Detailed information for compound 886333

Basic information

Technical information
  • TDR Targets ID: 886333
  • Name: methyl 2-[[2-(2-methylsulfonylbenzoyl)pyrazol idine-1-carbothioyl]amino]acetate
  • MW: 385.458 | Formula: C15H19N3O5S2
  • H donors: 1 H acceptors: 4 LogP: 0.79 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CNC(=S)N1CCCN1C(=O)c1ccccc1S(=O)(=O)C
  • InChi: 1S/C15H19N3O5S2/c1-23-13(19)10-16-15(24)18-9-5-8-17(18)14(20)11-6-3-4-7-12(11)25(2,21)22/h3-4,6-7H,5,8-10H2,1-2H3,(H,16,24)
  • InChiKey: KXXRAELACWZUJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[[2-[(2-methylsulfonylphenyl)-oxomethyl]-1-pyrazolidinyl]-thioxomethyl]amino]acetic acid methyl ester
  • 2-[[2-(2-mesylbenzoyl)pyrazolidine-1-carbothioyl]amino]acetic acid methyl ester
  • methyl 2-[[2-(2-methylsulfonylphenyl)carbonylpyrazolidin-1-yl]carbothioylamino]ethanoate
  • Oprea1_219443

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0248 0.0304
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.1366 0.2431
Brugia malayi TAR-binding protein 0.0074 0.0701 0.1094
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0279 0.0279
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.0166 0.0215
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0279 0.0563
Leishmania major hypothetical protein, conserved 0.0284 0.3064 1
Mycobacterium ulcerans hypothetical protein 0.015 0.1563 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0279 0.0279
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.015 0.1563 0.2655
Onchocerca volvulus 0.0284 0.3064 0.5372
Brugia malayi hypothetical protein 0.0026 0.0166 0.0126
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0701 0.1326
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0278 0.0662
Echinococcus multilocularis cpg binding protein 0.0034 0.0254 0.0254
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0167 0.5
Toxoplasma gondii kringle domain-containing protein 0.0284 0.3064 0.9206
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.0913 0.2174
Loa Loa (eye worm) hypothetical protein 0.0092 0.0913 0.1626
Trichomonas vaginalis chromobox protein, putative 0.0158 0.1654 0.5562
Trichomonas vaginalis CAMK family protein kinase 0.0215 0.2287 0.7928
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0256 0.0256
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0278 0.0328
Onchocerca volvulus 0.0511 0.5619 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0204 0.0141
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0026 0.0166 0.0215
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.1148 0.1903
Echinococcus multilocularis chromobox protein 1 0.0158 0.1654 0.1654
Echinococcus multilocularis Chromo domain 0.0026 0.0166 0.0166
Trichomonas vaginalis chromobox protein, putative 0.0095 0.0948 0.2922
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.021 0.0163
Schistosoma mansoni chromobox protein 0.0158 0.1654 0.3687
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0701 0.1326
Entamoeba histolytica hypothetical protein 0.0026 0.0167 0.0004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.2482 0.4416
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0633 0.334
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.015 0.1563 0.3462
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0296
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.015 0.1563 0.3462
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0215 0.2287 0.5443
Onchocerca volvulus 0.006 0.0547 0.0815
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0256 0.0493
Brugia malayi CHD4 protein 0.0028 0.0187 0.0163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.065 0.1198
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0278 0.0328
Echinococcus granulosus tar DNA binding protein 0.0074 0.0701 0.167
Echinococcus granulosus Chromobox protein 3 0.0026 0.0166 0.0396
Brugia malayi hypothetical protein 0.0511 0.5619 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0296
Schistosoma mansoni hypothetical protein 0.0385 0.4201 1
Echinococcus granulosus Chromo domain 0.0026 0.0166 0.0396
Onchocerca volvulus 0.0092 0.0913 0.1478
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Schistosoma mansoni kinase 0.0109 0.1101 0.2316
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0026 0.0166 0.0126
Onchocerca volvulus 0.0026 0.0166 0.0126
Onchocerca volvulus 0.0264 0.2841 0.4968
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0701 0.0701
Echinococcus multilocularis chromobox protein 1 0.0158 0.1654 0.1654
Brugia malayi Protein cec-1. 0.0026 0.0166 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0872 0.2639
Trypanosoma brucei polo-like protein kinase 0.0215 0.2287 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0173
Onchocerca volvulus 0.015 0.1563 0.2655
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0296
Schistosoma mansoni hypothetical protein 0.0385 0.4201 1
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0581 0.1551
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.0913 0.1478
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0701 0.1248
Echinococcus granulosus Mastin 0.015 0.1563 0.3721
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0633 0.0633
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0345 0.0345
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0701 0.1326
Loa Loa (eye worm) hypothetical protein 0.015 0.1563 0.2781
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.2287 0.5255
Brugia malayi hypothetical protein 0.015 0.1563 0.2655
Loa Loa (eye worm) CHromoDomain protein family member 0.0028 0.0187 0.0333
Trichomonas vaginalis chromobox protein, putative 0.0095 0.0948 0.2922
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0256 0.0222
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1069 0.3375
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.015 0.1563 0.3721
Trichomonas vaginalis set domain proteins, putative 0.0264 0.2841 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0279 0.0387
Giardia lamblia Kinase, PLK 0.0215 0.2287 0.5
Schistosoma mansoni cpg binding protein 0.0034 0.0254 0.0218
Loa Loa (eye worm) hypothetical protein 0.0036 0.0278 0.0495
Echinococcus granulosus chromobox protein 1 0.0158 0.1654 0.3937
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0278 0.0278
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.015 0.1563 0.3462
Echinococcus multilocularis Mastin 0.015 0.1563 0.1563
Brugia malayi Valyl-tRNA synthetase 0.0026 0.0166 0.0126
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0633 0.1508
Brugia malayi Trypsin family protein 0.015 0.1563 0.2655
Brugia malayi Trypsin family protein 0.015 0.1563 0.2655
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.1148 0.2043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0248 0.0304
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0097 0.0173
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0248 0.0304
Brugia malayi M-phase phosphoprotein, mpp8 0.0026 0.0166 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0581 0.1551
Echinococcus granulosus chromobox protein 2 0.0026 0.0166 0.0396
Brugia malayi Pre-SET motif family protein 0.0232 0.2482 0.4318
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0633 0.1609
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0173
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.007 0.0657 0.1169
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0701 0.1094
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0215 0.2287 0.2287
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0279 0.0496
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0296
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0279 0.0279
Trichomonas vaginalis CAMK family protein kinase 0.0215 0.2287 0.7928
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Echinococcus multilocularis tissue type plasminogen activator 0.0284 0.3064 0.3064
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0234 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.003 0.021 0.0163
Schistosoma mansoni hypothetical protein 0.0036 0.0278 0.0277
Brugia malayi MH2 domain containing protein 0.0133 0.1366 0.2298
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0167 0.5
Loa Loa (eye worm) hypothetical protein 0.015 0.1563 0.2781
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0279 0.0525
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0167 0.5
Plasmodium falciparum cysteine repeat modular protein 1 0.0284 0.3064 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0248 0.0304
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.015 0.1563 0.3462
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0279 0.0563
Onchocerca volvulus 0.015 0.1563 0.2655
Entamoeba histolytica hypothetical protein 0.0042 0.0345 0.084
Echinococcus multilocularis transmembrane protease serine 3 0.015 0.1563 0.1563
Schistosoma mansoni hypothetical protein 0.0036 0.0278 0.0277
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0296
Echinococcus granulosus cpg binding protein 0.0034 0.0254 0.0606
Trichomonas vaginalis CAMK family protein kinase 0.0215 0.2287 0.7928
Schistosoma mansoni hypothetical protein 0.0036 0.0278 0.0277
Trichomonas vaginalis CAMK family protein kinase 0.0215 0.2287 0.7928
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0279 0.0384
Schistosoma mansoni hypothetical protein 0.0284 0.3064 0.7182
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0028 0.0187 0.0051
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0279 0.0663
Trichomonas vaginalis CAMK family protein kinase 0.0215 0.2287 0.7928
Entamoeba histolytica serine/threonine protein kinase, putative 0.0215 0.2287 1
Onchocerca volvulus 0.015 0.1563 0.2655
Brugia malayi Trypsin family protein 0.015 0.1563 0.2655
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0279 0.0279
Onchocerca volvulus 0.0032 0.0234 0.0248
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.0166 0.0215
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0026 0.0166 0.0166
Onchocerca volvulus 0.015 0.1563 0.2655
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.0913 0.1852
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0278 0.0278
Onchocerca volvulus 0.015 0.1563 0.2655
Brugia malayi Trypsin-like protease protein 5 0.015 0.1563 0.2655
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0633 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.015 0.1563 0.1563
Onchocerca volvulus Serine\/threonine kinase homolog 0.0215 0.2287 0.3965
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0248 0.0304
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Loa Loa (eye worm) hypothetical protein 0.0113 0.1148 0.2043
Brugia malayi isocitrate dehydrogenase 0.0036 0.0279 0.0329
Brugia malayi serine/threonine-protein kinase plk-2 0.0215 0.2287 0.3965
Entamoeba histolytica hypothetical protein 0.0042 0.0345 0.084
Trypanosoma cruzi polo-like protein kinase, putative 0.0215 0.2287 0.7209
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0248 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0872 0.2639
Schistosoma mansoni hypothetical protein 0.015 0.1563 0.3462
Echinococcus multilocularis Chromobox protein 3 0.0026 0.0166 0.0166
Echinococcus granulosus glycoprotein Antigen 5 0.015 0.1563 0.3721
Loa Loa (eye worm) heterochromatin protein 1 0.0158 0.1654 0.2943
Brugia malayi CXXC zinc finger family protein 0.0032 0.0234 0.0248
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.015 0.1563 0.3462
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0167 0.0218
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0633 0.1158
Brugia malayi Pre-SET motif family protein 0.0034 0.0256 0.0288
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0095 0.0948 0.1541
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0296
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0026 0.0166 0.0396
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0028 0.0187 0.0187
Loa Loa (eye worm) trypsin family protein 0.015 0.1563 0.2781
Schistosoma mansoni hypothetical protein 0.0042 0.0345 0.0441
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0173
Loa Loa (eye worm) hypothetical protein 0.015 0.1563 0.2781
Trichomonas vaginalis chromobox protein, putative 0.0158 0.1654 0.5562
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0279 0.0387
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Schistosoma mansoni cpg binding protein 0.0032 0.0234 0.0167
Echinococcus multilocularis geminin 0.0385 0.4201 0.4201
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.1148 0.1903
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0173
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0256 0.0256
Onchocerca volvulus 0.015 0.1563 0.2655
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Brugia malayi Trypsin family protein 0.015 0.1563 0.2655
Echinococcus multilocularis chromobox protein 2 0.0026 0.0166 0.0166
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0167 0.0003
Plasmodium vivax SET domain protein, putative 0.0034 0.0256 0.0309
Trypanosoma cruzi polo-like protein kinase, putative 0.0215 0.2287 0.7209
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.015 0.1563 0.3462
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0173
Loa Loa (eye worm) hypothetical protein 0.0089 0.0872 0.1552
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0173
Echinococcus granulosus transmembrane protease serine 3 0.015 0.1563 0.3721
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0097 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0547 0.0943
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.1366 0.2431
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0633 0.334
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0633 0.334
Brugia malayi RNA binding protein 0.0074 0.0701 0.1094
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0278 0.0495
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0248 0.0304
Loa Loa (eye worm) hypothetical protein 0.0284 0.3064 0.5452
Schistosoma mansoni hypothetical protein 0.0077 0.0745 0.1435
Echinococcus granulosus enteropeptidase 0.015 0.1563 0.3721
Echinococcus granulosus geminin 0.0385 0.4201 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0701 0.1326
Schistosoma mansoni hypothetical protein 0.0036 0.0278 0.0277
Echinococcus multilocularis enteropeptidase 0.015 0.1563 0.1563
Loa Loa (eye worm) RNA binding protein 0.0074 0.0701 0.1248
Echinococcus granulosus tissue type plasminogen activator 0.0284 0.3064 0.7293
Schistosoma mansoni hypothetical protein 0.015 0.1563 0.3462
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0215 0.2287 0.7317
Trichomonas vaginalis CAMK family protein kinase 0.0215 0.2287 0.7928
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.015 0.1563 0.3462
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0256 0.0222
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0296
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0701 0.1248
Loa Loa (eye worm) hypothetical protein 0.0034 0.0256 0.0455
Loa Loa (eye worm) hypothetical protein 0.015 0.1563 0.2781
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0279 0.0525
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0256 0.0609
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0097 0.0173
Loa Loa (eye worm) helicase 0.0026 0.0166 0.0296
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0568 0.1463
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0173
Toxoplasma gondii PAN domain-containing protein 0.0307 0.332 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0278 0.0662
Loa Loa (eye worm) hypothetical protein 0.015 0.1563 0.2781
Echinococcus granulosus GPCR family 2 0.0036 0.0278 0.0662
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0279 0.0329
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0167 0.0218
Onchocerca volvulus 0.007 0.0657 0.1014
Loa Loa (eye worm) hypothetical protein 0.0511 0.5619 1
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0097 0.0173
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0089 0.0872 0.1404
Brugia malayi Associated with TFs and helicases family protein 0.0026 0.0166 0.0126
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0701 0.1326
Schistosoma mansoni cercarial elastase (S01 family) 0.015 0.1563 0.3462
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0345 0.082
Echinococcus granulosus chromobox protein 1 0.0158 0.1654 0.3937
Entamoeba histolytica hypothetical protein 0.0042 0.0345 0.084
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0234 0.0558
Loa Loa (eye worm) hypothetical protein 0.0077 0.0745 0.1326
Brugia malayi Kringle domain containing protein 0.0284 0.3064 0.5372
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.015 0.1563 0.3462
Brugia malayi SET domain containing protein 0.0028 0.0188 0.0165
Loa Loa (eye worm) hypothetical protein 0.015 0.1563 0.2781
Schistosoma mansoni chromobox protein 0.0158 0.1654 0.3687
Brugia malayi chromobox protein homolog 3 0.0089 0.0872 0.1404
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.015 0.1563 0.1563
Loa Loa (eye worm) TK/ROR protein kinase 0.0284 0.3064 0.5452
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0745 0.1174
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0345 0.0441
Brugia malayi Heterochromatin protein 1 0.0158 0.1654 0.2819
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0215 0.2287 0.4069
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0633 0.1665
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0284 0.3064 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0028 0.0187 0.0445
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0256 0.0222
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.015 0.1563 0.3721
Loa Loa (eye worm) hypothetical protein 0.015 0.1563 0.2781
Brugia malayi hypothetical protein 0.0042 0.0345 0.0448
Brugia malayi Protein kinase domain containing protein 0.0284 0.3064 0.5372
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0097 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1069 0.3375
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0633 0.1158
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.0913 0.0913
Entamoeba histolytica hypothetical protein 0.0042 0.0345 0.084
Onchocerca volvulus 0.0026 0.0166 0.0126
Toxoplasma gondii PAN domain-containing protein 0.0307 0.332 1
Schistosoma mansoni cpg binding protein 0.0034 0.0254 0.0218
Echinococcus multilocularis glycoprotein Antigen 5 0.015 0.1563 0.1563
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0167 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0167 0.5
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0279 0.2388
Trypanosoma cruzi hypothetical protein, conserved 0.0284 0.3064 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0248 0.0304
Echinococcus multilocularis GPCR, family 2 0.0036 0.0278 0.0278
Trichomonas vaginalis CAMK family protein kinase 0.0215 0.2287 0.7928

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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