Detailed information for compound 882850

Basic information

Technical information
  • TDR Targets ID: 882850
  • Name: 7-bromo-2-(2-hydroxyethyl)-1-phenyl-1H-chrome no[2,3-c]pyrrole-3,9-dione
  • MW: 400.223 | Formula: C19H14BrNO4
  • H donors: 1 H acceptors: 3 LogP: 2.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1C(=O)c2c(C1c1ccccc1)c(=O)c1c(o2)ccc(c1)Br
  • InChi: 1S/C19H14BrNO4/c20-12-6-7-14-13(10-12)17(23)15-16(11-4-2-1-3-5-11)21(8-9-22)19(24)18(15)25-14/h1-7,10,16,22H,8-9H2
  • InChiKey: ZNZRUHJGSVPQNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-bromo-2-(2-hydroxyethyl)-1-phenyl-1H-chromeno[2,3-c]pyrrole-3,9-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1092 0.1325
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.1092 0.1092
Echinococcus granulosus neuropeptide FF receptor 2 0.0101 0.1092 0.1325
Echinococcus granulosus peptide allatostatin:somatostatin 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Loa Loa (eye worm) TYRA-2 protein 0.0101 0.1092 0.1286
Brugia malayi Serotonin receptor 0.0101 0.1092 0.1325
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.1092 0.1286
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0247 0.0299
Loa Loa (eye worm) glutathione reductase 0.0046 0.0389 0.0429
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0037 0.0281
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0101 0.1092 0.1286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0369 0.0448
Echinococcus granulosus hypothetical protein 0.0101 0.1092 0.1325
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0037 0.0943
Echinococcus granulosus dna polymerase eta 0.0019 0.0037 0.0044
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Brugia malayi glutathione reductase 0.0046 0.0389 0.0472
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1092 0.1092
Echinococcus multilocularis G-protein coupled receptor, putative 0.0101 0.1092 0.1092
Brugia malayi Serotonin receptor 0.0101 0.1092 0.1325
Brugia malayi putative neuropeptide receptor 0.0101 0.1092 0.1325
Brugia malayi MH2 domain containing protein 0.0116 0.1296 0.1573
Schistosoma mansoni amine GPCR 0.0101 0.1092 0.1325
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1151 0.8837
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Entamoeba histolytica hypothetical protein 0.0035 0.0247 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0389 1
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.1092 0.1325
Brugia malayi neuropeptide F receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.1092 0.1286
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1092 0.1325
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus granulosus allatostatin A receptor 0.0101 0.1092 0.1325
Brugia malayi hypothetical protein 0.0101 0.1092 0.1325
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0101 0.1092 0.1325
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0943
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0101 0.1092 0.1092
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0101 0.1092 0.1286
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1303 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0101 0.1092 0.1092
Brugia malayi hypothetical protein 0.0101 0.1092 0.1325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1092 0.1325
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Brugia malayi Dopamine receptor protein 2 0.0101 0.1092 0.1325
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1296 0.1535
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1092 0.1325
Brugia malayi AKH receptor 0.0101 0.1092 0.1325
Schistosoma mansoni amine GPCR 0.0101 0.1092 0.1325
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.1092 0.1325
Brugia malayi hypothetical protein 0.0101 0.1092 0.1325
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Brugia malayi putative neuropeptide receptor NPR1 0.0101 0.1092 0.1325
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0101 0.1092 0.1286
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Schistosoma mansoni amine GPCR 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0369 0.0448
Echinococcus multilocularis fmrfamide receptor 0.0101 0.1092 0.1092
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus granulosus g protein coupled receptor 0.0101 0.1092 0.1325
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0101 0.1092 0.1092
Leishmania major DNA polymerase eta, putative 0.0019 0.0037 0.0943
Brugia malayi hypothetical protein 0.0101 0.1092 0.1325
Echinococcus granulosus neuropeptide s receptor 0.0101 0.1092 0.1325
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0037
Schistosoma mansoni vesicular acetylcholine transporter 0.0654 0.8242 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Brugia malayi Dopamine receptor 0.0101 0.1092 0.1325
Schistosoma mansoni hypothetical protein 0.0101 0.1092 0.1325
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.1092 0.1325
Echinococcus multilocularis neuropeptide receptor A26 0.0101 0.1092 0.1092
Echinococcus multilocularis orexin receptor type 2 0.0101 0.1092 0.1092
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.1092 0.1286
Brugia malayi hypothetical protein 0.0101 0.1092 0.1325
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0247 0.0299
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1092 0.1092
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1092 0.1325
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0191 0.0191
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.1092 0.1092
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0101 0.1092 0.1325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis neuropeptide s receptor 0.0101 0.1092 0.1092
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0101 0.1092 0.1286
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0369 0.0448
Echinococcus multilocularis g protein coupled receptor 0.0101 0.1092 0.1092
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1092 0.1325
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.1092 0.1325
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Brugia malayi ORL1-like opioid receptor 0.0101 0.1092 0.1325
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.1092 0.1092
Echinococcus granulosus 7TM GPCR rhodopsin 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis g-protein coupled receptor 0.0101 0.1092 0.1092
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0101 0.1092 0.1325
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0389 0.2985
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.1092 0.1325
Brugia malayi GnHR receptor homolog 0.0101 0.1092 0.1325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1092 0.1092
Schistosoma mansoni myosin xvIII 0.0101 0.1092 0.1325
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1151 0.8837
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0037 0.0037
Echinococcus granulosus g protein coupled receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0191 0.0188
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.1092 0.1325
Brugia malayi neuropeptide F receptor 0.0101 0.1092 0.1325
Echinococcus granulosus neuropeptide receptor A26 0.0101 0.1092 0.1325
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1092 0.1325
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis somatostatin receptor 0.0101 0.1092 0.1092
Brugia malayi G protein-coupled receptor F59B2.13 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1151 0.8837
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0044
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1092 0.1325
Schistosoma mansoni histamine h1 receptor 0.0101 0.1092 0.1325
Echinococcus granulosus GPCR family 2 0.0031 0.0191 0.0232
Brugia malayi Tachykinin-like peptides receptor 99D 0.0101 0.1092 0.1325
Schistosoma mansoni hypothetical protein 0.0031 0.0191 0.0232
Brugia malayi follicle stimulating hormone receptor 0.0101 0.1092 0.1325
Echinococcus granulosus sex peptide receptor 0.0101 0.1092 0.1325
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.1092 0.1325
Echinococcus granulosus vesicular acetylcholine transporter 0.0654 0.8242 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.0389 1
Schistosoma mansoni amine GPCR 0.0101 0.1092 0.1325
Echinococcus granulosus fmrfamide receptor 0.0101 0.1092 0.1325
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0191 0.0232
Treponema pallidum NADH oxidase 0.0016 0 0.5
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0191 0.0232
Brugia malayi hypothetical protein 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.1092 0.1325
Schistosoma mansoni DNA polymerase eta 0.0019 0.0037 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1092 0.1092
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.1092 0.1325
Schistosoma mansoni neuropeptide f receptor 76f 0.0101 0.1092 0.1325
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0654 0.8242 1
Schistosoma mansoni hypothetical protein 0.0101 0.1092 0.1325
Schistosoma mansoni neuropeptide receptor 0.0101 0.1092 0.1325
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0101 0.1092 0.1325
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0101 0.1092 0.1325
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0037 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.1092 0.1092
Plasmodium vivax glutathione reductase, putative 0.0046 0.0389 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0369 0.0448
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.1092 0.1325
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0031 0.0191 0.0232
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0101 0.1092 0.1325
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.1092 0.1325
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0101 0.1092 0.1092
Brugia malayi G protein-coupled receptor 0.0101 0.1092 0.1325
Echinococcus granulosus orexin receptor type 2 0.0101 0.1092 0.1325
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1303 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Loa Loa (eye worm) melatonin receptor type 1A 0.0101 0.1092 0.1286
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0369 0.0369
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0369 0.0448
Brugia malayi Thioredoxin reductase 0.0046 0.0389 0.0472
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0369 0.0406
Brugia malayi hypothetical protein 0.0035 0.0247 0.0299
Echinococcus granulosus alpha 1A adrenergic receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Schistosoma mansoni hypothetical protein 0.0165 0.1927 0.2338
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0101 0.1092 0.1325
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1049 0.1233
Giardia lamblia DINP protein human, muc B family 0.0019 0.0037 1
Schistosoma mansoni hypothetical protein 0.0031 0.0191 0.0232
Trypanosoma brucei unspecified product 0.0019 0.0037 0.0943
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0101 0.1092 0.1325
Trypanosoma brucei trypanothione reductase 0.0046 0.0389 1
Brugia malayi Dopamine receptor protein 1 0.0101 0.1092 0.1325
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0044
Brugia malayi vesicular acetylcholine transporter unc-17 0.0654 0.8242 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0101 0.1092 0.1325
Schistosoma mansoni hypothetical protein 0.0035 0.0247 0.0299
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus granulosus serotonin receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.1092 0.1325
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1151 0.8837
Echinococcus multilocularis GPCR, family 2 0.0031 0.0191 0.0191
Entamoeba histolytica hypothetical protein 0.0035 0.0247 1
Mycobacterium tuberculosis Probable reductase 0.0105 0.1151 0.8837
Echinococcus multilocularis G protein coupled receptor 139 0.0101 0.1092 0.1092
Schistosoma mansoni neuropeptide receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0066 0.0652 0.0749
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.1092 0.1286
Echinococcus multilocularis neuropeptide receptor 0.0101 0.1092 0.1092
Echinococcus multilocularis geminin 0.0165 0.1927 0.1927
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0101 0.1092 0.1092
Leishmania major DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Entamoeba histolytica hypothetical protein 0.0035 0.0247 1
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.1092 0.1325
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1092 0.1325
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0101 0.1092 0.1325
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0943
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1049 0.1272
Brugia malayi sulfakinin receptor protein 0.0101 0.1092 0.1325
Schistosoma mansoni neuropeptide receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1296 0.1535
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1092 0.1092
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0101 0.1092 0.1092
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0037 0.0943
Schistosoma mansoni biogenic amine receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0369 0.0369
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0101 0.1092 0.1325
Schistosoma mansoni opsin-like receptor 0.0101 0.1092 0.1325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1092 0.1325
Schistosoma mansoni biogenic amine receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0037 0.0281
Schistosoma mansoni amine GPCR 0.0101 0.1092 0.1325
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0037 0.0044
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.1092 0.1325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1092 0.1325
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.1092 0.1092
Brugia malayi larval opioid receptor 0.0101 0.1092 0.1325
Brugia malayi RE15519p 0.0101 0.1092 0.1325
Brugia malayi hypothetical protein 0.0101 0.1092 0.1325
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0389 0.0472
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0652 0.0791
Echinococcus multilocularis vesicular acetylcholine transporter 0.0654 0.8242 0.8242
Schistosoma mansoni growth hormone secretagogue receptor 0.0101 0.1092 0.1325
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0101 0.1092 0.1325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0097 0.1049 0.1233
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1049 0.1272
Schistosoma mansoni alpha-1 adrenergic receptor 0.0101 0.1092 0.1325
Echinococcus granulosus somatostatin receptor 0.0101 0.1092 0.1325
Schistosoma mansoni hypothetical protein 0.0101 0.1092 0.1325
Schistosoma mansoni hypothetical protein 0.0066 0.0652 0.0791
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Echinococcus granulosus dna polymerase kappa 0.0019 0.0037 0.0044
Schistosoma mansoni hypothetical protein 0.0031 0.0191 0.0232
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.1092 0.1325
Echinococcus granulosus neuropeptide receptor 0.0101 0.1092 0.1325
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0101 0.1092 0.1325
Schistosoma mansoni neuropeptide receptor 0.0101 0.1092 0.1325
Echinococcus granulosus dro:myosuppressin receptor 0.0101 0.1092 0.1325
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0191 0.0232
Echinococcus multilocularis dna polymerase eta 0.0019 0.0037 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1092 0.1325
Echinococcus multilocularis serotonin receptor 0.0101 0.1092 0.1092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1092 0.1325
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0037 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.1092 0.1092
Echinococcus granulosus geminin 0.0165 0.1927 0.2338
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0389 1
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.1092 0.1325
Schistosoma mansoni opsin-like receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis allatostatin A receptor 0.0101 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0037 0.0943
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0037 1
Echinococcus granulosus G protein coupled receptor 139 0.0101 0.1092 0.1325
Brugia malayi Melatonin receptor type 1A 0.0101 0.1092 0.1325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1092 0.1092
Entamoeba histolytica hypothetical protein 0.0035 0.0247 1
Echinococcus multilocularis sex peptide receptor 0.0101 0.1092 0.1092
Brugia malayi hypothetical protein 0.0101 0.1092 0.1325
Echinococcus granulosus 7tm_1 domain containing protein 0.0101 0.1092 0.1325
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.1092 0.1325
Echinococcus multilocularis neuropeptide FF receptor 2 0.0101 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis neuropeptide receptor 0.0101 0.1092 0.1092
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0191 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0943
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.1092 0.1092
Leishmania major trypanothione reductase 0.0046 0.0389 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0101 0.1092 0.1092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1092 0.1325
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0191 0.0232
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0101 0.1092 0.1325
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0101 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0389 0.0429
Echinococcus granulosus tachykinin peptides receptor 99D 0.0101 0.1092 0.1325
Schistosoma mansoni biogenic amine receptor 0.0101 0.1092 0.1325
Echinococcus granulosus g-protein coupled receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0369 0.0448
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.1092 0.1325
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1303 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0389 0.0389
Plasmodium falciparum glutathione reductase 0.0046 0.0389 1
Echinococcus multilocularis serotonin receptor 0.0101 0.1092 0.1092
Schistosoma mansoni adenoreceptor 0.0101 0.1092 0.1325
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0654 0.8242 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0188
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Schistosoma mansoni hypothetical protein 0.0165 0.1927 0.2338
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.1092 0.1325
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1303 1
Brugia malayi hypothetical protein 0.0101 0.1092 0.1325
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0101 0.1092 0.1325
Schistosoma mansoni hypothetical protein 0.0101 0.1092 0.1325
Echinococcus multilocularis g protein coupled receptor 0.0101 0.1092 0.1092
Schistosoma mansoni opsin-like receptor 0.0101 0.1092 0.1325
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.1092 0.1092
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0389 1
Echinococcus granulosus neuropeptide receptor 0.0101 0.1092 0.1325
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0101 0.1092 0.1092
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Echinococcus multilocularis g protein coupled receptor 0.0101 0.1092 0.1092
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1151 0.8837
Echinococcus granulosus g protein coupled receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0101 0.1092 0.1286
Echinococcus multilocularis dro:myosuppressin receptor 0.0101 0.1092 0.1092
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0943
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0101 0.1092 0.1092
Brugia malayi G-protein coupled receptor 0.0101 0.1092 0.1325
Loa Loa (eye worm) hypothetical protein 0.0101 0.1092 0.1286
Brugia malayi hypothetical protein 0.0101 0.1092 0.1325
Brugia malayi G-protein coupled receptor 0.0101 0.1092 0.1325

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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