Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.1002 | 0.1002 |
Entamoeba histolytica | cysteine protease, putative | 0.0026 | 0.1012 | 0.1005 |
Onchocerca volvulus | 0.0026 | 0.1012 | 0.1005 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Mycobacterium leprae | putative cytochrome p450 | 0.0017 | 0 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.1012 | 0.1012 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0009 | 0.0009 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.1002 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.1002 | 0.1002 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.1002 | 0.1002 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0103 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Onchocerca volvulus | 0.0026 | 0.1012 | 0.1005 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0103 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0103 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0103 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Onchocerca volvulus | 0.0026 | 0.1012 | 0.1005 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0026 | 0.1012 | 0.1005 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0103 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0017 | 0.0009 | 0.0009 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0103 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.1012 | 0.1012 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0103 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0103 | 1 | 1 |
Onchocerca volvulus | 0.0026 | 0.1012 | 0.1005 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 0.4364 | 0.4364 |
Onchocerca volvulus | 0.0026 | 0.1012 | 0.1005 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0009 | 0.0009 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.1012 | 0.1012 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.1012 | 0.1005 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0026 | 0.1012 | 0.1012 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0103 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0103 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0103 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.1012 | 0.1012 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0103 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0009 | 0.0009 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.1002 | 0.1002 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.1002 | 0.1002 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.1002 | 0.1002 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.1002 | 0.1002 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.4364 | 0.4364 |
Onchocerca volvulus | Cathepsin L homolog | 0.0026 | 0.1012 | 0.1005 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0103 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0026 | 0.1012 | 0.1012 |
Echinococcus granulosus | cathepsin l1 | 0.0026 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | ctsf protein | 0.0026 | 0.1012 | 0.1012 |
Echinococcus multilocularis | cysteine protease | 0.0026 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0009 | 0.0009 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0103 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Echinococcus multilocularis | cysteine protease | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0103 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.1012 | 0.1012 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.1012 | 0.1012 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0103 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0009 | 0.0009 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.1012 | 0.1012 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.1002 | 0.1002 |
Plasmodium vivax | RNA helicase-1, putative | 0.0103 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0009 | 0.0009 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.1012 | 0.1005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Leishmania major | cysteine peptidase A (CPA) | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.1012 | 0.1012 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0026 | 0.1012 | 0.1012 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.1012 | 0.1012 |
Onchocerca volvulus | 0.0026 | 0.1012 | 0.1005 | |
Mycobacterium leprae | Conserved hypothetical protein | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.1012 | 0.1012 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1012 | 0.1012 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0103 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0103 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0026 | 0.1012 | 0.1012 |
Onchocerca volvulus | 0.0026 | 0.1012 | 0.1005 | |
Toxoplasma gondii | cathepsin CPL | 0.0026 | 0.1012 | 0.1012 |
Leishmania major | cathepsin L-like protease | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.1002 | 0.1002 |
Loa Loa (eye worm) | fibroinase | 0.0026 | 0.1012 | 0.1012 |
Onchocerca volvulus | Cathepsin L homolog | 0.0026 | 0.1012 | 0.1005 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0103 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0017 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0026 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.1012 | 0.1012 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.1012 | 0.1012 |
Brugia malayi | cathepsin L-like precursor | 0.0017 | 0.0009 | 0.0009 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.1012 | 0.1005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.