TDR Targets

Basic information

Technical information

TDR Targets ID: 882460
Name: 2-(2-ethylphenoxy)-N-(6-methoxy-1,3-benzothia zol-2-yl)acetamide
MW: 342.412 | Formula: C18H18N2O3S
H donors: 1 H acceptors: 2 LogP: 4.35 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccccc1OCC(=O)Nc1nc2c(s1)cc(cc2)OC
InChi: 1S/C18H18N2O3S/c1-3-12-6-4-5-7-15(12)23-11-17(21)20-18-19-14-9-8-13(22-2)10-16(14)24-18/h4-10H,3,11H2,1-2H3,(H,19,20,21)
InChiKey: XIXJIZZOTMNCHY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2-ethylphenoxy)-N-(6-methoxy-1,3-benzothiazol-2-yl)ethanamide
AP-906/41471780
Oprea1_113413
ZINC00131233
ST5196003

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0004	0.0006
Entamoeba histolytica	hypothetical protein	0.0036	0.0372	1
Echinococcus multilocularis	neuroligin	0.0092	0.1072	0.1068
Loa Loa (eye worm)	carboxylesterase	0.0545	0.671	1
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0035	0.0032
Schistosoma mansoni	BC026374 protein (S09 family)	0.0092	0.1072	0.1597
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0158	0.1446
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0158	0.5
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0092	0.1072	0.1068
Onchocerca volvulus		0.0092	0.1072	0.4951
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0035	0.0047
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0035	0.0032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1603	0.2389
Brugia malayi	Carboxylesterase family protein	0.0092	0.1072	0.1592
Brugia malayi	hypothetical protein	0.0009	0.0035	0.0047
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0035	0.0047
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0092	0.1072	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0372	0.0369
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0372	0.0555
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.018	0.2161	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0158	0.4191
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0092	0.1072	0.1592
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0158	0.023
Schistosoma mansoni	hypothetical protein	0.0036	0.0372	0.0555
Schistosoma mansoni	ap endonuclease	0.0019	0.0158	0.0236
Brugia malayi	hypothetical protein	0.0092	0.1072	0.1592
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0035	0.0047
Brugia malayi	DIX domain containing protein	0.0009	0.0035	0.0047
Trichomonas vaginalis	spcc417.12 protein, putative	0.0092	0.1072	1
Schistosoma mansoni	ras GTP exchange factor	0.0006	0.0004	0.0006
Mycobacterium ulcerans	carboxylesterase, LipT	0.0092	0.1072	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0372	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0135	0.1603	0.16
Onchocerca volvulus		0.0092	0.1072	0.4951
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0035	0.0053
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0158	0.5
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0158	0.5
Schistosoma mansoni	dishevelled	0.0009	0.0035	0.0053
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0035	0.0047
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0158	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1072	0.1592
Echinococcus granulosus	acetylcholinesterase	0.0545	0.671	1
Echinococcus multilocularis	carboxylesterase 5A	0.0545	0.671	0.6709
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0372	0.055
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1603	0.2389
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0035	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0035	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1072	0.1592
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0035	0.0053
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0035	0.0047
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0158	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0092	0.1072	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0158	0.0236
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0158	0.023
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0135	0.1603	0.2385
Loa Loa (eye worm)	hypothetical protein	0.0545	0.671	1
Brugia malayi	hypothetical protein	0.0036	0.0372	0.055
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0035	0.0047
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0035	0.0047
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0035	0.0047
Onchocerca volvulus		0.0092	0.1072	0.4951
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0158	0.5
Echinococcus multilocularis	para nitrobenzyl esterase	0.0092	0.1072	0.1068
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0092	0.1072	1
Brugia malayi	N-terminal motif family protein	0.018	0.2161	0.3217
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0035	0.0047
Onchocerca volvulus		0.0092	0.1072	0.4951
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0006	0.0004	0.0006
Brugia malayi	Carboxylesterase family protein	0.0092	0.1072	0.1592
Schistosoma mansoni	hypothetical protein	0.0169	0.2031	0.3026
Echinococcus granulosus	carboxylesterase 5A	0.0545	0.671	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0035	0.0047
Echinococcus multilocularis	acetylcholinesterase	0.0545	0.671	0.6709
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0135	0.1603	0.2385
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1603	0.2389
Loa Loa (eye worm)	hypothetical protein	0.018	0.2161	0.3217
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0092	0.1072	0.1597
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0545	0.671	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0372	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0158	0.5
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0035	0.0053
Entamoeba histolytica	hypothetical protein	0.0036	0.0372	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0158	0.5
Echinococcus multilocularis	geminin	0.0169	0.2031	0.2028
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0135	0.1603	0.2385
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0158	0.1446
Brugia malayi	Carboxylesterase family protein	0.0092	0.1072	0.1592
Toxoplasma gondii	exonuclease III APE	0.0019	0.0158	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1072	0.1592
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0135	0.1603	0.16
Onchocerca volvulus		0.0092	0.1072	0.4951
Brugia malayi	hypothetical protein	0.0009	0.0035	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1072	0.1592
Loa Loa (eye worm)	acetylcholinesterase 1	0.0545	0.671	1
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0035	0.0047
Brugia malayi	Carboxylesterase family protein	0.0545	0.671	1
Echinococcus granulosus	BC026374 protein S09 family	0.0092	0.1072	0.1592
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1072	0.1592
Schistosoma mansoni	gliotactin	0.0092	0.1072	0.1597
Schistosoma mansoni	dep domain containing protein	0.0009	0.0035	0.0053
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0035	0.0047
Echinococcus multilocularis	acetylcholinesterase	0.0545	0.671	0.6709
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0004	0.0006
Loa Loa (eye worm)	carboxylesterase	0.0092	0.1072	0.1592
Schistosoma mansoni	dishevelled	0.0009	0.0035	0.0053
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0158	0.0155
Echinococcus granulosus	para nitrobenzyl esterase	0.0092	0.1072	0.1592
Loa Loa (eye worm)	hypothetical protein	0.0545	0.671	1
Brugia malayi	Carboxylesterase family protein	0.0092	0.1072	0.1592
Brugia malayi	Carboxylesterase family protein	0.0545	0.671	1
Echinococcus granulosus	neuroligin	0.0092	0.1072	0.1592
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0092	0.1072	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0135	0.1603	0.2385
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0035	0.0146
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0092	0.1072	0.1068
Schistosoma mansoni	hypothetical protein	0.0169	0.2031	0.3026
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1072	0.1592
Echinococcus granulosus	acetylcholinesterase	0.0545	0.671	1
Schistosoma mansoni	acetylcholinesterase	0.0092	0.1072	0.1597
Onchocerca volvulus		0.0009	0.0035	0.0146
Echinococcus granulosus	geminin	0.0169	0.2031	0.3022
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0035	0.0032
Loa Loa (eye worm)	carboxylesterase	0.0092	0.1072	0.1592
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0035	0.0032
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0158	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0092	0.1072	0.1597
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0092	0.1072	0.1597
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0158	0.023
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1072	0.1592
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0092	0.1072	0.1597

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 882460