Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | neuropeptide S receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0629 | 0.0115 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1404 | 0.3815 | 0.4491 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.1119 | 0.2457 | 0.2842 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0629 | 0.0115 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1127 | 0.2495 | 0.2407 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0949 | 0.1645 | 0.7806 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0629 | 0.0115 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0629 | 0.0115 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1119 | 0.2457 | 0.2842 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0629 | 0.0115 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0949 | 0.1645 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0629 | 0.0115 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1119 | 0.2457 | 0.2842 |
Brugia malayi | ecdysteroid receptor | 0.1127 | 0.2495 | 0.2888 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0629 | 0.0115 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2354 | 0.8355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.207 | 0.6997 | 0.8352 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0629 | 0.0115 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.1039 | 0.2075 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1127 | 0.2495 | 0.2888 |
Brugia malayi | nuclear hormone receptor | 0.2354 | 0.8355 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0629 | 0.0115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1059 | 0.217 | 0.2494 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.