Detailed information for compound 882847

Basic information

Technical information
  • TDR Targets ID: 882847
  • Name: 2-(1,2,4-triazol-1-yl)acetic acid
  • MW: 127.101 | Formula: C4H5N3O2
  • H donors: 1 H acceptors: 4 LogP: -0.3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cn1cncn1
  • InChi: 1S/C4H5N3O2/c8-4(9)1-7-3-5-2-6-7/h2-3H,1H2,(H,8,9)
  • InChiKey: RXDBSQXFIWBJSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1,2,4-triazol-1-yl)ethanoic acid
  • 1,2,4-Triazole-1-acetic acid
  • EC-000.1972
  • BAS 01185338
  • [1,2,4]Triazol-1-yl-acetic acid
  • SBB010156

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0077 0.0071
Schistosoma mansoni hypothetical protein 0.0023 0.0068 0.0068
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0023 0.0068 0.0062
Echinococcus granulosus neuropeptide receptor 0.0025 0.0077 0.0071
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Schistosoma mansoni amine GPCR 0.0025 0.0077 0.0077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0077 0.0077
Trypanosoma cruzi PAB1-binding protein , putative 0.0042 0.0167 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0087 0.039 1
Schistosoma mansoni opsin-like receptor 0.0025 0.0077 0.0077
Brugia malayi hypothetical protein 0.0027 0.0091 0.0091
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Echinococcus granulosus sex peptide receptor 0.0025 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.0104
Echinococcus granulosus dna polymerase kappa 0.003 0.0104 0.0098
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.0077 0.0071
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0077 0.0077
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0077 0.0071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0077 0.0077
Echinococcus granulosus g protein coupled receptor 0.0025 0.0077 0.0071
Schistosoma mansoni amine GPCR 0.0025 0.0077 0.0077
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0006 0.0006
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0012 0.0013 0.0007
Echinococcus granulosus serotonin receptor 0.0025 0.0077 0.0071
Brugia malayi G protein-coupled receptor 0.0025 0.0077 0.0077
Leishmania major DNA polymerase eta, putative 0.003 0.0104 0.6221
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus multilocularis vesicular acetylcholine transporter 0.1996 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0026 0.0084 0.0084
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0077 0.0077
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0077 0.0071
Trypanosoma brucei DNA polymerase eta, putative 0.003 0.0104 0.6221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0077 0.0077
Schistosoma mansoni amine GPCR 0.0025 0.0077 0.0077
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0077 0.0077
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0012 0.0013 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Schistosoma mansoni amine GPCR 0.0025 0.0077 0.0077
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0077 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0057 0.3421
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0077 0.0071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0023 0.0068 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0077 0.0077
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0077 0.0071
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0077 0.0071
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0077 0.0077
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0588 0.2911 0.2906
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0077 0.0071
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus multilocularis somatostatin receptor 0.0025 0.0077 0.0071
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0013 0.0777
Schistosoma mansoni hypothetical protein 0.0409 0.2009 0.2009
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0077 0.0071
Brugia malayi Melatonin receptor type 1A 0.0025 0.0077 0.0077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0025 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0049 0.0202 0.0202
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0077 0.0071
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0012 0.0013 0.1248
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0013 0.0777
Schistosoma mansoni biogenic amine receptor 0.0025 0.0077 0.0077
Brugia malayi follicle stimulating hormone receptor 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Brugia malayi glutathione reductase 0.0034 0.0126 0.0126
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0077 0.0077
Brugia malayi putative neuropeptide receptor 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Mycobacterium tuberculosis Probable oxidoreductase 0.0087 0.039 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0077 0.0077
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0123 1
Toxoplasma gondii thioredoxin reductase 0.0034 0.0126 0.752
Echinococcus granulosus somatostatin receptor 0.0025 0.0077 0.0071
Plasmodium vivax ataxin-2 like protein, putative 0.0042 0.0167 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0077 0.0077
Echinococcus granulosus geminin 0.0409 0.2009 0.2004
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0104 0.6221
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0104 0.6221
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0077 0.0071
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0135 0.0129
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0077 0.0071
Brugia malayi ORL1-like opioid receptor 0.0025 0.0077 0.0077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0013 0.0777
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0068
Mycobacterium tuberculosis Probable reductase 0.0078 0.0347 0.8837
Loa Loa (eye worm) hypothetical protein 0.0042 0.0167 0.0167
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0023 0.0068 0.0062
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0077 0.0071
Echinococcus multilocularis dna polymerase kappa 0.003 0.0104 0.0098
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0077 0.0077
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0078 0.0347 0.8837
Schistosoma mansoni biogenic amine receptor 0.0025 0.0077 0.0077
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0077 0.0071
Leishmania major trypanothione reductase 0.0034 0.0126 0.752
Loa Loa (eye worm) hypothetical protein 0.0072 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1996 1 1
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0104 0.6221
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0135 0.0129
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.003 0.0104 0.0098
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) MH2 domain-containing protein 0.0087 0.0389 0.0389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0077 0.0077
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0135 0.0135
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0012 0.0013 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0042 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0123 1
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0012 0.0013 0.0777
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0033 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0012 0.0013 0.0777
Brugia malayi hypothetical protein 0.0026 0.0084 0.0084
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0077 0.0071
Echinococcus granulosus neuropeptide s receptor 0.0025 0.0077 0.0071
Toxoplasma gondii LsmAD domain-containing protein 0.0042 0.0167 1
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0104 0.6221
Schistosoma mansoni neuropeptide receptor 0.0025 0.0077 0.0077
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0023 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0023 0.0068 0.0068
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0077 0.0077
Schistosoma mansoni myosin xvIII 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Trypanosoma brucei unspecified product 0.003 0.0104 0.6221
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0078 0.0347 0.8837
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0104 0.6221
Echinococcus multilocularis serotonin receptor 0.0025 0.0077 0.0071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.012 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.003 0.0104 0.0104
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0077 0.0071
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0077 0.0071
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0077 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.012 0.012
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0077 0.0077
Echinococcus multilocularis geminin 0.0409 0.2009 0.2004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0087 0.039 1
Schistosoma mansoni opsin-like receptor 0.0025 0.0077 0.0077
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0077 0.0077
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.0077 0.0071
Plasmodium falciparum thioredoxin reductase 0.0034 0.0126 0.752
Plasmodium falciparum glutathione reductase 0.0034 0.0126 0.752
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0049 0.0202 0.0202
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0077 0.0071
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0023 0.0068 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0026 0.0084 0.0079
Schistosoma mansoni hypothetical protein 0.0409 0.2009 0.2009
Brugia malayi G-protein coupled receptor 0.0025 0.0077 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0057 0.3421
Echinococcus multilocularis GPCR, family 2 0.0023 0.0068 0.0062
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0012 0.0013 0.0777
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0012 0.0013 0.0777
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0077 0.0077
Brugia malayi hypothetical protein 0.0042 0.0167 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Toxoplasma gondii NADPH-glutathione reductase 0.0012 0.0013 0.0777
Schistosoma mansoni opsin-like receptor 0.0025 0.0077 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0104 0.6221
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.0077 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0013 0.0777
Schistosoma mansoni hypothetical protein 0.0025 0.0077 0.0077
Treponema pallidum NADH oxidase 0.0012 0.0013 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0111
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0077 0.0077
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0077 0.0077
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0077 0.0077
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.003 0.0104 0.241
Brugia malayi larval opioid receptor 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0013 0.0777
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0006
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.003 0.0104 0.0098
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0077 0.0071
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0025 0.0077 0.0077
Giardia lamblia DINP protein human, muc B family 0.003 0.0104 1
Trypanosoma cruzi trypanothione reductase, putative 0.0012 0.0013 0.0777
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0012 0.0013 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0077 0.0071
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0077 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0104 0.6221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0077 0.0077
Trypanosoma brucei unspecified product 0.0021 0.0057 0.3421
Echinococcus multilocularis dna polymerase eta 0.003 0.0104 0.0098
Brugia malayi neuropeptide F receptor 0.0025 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0049
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0012 0.0013 0.0777
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0104 0.0104
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0012 0.0013 0.0777
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0077 0.0071
Echinococcus multilocularis sex peptide receptor 0.0025 0.0077 0.0071
Schistosoma mansoni hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) transcription factor SMAD2 0.0087 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Trypanosoma brucei unspecified product 0.0021 0.0057 0.3421
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0077 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0104 0.6221
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Trypanosoma brucei PAB1-binding protein , putative 0.0042 0.0167 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0013 0.0777
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0087 0.039 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0104 0.6221
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0012 0.0013 0.0013
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0077 0.0071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0072 0.0317 0.0317
Echinococcus granulosus fmrfamide receptor 0.0025 0.0077 0.0071
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0104 1
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0077 0.0071
Echinococcus multilocularis thioredoxin glutathione reductase 0.0034 0.0126 0.012
Echinococcus granulosus neuropeptide receptor 0.0025 0.0077 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0077 0.0071
Schistosoma mansoni hypothetical protein 0.0023 0.0068 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.0072 0.0317 0.0317
Echinococcus granulosus vesicular acetylcholine transporter 0.1996 1 1
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Echinococcus granulosus g protein coupled receptor 0.0025 0.0077 0.0071
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0077 0.0071
Plasmodium falciparum ataxin-2 like protein, putative 0.0042 0.0167 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0033 0.012 0.012
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0013 0.0777
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0012 0.0013 0.0777
Loa Loa (eye worm) latrophilin receptor protein 2 0.0023 0.0068 0.0068
Trichomonas vaginalis DNA polymerase eta, putative 0.003 0.0104 0.8276
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0077 0.0071
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0077 0.0071
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0012 0.0013 0.0777
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0077 0.0071
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0104 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0012 0.0013 0.1248
Leishmania major hypothetical protein, conserved 0.0042 0.0167 1
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0077 0.0077
Plasmodium vivax thioredoxin reductase, putative 0.0034 0.0126 0.752
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0077 0.0071
Echinococcus granulosus g protein coupled receptor 0.0025 0.0077 0.0071
Schistosoma mansoni neuropeptide receptor 0.0025 0.0077 0.0077
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.003 0.0104 0.8276
Plasmodium vivax glutathione reductase, putative 0.0034 0.0126 0.752
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0077 0.0071
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0077 0.0071
Brugia malayi RE15519p 0.0025 0.0077 0.0077
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0012 0.0013 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0077 0.0071
Brugia malayi neuropeptide F receptor 0.0025 0.0077 0.0077
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Echinococcus granulosus dna polymerase eta 0.003 0.0104 0.0098
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0077 0.0071
Plasmodium falciparum glutathione reductase 0.0012 0.0013 0.0777
Loa Loa (eye worm) glutathione reductase 0.0034 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0013 0.0777
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0077 0.0077
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Brugia malayi Thioredoxin reductase 0.0034 0.0126 0.0126
Leishmania major DNA polymerase kappa, putative 0.003 0.0104 0.6221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0152 0.0152
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0077 0.0071
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0077 0.0077
Echinococcus granulosus thioredoxin glutathione reductase 0.0034 0.0126 0.012
Brugia malayi Dopamine receptor protein 2 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Plasmodium falciparum ataxin-2 like protein, putative 0.0042 0.0167 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0077 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0013 0.0777
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0077 0.0077
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0077 0.0071
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0023 0.0068 0.0068
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0019 0.0049 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0013 0.0777
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0012 0.0013 0.1248
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0077 0.0071
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.003 0.0104 0.0104
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0077 0.0071
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0078 0.0347 0.8837
Brugia malayi MH2 domain containing protein 0.0087 0.0389 0.0389
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0077 0.0071
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0077 0.0071
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0077 0.0077
Schistosoma mansoni biogenic amine receptor 0.0025 0.0077 0.0077
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0077 0.0077
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0006 0.0006
Schistosoma mansoni vesicular acetylcholine transporter 0.1996 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.012 0.012
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0012 0.0013 0.0007
Trypanosoma brucei trypanothione reductase 0.0034 0.0126 0.752
Echinococcus multilocularis serotonin receptor 0.0025 0.0077 0.0071
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0077 0.0077
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0077 0.0077
Brugia malayi GnHR receptor homolog 0.0025 0.0077 0.0077
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0077 0.0071
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0078 0.0347 0.8837
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0152 0.0152
Schistosoma mansoni histamine h1 receptor 0.0025 0.0077 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0104 0.6221
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0077 0.0071
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0072 0.0317 0.0317
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0012 0.0013 0.0777
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.0077 0.0077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.012 0.0114
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Brugia malayi Serotonin receptor 0.0025 0.0077 0.0077
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Schistosoma mansoni DNA polymerase eta 0.003 0.0104 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0077 0.0077
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0104 0.6221
Echinococcus granulosus hypothetical protein 0.0025 0.0077 0.0071
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0077 0.0071
Schistosoma mansoni amine GPCR 0.0025 0.0077 0.0077
Echinococcus granulosus GPCR family 2 0.0023 0.0068 0.0062
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0077 0.0071
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0013 0.0777
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1996 1 1
Schistosoma mansoni neuropeptide receptor 0.0025 0.0077 0.0077
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0077 0.0071
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0077 0.0077
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0077 0.0077
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0077 0.0077
Brugia malayi AKH receptor 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Brugia malayi Serotonin receptor 0.0025 0.0077 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0057 0.3421
Plasmodium falciparum thioredoxin reductase 0.0012 0.0013 0.0777
Echinococcus granulosus allatostatin A receptor 0.0025 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Schistosoma mansoni adenoreceptor 0.0025 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0026 0.0084 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0104 0.6221
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Brugia malayi sulfakinin receptor protein 0.0025 0.0077 0.0077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0013 0.0777
Mycobacterium tuberculosis Conserved hypothetical protein 0.003 0.0104 0.241
Loa Loa (eye worm) thioredoxin reductase 0.0034 0.0126 0.0126
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0012 0.0013 0.1248
Schistosoma mansoni terminal deoxycytidyl transferase 0.003 0.0104 0.0104
Brugia malayi latrophilin 2 splice variant baaae 0.0049 0.0202 0.0202
Schistosoma mansoni neuropeptide receptor 0.0025 0.0077 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0104 0.6221
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0135 0.0135
Brugia malayi G-protein coupled receptor 0.0025 0.0077 0.0077
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.003 0.0104 0.6221
Brugia malayi Dopamine receptor protein 1 0.0025 0.0077 0.0077
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0104 0.0104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.012 0.0114
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.0077 0.0071
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0104 0.6221
Brugia malayi Latrophilin receptor protein 2 0.0023 0.0068 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0104 0.6221
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0077 0.0071
Brugia malayi Dopamine receptor 0.0025 0.0077 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0104 0.6221
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.012 0.012
Echinococcus granulosus orexin receptor type 2 0.0025 0.0077 0.0071
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0104 0.6221
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0077 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.012 0.0114
Mycobacterium tuberculosis Probable dehydrogenase 0.0078 0.0347 0.8837
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0019 0.0049 0.0043
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0034 0.0126 0.2985
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0104 0.6221
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0077 0.0071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0026 0.0084 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0077 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0077 0.0071
Brugia malayi hypothetical protein 0.0025 0.0077 0.0077
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0126 0.752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0077 0.0077
Entamoeba histolytica deoxycytidyl transferase, putative 0.003 0.0104 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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