Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0487 | 0.0473 | 0.3468 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0294 | 0.0073 | 0.0533 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.5078 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0487 | 0.0473 | 0.3468 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.5078 | 1 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0917 | 0.1365 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0493 | 0.0486 | 0.3563 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0917 | 0.1365 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.5078 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0294 | 0.0073 | 0.0533 |
Entamoeba histolytica | fatty acid elongase, putative | 0.066 | 0.0832 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0917 | 0.1365 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.066 | 0.0832 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0487 | 0.0473 | 0.3468 |
Schistosoma mansoni | tyrosine kinase | 0.0493 | 0.0486 | 0.3563 |
Schistosoma mansoni | tyrosine kinase | 0.0493 | 0.0486 | 0.3563 |
Echinococcus multilocularis | insulin receptor | 0.0294 | 0.0073 | 0.0533 |
Echinococcus granulosus | insulin receptor | 0.0294 | 0.0073 | 0.0533 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0917 | 0.1365 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.5078 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.066 | 0.0832 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.5078 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.5078 | 1 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0294 | 0.0073 | 0.0533 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0493 | 0.0486 | 0.3563 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0493 | 0.0486 | 0.3563 |
Entamoeba histolytica | fatty acid elongase, putative | 0.066 | 0.0832 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0294 | 0.0073 | 0.049 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0917 | 0.1365 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.066 | 0.0832 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0294 | 0.0073 | 0.0533 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.5078 | 1 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0294 | 0.0073 | 0.049 |
Echinococcus multilocularis | 0.0283 | 0.0052 | 0.0378 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.