Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.2442 | 0.3619 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.549 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.549 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.549 | 1 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.2442 | 0.3619 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.549 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1312 | 0.1254 | 0.32 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0713 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.549 | 1 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.078 | 0.0141 | 0.0145 |
Echinococcus multilocularis | insulin receptor | 0.078 | 0.0141 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.1298 | 0.1225 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.1298 | 0.1225 | 0.3117 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.549 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1312 | 0.1254 | 0.32 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0713 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1298 | 0.1225 | 0.3117 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.549 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.2442 | 0.3619 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0713 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2442 | 0.3619 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1312 | 0.1254 | 0.3299 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0713 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0713 | 0 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1312 | 0.1254 | 0.32 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.1312 | 0.1254 | 0.32 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.2442 | 0.3619 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.