TDR Targets

Basic information

Technical information

TDR Targets ID: 882093
Name: 5-bromo-N-[(2-bromophenyl)methyl]-2-methoxybe nzenesulfonamide
MW: 435.131 | Formula: C14H13Br2NO3S
H donors: 1 H acceptors: 2 LogP: 3.74 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1S(=O)(=O)NCc1ccccc1Br)Br
InChi: 1S/C14H13Br2NO3S/c1-20-13-7-6-11(15)8-14(13)21(18,19)17-9-10-4-2-3-5-12(10)16/h2-8,17H,9H2,1H3
InChiKey: XZYOYXNSJDJTBV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-bromo-N-[(2-bromophenyl)methyl]-2-methoxy-benzenesulfonamide
5-bromo-N-(2-bromobenzyl)-2-methoxy-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.005	0.0197	0.1965
Echinococcus multilocularis	lamin	0.0029	0.0082	0.1053
Schistosoma mansoni	tyrosine kinase	0.0084	0.0379	0.3858
Echinococcus multilocularis	insulin receptor	0.005	0.0197	0.2527
Brugia malayi	Protein kinase domain containing protein	0.005	0.0197	0.0569
Brugia malayi	Pre-SET motif family protein	0.0225	0.115	0.3439
Echinococcus granulosus	lamin	0.0029	0.0082	0.1053
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0082	0.0247
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0047	0.0043
Mycobacterium tuberculosis	Probable catechol-O-methyltransferase	0.1659	0.8954	1
Schistosoma mansoni	tyrosine kinase	0.0084	0.0379	0.3858
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0118	0.0564	1
Mycobacterium tuberculosis	Probable methyltransferase	0.0192	0.0969	0.1074
Onchocerca volvulus		0.0192	0.0969	0.7172
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0223
Loa Loa (eye worm)	6-phosphofructokinase	0.0118	0.0564	0.1695
Schistosoma mansoni	tyrosine kinase	0.005	0.0197	0.1965
Loa Loa (eye worm)	TK/INSR protein kinase	0.005	0.0197	0.0593
Brugia malayi	phosphofructokinase	0.0118	0.0564	0.1674
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0969	0.2914
Onchocerca volvulus		0.0192	0.0969	0.7172
Brugia malayi	6-phosphofructokinase	0.0118	0.0564	0.1674
Echinococcus multilocularis		0.0049	0.0189	0.2417
Echinococcus granulosus	6 phosphofructokinase	0.0118	0.0564	0.7219
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Trypanosoma brucei	DNA polymerase IV, putative	0.0037	0.0126	0.2122
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0096	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Echinococcus multilocularis	6 phosphofructokinase	0.0118	0.0564	0.7219
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0032	0.0096	0.5
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0093	0.1187
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0099	0.0943
Loa Loa (eye worm)	6-phosphofructokinase	0.0118	0.0564	0.1695
Echinococcus multilocularis	musashi	0.0029	0.0082	0.1053
Trichomonas vaginalis	DNA polymerase eta, putative	0.0044	0.0165	0.0564
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Echinococcus granulosus	lamin dm0	0.0029	0.0082	0.1053
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0106	0.1763
Brugia malayi	O-methyltransferase family protein	0.0192	0.0969	0.2896
Echinococcus granulosus	intermediate filament protein	0.0029	0.0082	0.1053
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0099	1
Schistosoma mansoni	o-methyltransferase	0.0192	0.0969	1
Echinococcus granulosus	insulin receptor	0.005	0.0197	0.2527
Trichomonas vaginalis	set domain proteins, putative	0.0256	0.1319	1
Brugia malayi	O-methyltransferase family protein	0.0192	0.0969	0.2896
Brugia malayi	small heat shock protein	0.0625	0.3326	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0099	0.0943
Schistosoma mansoni	6-phosphofructokinase	0.0118	0.0564	0.5779
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Schistosoma mansoni	tyrosine kinase	0.0084	0.0379	0.3858
Schistosoma mansoni	6-phosphofructokinase	0.0118	0.0564	0.5779
Loa Loa (eye worm)	hypothetical protein	0.0625	0.3326	1
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0135	0.1319
Schistosoma mansoni	tyrosine kinase	0.0158	0.0781	0.804
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.0564	0.3823
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0044	0.0165	0.0564
Brugia malayi	6-phosphofructokinase	0.0118	0.0564	0.1674
Onchocerca volvulus		0.0256	0.1319	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.0564	0.3823
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0106	0.1763
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.005	0.0197	0.2527
Wolbachia endosymbiont of Brugia malayi	O-methyltransferase	0.0192	0.0969	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0158	0.0781	1
Brugia malayi	intermediate filament protein	0.0029	0.0082	0.0222
Loa Loa (eye worm)	O-methyltransferase	0.0192	0.0969	0.2914
Brugia malayi	hypothetical protein	0.0039	0.0135	0.0382
Mycobacterium ulcerans	methyltransferase	0.0192	0.0969	0.0817
Echinococcus multilocularis	dna polymerase kappa	0.0044	0.0165	0.2116
Leishmania major	ATP-dependent phosphofructokinase	0.0118	0.0564	1
Schistosoma mansoni	lamin	0.0029	0.0082	0.0766
Onchocerca volvulus		0.0032	0.0099	0.0137
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0082	0.0766
Brugia malayi	Furin-like cysteine rich region family protein	0.0158	0.0781	0.2328
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0118	0.0564	0.0621
Entamoeba histolytica	hypothetical protein	0.0039	0.0135	0.2282
Schistosoma mansoni	lamin	0.0029	0.0082	0.0766
Mycobacterium leprae	PROBABLE METHYLTRANSFERASE	0.0192	0.0969	1
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.0564	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0135	0.2282
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0099	0.0943
Echinococcus multilocularis	lamin dm0	0.0029	0.0082	0.1053
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0099	0.0943
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0223
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.0564	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0044	0.0165	0.2822
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0158	0.0781	0.2348
Echinococcus multilocularis	dna polymerase eta	0.0016	0.0009	0.011
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Schistosoma mansoni	tyrosine kinase	0.0085	0.0384	0.3909
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0032	0.0096	0.5
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0099	0.127
Brugia malayi	O-methyltransferase family protein	0.0192	0.0969	0.2896
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0082	0.0247
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0099	0.127
Echinococcus granulosus	dna polymerase kappa	0.0044	0.0165	0.2116
Echinococcus multilocularis	epidermal growth factor receptor	0.0085	0.0384	0.4919
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0008	0.0025
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0032	0.0096	0.158
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0016	0.0009	0.011
Entamoeba histolytica	hypothetical protein	0.0039	0.0135	0.2282
Schistosoma mansoni	o-methyltransferase	0.0192	0.0969	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0135	0.1319
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.005	0.0197	0.2527
Plasmodium vivax	SET domain protein, putative	0.0032	0.0099	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.0564	0.3823
Trypanosoma brucei	unspecified product	0.0037	0.0126	0.2122
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0082	0.0222
Entamoeba histolytica	hypothetical protein	0.0039	0.0135	0.2282
Schistosoma mansoni	o-methyltransferase	0.0192	0.0969	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0158	0.0781	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0118	0.0564	1
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0032	0.0096	1
Schistosoma mansoni	o-methyltransferase	0.0192	0.0969	1
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0082	0.0247
Mycobacterium ulcerans	6-phosphofructokinase	0.0118	0.0564	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0099	0.0298
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0016	0.0009	0.0026
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0085	0.0384	0.4919
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0047	0.07
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0079	0.0238
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0096	0.5
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0047	0.07
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0135	0.1733
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.0564	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0135	0.1733
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0016	0.0009	0.011
Trypanosoma brucei	DNA polymerase IV, putative	0.0044	0.0165	0.2822
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0099	0.127
Loa Loa (eye worm)	phosphofructokinase	0.0118	0.0564	0.1695
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0223
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0047	0.07
Brugia malayi	Pre-SET motif family protein	0.0032	0.0099	0.0274
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.0564	0.3823
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0009	0.0026
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0165	0.2822
Echinococcus granulosus	epidermal growth factor receptor	0.0085	0.0384	0.4919
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0118	0.0564	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0106	0.032
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0225	0.115	0.3456
Brugia malayi	O-methyltransferase	0.0192	0.0969	0.2896
Brugia malayi	polk-prov protein	0.0034	0.0106	0.0295
Schistosoma mansoni	tyrosine kinase	0.0085	0.0384	0.3909
Echinococcus granulosus	dna polymerase eta	0.0016	0.0009	0.011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 882093