Detailed information for compound 881768

Basic information

Technical information
  • TDR Targets ID: 881768
  • Name: 3-(2-methoxyethyl)-2-(4-methoxynaphthalen-1-y l)-1,3-thiazolidin-4-one
  • MW: 317.403 | Formula: C17H19NO3S
  • H donors: 0 H acceptors: 1 LogP: 2.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN1C(=O)CSC1c1ccc(c2c1cccc2)OC
  • InChi: 1S/C17H19NO3S/c1-20-10-9-18-16(19)11-22-17(18)14-7-8-15(21-2)13-6-4-3-5-12(13)14/h3-8,17H,9-11H2,1-2H3
  • InChiKey: LHWOVWVKEPVYBP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2-methoxyethyl)-2-(4-methoxy-1-naphthyl)thiazolidin-4-one
  • 3-(2-methoxyethyl)-2-(4-methoxy-1-naphthyl)-4-thiazolidinone
  • Oprea1_358318

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serotonin receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Brugia malayi Dopamine receptor protein 1 0.0142 0.0175 0.0169
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0243 0.0366 0.0459
Loa Loa (eye worm) hypothetical protein 0.0132 0.0154 0.0148
Onchocerca volvulus 0.0821 0.1466 0.6239
Brugia malayi Receptor family ligand binding region containing protein 0.0248 0.0376 0.0371
Brugia malayi Protein kinase domain containing protein 0.0316 0.0506 0.05
Entamoeba histolytica hypothetical protein 0.0132 0.0154 1
Onchocerca volvulus 0.0142 0.0175 0.0554
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0076 0.0049 0.0051
Echinococcus granulosus transmembrane protease serine 3 0.02 0.0284 0.0352
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Schistosoma mansoni integrin alpha-ps 0.0535 0.0923 0.1497
Echinococcus multilocularis epidermal growth factor receptor 0.0155 0.0199 0.0244
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0522 0.0898 0.0892
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0111 0.0116 0.011
Schistosoma mansoni nAChR subunit 0.0111 0.0116 0.0188
Plasmodium falciparum cysteine repeat modular protein 1 0.0307 0.0488 0.5
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus multilocularis G protein coupled receptor 139 0.0142 0.0175 0.0213
Brugia malayi PAN domain containing protein 0.0199 0.0282 0.0276
Brugia malayi hypothetical protein 0.0076 0.0049 0.0043
Brugia malayi hypothetical protein 0.0142 0.0175 0.0169
Echinococcus multilocularis voltage dependent calcium channel 0.0122 0.0136 0.0163
Schistosoma mansoni myosin xvIII 0.0142 0.0175 0.0284
Loa Loa (eye worm) TK/INSR protein kinase 0.0055 0.0009 0.0004
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0243 0.0366 0.0361
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0122 0.0136 0.0163
Loa Loa (eye worm) hypothetical protein 0.0199 0.0282 0.0276
Echinococcus granulosus 7TM GPCR rhodopsin 0.0142 0.0175 0.0213
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0111 0.0116 0.011
Onchocerca volvulus 0.0142 0.0175 0.0554
Giardia lamblia Neurogenic locus Notch protein precursor 0.0157 0.0203 0.5
Loa Loa (eye worm) hypothetical protein 0.0199 0.0282 0.0276
Loa Loa (eye worm) calcium channel 0.0122 0.0136 0.013
Schistosoma mansoni neuropeptide F-like receptor 0.0142 0.0175 0.0284
Brugia malayi EGF-like domain containing protein 0.0157 0.0203 0.0198
Onchocerca volvulus 0.0821 0.1466 0.6239
Brugia malayi neuropeptide F receptor 0.0142 0.0175 0.0169
Echinococcus granulosus orexin receptor type 2 0.0142 0.0175 0.0213
Schistosoma mansoni opsin-like receptor 0.0142 0.0175 0.0284
Echinococcus multilocularis somatostatin receptor 0.0142 0.0175 0.0213
Brugia malayi hypothetical protein 0.0142 0.0175 0.0169
Trichomonas vaginalis hypothetical protein 0.0157 0.0203 0.5
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.02 0.0284 0.0352
Brugia malayi PAN domain containing protein 0.0199 0.0282 0.0276
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0076 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0243 0.0366 0.0361
Echinococcus granulosus tachykinin peptides receptor 99D 0.0142 0.0175 0.0213
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0243 0.0366 0.0459
Schistosoma mansoni integrin alpha 0.1428 0.262 0.4251
Echinococcus granulosus epidermal growth factor receptor 0.0087 0.007 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0076 0.0049 0.0043
Onchocerca volvulus 0.0215 0.0314 0.1164
Schistosoma mansoni tyrosine kinase 0.0078 0.0052 0.0085
Schistosoma mansoni hypothetical protein 0.02 0.0284 0.046
Brugia malayi Dopamine receptor 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Echinococcus multilocularis g protein coupled receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0199 0.0282 0.0276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus multilocularis sex peptide receptor 0.0142 0.0175 0.0213
Echinococcus granulosus biogenic amine 5HT receptor 0.0142 0.0175 0.0213
Brugia malayi RE15519p 0.0142 0.0175 0.0169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0175 0.0284
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Echinococcus granulosus neuropeptide s receptor 0.0142 0.0175 0.0213
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Onchocerca volvulus 0.0142 0.0175 0.0554
Echinococcus multilocularis neuropeptides capa receptor 0.0142 0.0175 0.0213
Brugia malayi jmjC domain containing protein 0.0093 0.008 0.0074
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0243 0.0366 0.0459
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0111 0.0116 0.011
Echinococcus multilocularis integrin alpha ps 0.0914 0.1643 0.2099
Brugia malayi Trypsin family protein 0.02 0.0284 0.0278
Loa Loa (eye worm) trypsin family protein 0.02 0.0284 0.0278
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Echinococcus granulosus allatostatin A receptor 0.0142 0.0175 0.0213
Echinococcus granulosus somatostatin receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0132 0.0154 0.0148
Loa Loa (eye worm) TK/EGFR protein kinase 0.0155 0.0199 0.0194
Schistosoma mansoni opsin-like receptor 0.0142 0.0175 0.0284
Brugia malayi follicle stimulating hormone receptor 0.0142 0.0175 0.0169
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0199 0.0282 0.0202
Brugia malayi G-protein coupled receptor 0.0142 0.0175 0.0169
Onchocerca volvulus 0.0199 0.0282 0.1024
Schistosoma mansoni tyrosine kinase 0.0078 0.0052 0.0085
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Loa Loa (eye worm) integrin beta-2 0.5306 1 1
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0157 0.0203 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0175 0.0284
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Echinococcus granulosus kelch ECH associated protein 1 0.0094 0.0083 0.0094
Brugia malayi EGF-like domain containing protein 0.0157 0.0203 0.0198
Schistosoma mansoni acetylcholine receptor subunit beta 0.0111 0.0116 0.0188
Loa Loa (eye worm) ACC-1 protein 0.0243 0.0366 0.0361
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0142 0.0175 0.0213
Echinococcus multilocularis serotonin receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.127 0.232 0.2316
Schistosoma mansoni voltage-gated cation channel 0.0122 0.0136 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0821 0.1466 0.1461
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0082 0.006 0.0239
Echinococcus multilocularis Kelch repeat type 1 0.0094 0.0083 0.0095
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0243 0.0366 0.0459
Loa Loa (eye worm) RGC/RGC protein kinase 0.0106 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0197 0.0278 0.0272
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0142 0.0175 0.0169
Onchocerca volvulus 0.0199 0.0282 0.1024
Loa Loa (eye worm) hypothetical protein 0.0199 0.0282 0.0276
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0122 0.0136 0.0163
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0111 0.0116 0.0137
Mycobacterium ulcerans hypothetical protein 0.02 0.0284 1
Loa Loa (eye worm) neuropeptide F receptor 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Schistosoma mansoni biogenic amine receptor 0.0142 0.0175 0.0284
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0111 0.0116 0.011
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0142 0.0175 0.0213
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.02 0.0284 0.046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0366 0.0361
Brugia malayi G protein-coupled receptor F59B2.13 0.0142 0.0175 0.0169
Onchocerca volvulus 0.0199 0.0282 0.1024
Giardia lamblia Tenascin-X 0.0157 0.0203 0.5
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0122 0.0136 0.0163
Loa Loa (eye worm) hypothetical protein 0.0076 0.0049 0.0043
Schistosoma mansoni serine-type protease inhibitor 0.1857 0.3437 0.5577
Brugia malayi Dopamine receptor protein 2 0.0142 0.0175 0.0169
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0243 0.0366 0.0361
Schistosoma mansoni alpha-1 adrenergic receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) G-protein coupled receptor 0.0142 0.0175 0.0169
Toxoplasma gondii microneme protein MIC17A 0.0199 0.0282 0.0202
Loa Loa (eye worm) hypothetical protein 0.0122 0.0136 0.013
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0142 0.0175 0.0169
Onchocerca volvulus 0.0111 0.0116 0.0294
Schistosoma mansoni tyrosine kinase 0.0087 0.007 0.0114
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Schistosoma mansoni amine GPCR 0.0142 0.0175 0.0284
Brugia malayi PAN domain containing protein 0.0199 0.0282 0.0276
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0243 0.0366 0.0459
Echinococcus granulosus integrin alpha ps 0.0914 0.1643 0.2099
Echinococcus granulosus G protein coupled receptor 139 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0243 0.0366 0.0361
Toxoplasma gondii PAN domain-containing protein 0.2205 0.4099 1
Brugia malayi Melatonin receptor type 1A 0.0142 0.0175 0.0169
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0142 0.0175 0.0169
Onchocerca volvulus 0.0215 0.0314 0.1164
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Loa Loa (eye worm) hypothetical protein 0.0157 0.0203 0.0198
Onchocerca volvulus Putative nachr subunit 0.0312 0.0498 0.1976
Loa Loa (eye worm) melatonin receptor type 1A 0.0142 0.0175 0.0169
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.02 0.0284 0.0278
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0111 0.0116 0.0137
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0142 0.0175 0.0213
Brugia malayi hypothetical protein 0.0111 0.0116 0.011
Loa Loa (eye worm) hypothetical protein 0.02 0.0284 0.0278
Giardia lamblia High cysteine protein 0.0157 0.0203 0.5
Onchocerca volvulus 0.0142 0.0175 0.0554
Brugia malayi GnHR receptor homolog 0.0142 0.0175 0.0169
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0142 0.0175 0.0169
Brugia malayi Protein kinase domain containing protein 0.0055 0.0009 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0175 0.0284
Brugia malayi hypothetical protein 0.0111 0.0116 0.011
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.02 0.0284 0.046
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Schistosoma mansoni tyrosine kinase 0.0055 0.0009 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0175 0.0284
Echinococcus multilocularis neuropeptide FF receptor 2 0.0142 0.0175 0.0213
Echinococcus multilocularis kelch ECH associated protein 1 0.0094 0.0083 0.0094
Brugia malayi Furin-like cysteine rich region family protein 0.0155 0.0199 0.0194
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0142 0.0175 0.0213
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0157 0.0203 0.0198
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0219 0.032 0.04
Schistosoma mansoni serine-type protease inhibitor 0.1857 0.3437 0.5577
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0142 0.0175 0.0213
Toxoplasma gondii PAN domain-containing protein 0.0199 0.0282 0.0202
Schistosoma mansoni voltage-gated potassium channel 0.0522 0.0898 0.1457
Schistosoma mansoni tyrosine kinase 0.0087 0.007 0.0114
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0142 0.0175 0.0284
Echinococcus granulosus 7tm_1 domain containing protein 0.0142 0.0175 0.0213
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0076 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0366 0.0361
Loa Loa (eye worm) hypothetical protein 0.0312 0.0498 0.0492
Loa Loa (eye worm) hypothetical protein 0.0124 0.014 0.0135
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1344 0.2461 0.3993
Schistosoma mansoni nAChR subunit 0.0243 0.0366 0.0594
Schistosoma mansoni neuropeptide F-like receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0076 0.0049 0.0043
Echinococcus multilocularis neuropeptide receptor 0.0142 0.0175 0.0213
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0122 0.0136 0.0221
Loa Loa (eye worm) G-protein coupled receptor 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0142 0.0175 0.0213
Onchocerca volvulus 0.0142 0.0175 0.0554
Echinococcus granulosus potassium voltage gated channel protein 0.0522 0.0898 0.1142
Schistosoma mansoni tyrosine kinase 0.0086 0.0067 0.0109
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0821 0.1466 0.2379
Echinococcus multilocularis potassium voltage gated channel protein 0.0522 0.0898 0.1142
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0366 0.0361
Brugia malayi metabotropic glutamate receptor type 2 0.0076 0.0049 0.0043
Schistosoma mansoni neuropeptide receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0076 0.0049 0.0043
Schistosoma mansoni biogenic amine (5HT) receptor 0.0142 0.0175 0.0284
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0243 0.0366 0.0594
Echinococcus multilocularis neuropeptide receptor 0.0142 0.0175 0.0213
Brugia malayi hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0307 0.0488 0.5
Schistosoma mansoni amine GPCR 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Onchocerca volvulus Neuropeptide F receptor homolog 0.0142 0.0175 0.0554
Onchocerca volvulus 0.0199 0.0282 0.1024
Echinococcus granulosus g protein coupled receptor 0.0142 0.0175 0.0213
Brugia malayi hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Brugia malayi Receptor family ligand binding region containing protein 0.0076 0.0049 0.0043
Echinococcus multilocularis G-protein coupled receptor, putative 0.0142 0.0175 0.0213
Echinococcus multilocularis fmrfamide receptor 0.0142 0.0175 0.0213
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.127 0.232 0.2316
Brugia malayi neuropeptide F receptor 0.0142 0.0175 0.0169
Echinococcus granulosus g protein coupled receptor 0.0142 0.0175 0.0213
Echinococcus granulosus neuropeptide receptor 0.0142 0.0175 0.0213
Toxoplasma gondii microneme protein MIC4 0.0199 0.0282 0.0202
Schistosoma mansoni acetylcholine receptor-related 0.0111 0.0116 0.0188
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0142 0.0175 0.0169
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0855 0.1531 0.1526
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0111 0.0116 0.011
Toxoplasma gondii microneme protein MIC17B 0.0199 0.0282 0.0202
Brugia malayi PAN domain containing protein 0.0199 0.0282 0.0276
Echinococcus granulosus peptide allatostatin:somatostatin 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0076 0.0049 0.0043
Schistosoma mansoni hypothetical protein 0.02 0.0284 0.046
Brugia malayi G protein-coupled receptor 0.0142 0.0175 0.0169
Echinococcus multilocularis glutamate receptor 2 0.0076 0.0049 0.0051
Onchocerca volvulus 0.0199 0.0282 0.1024
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Onchocerca volvulus 0.02 0.0284 0.1032
Schistosoma mansoni tyrosine kinase 0.0155 0.0199 0.0324
Loa Loa (eye worm) hypothetical protein 0.0199 0.0282 0.0276
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.02 0.0284 0.046
Onchocerca volvulus 0.127 0.232 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0142 0.0175 0.0213
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0243 0.0366 0.0459
Loa Loa (eye worm) RGC/RGC protein kinase 0.0248 0.0376 0.0371
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0076 0.0049 0.0051
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0243 0.0366 0.0459
Toxoplasma gondii PAN/Apple domain-containing protein 0.0199 0.0282 0.0202
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus granulosus neuropeptide Y receptor 0.0142 0.0175 0.0213
Onchocerca volvulus 0.0215 0.0314 0.1164
Brugia malayi PAN domain containing protein 0.0199 0.0282 0.0276
Loa Loa (eye worm) hypothetical protein 0.071 0.1254 0.1249
Loa Loa (eye worm) LGC-31 protein 0.0243 0.0366 0.0361
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Echinococcus multilocularis neuropeptide Y receptor 0.0142 0.0175 0.0213
Schistosoma mansoni nAChR subunit 0.0243 0.0366 0.0594
Echinococcus multilocularis integrin alpha ps 0.079 0.1406 0.1795
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Echinococcus multilocularis tissue type plasminogen activator 0.0307 0.0488 0.0615
Brugia malayi Serotonin receptor 0.0142 0.0175 0.0169
Brugia malayi putative neuropeptide receptor 0.0142 0.0175 0.0169
Loa Loa (eye worm) TYRA-2 protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0243 0.0366 0.0361
Brugia malayi Trypsin-like protease protein 5 0.02 0.0284 0.0278
Loa Loa (eye worm) glutamate receptor 0.0076 0.0049 0.0043
Brugia malayi Cation transporter family protein 0.0243 0.0366 0.0361
Brugia malayi PAN domain containing protein 0.0199 0.0282 0.0276
Loa Loa (eye worm) hypothetical protein 0.0076 0.0049 0.0043
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0199 0.0282 0.0276
Toxoplasma gondii PAN domain-containing protein 0.0199 0.0282 0.0202
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0312 0.0498 0.0628
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) PAN domain-containing protein 0.0199 0.0282 0.0276
Echinococcus multilocularis receptor type guanylyl cyclase 0.0248 0.0376 0.0472
Echinococcus multilocularis integrin alpha ps 0.0378 0.0624 0.079
Loa Loa (eye worm) hypothetical protein 0.0132 0.0154 0.0148
Leishmania major hypothetical protein, conserved 0.0307 0.0488 1
Echinococcus granulosus nAChR subunit 0.0132 0.0154 0.0186
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0142 0.0175 0.0213
Schistosoma mansoni integrin beta subunit 0.329 0.6163 1
Echinococcus multilocularis adam 0.0157 0.0203 0.0249
Onchocerca volvulus 0.0142 0.0175 0.0554
Echinococcus multilocularis fibrillin 2 0.0157 0.0203 0.0249
Onchocerca volvulus 0.0215 0.0314 0.1164
Brugia malayi EGF-like domain containing protein 0.0157 0.0203 0.0198
Loa Loa (eye worm) hypothetical protein 0.02 0.0284 0.0278
Schistosoma mansoni neuropeptide receptor 0.0142 0.0175 0.0284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0366 0.0361
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0122 0.0136 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0175 0.0284
Brugia malayi PAN domain containing protein 0.0199 0.0282 0.0276
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0243 0.0366 0.0459
Toxoplasma gondii kringle domain-containing protein 0.0307 0.0488 0.0731
Giardia lamblia High cysteine protein 0.0157 0.0203 0.5
Echinococcus granulosus adam 0.0157 0.0203 0.0249
Echinococcus granulosus tissue type plasminogen activator 0.0307 0.0488 0.0615
Echinococcus granulosus glutamate receptor 2 0.0076 0.0049 0.0051
Onchocerca volvulus 0.0142 0.0175 0.0554
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0086 0.0067 0.0061
Giardia lamblia Tenascin-37 0.0157 0.0203 0.5
Echinococcus multilocularis g protein coupled receptor 0.0142 0.0175 0.0213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Loa Loa (eye worm) PAN domain-containing protein 0.0199 0.0282 0.0276
Schistosoma mansoni metabotropic glutamate receptor 0.0076 0.0049 0.008
Echinococcus granulosus glycine receptor subunit alpha 1 0.0243 0.0366 0.0459
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0111 0.0116 0.011
Schistosoma mansoni hypothetical protein 0.0142 0.0175 0.0284
Brugia malayi Trypsin family protein 0.127 0.232 0.2316
Echinococcus granulosus hypothetical protein 0.0142 0.0175 0.0213
Schistosoma mansoni hypothetical protein 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Echinococcus multilocularis kelch ECH associated protein 1 0.0094 0.0083 0.0094
Schistosoma mansoni hypothetical protein 0.0215 0.0314 0.0509
Onchocerca volvulus 0.0142 0.0175 0.0554
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0243 0.0366 0.0361
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0076 0.0049 0.0051
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0243 0.0366 0.0361
Brugia malayi hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0638 0.1118 0.1112
Schistosoma mansoni nAChR subunit 0.0243 0.0366 0.0594
Loa Loa (eye worm) kelch domain-containing protein family protein 0.089 0.1597 0.1592
Echinococcus multilocularis epidermal growth factor receptor 0.0087 0.007 0.0078
Loa Loa (eye worm) hypothetical protein 0.0307 0.0488 0.0482
Loa Loa (eye worm) hypothetical protein 0.0076 0.0049 0.0043
Echinococcus multilocularis g-protein coupled receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Echinococcus multilocularis integrin alpha 3 0.1016 0.1838 0.235
Onchocerca volvulus 0.02 0.0284 0.1032
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0132 0.0154 0.0148
Onchocerca volvulus 0.0199 0.0282 0.1024
Echinococcus granulosus glycine receptor subunit beta 0.0243 0.0366 0.0459
Loa Loa (eye worm) hypothetical protein 0.02 0.0284 0.0278
Schistosoma mansoni hypothetical protein 0.0307 0.0488 0.0792
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0044 0.0071
Schistosoma mansoni nAChR subunit 0.0111 0.0116 0.0188
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0142 0.0175 0.0213
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0243 0.0366 0.0594
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Brugia malayi Integrin alpha cytoplasmic region family protein 0.091 0.1636 0.1631
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0082 0.006 0.5
Onchocerca volvulus 0.0132 0.0154 0.0462
Echinococcus granulosus Mastin 0.02 0.0284 0.0352
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0142 0.0175 0.0284
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus granulosus enteropeptidase 0.02 0.0284 0.0352
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0122 0.0136 0.0163
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0132 0.0154 0.0148
Echinococcus multilocularis neuropeptide receptor A26 0.0142 0.0175 0.0213
Echinococcus multilocularis neuropeptides capa receptor 0.0142 0.0175 0.0213
Schistosoma mansoni nAChR subunit 0.0243 0.0366 0.0594
Brugia malayi Cation transporter family protein 0.0243 0.0366 0.0361
Brugia malayi hypothetical protein 0.0142 0.0175 0.0169
Echinococcus multilocularis glutamate receptor 2 0.0076 0.0049 0.0051
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0142 0.0175 0.0554
Onchocerca volvulus 0.0199 0.0282 0.1024
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Echinococcus granulosus epidermal growth factor receptor 0.0155 0.0199 0.0244
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0132 0.0154 0.0148
Echinococcus multilocularis sodium channel protein 0.0063 0.0024 0.0019
Echinococcus granulosus atrial natriuretic peptide receptor 0.0219 0.032 0.04
Loa Loa (eye worm) hypothetical protein 0.0076 0.0049 0.0043
Brugia malayi G-protein coupled receptor 0.0142 0.0175 0.0169
Schistosoma mansoni hypothetical protein 0.0142 0.0175 0.0284
Echinococcus granulosus biogenic amine 5HT receptor 0.0142 0.0175 0.0213
Brugia malayi ORL1-like opioid receptor 0.0142 0.0175 0.0169
Brugia malayi hypothetical protein 0.0142 0.0175 0.0169
Echinococcus granulosus kelch ECH associated protein 1 like 0.0094 0.0083 0.0094
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0142 0.0175 0.0169
Echinococcus multilocularis transmembrane protease serine 3 0.02 0.0284 0.0352
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.02 0.0284 0.0352
Onchocerca volvulus 0.0199 0.0282 0.1024
Brugia malayi CUB domain containing protein 0.0074 0.0044 0.0039
Onchocerca volvulus 0.0821 0.1466 0.6239
Brugia malayi Kelch motif family protein 0.089 0.1597 0.1592
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0366 0.0361
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0122 0.0136 0.013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0243 0.0366 0.0361
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0142 0.0175 0.0284
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0243 0.0366 0.0459
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0142 0.0175 0.0284
Onchocerca volvulus 0.02 0.0284 0.1032
Toxoplasma gondii hypothetical protein 0.0199 0.0282 0.0202
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) PAN domain-containing protein 0.0199 0.0282 0.0276
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Schistosoma mansoni neuropeptide f receptor 76f 0.0142 0.0175 0.0284
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0312 0.0498 0.0628
Loa Loa (eye worm) GABA receptor subunit 0.0132 0.0154 0.0148
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0199 0.0282 0.0276
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0076 0.0049 0.0051
Echinococcus multilocularis nmda type glutamate receptor 0.0076 0.0049 0.0051
Schistosoma mansoni tyrosine kinase 0.0078 0.0052 0.0085
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Brugia malayi Kringle domain containing protein 0.0307 0.0488 0.0482
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0243 0.0366 0.0459
Echinococcus granulosus sex peptide receptor 0.0142 0.0175 0.0213
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0076 0.0049 0.0043
Onchocerca volvulus 0.02 0.0284 0.1032
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Schistosoma mansoni nAChR subunit 0.0243 0.0366 0.0594
Onchocerca volvulus 0.0142 0.0175 0.0554
Echinococcus granulosus fibrillin 2 0.0157 0.0203 0.0249
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0312 0.0498 0.0628
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0142 0.0175 0.0169
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0063 0.0024 0.0019
Brugia malayi Integrin alpha pat-2 precursor 0.1428 0.262 0.2616
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0111 0.0116 0.0137
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0132 0.0154 0.0148
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0142 0.0175 0.0213
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.02 0.0284 0.046
Loa Loa (eye worm) hypothetical protein 0.02 0.0284 0.0278
Loa Loa (eye worm) hypothetical protein 0.0821 0.1466 0.1461
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0821 0.1466 0.2379
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0243 0.0366 0.0361
Loa Loa (eye worm) RGC/RGC protein kinase 0.0248 0.0376 0.0371
Brugia malayi Trypsin family protein 0.02 0.0284 0.0278
Echinococcus granulosus metabotropic glutamate receptor 2 0.0076 0.0049 0.0051
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0243 0.0366 0.0459
Echinococcus granulosus glycoprotein Antigen 5 0.02 0.0284 0.0352
Echinococcus granulosus tm gpcr rhodopsin 0.0142 0.0175 0.0213
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0076 0.0049 0.0051
Toxoplasma gondii PAN domain-containing protein 0.0199 0.0282 0.0202
Onchocerca volvulus 0.02 0.0284 0.1032
Echinococcus multilocularis protein jagged 2 0.0157 0.0203 0.0249
Echinococcus granulosus dro:myosuppressin receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Echinococcus granulosus integrin alpha 3 0.1016 0.1838 0.235
Echinococcus granulosus neuropeptide receptor A26 0.0142 0.0175 0.0213
Echinococcus multilocularis serotonin receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Toxoplasma gondii microneme protein, putative 0.0199 0.0282 0.0202
Schistosoma mansoni biogenic amine (5HT) receptor 0.0142 0.0175 0.0284
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0076 0.0049 0.0051
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0015 0.0009
Onchocerca volvulus 0.0111 0.0116 0.0294
Echinococcus granulosus fmrfamide receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0076 0.0049 0.0043
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0243 0.0366 0.0361
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0142 0.0175 0.0169
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0142 0.0175 0.0213
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0132 0.0154 0.025
Schistosoma mansoni hypothetical protein 0.0378 0.0624 0.1013
Echinococcus multilocularis Mastin 0.02 0.0284 0.0352
Loa Loa (eye worm) hypothetical protein 0.0132 0.0154 0.0148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Loa Loa (eye worm) hypothetical protein 0.091 0.1636 0.1631
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0132 0.0154 0.0148
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0312 0.0498 0.0628
Schistosoma mansoni opsin-like receptor 0.0142 0.0175 0.0284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0111 0.0116 0.011
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.05 0.0855 0.1086
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Schistosoma mansoni integrin alpha-4 0.0393 0.0652 0.1059
Onchocerca volvulus 0.0243 0.0366 0.1396
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0142 0.0175 0.0213
Echinococcus granulosus alpha 1A adrenergic receptor 0.0142 0.0175 0.0213
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0142 0.0175 0.0284
Brugia malayi larval opioid receptor 0.0142 0.0175 0.0169
Brugia malayi solute carrier family 40, member 1 0.0197 0.0278 0.0272
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0312 0.0498 0.0492
Loa Loa (eye worm) DOMON domain-containing protein 0.0215 0.0314 0.0308
Brugia malayi Cation transporter family protein 0.0821 0.1466 0.1461
Loa Loa (eye worm) hypothetical protein 0.0132 0.0154 0.0148
Toxoplasma gondii PAN domain-containing protein 0.0199 0.0282 0.0202
Brugia malayi PAN domain containing protein 0.0199 0.0282 0.0276
Schistosoma mansoni amine GPCR 0.0142 0.0175 0.0284
Echinococcus granulosus integrin alpha ps 0.0378 0.0624 0.079
Onchocerca volvulus 0.0106 0.0105 0.0247
Loa Loa (eye worm) neuropeptide F receptor 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0122 0.0136 0.0163
Echinococcus granulosus integrin beta 2 0.4145 0.779 1
Echinococcus multilocularis allatostatin A receptor 0.0142 0.0175 0.0213
Onchocerca volvulus 0.0197 0.0278 0.1008
Brugia malayi Serotonin receptor 0.0142 0.0175 0.0169
Echinococcus multilocularis voltage dependent calcium channel 0.0122 0.0136 0.0163
Onchocerca volvulus 0.0199 0.0282 0.1024
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.008 0.0091
Schistosoma mansoni voltage-gated potassium channel 0.0522 0.0898 0.1457
Onchocerca volvulus 0.0243 0.0366 0.1396
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0243 0.0366 0.0361
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0234 0.0349 0.0567
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0142 0.0175 0.0213
Echinococcus granulosus neuropeptide receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Trypanosoma cruzi hypothetical protein, conserved 0.0307 0.0488 1
Loa Loa (eye worm) hypothetical protein 0.0522 0.0898 0.0892
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0248 0.0376 0.1441
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.02 0.0284 0.0352
Toxoplasma gondii hypothetical protein 0.0199 0.0282 0.0202
Echinococcus multilocularis glycine receptor subunit beta 0.0243 0.0366 0.0459
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Schistosoma mansoni biogenic amine receptor 0.0142 0.0175 0.0284
Echinococcus granulosus g-protein coupled receptor 0.0142 0.0175 0.0213
Echinococcus granulosus glutamate receptor 2 0.0076 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus granulosus voltage dependent calcium channel 0.0122 0.0136 0.0163
Echinococcus granulosus g protein coupled receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Echinococcus multilocularis fibrillin 1 0.0157 0.0203 0.0249
Onchocerca volvulus 0.0243 0.0366 0.1396
Loa Loa (eye worm) hypothetical protein 0.0132 0.0154 0.0148
Loa Loa (eye worm) hypothetical protein 0.02 0.0284 0.0278
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.0039
Echinococcus granulosus receptor type guanylyl cyclase 0.0248 0.0376 0.0472
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Echinococcus granulosus tm gpcr rhodopsin 0.0142 0.0175 0.0213
Brugia malayi hypothetical protein 0.02 0.0284 0.0278
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0312 0.0498 0.0628
Echinococcus multilocularis nAChR subunit 0.0243 0.0366 0.0459
Loa Loa (eye worm) hypothetical protein 0.0157 0.0203 0.0198
Schistosoma mansoni neurotransmitter gated ion channel 0.0132 0.0154 0.025
Schistosoma mansoni amine GPCR 0.0142 0.0175 0.0284
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0312 0.0498 0.0628
Echinococcus granulosus glycine receptor subunit alpha 1 0.0243 0.0366 0.0459
Onchocerca volvulus 0.0215 0.0314 0.1164
Brugia malayi hypothetical protein 0.0111 0.0116 0.011
Echinococcus granulosus glycine receptor subunit beta 0.0243 0.0366 0.0459
Brugia malayi PAN domain containing protein 0.0199 0.0282 0.0276
Brugia malayi hypothetical protein 0.0111 0.0116 0.011
Onchocerca volvulus 0.0157 0.0203 0.0678
Echinococcus multilocularis integrin beta 2 0.4145 0.779 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0132 0.0154 0.025
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) PAN domain-containing protein 0.0199 0.0282 0.0276
Loa Loa (eye worm) hypothetical protein 0.0157 0.0203 0.0198
Schistosoma mansoni glutamate receptor NMDA 0.0076 0.0049 0.008
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Onchocerca volvulus 0.0142 0.0175 0.0554
Onchocerca volvulus 0.0142 0.0175 0.0554
Loa Loa (eye worm) hypothetical protein 0.0215 0.0314 0.0308
Schistosoma mansoni histamine h1 receptor 0.0142 0.0175 0.0284
Onchocerca volvulus 0.0199 0.0282 0.1024
Giardia lamblia Tenascin precursor 0.0157 0.0203 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0142 0.0175 0.0284
Brugia malayi EGF-like domain containing protein 0.0157 0.0203 0.0198
Echinococcus multilocularis g protein coupled receptor 0.0142 0.0175 0.0213
Echinococcus granulosus glycine receptor subunit alpha 1 0.0243 0.0366 0.0459
Schistosoma mansoni neuropeptide receptor 0.0142 0.0175 0.0284
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0243 0.0366 0.0459
Echinococcus granulosus tm gpcr rhodopsin 0.0142 0.0175 0.0213
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0243 0.0366 0.0361
Loa Loa (eye worm) hypothetical protein 0.0215 0.0314 0.0308
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.127 0.232 0.3765
Brugia malayi hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Onchocerca volvulus 0.0142 0.0175 0.0554
Brugia malayi Metabotropic glutamate receptor precursor. 0.0076 0.0049 0.0043
Echinococcus granulosus tyrosine kinase 0.0086 0.0067 0.0074
Brugia malayi AKH receptor 0.0142 0.0175 0.0169
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0142 0.0175 0.0213
Brugia malayi SEA domain containing protein 0.0215 0.0314 0.0308
Schistosoma mansoni biogenic amine receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.1049 0.19 0.1895
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0142 0.0175 0.0169
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0122 0.0136 0.0163
Echinococcus granulosus nmda type glutamate receptor 0.0076 0.0049 0.0051
Schistosoma mansoni neuropeptide receptor 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Brugia malayi hypothetical protein 0.0142 0.0175 0.0169
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0111 0.0116 0.0137
Loa Loa (eye worm) integrin alpha pat-2 0.1835 0.3396 0.3392
Echinococcus granulosus fibrillin 1 0.0157 0.0203 0.0249
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Echinococcus granulosus metabotropic glutamate receptor 5 0.0076 0.0049 0.0051
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0243 0.0366 0.0361
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Brugia malayi Muscle positioning protein 4 0.0215 0.0314 0.0308
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.02 0.0284 0.0352
Echinococcus multilocularis fmrfamide receptor 0.0142 0.0175 0.0213
Onchocerca volvulus 0.0142 0.0175 0.0554
Brugia malayi sulfakinin receptor protein 0.0142 0.0175 0.0169
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0142 0.0175 0.0213
Schistosoma mansoni hypothetical protein 0.0142 0.0175 0.0284
Schistosoma mansoni adenoreceptor 0.0142 0.0175 0.0284
Schistosoma mansoni protein kinase 0.0248 0.0376 0.0611
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Echinococcus multilocularis glycoprotein Antigen 5 0.02 0.0284 0.0352
Onchocerca volvulus 0.1071 0.1941 0.8328
Schistosoma mansoni amine GPCR 0.0142 0.0175 0.0284
Toxoplasma gondii microneme protein MIC17C 0.0199 0.0282 0.0202
Loa Loa (eye worm) PAN domain-containing protein 0.0199 0.0282 0.0276
Brugia malayi Trypsin family protein 0.02 0.0284 0.0278
Loa Loa (eye worm) ACC-1 protein 0.0243 0.0366 0.0361
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0142 0.0175 0.0284
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.008 0.0091
Brugia malayi hypothetical protein 0.0855 0.1531 0.1526
Loa Loa (eye worm) hypothetical protein 0.0535 0.0923 0.0917
Schistosoma mansoni metabotropic glutamate receptor 0.0076 0.0049 0.008
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0243 0.0366 0.0594
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0522 0.0898 0.1142
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Echinococcus granulosus neuropeptide Y receptor 0.0142 0.0175 0.0213
Echinococcus granulosus kelch ECH associated protein 1 like 0.0094 0.0083 0.0094
Brugia malayi excitatory GABA receptor EXP-1A 0.0243 0.0366 0.0361
Giardia lamblia Neurogenic locus notch-like protein 0.0157 0.0203 0.5
Echinococcus granulosus nAChR subunit 0.0243 0.0366 0.0459
Onchocerca volvulus 0.0142 0.0175 0.0554
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.0039
Schistosoma mansoni nAChR subunit 0.0243 0.0366 0.0594
Toxoplasma gondii subtilisin SUB12 0.0199 0.0282 0.0202
Onchocerca volvulus 0.0111 0.0116 0.0294
Echinococcus multilocularis neuropeptide s receptor 0.0142 0.0175 0.0213
Onchocerca volvulus 0.0132 0.0154 0.0462
Onchocerca volvulus 0.0199 0.0282 0.1024
Onchocerca volvulus 0.0307 0.0488 0.1932
Echinococcus granulosus neuropeptides capa receptor 0.0142 0.0175 0.0213
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0076 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0503 0.086 0.0855
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0132 0.0154 0.0148
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0076 0.0049 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0175 0.0284
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0087 0.007 0.0078
Echinococcus multilocularis enteropeptidase 0.02 0.0284 0.0352
Brugia malayi PAN domain containing protein 0.0199 0.0282 0.0276
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Schistosoma mansoni neurotransmitter gated ion channel 0.0111 0.0116 0.0188
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0243 0.0366 0.0594
Schistosoma mansoni tyrosine kinase 0.0086 0.0067 0.0109
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus multilocularis nAChR subunit 0.0132 0.0154 0.0186
Schistosoma mansoni integrin alpha-ps 0.079 0.1406 0.2282
Onchocerca volvulus 0.0142 0.0175 0.0554
Echinococcus multilocularis tyrosine kinase 0.0086 0.0067 0.0074
Giardia lamblia hypothetical protein 0.0157 0.0203 0.5
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0312 0.0498 0.0492
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.02 0.0284 0.046
Giardia lamblia Tenascin-like 0.0157 0.0203 0.5
Echinococcus multilocularis glycine receptor subunit beta 0.0243 0.0366 0.0459
Schistosoma mansoni neurotransmitter gated ion channel 0.0111 0.0116 0.0188
Schistosoma mansoni growth hormone secretagogue receptor 0.0142 0.0175 0.0284
Brugia malayi Tachykinin-like peptides receptor 99D 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Brugia malayi hypothetical protein 0.0142 0.0175 0.0169
Onchocerca volvulus 0.0142 0.0175 0.0554
Echinococcus granulosus neuropeptides capa receptor 0.0142 0.0175 0.0213
Brugia malayi hypothetical protein 0.0111 0.0116 0.011
Loa Loa (eye worm) hypothetical protein 0.0243 0.0366 0.0361
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Schistosoma mansoni cercarial elastase (S01 family) 0.02 0.0284 0.046
Schistosoma mansoni tyrosine kinase 0.0055 0.0009 0.0015
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0243 0.0366 0.0361
Loa Loa (eye worm) acetylcholine receptor protein 0.0111 0.0116 0.011
Loa Loa (eye worm) hypothetical protein 0.0111 0.0116 0.011
Echinococcus multilocularis orexin receptor type 2 0.0142 0.0175 0.0213
Loa Loa (eye worm) TK/ROR protein kinase 0.0316 0.0506 0.05
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0243 0.0366 0.0361
Toxoplasma gondii PAN domain-containing protein 0.2205 0.4099 1
Brugia malayi Guanylyl cyclase protein 23 0.0106 0.0105 0.0099
Echinococcus granulosus neuropeptide FF receptor 2 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0076 0.0049 0.0043
Brugia malayi putative neuropeptide receptor NPR1 0.0142 0.0175 0.0169
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0122 0.0136 0.0163
Schistosoma mansoni hypothetical protein 0.0094 0.0083 0.0135
Onchocerca volvulus 0.0142 0.0175 0.0554
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0111 0.0116 0.011
Echinococcus multilocularis neuropeptide Y receptor 0.0142 0.0175 0.0213
Schistosoma mansoni nAChR subunit 0.0243 0.0366 0.0594
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0175 0.0213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0175 0.0169
Echinococcus multilocularis dro:myosuppressin receptor 0.0142 0.0175 0.0213
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0076 0.0049 0.0043
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0111 0.0116 0.0137

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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