p63	0.0336	0.7292	0.7274
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0093	0.1777	0.5776
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0827	0.0767
Schistosoma mansoni	cytochrome P450 reductase	0.015	0.3077	1
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0057	0.0979	0.3034
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0431	1
Trichomonas vaginalis	sulfite reductase, putative	0.015	0.3077	1
Plasmodium vivax	hypothetical protein, conserved	0.0057	0.0979	0.3034
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0827	0.2903
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0827	0.253
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0269	0.0873
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0057	0.0979	0.3033
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0017	0.0065	0.0004
Echinococcus multilocularis	methionine synthase reductase	0.0093	0.1777	0.1723
Schistosoma mansoni	cytochrome B5	0.0017	0.0065	0.0002
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.015	0.3077	1
Echinococcus granulosus	lamin	0.0026	0.0278	0.0214
Giardia lamblia	Flavohemoprotein lateral transfer candidate	0.0017	0.0065	0.0002
Echinococcus multilocularis	neuropeptide receptor A26	0.0456	1	1
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0057	0.0979	0.2071
Plasmodium falciparum	nitric oxide synthase, putative	0.015	0.3077	1
Mycobacterium ulcerans	pyruvate kinase	0.0033	0.0431	0.1213
Brugia malayi	FAD binding domain containing protein	0.0093	0.1777	0.5776
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0278	0.0904
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0827	0.1498
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0431	0.14
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0057	0.0979	0.3034
Loa Loa (eye worm)	hypothetical protein	0.015	0.3077	1
Echinococcus granulosus	pyruvate kinase	0.0033	0.0431	0.0368
Leishmania major	pyruvate kinase	0.0033	0.0431	0.1213
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0431	0.14
Echinococcus multilocularis	lamin dm0	0.0026	0.0278	0.0214
Entamoeba histolytica	type A flavoprotein, putative	0.0057	0.0979	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.015	0.3077	1
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0057	0.0979	0.2071
Toxoplasma gondii	flavodoxin domain-containing protein	0.0074	0.1365	1
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0431	0.14
Treponema pallidum	flavodoxin	0.0057	0.0979	1
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0057	0.0979	0.3033
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0278	0.0904
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0272	0.0209
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.015	0.3077	1
Echinococcus granulosus	neuropeptide receptor A26	0.0456	1	1
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.015	0.3077	0.3031
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.015	0.3077	0.3031
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.015	0.3077	0.3031
Schistosoma mansoni	lamin	0.0026	0.0278	0.0707
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.015	0.3077	1
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.015	0.3077	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0827	0.2689
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0827	0.0767
Schistosoma mansoni	pyruvate kinase	0.0033	0.0431	0.1215
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0827	0.5863
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0827	0.2531
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.015	0.3077	1
Plasmodium falciparum	ferredoxin--NADP reductase	0.0017	0.0065	0.0002
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0431	0.2134
Onchocerca volvulus		0.0026	0.0278	0.2919
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0793	0.2579
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.015	0.3077	0.3031
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0793	0.2419
Plasmodium vivax	flavodoxin domain containing protein	0.0133	0.269	0.8718
Brugia malayi	Cytochrome b5-like Heme/Steroid binding domain containing protein	0.0017	0.0065	0.0213
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0278	0.0707
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0827	0.253
Brugia malayi	diaphorase	0.0017	0.0065	0.0213
Plasmodium falciparum	NADH-cytochrome b5 reductase, putative	0.0017	0.0065	0.0002
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0431	0.1213
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.015	0.3077	1
Brugia malayi	flavodoxin family protein	0.015	0.3077	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0827	0.253
Giardia lamblia	Pyruvate kinase	0.0033	0.0431	0.1393
Plasmodium falciparum	pyruvate kinase	0.0033	0.0431	0.1215
Brugia malayi	intermediate filament protein	0.0026	0.0278	0.0904
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0431	0.1215
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0431	0.1213
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0278	0.0904
Echinococcus granulosus	methionine synthase reductase	0.0093	0.1777	0.1723
Onchocerca volvulus		0.0049	0.0793	1
Chlamydia trachomatis	sulfite reductase	0.0093	0.1777	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0827	0.253
Brugia malayi	FAD binding domain containing protein	0.015	0.3077	1
Echinococcus multilocularis	neuropeptide s receptor	0.0456	1	1
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.015	0.3077	1
Schistosoma mansoni	pyruvate kinase	0.0033	0.0431	0.1215
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0431	0.14
Entamoeba histolytica	type A flavoprotein, putative	0.0057	0.0979	1
Echinococcus granulosus	intermediate filament protein	0.0026	0.0278	0.0214
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0827	0.253
Brugia malayi	flavodoxin family protein	0.0057	0.0979	0.3181
Echinococcus granulosus	pyruvate kinase	0.0033	0.0431	0.0368
Leishmania major	pyruvate kinase	0.0033	0.0431	0.1213
Brugia malayi	MAP kinase sur-1	0.0051	0.0827	0.2689
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0827	0.1498
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.015	0.3077	1
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0057	0.0979	0.3033
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0827	0.253
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0431	0.5018
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0827	0.253
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0057	0.0979	0.2071
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0278	0.0904
Echinococcus granulosus	lamin dm0	0.0026	0.0278	0.0214
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0093	0.1777	0.5685
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0431	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0267	0.0868
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0827	0.1498
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0269	0.0873
Toxoplasma gondii	flavodoxin domain-containing protein	0.0074	0.1365	1
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0133	0.269	0.854
Loa Loa (eye worm)	diaphorase	0.0017	0.0065	0.0213
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0827	0.0767
Entamoeba histolytica	type A flavoprotein, putative	0.0057	0.0979	1
Plasmodium vivax	oxidoreductase NAD-binding domain containing protein	0.0017	0.0065	0.0002
Schistosoma mansoni	lamin	0.0026	0.0278	0.0707
Leishmania major	p450 reductase, putative	0.015	0.3077	1
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0431	0.1213
Echinococcus multilocularis	lamin	0.0026	0.0278	0.0214
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0057	0.0979	0.3033
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0076	0.1391	0.4402
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0431	0.5018
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0203	0.0661
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0033	0.0431	0.5
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.015	0.3077	1
Loa Loa (eye worm)	cytochrome b5 reductase 4	0.0017	0.0065	0.0213
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0431	0.0368
Giardia lamblia	Nitric oxide synthase, inducible	0.0133	0.269	1
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0017	0.0065	0.0004
Entamoeba histolytica	type A flavoprotein, putative	0.0057	0.0979	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 867783