TDR Targets

Basic information

Technical information

TDR Targets ID: 883634
Name: 2-(4-methoxyphenyl)-3-(2-methylsulfanylethyl) -1,3-thiazolidin-4-one
MW: 283.41 | Formula: C13H17NO2S2
H donors: 0 H acceptors: 1 LogP: 2.42 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CSCCN1C(=O)CSC1c1ccc(cc1)OC
InChi: 1S/C13H17NO2S2/c1-16-11-5-3-10(4-6-11)13-14(7-8-17-2)12(15)9-18-13/h3-6,13H,7-9H2,1-2H3
InChiKey: TVYQIQZZOVRREN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-methoxyphenyl)-3-(2-methylsulfanylethyl)thiazolidin-4-one
2-(4-methoxyphenyl)-3-[2-(methylthio)ethyl]-4-thiazolidinone
2-(4-methoxyphenyl)-3-[2-(methylthio)ethyl]thiazolidin-4-one
Oprea1_109167

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	ATP binding cassette sub family B	0.0087	0.2825	0.2621
Schistosoma mansoni	multidrug resistance protein	0.0271	1	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.0271	1	1
Trichomonas vaginalis	abcb9, putative	0.0271	1	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0099	0.3288	1
Echinococcus granulosus	ATP binding cassette sub family B	0.0084	0.2706	0.2499
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0271	1	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.003	0.0575	0.0307
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0271	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0271	1	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0099	0.3288	0.3097
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.0087	0.2825	0.2719
Loa Loa (eye worm)	hypothetical protein	0.003	0.0575	0.0575
Schistosoma mansoni	multidrug resistance protein	0.0087	0.2825	0.2719
Echinococcus granulosus	multidrug resistance protein 1	0.0186	0.6712	0.6619
Giardia lamblia	ABC transporter, putative	0.0099	0.3288	1
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0099	0.3288	0.3288
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0271	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0089	0.2886	0.2684
Giardia lamblia	Multidrug resistance-associated protein 1	0.0096	0.3169	0.7958
Brugia malayi	ABC transporter family protein	0.0087	0.2825	0.2621
Entamoeba histolytica	P-glycoprotein-2	0.0271	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0271	1	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0022	0.0276	0.0133
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0186	0.6712	0.6619
Loa Loa (eye worm)	hypothetical protein	0.0099	0.3288	0.3288
Entamoeba histolytica	P-glycoprotein-2, putative	0.0271	1	1
Schistosoma mansoni	multidrug resistance protein	0.0099	0.3288	0.3189
Echinococcus granulosus	multidrug resistance associated protein 7	0.0099	0.3288	0.3097
Echinococcus multilocularis	multidrug resistance protein 1	0.0271	1	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0022	0.0276	0.0133
Echinococcus granulosus	multidrug resistance protein 1	0.0186	0.6712	0.6619
Echinococcus granulosus	multidrug resistance protein 1	0.0271	1	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0267	0.9881	0.9878
Loa Loa (eye worm)	hypothetical protein	0.0267	0.9881	0.9881
Trichomonas vaginalis	taga, putative	0.0271	1	1
Echinococcus granulosus	voltage gated potassium channel	0.003	0.0575	0.0307
Trichomonas vaginalis	ABC transporter, putative	0.0271	1	1
Leishmania major	p-glycoprotein	0.0271	1	1
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0087	0.2825	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0271	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0271	1	1
Loa Loa (eye worm)	ABC transporter	0.0087	0.2825	0.2825
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0099	0.3288	1
Brugia malayi	hypothetical protein	0.0087	0.2825	0.2621
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0022	0.0276	0.0276
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0087	0.2825	0.5
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0271	1	1
Trypanosoma brucei	p-glycoprotein	0.0099	0.3288	1
Echinococcus granulosus	multidrug resistance associated protein 1	0.0099	0.3288	0.3097
Plasmodium vivax	multidrug resistance protein 1, putative	0.0271	1	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0022	0.0276	0.0133
Echinococcus multilocularis	sodium channel protein	0.009	0.2942	0.2741
Leishmania major	ABC-thiol transporter	0.0099	0.3288	0.0645
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.0087	0.2825	0.2621
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0271	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0271	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0271	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0271	1	1
Brugia malayi	ABC transporter family protein	0.0087	0.2825	0.2621
Onchocerca volvulus		0.0271	1	0.5
Echinococcus multilocularis	ATP binding cassette sub family B	0.0087	0.2825	0.2621
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0099	0.3288	0.0797
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0271	1	1
Trichomonas vaginalis	abcb9, putative	0.0271	1	1
Trypanosoma brucei	multidrug resistance protein E	0.0099	0.3288	1
Schistosoma mansoni	multidrug resistance protein	0.0099	0.3288	0.3189
Loa Loa (eye worm)	hypothetical protein	0.0191	0.6872	0.6872
Loa Loa (eye worm)	ABC transporter	0.0087	0.2825	0.2825
Schistosoma mansoni	voltage-gated potassium channel	0.003	0.0575	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0191	0.6872	0.6872
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0271	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0271	1	1
Brugia malayi	ABC transporter	0.0084	0.2706	0.2499
Entamoeba histolytica	P-glycoprotein 6, putative	0.0087	0.2825	0.0163
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.0276	0.0133
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0099	0.3288	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0078	0.2458	0.2244
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0084	0.2706	0.2599
Echinococcus multilocularis	ATP binding cassette sub family B	0.0087	0.2825	0.2621
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0099	0.3288	0.0797
Echinococcus multilocularis	ATP binding cassette sub family B	0.0087	0.2825	0.2621
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0271	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.2706	0.2499
Schistosoma mansoni	multidrug resistance protein	0.0271	1	1
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0087	0.2825	0.5
Brugia malayi	ABC transporter family protein	0.0087	0.2825	0.2621
Loa Loa (eye worm)	hypothetical protein	0.0084	0.2706	0.2706
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0099	0.3288	0.0645
Schistosoma mansoni	smdr2	0.0271	1	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0186	0.6712	0.6619
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0271	1	1
Entamoeba histolytica	P-glycoprotein-2	0.0271	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0271	1	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0087	0.2825	0.2621
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0271	1	1
Schistosoma mansoni	multidrug resistance protein	0.0099	0.3288	0.3189
Loa Loa (eye worm)	hypothetical protein	0.0271	1	1
Schistosoma mansoni	multidrug resistance protein	0.0271	1	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0022	0.0276	0.0133
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0099	0.3288	0.0645
Echinococcus multilocularis	ATP binding cassette sub family B	0.0087	0.2825	0.2621
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0271	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0096	0.3185	0.3085
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0099	0.3288	0.0797
Entamoeba histolytica	P-glycoprotein-1	0.0271	1	1
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0087	0.2825	0.5
Giardia lamblia	Multidrug resistance-associated protein 1	0.0099	0.3288	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0271	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.003	0.0575	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0099	0.3288	0.3288
Entamoeba histolytica	multidrug resistance protein, putative	0.0099	0.3288	0.0797
Brugia malayi	multidrug resistance related protein 1	0.0099	0.3288	0.3097
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0271	1	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.2825	0.2825
Echinococcus multilocularis	voltage gated potassium channel	0.003	0.0575	0.0307
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0087	0.2825	0.5
Brugia malayi	ABC transporter transmembrane region family protein	0.0084	0.2706	0.2499
Entamoeba histolytica	hypothetical protein	0.0099	0.3288	0.0797
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0087	0.2825	0.5
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0099	0.3288	0.0797
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0099	0.3288	1
Giardia lamblia	MRP-like ABC transporter	0.0099	0.3288	1
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0099	0.3288	0.3097
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0099	0.3288	0.0645
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0084	0.2706	0.2499
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0271	1	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0087	0.2825	0.5
Leishmania major	p-glycoprotein e	0.0099	0.3288	0.0645
Entamoeba histolytica	P-glycoprotein-5	0.0271	1	1
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0099	0.3288	1
Echinococcus granulosus	sodium channel protein	0.009	0.2942	0.2741
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0271	1	1
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0099	0.3288	0.0645
Leishmania major	pentamidine resistance protein 1	0.0099	0.3288	0.0645
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0267	0.9881	0.9878
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0089	0.2886	0.2886
Echinococcus multilocularis		0.0087	0.2825	0.2621
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0271	1	1
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0087	0.2825	0.5
Loa Loa (eye worm)	multidrug resistance protein 3	0.0271	1	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0271	1	1
Toxoplasma gondii	hypothetical protein	0.0191	0.6872	0.564
Loa Loa (eye worm)	hypothetical protein	0.0271	1	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0271	1	1
Entamoeba histolytica	P-glyco protein 6, putative	0.0271	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0271	1	1
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.009	0.2942	0.0162
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0271	1	1
Echinococcus granulosus	ATP binding cassette sub family B	0.0087	0.2825	0.2621
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0084	0.2706	0.2499
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0089	0.2886	0.2684
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0271	1	1
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0099	0.3288	0.0645
Trichomonas vaginalis	ABC transporter, putative	0.0271	1	1
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0099	0.3288	0.3097
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0271	1	1
Schistosoma mansoni	multidrug resistance protein	0.0084	0.2706	0.2599
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0087	0.2825	0.2621
Brugia malayi	ABC transporter	0.0087	0.2825	0.2621
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0271	1	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0271	1	1
Entamoeba histolytica	P-glycoprotein 6, putative	0.0087	0.2825	0.0163
Brugia malayi	ABC transporter family protein	0.0271	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0078	0.2458	0.2244
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0276	0.0276
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0022	0.0276	0.0276
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0271	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0271	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0096	0.3185	0.3085
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0271	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0089	0.2886	0.2684
Trichomonas vaginalis	ABC transporter, putative	0.0271	1	1
Loa Loa (eye worm)	ABC transporter	0.0087	0.2825	0.2825
Trichomonas vaginalis	abcb9, putative	0.0271	1	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0271	1	0.5
Brugia malayi	P-glycoprotein-like protein	0.0087	0.2825	0.2621
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0271	1	1
Loa Loa (eye worm)	hypothetical protein	0.0191	0.6872	0.6872
Schistosoma mansoni	voltage-gated potassium channel	0.003	0.0575	0.0436
Schistosoma mansoni	multidrug resistance protein	0.0099	0.3288	0.3189
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0087	0.2825	0.5
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0099	0.3288	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.003	0.0575	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0078	0.2457	0.2457
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.009	0.2942	0.2741
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0271	1	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0022	0.0276	0.0133
Echinococcus granulosus	multidrug resistance protein 1	0.0271	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0271	1	1
Plasmodium falciparum	multidrug resistance protein 1	0.0271	1	1
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0191	0.6872	0.6872
Loa Loa (eye worm)	hypothetical protein	0.0096	0.3169	0.3169
Schistosoma mansoni	smdr1	0.0087	0.2825	0.2719
Entamoeba histolytica	ABC transporter, putative	0.0099	0.3288	0.0797
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0084	0.2706	0.2499

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 883634