TDR Targets

Basic information

Technical information

TDR Targets ID: 886266
Name: N-(2-bromo-4-propan-2-ylphenyl)-2-nitrobenzen esulfonamide
MW: 399.26 | Formula: C15H15BrN2O4S
H donors: 1 H acceptors: 4 LogP: 4.09 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Brc1cc(ccc1NS(=O)(=O)c1ccccc1[N+](=O)[O-])C(C)C
InChi: 1S/C15H15BrN2O4S/c1-10(2)11-7-8-13(12(16)9-11)17-23(21,22)15-6-4-3-5-14(15)18(19)20/h3-10,17H,1-2H3
InChiKey: XMBYVKQFKIWUHV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-bromo-4-isopropyl-phenyl)-2-nitro-benzenesulfonamide
N-(2-bromo-4-isopropylphenyl)-2-nitrobenzenesulfonamide
N-(2-bromo-4-propan-2-yl-phenyl)-2-nitro-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0126	0.0178	0.0532
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.1107	0.3348	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0272	0.0652	0.0652
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0135	0.0209	0.0209
Onchocerca volvulus		0.0156	0.0276	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0341	0.0874	0.2196
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0126	0.0178	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1107	0.3348	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1107	0.3348	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0135	0.0209	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0246	0.0246
Onchocerca volvulus		0.0126	0.0178	0.0532
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0126	0.0178	0.0178
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0135	0.0209	0.0031
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0135	0.0209	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0341	0.0874	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1107	0.3348	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.3165	1	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.3165	1	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0135	0.0209	0.0031
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1107	0.3348	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Trypanosoma cruzi	hypothetical protein, conserved	0.0341	0.0874	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0135	0.0209	0.0209
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0126	0.0178	0.0178
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0126	0.0178	0.0178
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase 1	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0341	0.0874	0.2196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase	0.0282	0.0682	0.0682
Brugia malayi	Protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Leishmania major	hypothetical protein, conserved	0.0341	0.0874	1
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.1107	0.3348	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0135	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0246	0.0246
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0135	0.0209	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0135	0.0209	0.0031
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1107	0.3348	1
Onchocerca volvulus		0.0126	0.0178	0.0532
Brugia malayi	hypothetical protein	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0135	0.0209	0.0209
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.3165	1	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0135	0.0209	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1107	0.3348	1
Onchocerca volvulus	4.1 G protein, putative homolog	0.0126	0.0178	0.0532
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Brugia malayi	hypothetical protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1107	0.3348	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0135	0.0209	0.0031
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0135	0.0209	0.0031
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Brugia malayi	hypothetical protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Schistosoma mansoni	protein tyrosine phosphatase	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1107	0.3348	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0135	0.0209	0.0031
Onchocerca volvulus		0.0126	0.0178	0.0532
Onchocerca volvulus		0.0126	0.0178	0.0532
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0135	0.0209	0.0209
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Trypanosoma cruzi	hypothetical protein, conserved	0.0341	0.0874	1
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0126	0.0178	0.0178
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.3165	1	1
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0135	0.0209	0.0209
Onchocerca volvulus		0.1107	0.3348	1
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Brugia malayi	hypothetical protein	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Schistosoma mansoni	pcd6 interacting protein-related	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.1107	0.3348	0.3348
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0766	0.2246	0.5
Brugia malayi	hypothetical protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.1107	0.3348	0.5
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0126	0.0178	0.0178
Schistosoma mansoni	protein tyrosine phosphatase	0.0135	0.0209	0.0209
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0178	0.0178
Onchocerca volvulus		0.0126	0.0178	0.0532
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0178	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0178	0.0178

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 886266