Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0046 | 0.0651 | 0.0886 |
Onchocerca volvulus | Huntingtin homolog | 0.0118 | 0.3048 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0053 | 0.0876 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.3048 | 0.4149 |
Echinococcus granulosus | geminin | 0.0163 | 0.4563 | 0.4563 |
Onchocerca volvulus | 0.0047 | 0.069 | 0.2265 | |
Schistosoma mansoni | survival motor neuron protein | 0.0046 | 0.0651 | 0.0898 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0213 | 0.6272 | 1 |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.0245 | 0.7348 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0118 | 0.3048 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0053 | 0.0876 | 0.0876 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0227 | 0.6726 | 0.6726 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.069 | 0.094 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.4563 | 0.6293 |
Echinococcus multilocularis | tumor protein p63 | 0.0324 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.3048 | 0.4149 |
Schistosoma mansoni | lipoxygenase | 0.0053 | 0.0876 | 0.1208 |
Echinococcus granulosus | protein tyrosine kinase | 0.0243 | 0.7251 | 0.7251 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0227 | 0.6726 | 0.6726 |
Trypanosoma cruzi | MFS transporter, putative | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0163 | 0.4563 | 0.4563 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.6726 | 0.9154 |
Brugia malayi | Protein kinase domain containing protein | 0.0245 | 0.7348 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0651 | 0.0898 |
Echinococcus multilocularis | protein tyrosine kinase | 0.0243 | 0.7251 | 0.7251 |
Schistosoma mansoni | tyrosine kinase | 0.0243 | 0.7251 | 1 |
Brugia malayi | hypothetical protein | 0.0227 | 0.6726 | 0.9154 |
Brugia malayi | hypothetical protein | 0.0118 | 0.3048 | 0.4149 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.4563 | 0.6293 |
Onchocerca volvulus | 0.0046 | 0.0651 | 0.2135 | |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0047 | 0.069 | 0.0952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.