TDR Targets

Basic information

Technical information

TDR Targets ID: 868408
Name: 3-(4-chlorophenyl)-N-(2,5-dimethoxyphenyl)-6, 7,8,9-tetrahydro-5H-imidazo[1,5-a]azepine-1-c arboxamide
MW: 425.908 | Formula: C23H24ClN3O3
H donors: 1 H acceptors: 2 LogP: 4.49 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)NC(=O)c1nc(n2c1CCCCC2)c1ccc(cc1)Cl)OC
InChi: 1S/C23H24ClN3O3/c1-29-17-11-12-20(30-2)18(14-17)25-23(28)21-19-6-4-3-5-13-27(19)22(26-21)15-7-9-16(24)10-8-15/h7-12,14H,3-6,13H2,1-2H3,(H,25,28)
InChiKey: NGRHNTOYPZSYQR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Melatonin receptor type 1A	0.0033	0.0069	0.0317
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0287	0.2187	0.2187
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0033	0.0069	0.0384
Brugia malayi	hypothetical protein	0.0033	0.0069	0.0317
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0071	0.0384	1
Brugia malayi	Dopamine receptor protein 2	0.0033	0.0069	0.0317
Toxoplasma gondii	hypothetical protein	0.0052	0.0227	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	G-protein coupled receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	PAN domain-containing protein	0.0052	0.0227	0.1039
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0071	0.0384	0.1754
Schistosoma mansoni	growth hormone secretagogue receptor	0.0033	0.0069	0.0069
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0033	0.0069	0.0069
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0033	0.0069	0.0317
Echinococcus multilocularis	orexin receptor type 2	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.017	0.1211	0.5535
Onchocerca volvulus		0.0033	0.0069	0.0384
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0195	0.1419	0.6486
Echinococcus granulosus	dro:myosuppressin receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0227	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus granulosus	neuropeptide receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	neuropeptide F receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0216	0.1594	0.7289
Echinococcus granulosus	neuropeptide FF receptor 2	0.0033	0.0069	0.0317
Brugia malayi	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0221	0.1008
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0033	0.0069	0.0069
Brugia malayi	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus granulosus	fmrfamide receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1562	0.7142
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0033	0.0069	0.0384
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1562	0.7142
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0071	0.0384	0.1754
Mycobacterium leprae	probable zinc metalloprotease	0.0287	0.2187	0.5
Brugia malayi	Serotonin receptor	0.0033	0.0069	0.0317
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0033	0.0069	0.0317
Echinococcus granulosus	serotonin receptor	0.0033	0.0069	0.0317
Brugia malayi	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0052	0.0227	0.1261
Brugia malayi	putative neuropeptide receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0033	0.0069	0.0069
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0052	0.0227	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	G protein coupled receptor 139	0.0033	0.0069	0.0317
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0033	0.0069	0.0317
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.0069	0.0317
Schistosoma mansoni	hypothetical protein	0.0033	0.0069	0.0069
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0071	0.0384	1
Echinococcus granulosus	G protein coupled receptor 139	0.0033	0.0069	0.0317
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0026	0.0005	0.0024
Brugia malayi	putative neuropeptide receptor NPR1	0.0033	0.0069	0.0317
Loa Loa (eye worm)	PAN domain-containing protein	0.0052	0.0227	0.1039
Brugia malayi	PAN domain containing protein	0.0052	0.0227	0.1039
Echinococcus granulosus	orexin receptor type 2	0.0033	0.0069	0.0317
Brugia malayi	hypothetical protein	0.0033	0.0069	0.0317
Brugia malayi	G-protein coupled receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0033	0.0069	0.0069
Onchocerca volvulus		0.0033	0.0069	0.0384
Echinococcus granulosus	g-protein coupled receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	hypothetical protein	0.0033	0.0069	0.0069
Echinococcus multilocularis	fmrfamide receptor	0.0033	0.0069	0.0317
Echinococcus multilocularis	somatostatin receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	hypothetical protein	0.0051	0.0221	0.0221
Onchocerca volvulus		0.0052	0.0227	0.1261
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0033	0.0069	0.0069
Schistosoma mansoni	biogenic amine receptor	0.0033	0.0069	0.0069
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0212	0.1562	0.7142
Onchocerca volvulus		0.0052	0.0227	0.1261
Brugia malayi	PAN domain containing protein	0.0052	0.0227	0.1039
Echinococcus multilocularis	neuropeptide receptor	0.0033	0.0069	0.0317
Echinococcus granulosus	allatostatin A receptor	0.0033	0.0069	0.0317
Toxoplasma gondii	microneme protein MIC17B	0.0052	0.0227	0.0473
Onchocerca volvulus		0.0033	0.0069	0.0384
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.007	0.0375	0.0375
Onchocerca volvulus		0.0033	0.0069	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1604	0.7332
Echinococcus granulosus	sex peptide receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	hypothetical protein	0.0075	0.0417	0.0417
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0033	0.0069	0.0069
Schistosoma mansoni	hypothetical protein	0.0075	0.0417	0.0417
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.007	0.0375	0.0375
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0071	0.0384	0.1754
Schistosoma mansoni	biogenic amine receptor	0.0033	0.0069	0.0069
Schistosoma mansoni	biogenic amine receptor	0.0033	0.0069	0.0069
Echinococcus multilocularis	sex peptide receptor	0.0033	0.0069	0.0317
Toxoplasma gondii	PAN domain-containing protein	0.0052	0.0227	0.0473
Echinococcus multilocularis	neuropeptide Y receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1604	0.7332
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0026	0.0005	0.0024
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0051	0.0221	1
Schistosoma mansoni	hypothetical protein	0.0075	0.0417	0.0417
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Toxoplasma gondii	subtilisin SUB12	0.0052	0.0227	0.0473
Schistosoma mansoni	hypothetical protein	0.0075	0.0417	0.0417
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.007	0.0375	0.0375
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0071	0.0384	0.1754
Brugia malayi	neuropeptide F receptor	0.0033	0.0069	0.0317
Plasmodium falciparum	cysteine repeat modular protein 1	0.0051	0.0221	1
Toxoplasma gondii	peptidase family M13 protein	0.0287	0.2187	0.4548
Brugia malayi	PAN domain containing protein	0.0052	0.0227	0.1039
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Brugia malayi	G protein-coupled receptor F59B2.13	0.0033	0.0069	0.0317
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0071	0.0384	1
Brugia malayi	Dopamine receptor	0.0033	0.0069	0.0317
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0033	0.0069	0.0317
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0069	0.0069
Brugia malayi	hypothetical protein	0.0071	0.0384	0.1754
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0033	0.0069	0.0317
Brugia malayi	neuropeptide F receptor	0.0033	0.0069	0.0317
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0033	0.0069	0.0317
Brugia malayi	hypothetical protein	0.0033	0.0069	0.0317
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0145	0.1001	0.1001
Echinococcus granulosus	7TM GPCR rhodopsin	0.0033	0.0069	0.0317
Echinococcus multilocularis	g-protein coupled receptor	0.0033	0.0069	0.0317
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0176	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Brugia malayi	hypothetical protein	0.0033	0.0069	0.0317
Schistosoma mansoni	protein kinase	0.0026	0.0005	0.0005
Echinococcus multilocularis	endothelin converting enzyme 1	0.0287	0.2187	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	melatonin receptor type 1A	0.0033	0.0069	0.0317
Brugia malayi	Peptidase family M13 containing protein	0.0287	0.2187	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	dro:myosuppressin receptor	0.0033	0.0069	0.0317
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0071	0.0384	0.1754
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0229	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Toxoplasma gondii	microneme protein, putative	0.0052	0.0227	0.0473
Echinococcus multilocularis	aminopeptidase N	0.0241	0.1803	0.8241
Brugia malayi	PAN domain containing protein	0.0052	0.0227	0.1039
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0145	0.1001	0.1001
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0071	0.0384	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0033	0.0069	0.0317
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0033	0.0069	0.0317
Toxoplasma gondii	PAN domain-containing protein	0.0601	0.481	1
Echinococcus granulosus	g protein coupled receptor	0.0033	0.0069	0.0317
Echinococcus multilocularis	neuropeptide s receptor	0.0033	0.0069	0.0317
Echinococcus granulosus	neuropeptide s receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0052	0.0227	0.0473
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0071	0.0384	0.1754
Schistosoma mansoni	opsin-like receptor	0.0033	0.0069	0.0069
Echinococcus granulosus	g protein coupled receptor	0.0033	0.0069	0.0317
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Brugia malayi	Kringle domain containing protein	0.0051	0.0221	0.1008
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0071	0.0384	1
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.0069	0.0317
Brugia malayi	PAN domain containing protein	0.0052	0.0227	0.1039
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1604	0.7332
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0071	0.0384	1
Toxoplasma gondii	microneme protein MIC4	0.0052	0.0227	0.0473
Brugia malayi	hypothetical protein	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0051	0.0221	0.1224
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1604	0.7332
Brugia malayi	G protein-coupled receptor	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0052	0.0227	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.007	0.0375	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1604	0.7332
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0221	0.5747
Echinococcus granulosus	7tm_1 domain containing protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	neuropeptide Y receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.0069	0.0069
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0287	0.2187	1
Schistosoma mansoni	adenoreceptor	0.0033	0.0069	0.0069
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0033	0.0069	0.0317
Brugia malayi	PAN domain containing protein	0.0052	0.0227	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Brugia malayi	PAN domain containing protein	0.0052	0.0227	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0033	0.0069	0.0317
Schistosoma mansoni	hypothetical protein	0.0033	0.0069	0.0069
Loa Loa (eye worm)	G-protein coupled receptor	0.0033	0.0069	0.0317
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0033	0.0069	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2187	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0033	0.0069	0.0069
Echinococcus multilocularis	neuropeptides capa receptor	0.0033	0.0069	0.0317
Echinococcus multilocularis	serotonin receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0068	0.0362	0.0362
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0033	0.0069	0.0384
Brugia malayi	Peptidase family M1 containing protein	0.0241	0.1803	0.8241
Onchocerca volvulus		0.0033	0.0069	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1562	0.7142
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0227	0.1039
Brugia malayi	PAN domain containing protein	0.0052	0.0227	0.1039
Schistosoma mansoni	hypothetical protein	0.0075	0.0417	0.0417
Toxoplasma gondii	kringle domain-containing protein	0.0051	0.0221	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2187	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0069	0.0069
Schistosoma mansoni	neuropeptide F-like receptor	0.0033	0.0069	0.0069
Schistosoma mansoni	amine GPCR	0.0033	0.0069	0.0069
Schistosoma mansoni	hypothetical protein	0.0075	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Brugia malayi	follicle stimulating hormone receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0145	0.1001	0.1001
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0222	0.1648	0.1648
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0033	0.0069	0.0069
Onchocerca volvulus		0.0033	0.0069	0.0384
Echinococcus multilocularis	neuropeptides capa receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0227	0.1039
Brugia malayi	GnHR receptor homolog	0.0033	0.0069	0.0317
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0071	0.0384	0.1754
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0176	0.0803
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0033	0.0069	0.0317
Toxoplasma gondii	PAN domain-containing protein	0.0601	0.481	1
Schistosoma mansoni	opsin-like receptor	0.0033	0.0069	0.0069
Toxoplasma gondii	PAN domain-containing protein	0.0052	0.0227	0.0473
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Mycobacterium ulcerans	aminopeptidase N PepN	0.0071	0.0384	0.1754
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0046	0.0176	0.4578
Brugia malayi	hypothetical protein	0.0033	0.0069	0.0317
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0075	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0069	0.0069
Brugia malayi	Receptor family ligand binding region containing protein	0.0026	0.0005	0.0024
Onchocerca volvulus		0.0033	0.0069	0.0384
Echinococcus granulosus	neuropeptide receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0069	0.0069
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0069	0.0069
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0033	0.0069	0.0317
Toxoplasma gondii	microneme protein MIC17C	0.0052	0.0227	0.0473
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.0069	0.0317
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0071	0.0384	0.1754
Echinococcus granulosus	g protein coupled receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0287	0.2187	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0026	0.0005	0.0024
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0033	0.0069	0.0069
Loa Loa (eye worm)	PAN domain-containing protein	0.0052	0.0227	0.1039
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0033	0.0069	0.0069
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0046	0.0176	0.0176
Schistosoma mansoni	amine GPCR	0.0033	0.0069	0.0069
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0069	0.0069
Brugia malayi	ORL1-like opioid receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0052	0.0227	0.1261
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0033	0.0069	0.0384
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.0069	0.0317
Schistosoma mansoni	amine GPCR	0.0033	0.0069	0.0069
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.0069	0.0317
Schistosoma mansoni	amine GPCR	0.0033	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus granulosus	neuropeptide Y receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0227	0.1039
Schistosoma mansoni	neuropeptide F-like receptor	0.0033	0.0069	0.0069
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0069	0.0069
Echinococcus multilocularis	serotonin receptor	0.0033	0.0069	0.0317
Echinococcus granulosus	endothelin converting enzyme 1	0.0287	0.2187	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0033	0.0069	0.0317
Brugia malayi	larval opioid receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.007	0.0375	0.0375
Brugia malayi	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	TYRA-2 protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0071	0.0384	0.1754
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0033	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0033	0.0069	0.0069
Brugia malayi	PAN domain containing protein	0.0052	0.0227	0.1039
Echinococcus multilocularis	allatostatin A receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0033	0.0069	0.0384
Leishmania major	hypothetical protein, conserved	0.0051	0.0221	0.5747
Brugia malayi	sulfakinin receptor protein	0.0033	0.0069	0.0317
Echinococcus granulosus	hypothetical protein	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0241	0.1803	1
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0071	0.0384	0.0384
Echinococcus granulosus	tissue type plasminogen activator	0.0051	0.0221	0.1008
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0033	0.0069	0.0317
Echinococcus multilocularis	tissue type plasminogen activator	0.0051	0.0221	0.1008
Mycobacterium ulcerans	zinc metalloprotease	0.0287	0.2187	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0227	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1604	0.7332
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0046	0.0176	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0033	0.0069	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0979	0.4474
Onchocerca volvulus		0.0052	0.0227	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1562	0.7142
Brugia malayi	Peptidase family M1 containing protein	0.0071	0.0384	0.1754
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0069	0.0069
Echinococcus granulosus	neuropeptide receptor A26	0.0033	0.0069	0.0317
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0052	0.0227	0.0473
Echinococcus multilocularis	neuropeptide receptor A26	0.0033	0.0069	0.0317
Echinococcus granulosus	neuropeptides capa receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0227	0.1039
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0052	0.0227	0.1261
Trypanosoma cruzi	aminopeptidase, putative	0.0071	0.0384	1
Onchocerca volvulus		0.0033	0.0069	0.0384
Schistosoma mansoni	histamine h1 receptor	0.0033	0.0069	0.0069
Schistosoma mansoni	opsin-like receptor	0.0033	0.0069	0.0069
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0145	0.1001	0.1001
Echinococcus granulosus	receptor type guanylyl cyclase	0.0026	0.0005	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0033	0.0069	0.0317
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0071	0.0384	0.1754
Echinococcus granulosus	neuropeptides capa receptor	0.0033	0.0069	0.0317
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0033	0.0069	0.0317
Toxoplasma gondii	microneme protein MIC17A	0.0052	0.0227	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0033	0.0069	0.0317
Schistosoma mansoni	neuropeptide receptor	0.0033	0.0069	0.0069
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0069	0.0069
Trypanosoma brucei	Aminopeptidase M1, putative	0.0071	0.0384	1
Echinococcus granulosus	neuropeptide Y receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.0069	0.0069
Echinococcus multilocularis	fmrfamide receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	zinc metallopeptidase 4	0.007	0.0375	0.1716
Onchocerca volvulus		0.0071	0.0384	0.2129
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0026	0.0005	0.0029
Onchocerca volvulus		0.0033	0.0069	0.0384
Loa Loa (eye worm)	aminopeptidase N	0.0071	0.0384	0.1754
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0071	0.0384	1
Brugia malayi	AKH receptor	0.0033	0.0069	0.0317
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0033	0.0069	0.0317
Echinococcus granulosus	biogenic amine 5HT receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	amine GPCR	0.0033	0.0069	0.0069
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Brugia malayi	PAN domain containing protein	0.0052	0.0227	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0033	0.0069	0.0317
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0033	0.0069	0.0317
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0033	0.0069	0.0317
Echinococcus granulosus	somatostatin receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0227	0.1039
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0033	0.0069	0.0069
Brugia malayi	Dopamine receptor protein 1	0.0033	0.0069	0.0317
Schistosoma mansoni	myosin xvIII	0.0033	0.0069	0.0069
Schistosoma mansoni	endothelin-converting enzyme-related	0.007	0.0375	0.0375
Entamoeba histolytica	aminopeptidase, putative	0.0071	0.0384	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0033	0.0069	0.0317
Trypanosoma brucei	Aminopeptidase M1, putative	0.0071	0.0384	1
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0287	0.2187	0.5
Brugia malayi	Serotonin receptor	0.0033	0.0069	0.0317
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0069	0.0069
Brugia malayi	RE15519p	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0033	0.0069	0.0384
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0212	0.1562	0.7142
Echinococcus granulosus	aminopeptidase N	0.0241	0.1803	0.8241
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.0069	0.0069
Onchocerca volvulus		0.0052	0.0227	0.1261
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0086	0.0512	0.0512
Brugia malayi	peptidase family M13 containing protein	0.007	0.0375	0.1716
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.0069	0.0317
Brugia malayi	G-protein coupled receptor	0.0033	0.0069	0.0317
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0033	0.0069	0.0317
Toxoplasma gondii	PAN domain-containing protein	0.0052	0.0227	0.0473
Onchocerca volvulus		0.0052	0.0227	0.1261
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0033	0.0069	0.0317
Loa Loa (eye worm)	neuropeptide F receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Loa Loa (eye worm)	PAN domain-containing protein	0.0052	0.0227	0.1039
Schistosoma mansoni	neuropeptide f receptor 76f	0.0033	0.0069	0.0069
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.0069	0.0317
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0033	0.0069	0.0317
Loa Loa (eye worm)	PAN domain-containing protein	0.0052	0.0227	0.1039
Echinococcus granulosus	biogenic amine 5HT receptor	0.0033	0.0069	0.0317
Loa Loa (eye worm)	TK/ROR protein kinase	0.0052	0.0229	0.1048
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.0069	0.0317
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0145	0.1001	0.1001
Toxoplasma gondii	PAN domain-containing protein	0.0052	0.0227	0.0473
Onchocerca volvulus		0.0052	0.0227	0.1261
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0033	0.0069	0.0384
Schistosoma mansoni	neprilysin	0.0075	0.0417	0.0417
Echinococcus multilocularis	neuropeptide receptor	0.0033	0.0069	0.0317
Onchocerca volvulus		0.0033	0.0069	0.0384
Onchocerca volvulus		0.0142	0.0979	0.5429
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0317
Toxoplasma gondii	hypothetical protein	0.0052	0.0227	0.0473

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 868408