Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0218 | 0.1618 | 0.1618 |
Chlamydia trachomatis | glutamine binding protein | 0.0157 | 0.0829 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0651 | 0.7188 | 0.7188 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0744 | 0.8382 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0157 | 0.0829 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0157 | 0.0829 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0869 | 1 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0157 | 0.0829 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0651 | 0.7188 | 0.7188 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0157 | 0.0829 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0682 | 0.7592 | 0.7592 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0682 | 0.7592 | 0.7592 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0157 | 0.0829 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.