TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 422.624 | Formula: C26H47O2P
H donors: 1 H acceptors: 2 LogP: 9.68 Rotable bonds: 20
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCCCCCCCCCCCP(=O)(CCc1ccccc1)O
InChi: 1S/C26H47O2P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-24-29(27,28)25-23-26-21-18-17-19-22-26/h17-19,21-22H,2-16,20,23-25H2,1H3,(H,27,28)
InChiKey: FHIVBAGIMHKAOW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholesteryl ester transfer protein, plasma	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0025	0.0088	0.0088
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0025	0.0088	0.0282
Entamoeba histolytica	pyruvate kinase, putative	0.0024	0.0076	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Brugia malayi	Cation transporter family protein	0.0025	0.0088	0.0282
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0267	0.0267
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0312	0.4521	1
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0035	0.0238	0.0921
Echinococcus multilocularis	pyruvate kinase	0.0027	0.0125	0.0125
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0196	0.0196
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0238	0.0329
Toxoplasma gondii	pyruvate kinase PyK1	0.0035	0.0238	0.8917
Onchocerca volvulus		0.0041	0.0331	0.0505
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.1536	0.4901
Schistosoma mansoni	microtubule-associated protein tau	0.0667	1	1
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0041	0.0331	0.1057
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0025	0.0088	0.0282
Brugia malayi	Thioredoxin family protein	0.0186	0.258	0.8234
Brugia malayi	hypothetical protein	0.0023	0.0063	0.0202
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0025	0.0088	0.0088
Giardia lamblia	Transglutaminase/protease, putative	0.0186	0.258	0.5708
Schistosoma mansoni	alpha glucosidase	0.0036	0.0267	0.0267
Onchocerca volvulus		0.0032	0.0196	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0196	0.7333
Schistosoma mansoni	alpha-glucosidase	0.0141	0.1888	0.1888
Schistosoma mansoni	nAChR subunit	0.0025	0.0088	0.0088
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0312	0.4521	1
Brugia malayi	hypothetical protein	0.0023	0.0063	0.0202
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0267	0.059
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0166	0.2273	0.2273
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0025	0.0088	0.0282
Brugia malayi	Cation transporter family protein	0.0025	0.0088	0.0282
Onchocerca volvulus		0.0367	0.5369	1
Schistosoma mansoni	alpha-glucosidase	0.0141	0.1888	0.1888
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0025	0.0088	0.0088
Echinococcus granulosus	Transglutaminase	0.0186	0.258	0.258
Mycobacterium ulcerans	hypothetical protein	0.0186	0.258	1
Schistosoma mansoni	pyruvate kinase	0.0035	0.0238	0.0238
Echinococcus multilocularis	glycine receptor subunit beta	0.0025	0.0088	0.0088
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0025	0.0088	0.0088
Onchocerca volvulus		0.0025	0.0088	0.0047
Plasmodium vivax	SET domain protein, putative	0.0032	0.0196	0.8224
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0267	0.0267
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0025	0.0088	0.0282
Onchocerca volvulus		0.0025	0.0088	0.0047
Schistosoma mansoni	pyruvate kinase	0.0035	0.0238	0.0238
Echinococcus granulosus	glycine receptor subunit beta	0.0025	0.0088	0.0088
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0088	0.0282
Loa Loa (eye worm)	LGC-31 protein	0.0025	0.0088	0.0282
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0025	0.0088	0.0088
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0267	1
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0023	0.0063	0.0202
Mycobacterium tuberculosis	Long conserved protein	0.0186	0.258	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0	0.5
Mycobacterium leprae	Conserved hypothetical protein	0.0186	0.258	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0166	0.2273	0.7254
Plasmodium falciparum	pyruvate kinase	0.0035	0.0238	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0025	0.0088	0.0088
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0267	0.059
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0238	0.0759
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0196	0.0196
Onchocerca volvulus		0.0041	0.0331	0.0505
Mycobacterium ulcerans	transglutaminase family protein	0.0186	0.258	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0166	0.2273	0.2273
Schistosoma mansoni	nAChR subunit	0.0025	0.0088	0.0088
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0267	1
Schistosoma mansoni	nAChR subunit	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0076	0.0243
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0035	0.0238	0.0759
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0035	0.0238	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0063	0.0202
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0041	0.0331	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Onchocerca volvulus		0.0025	0.0088	0.0047
Echinococcus multilocularis	pyruvate kinase	0.0035	0.0238	0.0238
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0041	0.0331	0.1057
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0267	0.059
Leishmania major	pyruvate kinase	0.0035	0.0238	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0307	0.0981
Echinococcus granulosus	pyruvate kinase	0.0035	0.0238	0.0238
Trichomonas vaginalis	conserved hypothetical protein	0.0184	0.2547	0.5634
Loa Loa (eye worm)	hypothetical protein	0.0166	0.2273	0.7254
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0587	0.1872
Mycobacterium tuberculosis	Conserved protein	0.0186	0.258	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0025	0.0088	0.0088
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0063	0.0202
Mycobacterium leprae	Conserved hypothetical protein	0.0186	0.258	1
Onchocerca volvulus		0.0253	0.3608	0.6681
Brugia malayi	excitatory GABA receptor EXP-1A	0.0025	0.0088	0.0282
Onchocerca volvulus		0.0025	0.0088	0.0047
Schistosoma mansoni	hypothetical protein	0.0186	0.258	0.258
Echinococcus multilocularis	pyruvate kinase	0.0035	0.0238	0.0238
Giardia lamblia	Pyruvate kinase	0.0035	0.0238	0.0526
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0025	0.0088	0.0282
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0166	0.2273	0.2273
Chlamydia trachomatis	pyruvate kinase	0.0035	0.0238	0.5
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0164	0.2241	0.7152
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0025	0.0088	0.0088
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0023	0.0063	0.0202
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0196	0.0196
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0193	0.2682	0.2682
Trichomonas vaginalis	pyruvate kinase, putative	0.0035	0.0238	0.0526
Trypanosoma brucei	pyruvate kinase 1, putative	0.0035	0.0238	0.8917
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0164	0.2241	0.2241
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0222	0.3134	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0025	0.0088	0.0088
Echinococcus granulosus	pyruvate kinase	0.0035	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0063	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0196	0.0624
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0025	0.0088	0.0088
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0088	0.0282
Onchocerca volvulus		0.0025	0.0088	0.0047
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0267	0.059
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0025	0.0088	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Echinococcus multilocularis	Transglutaminase	0.0186	0.258	0.258
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0587	0.1872
Echinococcus multilocularis	nAChR subunit	0.0025	0.0088	0.0088
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0196	0.0196
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0193	0.2682	0.2682
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0312	0.4521	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0193	0.2682	0.8558
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Trypanosoma brucei	glucosidase, putative	0.0036	0.0267	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0025	0.0088	0.0088
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0166	0.2273	0.2273
Echinococcus granulosus	lysosomal alpha glucosidase	0.0164	0.2241	0.2241
Schistosoma mansoni	nAChR subunit	0.0025	0.0088	0.0088
Onchocerca volvulus		0.0041	0.0331	0.0505
Brugia malayi	Cation transporter family protein	0.0025	0.0088	0.0282
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0177	0.0177
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0193	0.2682	0.2682
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0267	0.059
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0088	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2627	0.8383
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0186	0.258	1
Loa Loa (eye worm)	pyruvate kinase-PB	0.0024	0.0076	0.0243
Onchocerca volvulus		0.0041	0.0331	0.0505
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0193	0.2682	0.2682
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0023	0.0063	0.0202
Mycobacterium ulcerans	pyruvate kinase	0.0035	0.0238	0.0921
Brugia malayi	MH2 domain containing protein	0.0119	0.1536	0.4901
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0025	0.0088	0.0282
Onchocerca volvulus	Putative nachr subunit	0.0166	0.2273	0.4165
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0238	0.0329
Trichomonas vaginalis	peptide N-glycanase, putative	0.0186	0.258	0.5708
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0196	0.0196
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0025	0.0088	0.0088
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0164	0.2241	0.2241
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0312	0.4521	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0025	0.0088	0.0282
Plasmodium vivax	pyruvate kinase, putative	0.0035	0.0238	1
Loa Loa (eye worm)	ACC-1 protein	0.0025	0.0088	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0238	0.0759
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0025	0.0088	0.0088
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0312	0.4521	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0267	0.059
Onchocerca volvulus		0.0041	0.0331	0.0505
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0023	0.0063	0.0202
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0025	0.0088	0.0282
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0267	0.059
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0152	0.2057	0.797
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0312	0.4521	1
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0023	0.0063	0.0202
Leishmania major	pyruvate kinase	0.0035	0.0238	0.8917
Schistosoma mansoni	hypothetical protein	0.0039	0.0307	0.0307
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0041	0.0331	0.1057
Echinococcus multilocularis	microtubule associated protein 2	0.0667	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0587	0.1872
Onchocerca volvulus		0.0095	0.1171	0.2088
Onchocerca volvulus		0.0025	0.0088	0.0047
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0196	0.0196
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0267	0.059
Echinococcus granulosus	nAChR subunit	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0063	0.0202
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Mycobacterium tuberculosis	Hypothetical protein	0.0186	0.258	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0312	0.4521	1
Onchocerca volvulus		0.0041	0.0331	0.0505
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0025	0.0088	0.0088
Schistosoma mansoni	nAChR subunit	0.0025	0.0088	0.0088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0193	0.2682	0.2682
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0186	0.258	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0312	0.4521	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0166	0.2273	0.2273
Onchocerca volvulus		0.0041	0.0331	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Mycobacterium ulcerans	putative transglutaminase-like protein	0.0186	0.258	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0267	0.0851
Echinococcus granulosus	glycine receptor subunit beta	0.0025	0.0088	0.0088
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0267	0.059
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0025	0.0088	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Treponema pallidum	fructose-bisphosphate aldolase	0.0312	0.4521	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0267	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0025	0.0088	0.0282
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0025	0.0088	0.0282
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0267	0.059
Brugia malayi	Pre-SET motif family protein	0.0032	0.0196	0.0624
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0267	1
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0238	0.0759
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0307	0.0981
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0267	0.059
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0025	0.0088	0.0282
Trichomonas vaginalis	set domain proteins, putative	0.0253	0.3608	0.798
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0025	0.0088	0.0088
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0189	0.2627	0.8383
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.1536	0.4901
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0267	0.0851
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0193	0.2682	0.2682
Schistosoma mansoni	nAChR subunit	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0035	0.0238	0.8917
Trypanosoma brucei	pyruvate kinase 1	0.0035	0.0238	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0063	0.0202
Brugia malayi	Pre-SET motif family protein	0.0222	0.3134	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0025	0.0088	0.0282
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0164	0.2241	0.7152
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Onchocerca volvulus		0.0041	0.0331	0.0505
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0193	0.2682	0.2682
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0088	0.0282
Loa Loa (eye worm)	ACC-1 protein	0.0025	0.0088	0.0282
Schistosoma mansoni	nAChR subunit	0.0025	0.0088	0.0088
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0152	0.2057	0.797
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Echinococcus multilocularis	glycine receptor subunit beta	0.0025	0.0088	0.0088
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0025	0.0088	0.0088
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0166	0.2273	0.7254
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0088	0.0282
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0025	0.0088	0.0088
Giardia lamblia	Hypothetical protein	0.0186	0.258	0.5708
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0025	0.0088	0.0088
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0312	0.4521	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0166	0.2273	0.2273
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0312	0.4521	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0331	0.1057
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0035	0.0238	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0587	0.1872
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0312	0.4521	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0282
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0193	0.2682	0.8558
Trichomonas vaginalis	pyruvate kinase, putative	0.0035	0.0238	0.0526
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0025	0.0088	0.0282
Mycobacterium ulcerans	hypothetical protein	0.0186	0.258	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0152	0.2057	0.7765
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0238	0.0759
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0238	0.0329

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 14 uM	Tested for inhibition of [3H]-cholesteryl linoleate(CE) transfer from donor HDL to acceptor LDL driven by recombinant human cholesteryl ester transfer protein	ChEMBL.	No reference
IC50 (binding)	= 14 uM	Tested for inhibition of [3H]-cholesteryl linoleate(CE) transfer from donor HDL to acceptor LDL driven by recombinant human cholesteryl ester transfer protein	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 87574