TDR Targets

Basic information

Technical information

TDR Targets ID: 877618
Name: 1-(6-methylpyridin-2-yl)-4-[4-(trifluorometho xy)phenyl]sulfonylpiperazine
MW: 401.403 | Formula: C17H18F3N3O3S
H donors: 0 H acceptors: 3 LogP: 3.51 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(n1)N1CCN(CC1)S(=O)(=O)c1ccc(cc1)OC(F)(F)F
InChi: 1S/C17H18F3N3O3S/c1-13-3-2-4-16(21-13)22-9-11-23(12-10-22)27(24,25)15-7-5-14(6-8-15)26-17(18,19)20/h2-8H,9-12H2,1H3
InChiKey: BWKXRCXIULAUAN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(6-methyl-2-pyridyl)-4-[4-(trifluoromethoxy)phenyl]sulfonyl-piperazine
1-(6-methyl-2-pyridyl)-4-[4-(trifluoromethoxy)phenyl]sulfonylpiperazine
1-(6-methylpyridin-2-yl)-4-[4-(trifluoromethoxy)phenyl]sulfonyl-piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neuropeptide FF receptor 2	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0046	0.032	0.0282
Brugia malayi	hypothetical protein	0.0046	0.032	0.0818
Echinococcus multilocularis	somatostatin receptor	0.0046	0.032	0.0282
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0119	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.032	0.0462
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.032	0.0462
Echinococcus granulosus	g-protein coupled receptor	0.0046	0.032	0.0462
Schistosoma mansoni	biogenic amine receptor	0.0046	0.032	0.0462
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Schistosoma mansoni	voltage-gated potassium channel	0.0121	0.1194	0.1897
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	melatonin receptor type 1A	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Brugia malayi	Dopamine receptor protein 1	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.032	0.0282
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0046	0.032	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0119	0.013
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.032	0.0282
Brugia malayi	RE15519p	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus granulosus	neuropeptide receptor	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.032	0.0462
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0046	0.032	0.0462
Echinococcus granulosus	neuropeptide receptor A26	0.0046	0.032	0.0462
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0046	0.0316	0.0455
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.032	0.0462
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0046	0.032	0.0282
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0108	0.1043	0.1649
Echinococcus granulosus	sterol regulatory element binding protein	0.0046	0.0316	0.0455
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.032	0.0462
Schistosoma mansoni	hypothetical protein	0.0046	0.032	0.0462
Brugia malayi	sulfakinin receptor protein	0.0046	0.032	0.0818
Schistosoma mansoni	neuropeptide receptor	0.0046	0.032	0.0462
Brugia malayi	G protein-coupled receptor F59B2.13	0.0046	0.032	0.0818
Schistosoma mansoni	amine GPCR	0.0383	0.4233	0.689
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0285	0.3092	0.7829
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0046	0.032	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.032	0.0282
Brugia malayi	hypothetical protein	0.0029	0.0119	0.0303
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0237	0.0198
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0104	0.099	1
Schistosoma mansoni	amine GPCR	0.0046	0.032	0.0462
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.032	0.0462
Loa Loa (eye worm)	TYRA-2 protein	0.0046	0.032	0.0462
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.032	0.0462
Echinococcus multilocularis	dro:myosuppressin receptor	0.0046	0.032	0.0282
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1024	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Leishmania major	hypothetical protein, conserved	0.0285	0.3092	0.7829
Schistosoma mansoni	biogenic amine receptor	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus granulosus	serotonin receptor	0.0046	0.032	0.0462
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0107	0.1024	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.032	0.0462
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.032	0.0282
Echinococcus granulosus	allatostatin A receptor	0.0046	0.032	0.0462
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0046	0.032	0.0818
Schistosoma mansoni	myosin xvIII	0.0046	0.032	0.0462
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0046	0.032	0.0282
Brugia malayi	hypothetical protein	0.0046	0.032	0.0818
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0111	0.1075	0.1702
Schistosoma mansoni	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1896	0.305
Echinococcus granulosus	expressed conserved protein	0.01	0.0949	0.1494
Brugia malayi	Dopamine receptor	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0104	0.099	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0119	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0046	0.032	0.0462
Schistosoma mansoni	opsin-like receptor	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.032	0.0462
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0046	0.032	0.0462
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0285	0.3092	0.7829
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.032	0.0282
Brugia malayi	larval opioid receptor	0.0046	0.032	0.0818
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0316	0.291
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.032	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus granulosus	fmrfamide receptor	0.0046	0.032	0.0462
Echinococcus granulosus	7tm_1 domain containing protein	0.0046	0.032	0.0462
Echinococcus multilocularis	serotonin receptor	0.0546	0.6126	0.6111
Schistosoma mansoni	hypothetical protein	0.0044	0.0297	0.0423
Schistosoma mansoni	hypothetical protein	0.0039	0.0237	0.0325
Brugia malayi	neuropeptide F receptor	0.0046	0.032	0.0818
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0032	0.0158	0.0119
Echinococcus multilocularis	orexin receptor type 2	0.0046	0.032	0.0282
Brugia malayi	Serotonin receptor	0.0046	0.032	0.0818
Echinococcus multilocularis	protein patched	0.0046	0.0316	0.0278
Schistosoma mansoni	amine GPCR	0.0046	0.032	0.0462
Schistosoma mansoni	hypothetical protein	0.0044	0.0297	0.0423
Schistosoma mansoni	opsin-like receptor	0.0046	0.032	0.0462
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0046	0.032	0.0462
Brugia malayi	AKH receptor	0.0046	0.032	0.0818
Brugia malayi	hypothetical protein	0.0046	0.032	0.0818
Echinococcus granulosus	7TM GPCR rhodopsin	0.0046	0.032	0.0462
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0046	0.032	0.0462
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.032	0.0462
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.032	0.0462
Schistosoma mansoni	voltage-gated potassium channel	0.0121	0.1194	0.1897
Schistosoma mansoni	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0046	0.032	0.0462
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.032	0.0462
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.032	0.0282
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0436	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0546	0.6126	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0107	0.1024	0.1618
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.1288	0.2051
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0111	0.1075	0.1702
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.032	0.0462
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus granulosus	biogenic amine 5HT receptor	0.0546	0.6126	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0107	0.1024	0.2615
Echinococcus multilocularis	protein dispatched 1	0.0052	0.0391	0.0353
Onchocerca volvulus		0.0285	0.3092	1
Schistosoma mansoni	patched 1	0.0046	0.0316	0.0455
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0046	0.032	0.0462
Echinococcus granulosus	somatostatin receptor	0.0046	0.032	0.0462
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0356	0.3916	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0046	0.032	0.0282
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0119	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0158	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.032	0.0462
Brugia malayi	G-protein coupled receptor	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	serotonin receptor	0.0546	0.6126	0.6111
Schistosoma mansoni	neuropeptide receptor	0.0046	0.032	0.0462
Echinococcus granulosus	dro:myosuppressin receptor	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0356	0.3916	0.6369
Loa Loa (eye worm)	hypothetical protein	0.0546	0.6126	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Leishmania major	C-8 sterol isomerase-like protein	0.0356	0.3916	1
Brugia malayi	Melatonin receptor type 1A	0.0046	0.032	0.0818
Brugia malayi	hypothetical protein	0.0046	0.032	0.0818
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0046	0.032	0.0282
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.032	0.0282
Trypanosoma brucei	Emopamil binding protein, putative	0.0285	0.3092	0.7829
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0032	0.0158	0.0195
Brugia malayi	MH2 domain containing protein	0.0129	0.1288	0.3289
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0111	0.1075	0.104
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.032	0.0282
Brugia malayi	hypothetical protein	0.0039	0.0237	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	voltage gated potassium channel	0.0032	0.0158	0.0119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.032	0.0462
Brugia malayi	G-protein coupled receptor	0.0046	0.032	0.0818
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.032	0.0462
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.032	0.0462
Echinococcus granulosus	voltage gated potassium channel	0.0032	0.0158	0.0195
Schistosoma mansoni	amine GPCR	0.0046	0.032	0.0462
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.032	0.0282
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.032	0.0462
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.032	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0158	0.0195
Echinococcus multilocularis	g-protein coupled receptor	0.0046	0.032	0.0282
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.032	0.0282
Echinococcus multilocularis	Niemann Pick C1 protein	0.0107	0.1024	0.0989
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.032	0.0462
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0046	0.032	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0356	0.3916	1
Schistosoma mansoni	adenoreceptor	0.0046	0.032	0.0462
Schistosoma mansoni	biogenic amine receptor	0.0046	0.032	0.0462
Echinococcus multilocularis	neuropeptide receptor A26	0.0046	0.032	0.0282
Echinococcus multilocularis	expressed conserved protein	0.01	0.0949	0.0913
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.032	0.0462
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.032	0.0282
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0285	0.3092	0.7829
Schistosoma mansoni	neuropeptide receptor	0.0046	0.032	0.0462
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0119	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0046	0.032	0.0462
Schistosoma mansoni	histamine h1 receptor	0.0046	0.032	0.0462
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.032	0.0282
Brugia malayi	ORL1-like opioid receptor	0.0046	0.032	0.0818
Brugia malayi	putative neuropeptide receptor	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.032	0.0282
Brugia malayi	hypothetical protein	0.0046	0.032	0.0818
Brugia malayi	hypothetical protein	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0046	0.032	0.0462
Echinococcus multilocularis	neuropeptide s receptor	0.0046	0.032	0.0282
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0046	0.032	0.0462
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0046	0.032	0.0282
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.032	0.0462
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus granulosus	hypothetical protein	0.0046	0.032	0.0462
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0046	0.032	0.0462
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.032	0.0462
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0046	0.032	0.0462
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0046	0.032	0.0282
Brugia malayi	Dopamine receptor protein 2	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Schistosoma mansoni	growth hormone secretagogue receptor	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0316	0.0455
Brugia malayi	CHE-14 protein	0.0046	0.0316	0.0807
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0111	0.1075	0.2746
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0046	0.032	0.0818
Brugia malayi	Serotonin receptor	0.0046	0.032	0.0818
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.032	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.032	0.0282
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0046	0.032	0.0462
Echinococcus granulosus	Protein patched homolog 1	0.0046	0.0316	0.0455
Brugia malayi	putative neuropeptide receptor NPR1	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	sex peptide receptor	0.0046	0.032	0.0282
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0046	0.032	0.0462
Echinococcus granulosus	neuropeptide receptor	0.0046	0.032	0.0462
Brugia malayi	hypothetical protein	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.032	0.0282
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.032	0.0282
Echinococcus granulosus	neuropeptide s receptor	0.0046	0.032	0.0462
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.032	0.0462
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.032	0.0462
Echinococcus granulosus	sex peptide receptor	0.0046	0.032	0.0462
Echinococcus granulosus	g protein coupled receptor	0.0046	0.032	0.0462
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0158	0.0195
Brugia malayi	hypothetical protein	0.0046	0.032	0.0818
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0032	0.0158	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0905	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0046	0.032	0.0282
Echinococcus granulosus	g protein coupled receptor	0.0046	0.032	0.0462
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.032	0.0282
Echinococcus multilocularis	Niemann Pick C1 protein	0.0153	0.1557	0.1523
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0046	0.032	0.0818
Schistosoma mansoni	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.032	0.0282
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0546	0.6126	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus granulosus	Niemann Pick C1 protein	0.0153	0.1557	0.2492
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0046	0.032	0.0462
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.032	0.0462
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.032	0.0462
Brugia malayi	G protein-coupled receptor	0.0046	0.032	0.0818
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.032	0.0462
Schistosoma mansoni	hypothetical protein	0.0044	0.0297	0.0423
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0046	0.032	0.0462
Schistosoma mansoni	hypothetical protein	0.0044	0.0297	0.0423
Echinococcus multilocularis	allatostatin A receptor	0.0046	0.032	0.0282
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.032	0.0462
Echinococcus multilocularis	sterol regulatory element binding protein	0.0046	0.0316	0.0278
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.032	0.0462
Brugia malayi	neuropeptide F receptor	0.0046	0.032	0.0818
Brugia malayi	GnHR receptor homolog	0.0046	0.032	0.0818
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.032	0.0462
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.032	0.0462
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0046	0.032	0.0462
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.1288	0.2051
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0046	0.032	0.0462
Trypanosoma cruzi	Emopamil binding protein, putative	0.0285	0.3092	0.7829
Echinococcus granulosus	g protein coupled receptor	0.0046	0.032	0.0462
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0356	0.3916	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Brugia malayi	hypothetical protein	0.0046	0.032	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0046	0.032	0.0462
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.032	0.0462
Trypanosoma cruzi	Emopamil binding protein, putative	0.0285	0.3092	0.7829
Echinococcus granulosus	orexin receptor type 2	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Schistosoma mansoni	amine GPCR	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.032	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0046	0.032	0.0462
Schistosoma mansoni	neuropeptide f receptor 76f	0.0046	0.032	0.0462
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0237	0.0325
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.032	0.0462
Brugia malayi	hypothetical protein	0.0046	0.032	0.0818
Schistosoma mansoni	neuropeptide receptor	0.0046	0.032	0.0462
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.032	0.0282
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.032	0.0282
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.032	0.0282
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0237	0.0325
Schistosoma mansoni	opsin-like receptor	0.0046	0.032	0.0462
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0022	0.0039	0.0101
Brugia malayi	follicle stimulating hormone receptor	0.0046	0.032	0.0818

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 877618