Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | fatty acid elongase, putative | 0.0657 | 0.0952 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0657 | 0.0952 | 0.5 |
Echinococcus granulosus | protein tyrosine kinase | 0.0253 | 0.0121 | 0.1212 |
Schistosoma mansoni | tyrosine kinase | 0.0334 | 0.0286 | 0.3092 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0628 | 0.0892 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0202 | 0.0015 | 0.0169 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0657 | 0.0952 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0338 | 0.0296 | 0.32 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0628 | 0.0892 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0253 | 0.0121 | 0.1212 |
Schistosoma mansoni | tyrosine kinase | 0.0628 | 0.0892 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.5062 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0628 | 0.0892 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.5062 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.5062 | 1 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0628 | 0.0892 | 1 |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.0256 | 0.0127 | 0.1282 |
Schistosoma mansoni | tyrosine kinase | 0.0334 | 0.0286 | 0.3092 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.5062 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.5062 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0338 | 0.0296 | 0.32 |
Echinococcus multilocularis | insulin receptor | 0.0202 | 0.0015 | 0.0169 |
Echinococcus multilocularis | protein tyrosine kinase | 0.0253 | 0.0121 | 0.1361 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.5062 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0338 | 0.0296 | 0.32 |
Brugia malayi | Protein kinase domain containing protein | 0.0256 | 0.0127 | 0.1282 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0657 | 0.0952 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0657 | 0.0952 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0334 | 0.0286 | 0.3092 |
Schistosoma mansoni | tyrosine kinase | 0.0338 | 0.0296 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0338 | 0.0296 | 0.3315 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.5062 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.