TDR Targets

Basic information

Technical information

TDR Targets ID: 902158
Name: STK010674
MW: 437.672 | Formula: C18H14BrClN2O4
H donors: 2 H acceptors: 3 LogP: 4.12 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(C=C2C(=O)NN(C2=O)c2ccc(cc2)Br)cc(c1O)Cl
InChi: 1S/C18H14BrClN2O4/c1-2-26-15-9-10(8-14(20)16(15)23)7-13-17(24)21-22(18(13)25)12-5-3-11(19)4-6-12/h3-9,23H,2H2,1H3,(H,21,24)/b13-7-
InChiKey: FZDSRPKOEBQXPJ-QPEQYQDCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0099	0.278	0.7467
Onchocerca volvulus		0.0016	0.007	0.0067
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0016	0.007	0.5
Leishmania major	fk506-binding protein 1-like protein	0.0115	0.3295	1
Echinococcus multilocularis	fk506 binding protein	0.0115	0.3295	0.8858
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0016	0.007	0.5
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0115	0.3295	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0115	0.3295	1
Echinococcus granulosus	twitchin	0.0021	0.0236	0.059
Echinococcus granulosus	titin	0.0017	0.0093	0.0205
Schistosoma mansoni	neuroglian	0.0016	0.009	0.0055
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0115	0.3295	0.8858
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0018	0.0154	0.0369
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0115	0.3295	0.3295
Loa Loa (eye worm)	hypothetical protein	0.0016	0.007	0.007
Schistosoma mansoni	nephrin	0.0016	0.009	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0064	0.0064
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0093	0.0063
Schistosoma mansoni	ephrin receptor	0.0128	0.3718	1
Plasmodium vivax	peptidyl-prolyl cis-trans isomerase, putative	0.0016	0.007	0.0155
Schistosoma mansoni	nephrin	0.0019	0.0169	0.0269
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0322	1	1
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.0016	0.007	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0093	0.0093
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0016	0.007	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0016	0.009	0.0197
Echinococcus multilocularis		0.0016	0.007	0.0143
Echinococcus multilocularis	FK506 binding protein 8, 38 kDa	0.0016	0.007	0.0143
Echinococcus multilocularis	roundabout 2	0.0016	0.009	0.0197
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0115	0.3295	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0016	0.009	0.009
Schistosoma mansoni	tyrosine kinase	0.0016	0.0088	0.0049
Echinococcus granulosus	roundabout 2	0.0016	0.009	0.0197
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0115	0.3295	1
Echinococcus granulosus	neuroglian	0.0016	0.009	0.0197
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0016	0.0064	0.0126
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0115	0.3295	0.8858
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13	0.0016	0.007	0.007
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0115	0.3295	0.8841
Schistosoma mansoni	cell adhesion molecule	0.0016	0.009	0.0055
Trichomonas vaginalis	immunophilin, putative	0.0115	0.3295	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.009	0.009
Echinococcus granulosus	titin	0.0017	0.0093	0.0205
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0115	0.3295	1
Loa Loa (eye worm)	CAMK protein kinase	0.0017	0.0093	0.0093
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.009	0.009
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30	0.0016	0.007	0.007
Echinococcus multilocularis	neuroglian	0.0016	0.009	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0124	0.3569	0.3569
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0016	0.009	0.0197
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0115	0.3295	0.3295
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0023	0.0309	0.0309
Schistosoma mansoni	titin	0.0017	0.0093	0.0063
Schistosoma mansoni	immunophilin	0.0115	0.3295	0.8841
Schistosoma mansoni	immunophilin	0.0115	0.3295	0.8841
Onchocerca volvulus		0.0302	0.9343	0.9671
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0115	0.3295	1
Trichomonas vaginalis	fk506-binding protein, putative	0.0115	0.3295	1
Mycobacterium tuberculosis	Probable trigger factor (TF) protein Tig	0.0016	0.007	0.5
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-33	0.0016	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1598	0.1598
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0233	0.0233
Onchocerca volvulus		0.0124	0.3569	0.3691
Mycobacterium leprae	PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG	0.0016	0.007	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	0.278	0.278
Echinococcus granulosus	roundabout 2	0.0026	0.0384	0.099
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0115	0.3295	0.8858
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0115	0.3295	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.009	0.009
Echinococcus granulosus	ephrin type A receptor 4 A	0.0128	0.3718	1
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0099	0.278	0.7467
Brugia malayi	protein unc-22	0.0017	0.0093	0.0093
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0016	0.009	0.0197
Echinococcus multilocularis	titin	0.0017	0.0093	0.0205
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0016	0.009	0.0197
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0016	0.007	0.5
Leishmania major	peptidylprolyl isomerase-like protein	0.0115	0.3295	1
Echinococcus granulosus	roundabout 2	0.0016	0.009	0.0197
Echinococcus multilocularis	roundabout 2	0.0016	0.009	0.0197
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0115	0.3295	1
Schistosoma mansoni	cell adhesion molecule	0.0016	0.009	0.0055
Echinococcus granulosus	FK506 binding protein 8 38 kDa	0.0016	0.007	0.0143
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0115	0.3295	1
Onchocerca volvulus		0.0017	0.0093	0.0091
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0115	0.3295	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-13	0.0016	0.007	0.007
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0016	0.009	0.009
Echinococcus multilocularis	roundabout 2	0.0026	0.0384	0.099
Schistosoma mansoni	cell adhesion molecule	0.002	0.0215	0.0397
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0115	0.3295	1
Schistosoma mansoni	immunophilin	0.0099	0.278	0.743
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0115	0.3295	0.3295
Loa Loa (eye worm)	TK/EPH protein kinase	0.0162	0.4818	0.4818
Echinococcus granulosus	contactin	0.0016	0.009	0.0197
Onchocerca volvulus		0.0016	0.007	0.0067
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0115	0.3295	1
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0115	0.3295	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0128	0.3718	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0017	0.0093	0.0093
Loa Loa (eye worm)	FKBP5 protein	0.0115	0.3295	0.3295
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0115	0.3295	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0311	0.966	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-30	0.0016	0.007	0.007
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0115	0.3295	1
Brugia malayi	ephrin receptor 1 precursor	0.0063	0.1596	0.1596
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0115	0.3295	1
Echinococcus granulosus	FK506 binding protein 2	0.0016	0.007	0.0143
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33	0.0016	0.007	0.007
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0016	0.007	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0016	0.009	0.0197
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0016	0.009	0.0055
Toxoplasma gondii	peptidyl-prolyl isomerase FKBP12, putative	0.0016	0.007	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 902158