Detailed information for compound 888400

Basic information

Technical information
  • TDR Targets ID: 888400
  • Name: 2-(4-ethylphenyl)-3-(2-pyridin-4-ylethyl)-1,3 -thiazolidin-4-one
  • MW: 312.429 | Formula: C18H20N2OS
  • H donors: 0 H acceptors: 2 LogP: 3.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)C1SCC(=O)N1CCc1ccncc1
  • InChi: 1S/C18H20N2OS/c1-2-14-3-5-16(6-4-14)18-20(17(21)13-22-18)12-9-15-7-10-19-11-8-15/h3-8,10-11,18H,2,9,12-13H2,1H3
  • InChiKey: VYYIQJYMSVHGNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-ethylphenyl)-3-[2-(4-pyridyl)ethyl]thiazolidin-4-one
  • 2-(4-ethylphenyl)-3-[2-(4-pyridyl)ethyl]-4-thiazolidinone
  • Oprea1_412542

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0204 0.6418 0.6696
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0274 0.9396 1
Echinococcus multilocularis dual specificity protein kinase clk2 0.0274 0.9396 0.9396
Loa Loa (eye worm) hypothetical protein 0.02 0.6264 0.6264
Entamoeba histolytica protein kinase, putative 0.0204 0.6418 0.5
Brugia malayi Protein kinase domain containing protein 0.0204 0.6418 0.6831
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0274 0.9396 0.9396
Echinococcus multilocularis kinesin protein KIF20A 0.0281 0.9658 0.9658
Brugia malayi MAP kinase sur-1 0.0061 0.0383 0.0408
Schistosoma mansoni serine/threonine protein kinase 0.0274 0.9396 0.9396
Plasmodium falciparum protein serine/threonine kinase-1 0.0274 0.9396 0.5
Loa Loa (eye worm) hypothetical protein 0.0289 1 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0274 0.9396 0.5
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0204 0.6418 0.6696
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.0383 0.0383
Leishmania major protein kinase, putative 0.0274 0.9396 1
Entamoeba histolytica protein kinase domain containing protein 0.0204 0.6418 0.5
Echinococcus granulosus dual specificity protein kinase clk2 0.0274 0.9396 0.9396
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.6418 0.6418
Echinococcus multilocularis dual specificity 0.0204 0.6418 0.6418
Loa Loa (eye worm) hypothetical protein 0.02 0.6264 0.6264
Loa Loa (eye worm) hypothetical protein 0.0269 0.9186 0.9186
Loa Loa (eye worm) hypothetical protein 0.0138 0.3639 0.3639
Echinococcus multilocularis 0.0271 0.9242 0.9242
Trichomonas vaginalis CMGC family protein kinase 0.0274 0.9396 1
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.0383 0.0383
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0274 0.9396 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0274 0.9396 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.0383 0.0383
Schistosoma mansoni hypothetical protein 0.0055 0.012 0.012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.012 0.0128
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0274 0.9396 1
Echinococcus granulosus hypothetical protein 0.0271 0.9242 0.9242
Brugia malayi Protein kinase domain containing protein 0.0274 0.9396 1
Entamoeba histolytica hypothetical protein 0.0204 0.6418 0.5
Giardia lamblia Kinase, CMGC CLK 0.0274 0.9396 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0204 0.6418 0.6418
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0204 0.6418 0.6696
Loa Loa (eye worm) hypothetical protein 0.0138 0.3639 0.3639
Onchocerca volvulus 0.0055 0.012 0.5
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0274 0.9396 1
Schistosoma mansoni serine/threonine protein kinase 0.0274 0.9396 0.9396
Schistosoma mansoni survival motor neuron protein 0.0055 0.012 0.012
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0274 0.9396 1
Leishmania major protein kinase, putative 0.0274 0.9396 1
Brugia malayi hypothetical protein 0.0138 0.3639 0.3872
Echinococcus multilocularis kinesin protein KIF20A 0.0281 0.9658 0.9658
Echinococcus granulosus survival motor neuron protein 1 0.0269 0.9186 0.9186
Echinococcus multilocularis survival motor neuron protein 1 0.0269 0.9186 0.9186
Echinococcus granulosus kinesin protein KIF20A 0.0281 0.9658 0.9658
Loa Loa (eye worm) hypothetical protein 0.0271 0.9242 0.9242
Echinococcus granulosus dual specificity 0.0204 0.6418 0.6418
Entamoeba histolytica protein kinase, putative 0.0204 0.6418 0.5
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0289 1 1
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0289 1 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.0383 0.0383
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0204 0.6418 0.6696
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0274 0.9396 1
Echinococcus granulosus kinesin protein KIF20A 0.0281 0.9658 0.9658
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.0383 0.0383
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0383 0.0383
Brugia malayi hypothetical protein 0.0269 0.9186 0.9776

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.