TDR Targets

Basic information

Technical information

TDR Targets ID: 869849
Name: 6-chloro-2-ethyl-N-(3-methylphenyl)-2,3-dihyd ro-1,4-benzoxazine-4-carboxamide
MW: 330.809 | Formula: C18H19ClN2O2
H donors: 1 H acceptors: 1 LogP: 4.37 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCC1Oc2ccc(cc2N(C1)C(=O)Nc1cccc(c1)C)Cl
InChi: 1S/C18H19ClN2O2/c1-3-15-11-21(16-10-13(19)7-8-17(16)23-15)18(22)20-14-6-4-5-12(2)9-14/h4-10,15H,3,11H2,1-2H3,(H,20,22)
InChiKey: IINYLHAXXOIWSD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	unspecified product	0.0896	0.1904	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0896	0.1904	0.1771
Leishmania major	cathepsin L-like protease	0.1625	0.3896	0.0072
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0896	0.1904	0.1436
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Brugia malayi	Cathepsin L-like precursor	0.1128	0.2538	0.309
Echinococcus multilocularis	cathepsin b	0.3206	0.8214	1
Onchocerca volvulus		0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0398	0.0547	0.0666
Brugia malayi	Papain family cysteine protease containing protein	0.0398	0.0547	0.0666
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Loa Loa (eye worm)	hypothetical protein	0.1128	0.2538	0.309
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3206	0.8214	1
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Schistosoma mansoni	cathepsin s	0.0497	0.0816	0.0351
Trichomonas vaginalis	conserved hypothetical protein	0.0398	0.0547	0.1236
Echinococcus granulosus	cathepsin l1	0.1625	0.3896	0.4368
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0896	0.1904	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Toxoplasma gondii	cathepsin B	0.1608	0.3851	0.9867
Leishmania major	cysteine peptidase A (CPA)	0.1625	0.3896	0.0072
Leishmania major	cathepsin L-like protease	0.1625	0.3896	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Echinococcus granulosus	cysteine protease	0.0896	0.1904	0.1771
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Echinococcus multilocularis	cathepsin b	0.3206	0.8214	1
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0497	0.0816	0.0994
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0398	0.0547	0.1236
Loa Loa (eye worm)	hypothetical protein	0.1128	0.2538	0.309
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0398	0.0547	0.0666
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1625	0.3896	0.4743
Echinococcus multilocularis	cathepsin L	0.0896	0.1904	0.1771
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Echinococcus granulosus	cathepsin b	0.3206	0.8214	1
Entamoeba histolytica	cysteine proteinase, putative	0.1625	0.3896	1
Brugia malayi	Papain family cysteine protease containing protein	0.0896	0.1904	0.2319
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1128	0.2538	0.6447
Brugia malayi	cathepsin L-like cysteine proteinase	0.0398	0.0547	0.0666
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1625	0.3896	0.4368
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3206	0.8214	1
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0896	0.1904	0.1771
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0896	0.1904	0.1771
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0896	0.1904	0.4054
Echinococcus multilocularis	cysteine protease	0.1625	0.3896	0.4368
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0398	0.0547	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0497	0.0816	0.0994
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0398	0.0547	0.1236
Schistosoma mansoni	cathepsin F (C01 family)	0.1128	0.2538	0.2597
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.3363	0.8642	0.8564
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0497	0.0816	0.0994
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1625	0.3896	0.4743
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1608	0.3851	0.3495
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	conserved hypothetical protein	0.0398	0.0547	0.1236
Brugia malayi	Papain family cysteine protease containing protein	0.0398	0.0547	0.0666
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1128	0.2538	0.309
Entamoeba histolytica	cysteine proteinase, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Leishmania major	cathepsin L-like protease	0.1625	0.3896	0.0072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Plasmodium vivax	vivapain-2	0.1625	0.3896	1
Giardia lamblia	Cathepsin B precursor	0.1608	0.3851	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1625	0.3896	0.4368
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1625	0.3896	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1625	0.3896	0.4368
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1625	0.3896	0.4368
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Brugia malayi	cathepsin L-like precursor	0.1128	0.2538	0.309
Echinococcus granulosus	cathepsin l1	0.1128	0.2538	0.2597
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0398	0.0547	0.1236
Trypanosoma cruzi	major cysteine proteinase, putative	0.2634	0.6651	0.6458
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0398	0.0547	0.0666
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0398	0.0547	0.1236
Brugia malayi	cathepsin B-like cysteine proteinase	0.3206	0.8214	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Entamoeba histolytica	cysteine proteinase, putative	0.1128	0.2538	0.5946
Plasmodium vivax	vivapain-2	0.1625	0.3896	1
Brugia malayi	Papain family cysteine protease containing protein	0.0398	0.0547	0.0666
Schistosoma mansoni	cathepsin F (C01 family)	0.1625	0.3896	0.4368
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0398	0.0547	0.1236
Onchocerca volvulus		0.1625	0.3896	1
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1625	0.3896	1
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Loa Loa (eye worm)	ctsf protein	0.1625	0.3896	0.4743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0896	0.1904	0.4789
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Trypanosoma cruzi	cysteine peptidase, putative	0.1625	0.3896	0.3542
Brugia malayi	Papain family cysteine protease containing protein	0.1625	0.3896	0.4743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Onchocerca volvulus		0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1625	0.3896	1
Onchocerca volvulus		0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Entamoeba histolytica	cysteine proteinase, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1608	0.3851	0.2405
Onchocerca volvulus	Cathepsin L homolog	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0398	0.0547	0.1236
Entamoeba histolytica	cysteine proteinase, putative	0.1625	0.3896	1
Giardia lamblia	Cathepsin B precursor	0.1608	0.3851	1
Trypanosoma cruzi	cruzipain precursor, putative	0.386	1	1
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Brugia malayi	cathepsin F-like cysteine proteinase	0.0398	0.0547	0.0666
Echinococcus granulosus	cathepsin L cysteine protease	0.0896	0.1904	0.1771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Trypanosoma cruzi	cysteine peptidase, putative	0.386	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1625	0.3896	1
Toxoplasma gondii	cathepsin CPL	0.1625	0.3896	1
Plasmodium vivax	vivapain-3	0.0896	0.1904	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3206	0.8214	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0398	0.0547	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Brugia malayi	Papain family cysteine protease containing protein	0.0896	0.1904	0.2319
Trypanosoma cruzi	cysteine protease, putative	0.0896	0.1904	0.1436
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0497	0.0816	0.0994
Leishmania major	cathepsin L-like protease	0.386	1	1
Loa Loa (eye worm)	hypothetical protein	0.1128	0.2538	0.309
Echinococcus granulosus	cathepsin L	0.0896	0.1904	0.1771
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Echinococcus granulosus	cathepsin b	0.3206	0.8214	1
Entamoeba histolytica	cysteine proteinase, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Onchocerca volvulus	Cathepsin L homolog	0.0398	0.0547	0.1236
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1625	0.3896	0.4368
Onchocerca volvulus		0.0398	0.0547	0.1236
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0497	0.0816	0.0994
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0896	0.1904	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.386	1	1
Echinococcus multilocularis	cysteine protease	0.1625	0.3896	0.4368
Trypanosoma cruzi	cysteine peptidase, putative	0.0896	0.1904	0.1436
Trypanosoma cruzi	cysteine peptidase, putative	0.386	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3206	0.8214	0.811
Trypanosoma cruzi	cysteine proteinase, putative	0.0896	0.1904	0.1436
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0896	0.1904	0.4789
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0398	0.0547	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Leishmania major	cathepsin L-like protease	0.1625	0.3896	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1608	0.3851	0.9884
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.3206	0.8214	1
Onchocerca volvulus		0.1128	0.2538	0.6447
Schistosoma mansoni	cathepsin F (C01 family)	0.1625	0.3896	0.4368
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Loa Loa (eye worm)	cathepsin B	0.1608	0.3851	0.4689
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Onchocerca volvulus		0.1625	0.3896	1
Leishmania major	cathepsin L-like protease	0.1625	0.3896	0.0072
Echinococcus multilocularis	cathepsin L cysteine protease	0.1625	0.3896	0.4368
Entamoeba histolytica	cysteine protease, putative	0.1625	0.3896	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0497	0.0816	0.0285
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0398	0.0547	0.1236
Loa Loa (eye worm)	fibroinase	0.1625	0.3896	0.4743
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0398	0.0547	0.1236
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Loa Loa (eye worm)	cysteine protease	0.1625	0.3896	0.4743
Loa Loa (eye worm)	hypothetical protein	0.1625	0.3896	0.4743
Leishmania major	cathepsin L-like protease	0.386	1	1
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Onchocerca volvulus	Cathepsin F homolog	0.1625	0.3896	1
Brugia malayi	cathepsin L precursor	0.0398	0.0547	0.0666
Loa Loa (eye worm)	hypothetical protein	0.3206	0.8214	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0398	0.0547	0.0666
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0398	0.0547	0.1236
Brugia malayi	fibroinase precursor	0.0398	0.0547	0.0666
Plasmodium vivax	unspecified product	0.0497	0.0816	0.0804
Trypanosoma cruzi	cysteine proteinase, putative	0.0896	0.1904	0.1436
Trypanosoma cruzi	cysteine peptidase, putative	0.0497	0.0816	0.0285
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1128	0.2538	0.6447
Giardia lamblia	Cathepsin B precursor	0.1608	0.3851	1
Entamoeba histolytica	cysteine proteinase 2	0.0896	0.1904	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Brugia malayi	Cathepsin L-like precursor	0.1128	0.2538	0.309
Onchocerca volvulus		0.1625	0.3896	1
Plasmodium vivax	vivapain-1	0.0896	0.1904	0.4054
Onchocerca volvulus		0.1625	0.3896	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0398	0.0547	0.0666
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Brugia malayi	Cathepsin L-like precursor	0.0497	0.0816	0.0994
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1608	0.3851	0.431
Loa Loa (eye worm)	hypothetical protein	0.0497	0.0816	0.0994

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 869849