TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.522 | Formula: C27H28N2O4
H donors: 2 H acceptors: 2 LogP: 2.44 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)n(Cc1ccc(cc1)OC)c(c2CNCCc1ccccc1)C(=O)O
InChi: 1S/C27H28N2O4/c1-32-21-10-8-20(9-11-21)18-29-25-16-22(33-2)12-13-23(25)24(26(29)27(30)31)17-28-15-14-19-6-4-3-5-7-19/h3-13,16,28H,14-15,17-18H2,1-2H3,(H,30,31)
InChiKey: XENNMMQHRBILLV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0051	0.0367	0.0354
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0367	0.0354
Brugia malayi	Dopamine receptor protein 1	0.0051	0.0367	0.1479
Echinococcus multilocularis	protein dispatched 1	0.0053	0.0385	0.0284
Echinococcus granulosus	orexin receptor type 2	0.0051	0.0367	0.0301
Onchocerca volvulus		0.0051	0.0367	1
Onchocerca volvulus		0.0051	0.0367	1
Echinococcus multilocularis	protein patched	0.0046	0.0309	0.0207
Schistosoma mansoni	glutamate receptor AMPA	0.0055	0.0415	0.0419
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0076	0.0477
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0367	0.0301
Schistosoma mansoni	glutamate receptor AMPA	0.0055	0.0415	0.0419
Echinococcus multilocularis	Niemann Pick C1 protein	0.0108	0.1018	0.0923
Brugia malayi	hypothetical protein	0.0233	0.2464	1
Brugia malayi	metabotropic glutamate receptor type 2	0.0028	0.0104	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus multilocularis	somatostatin receptor	0.0051	0.0367	0.0266
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0367	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.015	0.1267
Echinococcus multilocularis	allatostatin A receptor	0.0051	0.0367	0.0266
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0367	0.0354
Schistosoma mansoni	hypothetical protein	0.0045	0.029	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0888	0.3602
Loa Loa (eye worm)	melatonin receptor type 1A	0.0051	0.0367	0.1489
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0367	0.0301
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0055	0.0415	0.0357
Schistosoma mansoni	opsin-like receptor	0.0051	0.0367	0.0354
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0051	0.0367	0.1479
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0367	0.0354
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0051	0.0367	0.0266
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0325	0.1308
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0367	0.0354
Brugia malayi	hypothetical protein	0.0051	0.0367	0.1479
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0109	0.1037	0.1258
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0146	0.1138
Echinococcus granulosus	7TM GPCR rhodopsin	0.0051	0.0367	0.0301
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0051	0.0367	0.1479
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0104	0.0422
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0367	0.0266
Echinococcus multilocularis	sterol regulatory element binding protein	0.0046	0.0309	0.0207
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0367	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus granulosus	Protein patched homolog 1	0.0046	0.0309	0.0235
Brugia malayi	hypothetical protein	0.0051	0.0367	0.1479
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.0402	0.0959
Echinococcus granulosus	glutamate receptor 2	0.0084	0.0743	0.0732
Schistosoma mansoni	glutamate receptor kainate	0.0055	0.0415	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0051	0.0367	0.0354
Schistosoma mansoni	glutamate receptor kainate	0.0055	0.0415	0.0419
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0367	0.0266
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0055	0.0415	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0402	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0051	0.0367	0.0266
Brugia malayi	hypothetical protein	0.0096	0.0888	0.3594
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0055	0.0415	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0367	0.0354
Schistosoma mansoni	eyes absent homolog	0.0096	0.0888	0.1056
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0028	0.0104	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus granulosus	Niemann Pick C1 protein	0.0154	0.1551	0.1657
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0367	0.0266
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0367	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0241	0.444
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0051	0.0367	0.0354
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.0402	0.163
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0055	0.0415	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0104	0.0422
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0051	0.0367	0.0266
Echinococcus granulosus	neuropeptide s receptor	0.0051	0.0367	0.0301
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0367	0.0301
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.1401	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0104	0.0422
Onchocerca volvulus		0.0051	0.0367	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus granulosus	sex peptide receptor	0.0051	0.0367	0.0301
Brugia malayi	ORL1-like opioid receptor	0.0051	0.0367	0.1479
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0367	0.0301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0241	0.444
Echinococcus granulosus	nmda type glutamate receptor	0.0786	0.8833	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0051	0.0367	0.0301
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.0402	0.0959
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0402	1
Echinococcus multilocularis	nmda type glutamate receptor	0.0786	0.8833	0.8821
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0076	0.0477
Echinococcus multilocularis	g-protein coupled receptor	0.0051	0.0367	0.0266
Schistosoma mansoni	neuropeptide f receptor 76f	0.0051	0.0367	0.0354
Brugia malayi	G protein-coupled receptor F59B2.13	0.0051	0.0367	0.1479
Schistosoma mansoni	hypothetical protein	0.0051	0.0367	0.0354
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0367	0.0354
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0051	0.0367	0.0266
Onchocerca volvulus		0.0051	0.0367	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0241	0.5628
Echinococcus multilocularis	orexin receptor type 2	0.0051	0.0367	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Leishmania major	extracellular receptor, putative	0.0028	0.0104	0.0091
Leishmania major	hypothetical protein, conserved	0.003	0.0127	0.0165
Schistosoma mansoni	hypothetical protein	0.0051	0.0367	0.0354
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0367	0.0301
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0367	0.0266
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0367	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus multilocularis	dro:myosuppressin receptor	0.0051	0.0367	0.0266
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0367	0.0266
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0198	0.2052	0.1969
Echinococcus multilocularis	glutamate receptor 2	0.0055	0.0415	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0259	0.05
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0104	0.0422
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.3209	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0367	0.0354
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0114	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1018	0.4131
Echinococcus granulosus	expressed conserved protein	0.0101	0.0943	0.0961
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0051	0.0367	0.0354
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0051	0.0367	0.1489
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Giardia lamblia	GTOR	0.0054	0.0402	0.5
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0028	0.0104	0.0422
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0084	0.0743	0.0732
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0367	0.1489
Schistosoma mansoni	amine GPCR	0.0051	0.0367	0.0354
Schistosoma mansoni	growth hormone secretagogue receptor	0.0051	0.0367	0.0354
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0055	0.0415	0.0357
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0367	0.0266
Brugia malayi	sulfakinin receptor protein	0.0051	0.0367	0.1479
Onchocerca volvulus		0.0051	0.0367	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0084	0.0743	0.0645
Schistosoma mansoni	myosin xvIII	0.0051	0.0367	0.0354
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.0402	0.0341
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0367	0.0266
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0142	0.1413	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0367	0.0354
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.0072	0.0113
Onchocerca volvulus		0.0051	0.0367	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.0402	0.0301
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.2464	0.2704
Brugia malayi	hypothetical protein	0.0051	0.0367	0.1479
Brugia malayi	Dopamine receptor	0.0051	0.0367	0.1479
Brugia malayi	G protein-coupled receptor	0.0051	0.0367	0.1479
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0367	0.0354
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0055	0.0415	0.0314
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.0274	0.0548
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0051	0.0367	0.1489
Echinococcus granulosus	fmrfamide receptor	0.0051	0.0367	0.0301
Onchocerca volvulus		0.0051	0.0367	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0274	0.556
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0051	0.0367	0.1479
Echinococcus multilocularis	serotonin receptor	0.0051	0.0367	0.0266
Brugia malayi	Glutamate receptor 2 precursor	0.0055	0.0415	0.1675
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0104	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0182	0.2387
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0076	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0367	0.0354
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0367	0.0266
Mycobacterium ulcerans	hypothetical protein	0.0157	0.1585	1
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0367	0.0266
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0028	0.0104	0.0411
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0367	0.0354
Brugia malayi	GnHR receptor homolog	0.0051	0.0367	0.1479
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0367	0.0266
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0367	0.0354
Schistosoma mansoni	hypothetical protein	0.0045	0.029	0.0251
Schistosoma mansoni	ATP-binding cassette transporter	0.0055	0.0415	0.0419
Brugia malayi	hypothetical protein	0.0051	0.0367	0.1479
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0084	0.0743	0.0732
Onchocerca volvulus		0.0051	0.0367	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0274	0.556
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0076	0.0295
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0402	0.1152
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0146	0.1138
Brugia malayi	Glutamate receptor 1 precursor	0.0055	0.0415	0.1675
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0367	0.0354
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0367	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0104	0.0422
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0367	0.0301
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0367	0.0301
Echinococcus granulosus	G protein coupled receptor 139	0.0051	0.0367	0.0301
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.1401	0.423
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0367	0.0266
Brugia malayi	Receptor family ligand binding region containing protein	0.0028	0.0104	0.0411
Echinococcus multilocularis	glutamate receptor NMDA	0.0589	0.6558	0.6522
Echinococcus granulosus	neuropeptide receptor A26	0.0051	0.0367	0.0301
Brugia malayi	CHE-14 protein	0.0046	0.0309	0.1245
Brugia malayi	follicle stimulating hormone receptor	0.0051	0.0367	0.1479
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0076	0.0477
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0076	0.0477
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.0402	0.1041
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0051	0.0367	0.0301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0241	0.444
Schistosoma mansoni	glutamate receptor NMDA	0.0055	0.0415	0.0419
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0367	0.0301
Echinococcus multilocularis	NMDA receptor	0.0055	0.0415	0.0314
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0259	0.05
Echinococcus multilocularis	sex peptide receptor	0.0051	0.0367	0.0266
Schistosoma mansoni	amine GPCR	0.0051	0.0367	0.0354
Chlamydia trachomatis	glutamine binding protein	0.0142	0.1413	1
Brugia malayi	AKH receptor	0.0051	0.0367	0.1479
Brugia malayi	Dopamine receptor protein 2	0.0051	0.0367	0.1479
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0367	0.0301
Onchocerca volvulus		0.0051	0.0367	1
Echinococcus granulosus	glutamate receptor NMDA	0.0589	0.6558	0.7393
Brugia malayi	hypothetical protein	0.0051	0.0367	0.1479
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0055	0.0415	0.0314
Echinococcus multilocularis	neuropeptide s receptor	0.0051	0.0367	0.0266
Echinococcus multilocularis	neuropeptide receptor A26	0.0051	0.0367	0.0266
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0051	0.0367	0.0354
Brugia malayi	G-protein coupled receptor	0.0051	0.0367	0.1479
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0051	0.0367	0.1479
Echinococcus granulosus	hypothetical protein	0.0051	0.0367	0.0301
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0127	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.3209	1
Schistosoma mansoni	opsin-like receptor	0.0051	0.0367	0.0354
Leishmania major	mitochondrial DNA polymerase beta	0.0298	0.3209	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0051	0.0367	1
Echinococcus granulosus	serotonin receptor	0.0051	0.0367	0.0301
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0051	0.0367	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus granulosus	g-protein coupled receptor	0.0051	0.0367	0.0301
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.0274	0.075
Echinococcus granulosus	dro:myosuppressin receptor	0.0051	0.0367	0.0301
Schistosoma mansoni	glutamate receptor kainate	0.0055	0.0415	0.0419
Schistosoma mansoni	amine GPCR	0.0051	0.0367	0.0354
Echinococcus multilocularis	G protein coupled receptor 139	0.0051	0.0367	0.0266
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0367	0.0301
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0051	0.0367	0.1489
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0429	0.1742
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0157	0.1585	1
Schistosoma mansoni	hypothetical protein	0.0045	0.029	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Brugia malayi	hypothetical protein	0.0051	0.0367	0.1479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0274	0.556
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0367	0.0354
Onchocerca volvulus		0.0051	0.0367	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0108	0.1018	0.1047
Loa Loa (eye worm)	glutamate receptor 2	0.0055	0.0415	0.1685
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0051	0.0367	0.0301
Schistosoma mansoni	hypothetical protein	0.0051	0.0367	0.0354
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.0402	0.0401
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0028	0.0104	0.0422
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0127	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0076	0.0307
Toxoplasma gondii	hypothetical protein	0.0048	0.033	1
Brugia malayi	Melatonin receptor type 1A	0.0051	0.0367	0.1479
Brugia malayi	hypothetical protein	0.0051	0.0367	0.1479
Onchocerca volvulus		0.0051	0.0367	1
Schistosoma mansoni	hypothetical protein	0.0055	0.0415	0.0419
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0367	0.0301
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0141	0.1401	0.4302
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0051	0.0367	0.0266
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0367	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0309	0.1255
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0367	0.0354
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0127	0.0075
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0051	0.0367	0.0301
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0127	0.0075
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0367	0.0354
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0108	0.1018	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0367	0.0301
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0367	0.0301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0241	0.444
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0051	0.0367	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Schistosoma mansoni	patched 1	0.0046	0.0309	0.0277
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0367	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0076	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.015	0.1267
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0051	0.0367	0.1479
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0104	0.0422
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0051	0.0367	0.0301
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0076	0.0477
Onchocerca volvulus		0.0051	0.0367	1
Loa Loa (eye worm)	glutamate receptor 1	0.0055	0.0415	0.1685
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0076	0.0295
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0367	0.1489
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0367	0.0301
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0367	0.0354
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.0402	0.1041
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0084	0.0743	0.0645
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0365	0.084
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0367	0.0301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0402	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0367	0.0266
Brugia malayi	hypothetical protein	0.0028	0.0104	0.0411
Brugia malayi	hypothetical protein	0.0051	0.0367	0.1479
Brugia malayi	Serotonin receptor	0.0051	0.0367	0.1479
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0076	0.0477
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.0402	0.162
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus multilocularis	expressed conserved protein	0.0101	0.0943	0.0847
Schistosoma mansoni	hypothetical protein	0.0048	0.0325	0.0298
Schistosoma mansoni	amine GPCR	0.0051	0.0367	0.0354
Onchocerca volvulus		0.0051	0.0367	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0051	0.0367	0.0301
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0367	0.0266
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0028	0.0104	0.0422
Onchocerca volvulus		0.0051	0.0367	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0076	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0367	0.0266
Onchocerca volvulus		0.0048	0.0325	0.8552
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.2464	0.2385
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0142	0.1413	0.5
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0076	0.0477
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0367	0.0266
Schistosoma mansoni	hypothetical protein	0.0051	0.0367	0.0354
Loa Loa (eye worm)	TYRA-2 protein	0.0051	0.0367	0.1489
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0051	0.0367	0.0354
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0051	0.0367	0.0266
Echinococcus granulosus	somatostatin receptor	0.0051	0.0367	0.0301
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0028	0.0104	0.0422
Echinococcus granulosus	nmda type glutamate receptor	0.0617	0.6885	0.7768
Brugia malayi	Receptor family ligand binding region containing protein	0.0028	0.0104	0.0411
Schistosoma mansoni	glutamate receptor NMDA	0.0673	0.7524	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0367	0.0354
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0051	0.0367	0.1489
Loa Loa (eye worm)	glutamate receptor	0.0028	0.0104	0.0422
Echinococcus multilocularis	Niemann Pick C1 protein	0.0154	0.1551	0.1462
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0196	0.2856
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0367	0.0301
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0076	0.0295
Echinococcus multilocularis	glutamate receptor 2	0.0084	0.0743	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0142	0.1413	0.892
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0051	0.0367	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0888	0.3602
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0367	0.0301
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0084	0.0743	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0084	0.0743	0.0645
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.0402	0.346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0274	0.556
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0298	0.3209	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0076	0.0477
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0127	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0367	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0142	0.1413	0.892
Schistosoma mansoni	histamine h1 receptor	0.0051	0.0367	0.0354
Schistosoma mansoni	opsin-like receptor	0.0051	0.0367	0.0354
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0325	0.0298
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0051	0.0367	0.0266
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0028	0.0104	0.0411
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0367	0.0266
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0142	0.1413	0.5
Brugia malayi	hypothetical protein	0.0051	0.0367	0.1479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.031	0.6827
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0367	0.0301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.015	0.1267
Brugia malayi	neuropeptide F receptor	0.0051	0.0367	0.1479
Brugia malayi	hypothetical protein	0.003	0.0127	0.0505
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0259	0.0703
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0367	0.0266
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.0274	0.0634
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0051	0.0367	0.0266
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0241	0.444
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0367	0.0266
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0055	0.0415	0.0357
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0114	0.0018
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0046	0.0309	0.1255
Onchocerca volvulus		0.0028	0.0104	0.0977
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.0402	0.346
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0309	0.6795
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0367	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Onchocerca volvulus		0.0051	0.0367	1
Onchocerca volvulus		0.0051	0.0367	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0051	0.0367	0.0266
Schistosoma mansoni	amine GPCR	0.0051	0.0367	0.0354
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0367	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0104	0.0422
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0367	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0367	0.0266
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0114	0.0018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0274	0.556
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0051	0.0367	0.1489
Onchocerca volvulus		0.0051	0.0367	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0051	0.0367	0.0301
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0028	0.0104	0.0422
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0028	0.0104	0.0422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0241	0.444
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0076	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.0402	0.1152
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0367	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0367	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0233	0.2464	1
Brugia malayi	larval opioid receptor	0.0051	0.0367	0.1479
Brugia malayi	neuropeptide F receptor	0.0051	0.0367	0.1479
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0084	0.0743	0.0645
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0367	0.0266
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0055	0.0415	0.0314
Brugia malayi	Guanylyl cyclase protein 23	0.0028	0.0104	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Entamoeba histolytica	hypothetical protein	0.0028	0.0104	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0259	0.05
Brugia malayi	RE15519p	0.0051	0.0367	0.1479
Brugia malayi	Serotonin receptor	0.0051	0.0367	0.1479
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0367	0.1489
Brugia malayi	putative neuropeptide receptor NPR1	0.0051	0.0367	0.1479
Brugia malayi	G-protein coupled receptor	0.0051	0.0367	0.1479
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0127	0.0287
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0367	0.0354
Brugia malayi	putative neuropeptide receptor	0.0051	0.0367	0.1479
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0084	0.0743	0.0732
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0367	0.0354
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0367	0.0301
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0051	0.0367	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0367	0.1489
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0076	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0051	0.0367	0.0354
Schistosoma mansoni	hypothetical protein	0.0045	0.029	0.0251
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0114	0.0018
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0367	0.0266
Schistosoma mansoni	adenoreceptor	0.0051	0.0367	0.0354
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0076	0.0477
Brugia malayi	Niemann-Pick C1 protein precursor	0.0108	0.1018	0.4124
Echinococcus granulosus	allatostatin A receptor	0.0051	0.0367	0.0301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0241	0.444
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0367	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0104	0.0422
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0051	0.0367	0.0301
Echinococcus multilocularis	nmda type glutamate receptor	0.0617	0.6885	0.6852
Echinococcus granulosus	sterol regulatory element binding protein	0.0046	0.0309	0.0235
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0051	0.0367	0.1479
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0367	0.1489
Echinococcus multilocularis	serotonin receptor	0.0051	0.0367	0.0266
Onchocerca volvulus		0.0028	0.0104	0.0977
Loa Loa (eye worm)	hypothetical protein	0.003	0.0127	0.0516
Brugia malayi	hypothetical protein	0.0051	0.0367	0.1479

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 872765