Detailed information for compound 879316

Basic information

Technical information
  • TDR Targets ID: 879316
  • Name: 1-(2,6-dimethylphenyl)-4-(3-fluorophenyl)sulf onylpiperazine
  • MW: 348.435 | Formula: C18H21FN2O2S
  • H donors: 0 H acceptors: 2 LogP: 3.49 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)S(=O)(=O)N1CCN(CC1)c1c(C)cccc1C
  • InChi: 1S/C18H21FN2O2S/c1-14-5-3-6-15(2)18(14)20-9-11-21(12-10-20)24(22,23)17-8-4-7-16(19)13-17/h3-8,13H,9-12H2,1-2H3
  • InChiKey: MXSCGNAOAWASEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,6-dimethylphenyl)-4-(3-fluorophenyl)sulfonyl-piperazine
  • Oprea1_424941

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei glucose transporter, putative 0.0032 0.033 0.2352
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0138 0.0185
Toxoplasma gondii protein kinase, putative 0.0291 0.5862 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0307 0.0251
Leishmania major glucose transporter, lmgt2 0.0032 0.033 0.2352
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.033 0.2352
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0147 0.1126
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0147 0.1284
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0147 0.0147
Schistosoma mansoni microsomal glutathione s-transferase 0.0111 0.202 0.1974
Schistosoma mansoni protein kinase 0.0032 0.0321 0.0265
Echinococcus granulosus aldo keto reductase family 1 member B4 0.007 0.1141 0.2473
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0147 0.0626
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.002 0.008 0.0098
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Onchocerca volvulus 0.007 0.1141 1
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0321 0.0265
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1847 0.4085
Echinococcus granulosus aldo keto reductase family 1 member B4 0.007 0.1141 0.2473
Loa Loa (eye worm) hypothetical protein 0.0031 0.0307 0.0471
Plasmodium falciparum protein kinase 6 0.0437 0.8983 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0321 0.0336
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0138 0.055
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1847 0.4085
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0307 0.057
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3202 0.5399
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0147 0.0626
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0138 0.0134
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Loa Loa (eye worm) hypothetical protein 0.0046 0.063 0.1001
Mycobacterium tuberculosis Conserved protein 0.002 0.008 0.0702
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0307 0.1685
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0138 0.0687
Plasmodium falciparum aldehyde reductase, putative 0.002 0.008 0.0067
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0138 0.0101
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3202 0.355
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0321 0.0336
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0147 0.1126
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.007 0.1141 0.1789
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0321 0.0601
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.033 0.2352
Trichomonas vaginalis sugar transporter, putative 0.0032 0.033 0.1423
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0321 0.0417
Leishmania major prostaglandin f synthase, putative 0.007 0.1141 1
Schistosoma mansoni aldo-keto reductase 0.007 0.1141 0.109
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0321 0.0336
Entamoeba histolytica aldose reductase, putative 0.007 0.1141 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0321 0.0601
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0321 0.0336
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0147 0.0626
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.063 0.1001
Trypanosoma cruzi aldo-keto reductase 0.007 0.1141 1
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Schistosoma mansoni protein kinase 0.0032 0.0321 0.0265
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Trypanosoma brucei aldo-keto reductase, putative 0.007 0.1141 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0147 0.1126
Trichomonas vaginalis aldo/keto reductase, putative 0.007 0.1141 0.6009
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0417 0.3173
Schistosoma mansoni glucose transport protein 0.0103 0.1847 0.18
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.007 0.1141 0.6009
Entamoeba histolytica protein kinase, putative 0.0032 0.0321 0.2271
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0147 0.1126
Schistosoma mansoni glucose transport protein 0.0103 0.1847 0.18
Brugia malayi glutamate-cysteine ligase modifier subunit 0.002 0.008 0.0037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0147 0.0762
Trypanosoma brucei glucose transporter, putative 0.0032 0.033 0.2352
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0321 0.0336
Mycobacterium ulcerans oxidoreductase 0.007 0.1141 1
Brugia malayi Integrin beta pat-3 precursor 0.0303 0.6115 1
Echinococcus multilocularis General substrate transporter 0.0088 0.1538 0.3379
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0321 0.0601
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0138 0.1054
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0321 0.1374
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0321 0.0336
Trichomonas vaginalis aldo-keto reductase, putative 0.002 0.008 0.0012
Onchocerca volvulus 0.007 0.1141 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.1847 0.3056
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0307 0.2143
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.033 0.1423
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0147 0.1126
Trypanosoma cruzi hexose transporter, putative 0.0032 0.033 0.276
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0417 0.0442
Mycobacterium leprae Conserved hypothetical protein 0.005 0.0708 0.5982
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0307 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1847 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.033 0.276
Trichomonas vaginalis sugar transporter, putative 0.0032 0.033 0.1423
Trypanosoma brucei glucose transporter 1E 0.0032 0.033 0.2352
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3202 0.355
Trichomonas vaginalis aldo/keto reductase, putative 0.007 0.1141 0.6009
Echinococcus multilocularis aldo keto reductase 0.007 0.1141 0.2473
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1847 0.4085
Plasmodium falciparum protein kinase 7 0.0291 0.5862 0.6518
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0321 0.0336
Trypanosoma cruzi aldo/keto reductase, putative 0.002 0.008 0.0533
Echinococcus granulosus aldo keto reductase family 1 member B4 0.007 0.1141 0.2473
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1847 0.4085
Echinococcus granulosus General substrate transporter 0.0088 0.1538 0.3379
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0417 0.3173
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.007 0.1141 0.1789
Brugia malayi Kelch motif family protein 0.0046 0.063 0.0945
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.007 0.1141 0.6009
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0058 0.0042
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.1847 0.4085
Plasmodium vivax aldehyde reductase, putative 0.002 0.008 0.0067
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0321 0.0601
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0279 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.033 0.1423
Loa Loa (eye worm) integrin beta-2 0.0303 0.6115 1
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0279 0.0506
Loa Loa (eye worm) oxidoreductase 0.007 0.1141 0.1839
Schistosoma mansoni lipoxygenase 0.008 0.1362 0.1312
Echinococcus granulosus aldo keto reductase family 1 member B4 0.007 0.1141 0.2473
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0138 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.033 0.1423
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0321 0.0336
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Trichomonas vaginalis aldo-keto reductase, putative 0.002 0.008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0061
Onchocerca volvulus 0.007 0.1141 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0147 0.1284
Toxoplasma gondii MAPEG family protein 0.0111 0.202 0.3355
Mycobacterium leprae Possible oxidoreductase 0.002 0.008 0.0145
Trichomonas vaginalis glucose transporter, putative 0.0032 0.033 0.1423
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0147 0.0147
Echinococcus granulosus aldo keto reductase family 1 member B4 0.007 0.1141 0.2473
Trypanosoma brucei glucose transporter, putative 0.0032 0.033 0.2352
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0307 0.057
Trichomonas vaginalis aldo-keto reductase, putative 0.002 0.008 0.0012
Brugia malayi NADH-dependent xylose reductase 0.002 0.008 0.0037
Trypanosoma brucei glucose transporter, putative 0.0032 0.033 0.2352
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0417 0.0442
Loa Loa (eye worm) hypothetical protein 0.0023 0.0147 0.0207
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0138 0.0185
Loa Loa (eye worm) hypothetical protein 0.0023 0.0138 0.0194
Echinococcus granulosus hypothetical protein 0.007 0.1141 0.2473
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0307 0.1297
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0138 0.0132
Trypanosoma cruzi hexose transporter, putative 0.0032 0.033 0.276
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0417 0.3537
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0064 0.0565
Trypanosoma brucei glucose transporter 2A 0.0032 0.033 0.2352
Leishmania major glucose transporter, lmgt1 0.0032 0.033 0.2352
Loa Loa (eye worm) sugar transporter 0.0103 0.1847 0.2997
Echinococcus granulosus aldo keto reductase 0.007 0.1141 0.2473
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Trypanosoma brucei prostaglandin f synthase 0.007 0.1141 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.007 0.1141 0.2473
Trypanosoma brucei glucose transporter, putative 0.0032 0.033 0.2352
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0321 0.2271
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0307 0.0412
Leishmania major aldo-keto reductase-like protein 0.007 0.1141 1
Giardia lamblia Aldose reductase 0.007 0.1141 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0147 0.0762
Trichomonas vaginalis alcohol dehydrogenase, putative 0.002 0.008 0.0012
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0138 0.0132
Schistosoma mansoni pol-related 0.007 0.1141 0.109
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Entamoeba histolytica protein kinase, putative 0.0032 0.0321 0.2271
Echinococcus granulosus aldo keto reductase family 1 member B4 0.007 0.1141 0.2473
Brugia malayi hypothetical protein 0.0046 0.063 0.0945
Echinococcus multilocularis aldehyde reductase 0.005 0.0708 0.1486
Echinococcus multilocularis voltage gated potassium channel subunit 0.002 0.008 0.0051
Onchocerca volvulus 0.0023 0.0147 0.0821
Plasmodium vivax hexose transporter 0.0103 0.1847 0.2038
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0064 0.0565
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0321 0.0493
Echinococcus multilocularis aldo keto reductase 0.007 0.1141 0.2473
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.002 0.008 0.0067
Giardia lamblia Aldose reductase 0.007 0.1141 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0321 0.0601
Entamoeba histolytica hypothetical protein 0.0023 0.0138 0.055
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0321 0.0417
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0147 0.1126
Schistosoma mansoni potassium channel beta 0.002 0.008 0.0023
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.007 0.1141 0.6009
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0307 0.0471
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.033 0.2352
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0138 0.055
Brugia malayi Cam kinase protein 1 0.0032 0.0321 0.0435
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0321 0.0601
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Echinococcus granulosus microsomal glutathione S transferase 3 0.0111 0.202 0.4479
Loa Loa (eye worm) oxidoreductase 0.007 0.1141 0.1839
Leishmania major protein kinase, putative 0.0032 0.0321 0.2271
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0138 0.0342
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0321 0.0601
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.007 0.1141 0.1789
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Schistosoma mansoni protein kinase 0.0032 0.0321 0.0265
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Echinococcus granulosus aldehyde reductase 0.005 0.0708 0.1486
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0417 0.3537
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0417 0.0582
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0147 0.0626
Trichomonas vaginalis aldo/keto reductase, putative 0.007 0.1141 0.6009
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0147 0.0626
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.2101 0.4664
Echinococcus multilocularis aldo keto reductase 0.007 0.1141 0.2473
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Loa Loa (eye worm) hypothetical protein 0.0032 0.0321 0.0493
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0138 0.1054
Onchocerca volvulus 0.007 0.1141 1
Toxoplasma gondii aldose reductase, putative 0.007 0.1141 0.1835
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0147 0.0626
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0147 0.1126
Trichomonas vaginalis sugar transporter, putative 0.0032 0.033 0.1423
Leishmania major glucose transporter, lmgt3 0.0032 0.033 0.2352
Schistosoma mansoni lipoxygenase 0.0115 0.2101 0.2055
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0147 0.1126
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0321 0.0417
Onchocerca volvulus 0.007 0.1141 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0417 0.3173
Loa Loa (eye worm) oxidoreductase 0.007 0.1141 0.1839
Echinococcus granulosus aldo keto reductase family 1 member B4 0.007 0.1141 0.2473
Trypanosoma cruzi hexose transporter 0.0032 0.033 0.276
Loa Loa (eye worm) hypothetical protein 0.0023 0.0147 0.0207
Loa Loa (eye worm) hypothetical protein 0.0023 0.0147 0.0207
Trypanosoma cruzi aldo/keto reductase, putative 0.007 0.1141 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.2101 0.4664
Echinococcus multilocularis aldo keto reductase 0.007 0.1141 0.2473
Trypanosoma brucei glucose transporter, putative 0.0032 0.033 0.2352
Onchocerca volvulus 0.002 0.008 0.0208
Mycobacterium ulcerans hypothetical protein 0.002 0.008 0.0533
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0138 0.1054
Brugia malayi Sugar transporter family protein 0.0103 0.1847 0.2954
Trypanosoma brucei glucose transporter, putative 0.0032 0.033 0.2352
Echinococcus granulosus aldo keto reductase family 1, member B4 0.002 0.008 0.0051
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1847 0.4085
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0321 0.0601
Echinococcus granulosus voltage gated potassium channel subunit 0.002 0.008 0.0051
Schistosoma mansoni integrin beta subunit 0.0178 0.3456 0.3418
Schistosoma mansoni hypothetical protein 0.0103 0.1847 0.18
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0307 0.0251
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0307 0.2257
Entamoeba histolytica aldose reductase, putative 0.007 0.1141 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.007 0.1141 0.2473
Entamoeba histolytica aldose reductase, putative 0.007 0.1141 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0437 0.8983 1
Echinococcus multilocularis integrin beta 2 0.0224 0.4438 1
Loa Loa (eye worm) hypothetical protein 0.007 0.1141 0.1839
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.007 0.1141 1
Loa Loa (eye worm) oxidoreductase 0.007 0.1141 0.1839
Plasmodium falciparum hexose transporter 0.0103 0.1847 0.2038
Onchocerca volvulus 0.007 0.1141 1
Loa Loa (eye worm) oxidoreductase 0.007 0.1141 0.1839
Mycobacterium tuberculosis Probable oxidoreductase 0.007 0.1141 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.007 0.1141 1
Schistosoma mansoni glucose transport protein 0.0103 0.1847 0.18
Loa Loa (eye worm) hypothetical protein 0.0025 0.0184 0.0268
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.002 0.0178
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.033 0.2352
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0138 0.0081
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0321 0.0435
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1847 0.4085
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.007 0.1141 0.2473
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1847 0.4085
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0058 0.0042
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0111 0.202 0.4479
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.007 0.1141 0.1789
Echinococcus granulosus aldo keto reductase 0.007 0.1141 0.2473
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0321 0.0493
Schistosoma mansoni aldo-keto reductase 0.007 0.1141 0.109
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.007 0.1141 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0147 0.0147
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0321 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.002 0.008 0.0012
Trypanosoma brucei glucose transporter, putative 0.0032 0.033 0.2352
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0138 0.0081
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0058 0.0061
Trichomonas vaginalis aldo-keto reductase, putative 0.007 0.1141 0.6009
Echinococcus granulosus aldo keto reductase 0.007 0.1141 0.2473
Echinococcus granulosus integrin beta 2 0.0224 0.4438 1
Plasmodium falciparum aldo-keto reductase, putative 0.002 0.008 0.0067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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