TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 351.414 | Formula: C17H19F2N3OS
H donors: 0 H acceptors: 2 LogP: 3.22 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)F)c1scc(n1)C(=O)N1CCN(CC1)C(C)C
InChi: 1S/C17H19F2N3OS/c1-11(2)21-5-7-22(8-6-21)17(23)15-10-24-16(20-15)13-4-3-12(18)9-14(13)19/h3-4,9-11H,5-8H2,1-2H3
InChiKey: RUSSHWWQGNPJSW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	p2X purinoceptor 4	0.0456	0.688	0.688
Brugia malayi	Receptor family ligand binding region containing protein	0.0039	0.0231	0.0476
Treponema pallidum	sodium- and chloride- dependent transporter	0.0103	0.1246	0.5
Echinococcus granulosus	serotonin receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.0608	0.0795
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0063	0.0608	0.1251
Schistosoma mansoni	glutaminase	0.0316	0.465	0.6079
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0231	0.0476
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	neuropeptide F-like receptor	0.0063	0.0608	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1228	0.2527
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	somatostatin receptor	0.0063	0.0608	0.0608
Echinococcus granulosus	fmrfamide receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0608	0.0795
Brugia malayi	Melatonin receptor type 1A	0.0063	0.0608	0.1251
Schistosoma mansoni	amine GPCR	0.0063	0.0608	0.0795
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0063	0.0608	0.0608
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0152	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus multilocularis	neuropeptide receptor	0.0063	0.0608	0.0608
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0063	0.0608	0.0608
Onchocerca volvulus		0.0063	0.0608	0.1251
Echinococcus granulosus	neuropeptide Y receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0063	0.0608	0.0795
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0063	0.0608	0.1251
Loa Loa (eye worm)	glutamate receptor	0.0039	0.0231	0.0476
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0329	0.4861	1
Schistosoma mansoni	biogenic amine receptor	0.0063	0.0608	0.0795
Brugia malayi	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus multilocularis	neuropeptide s receptor	0.0063	0.0608	0.0608
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0063	0.0608	0.1251
Onchocerca volvulus		0.0063	0.0608	0.1251
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.0608	0.0608
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0063	0.0608	0.0608
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0608	0.0795
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0063	0.0608	0.0608
Echinococcus granulosus	g-protein coupled receptor	0.0063	0.0608	0.0608
Echinococcus multilocularis	somatostatin receptor	0.0063	0.0608	0.0608
Onchocerca volvulus		0.0063	0.0608	0.1251
Brugia malayi	hypothetical protein	0.0063	0.0608	0.1251
Onchocerca volvulus		0.0035	0.0152	0.0313
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Schistosoma mansoni	opsin-like receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0608	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	p2X purinoceptor 4	0.0456	0.688	0.688
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1228	0.2527
Echinococcus granulosus	sortilin	0.0076	0.0819	0.0819
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0608	0.0795
Brugia malayi	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Loa Loa (eye worm)	glutaminase 2	0.0316	0.465	0.9566
Echinococcus multilocularis	neuropeptide Y receptor	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	neuropeptide receptor	0.0063	0.0608	0.0608
Echinococcus multilocularis	fmrfamide receptor	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0651	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0152	0.0313
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0103	0.1246	0.2564
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0039	0.0231	0.0476
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0063	0.0608	0.1251
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0075	0.0799	0.0799
Brugia malayi	Serotonin receptor	0.0063	0.0608	0.1251
Brugia malayi	G-protein coupled receptor	0.0063	0.0608	0.1251
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0063	0.0608	0.0795
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0608	0.0795
Onchocerca volvulus		0.0103	0.1246	0.2564
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Loa Loa (eye worm)	TYRA-2 protein	0.0063	0.0608	0.1251
Brugia malayi	ORL1-like opioid receptor	0.0063	0.0608	0.1251
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0608	0.0795
Echinococcus granulosus	g protein coupled receptor	0.0063	0.0608	0.0608
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0063	0.0608	0.0608
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0075	0.0799	0.0799
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.0608	0.0608
Onchocerca volvulus		0.0063	0.0608	0.1251
Onchocerca volvulus		0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	putative neuropeptide receptor	0.0063	0.0608	0.1251
Echinococcus multilocularis	serotonin transporter	0.0103	0.1246	0.1246
Echinococcus granulosus	neuropeptides capa receptor	0.0063	0.0608	0.0608
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	hypothetical protein	0.0063	0.0608	0.0795
Schistosoma mansoni	metabotropic glutamate receptor	0.0504	0.7649	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1246	0.2564
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus multilocularis	G protein coupled receptor 139	0.0063	0.0608	0.0608
Echinococcus multilocularis	sortilin	0.0076	0.0819	0.0819
Brugia malayi	Dopamine receptor protein 1	0.0063	0.0608	0.1251
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0152	0.0152
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	P2X receptor subunit	0.0456	0.688	0.8995
Echinococcus multilocularis	fmrfamide receptor	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0799	0.1645
Echinococcus granulosus	p2X purinoceptor 4	0.0456	0.688	0.688
Brugia malayi	Serotonin receptor	0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1246	0.2564
Brugia malayi	GnHR receptor homolog	0.0063	0.0608	0.1251
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0608	0.0795
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Onchocerca volvulus		0.0063	0.0608	0.1251
Loa Loa (eye worm)	G-protein coupled receptor	0.0063	0.0608	0.1251
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0329	0.4861	1
Onchocerca volvulus		0.0274	0.3976	0.8179
Schistosoma mansoni	myosin xvIII	0.0063	0.0608	0.0795
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0329	0.4861	0.4861
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0608	0.0795
Onchocerca volvulus		0.0063	0.0608	0.1251
Schistosoma mansoni	opsin-like receptor	0.0063	0.0608	0.0795
Loa Loa (eye worm)	serotonin transporter b	0.0103	0.1246	0.2564
Brugia malayi	follicle stimulating hormone receptor	0.0063	0.0608	0.1251
Brugia malayi	sulfakinin receptor protein	0.0063	0.0608	0.1251
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0608	0.0795
Brugia malayi	hypothetical protein	0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	neuropeptide Y receptor	0.0063	0.0608	0.0608
Loa Loa (eye worm)	neuropeptide F receptor	0.0063	0.0608	0.1251
Echinococcus granulosus	orexin receptor type 2	0.0063	0.0608	0.0608
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0152	0.0199
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0063	0.0608	0.0608
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0132	0.0132
Echinococcus multilocularis	orexin receptor type 2	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0063	0.0608	0.1251
Brugia malayi	metabotropic glutamate receptor type 2	0.0075	0.0799	0.1645
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0063	0.0608	0.1251
Echinococcus granulosus	serotonin transporter	0.0103	0.1246	0.1246
Onchocerca volvulus		0.0063	0.0608	0.1251
Echinococcus multilocularis	g-protein coupled receptor	0.0063	0.0608	0.0608
Echinococcus granulosus	biogenic amine 5HT receptor	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	G protein-coupled receptor F59B2.13	0.0063	0.0608	0.1251
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0063	0.0608	0.0608
Echinococcus multilocularis	p2X purinoceptor 4	0.0456	0.688	0.688
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0152	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	7tm_1 domain containing protein	0.0063	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Echinococcus granulosus	allatostatin A receptor	0.0063	0.0608	0.0608
Echinococcus multilocularis	allatostatin A receptor	0.0063	0.0608	0.0608
Echinococcus multilocularis	neuropeptides capa receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	growth hormone secretagogue receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	eyes absent homolog	0.0102	0.1228	0.1606
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1246	0.2564
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0063	0.0608	0.0608
Brugia malayi	Pre-SET motif family protein	0.0241	0.3445	0.7087
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	g protein coupled receptor	0.0063	0.0608	0.0608
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0039	0.0231	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	neuropeptide receptor A26	0.0063	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	RE15519p	0.0063	0.0608	0.1251
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0329	0.4861	0.4861
Brugia malayi	Pre-SET motif family protein	0.0035	0.0152	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	neuropeptide F receptor	0.0063	0.0608	0.1251
Schistosoma mansoni	neuropeptide receptor	0.0063	0.0608	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0063	0.0608	0.0795
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0063	0.0608	0.1251
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	P2X receptor subunit	0.0456	0.688	0.8995
Echinococcus granulosus	p2X purinoceptor 4	0.0456	0.688	0.688
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	larval opioid receptor	0.0063	0.0608	0.1251
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0063	0.0608	0.1251
Onchocerca volvulus		0.0063	0.0608	0.1251
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus multilocularis	sex peptide receptor	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0152	0.0199
Onchocerca volvulus		0.0063	0.0608	0.1251
Schistosoma mansoni	P2X receptor subunit	0.0456	0.688	0.8995
Schistosoma mansoni	amine GPCR	0.0063	0.0608	0.0795
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Toxoplasma gondii	sortilin, putative	0.0076	0.0819	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Brugia malayi	glutaminase DH11.1	0.0316	0.465	0.9566
Schistosoma mansoni	histamine h1 receptor	0.0063	0.0608	0.0795
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0063	0.0608	0.1251
Echinococcus granulosus	g protein coupled receptor	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Onchocerca volvulus		0.0063	0.0608	0.1251
Onchocerca volvulus		0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	AKH receptor	0.0063	0.0608	0.1251
Brugia malayi	G-protein coupled receptor	0.0063	0.0608	0.1251
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0063	0.0608	0.0608
Onchocerca volvulus		0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	neuropeptides capa receptor	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0063	0.0608	0.0608
Echinococcus multilocularis	p2X purinoceptor 4	0.0456	0.688	0.688
Echinococcus multilocularis	neuropeptides capa receptor	0.0063	0.0608	0.0608
Echinococcus granulosus	dro:myosuppressin receptor	0.0063	0.0608	0.0608
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.0608	0.0608
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0063	0.0608	0.0608
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0608	0.0795
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0063	0.0608	0.0608
Schistosoma mansoni	adenoreceptor	0.0063	0.0608	0.0795
Mycobacterium ulcerans	glutaminase	0.0316	0.465	0.5
Loa Loa (eye worm)	glutaminase	0.0316	0.465	0.9566
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0063	0.0608	0.0608
Brugia malayi	Protein kinase domain containing protein	0.0329	0.4861	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	hypothetical protein	0.0102	0.1228	0.2527
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0063	0.0608	0.0795
Trichomonas vaginalis	glutaminase, putative	0.0316	0.465	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0063	0.0608	0.1251
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0063	0.0608	0.0795
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0152	0.0152
Schistosoma mansoni	hypothetical protein	0.0063	0.0608	0.0795
Brugia malayi	hypothetical protein	0.0063	0.0608	0.1251
Brugia malayi	G protein-coupled receptor	0.0063	0.0608	0.1251
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.0608	0.0795
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0039	0.0231	0.0476
Echinococcus multilocularis	serotonin receptor	0.0063	0.0608	0.0608
Onchocerca volvulus		0.0063	0.0608	0.1251
Brugia malayi	neuropeptide F receptor	0.0063	0.0608	0.1251
Loa Loa (eye worm)	neuropeptide F receptor	0.0063	0.0608	0.1251
Echinococcus granulosus	7TM GPCR rhodopsin	0.0063	0.0608	0.0608
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0063	0.0608	0.0608
Brugia malayi	Dopamine receptor protein 2	0.0063	0.0608	0.1251
Brugia malayi	hypothetical protein	0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0241	0.3445	0.7087
Echinococcus granulosus	hypothetical protein	0.0063	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Schistosoma mansoni	sodium/chloride dependent transporter	0.0103	0.1246	0.1629
Brugia malayi	putative neuropeptide receptor NPR1	0.0063	0.0608	0.1251
Brugia malayi	Dopamine receptor	0.0063	0.0608	0.1251
Schistosoma mansoni	biogenic amine receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0152	0.0199
Echinococcus multilocularis	dro:myosuppressin receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	neuropeptide f receptor 76f	0.0063	0.0608	0.0795
Echinococcus multilocularis	neuropeptide receptor A26	0.0063	0.0608	0.0608
Onchocerca volvulus		0.0063	0.0608	0.1251
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.0608	0.0608
Loa Loa (eye worm)	norepinephrine transporter	0.0103	0.1246	0.2564
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0329	0.4861	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	neuropeptide receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	amine GPCR	0.0063	0.0608	0.0795
Echinococcus granulosus	G protein coupled receptor 139	0.0063	0.0608	0.0608
Schistosoma mansoni	amine GPCR	0.0063	0.0608	0.0795
Echinococcus multilocularis	serotonin receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	biogenic amine receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0608	0.0795
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0063	0.0608	0.0795
Schistosoma mansoni	hypothetical protein	0.0063	0.0608	0.0795
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0063	0.0608	0.0795
Echinococcus granulosus	neuropeptide FF receptor 2	0.0063	0.0608	0.0608
Plasmodium falciparum	sortilin	0.0076	0.0819	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	hypothetical protein	0.0063	0.0608	0.0795
Schistosoma mansoni	neuropeptide F-like receptor	0.0063	0.0608	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	neuropeptide s receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	serine/threonine protein kinase	0.0329	0.4861	0.6355
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0063	0.0608	0.1251
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0063	0.0608	0.1251
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0103	0.1246	0.2564
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Echinococcus granulosus	sex peptide receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	P2X receptor subunit	0.0456	0.688	0.8995
Echinococcus multilocularis	neuropeptide receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	opsin-like receptor	0.0063	0.0608	0.0795
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.0608	0.0795
Schistosoma mansoni	sortilin	0.0054	0.0464	0.0606
Onchocerca volvulus		0.0063	0.0608	0.1251
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0329	0.4861	1
Loa Loa (eye worm)	glutamate receptor	0.0061	0.0568	0.1169
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0061	0.0568	0.0743
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0103	0.1246	0.1629
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0063	0.0608	0.0795
Onchocerca volvulus		0.0063	0.0608	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0608	0.1251
Plasmodium vivax	sortilin, putative	0.0076	0.0819	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0063	0.0608	0.0608
Schistosoma mansoni	amine GPCR	0.0063	0.0608	0.0795
Loa Loa (eye worm)	melatonin receptor type 1A	0.0063	0.0608	0.1251
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0063	0.0608	0.0608

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 879608