Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0055 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.018 | 0.1439 | 0.5 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.0683 | 0.7211 | 1 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.0683 | 0.7211 | 1 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.0683 | 0.7211 | 0.5 |
Chlamydia trachomatis | replicative DNA helicase | 0.0683 | 0.7211 | 1 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0688 | 0.7266 | 1 |
Schistosoma mansoni | Replicative DNA helicase | 0.0683 | 0.7211 | 1 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.0683 | 0.7211 | 1 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.0683 | 0.7211 | 1 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0688 | 0.7266 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.018 | 0.1439 | 0.5 |
Loa Loa (eye worm) | twinkle helicase | 0.0195 | 0.161 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.018 | 0.1439 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.