TDR Targets

Basic information

Technical information

TDR Targets ID: 903098
Name: 2-(2,4-dichlorophenoxy)-N-[2-(difluoromethoxy )phenyl]propanamide
MW: 376.182 | Formula: C16H13Cl2F2NO3
H donors: 1 H acceptors: 1 LogP: 5.37 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: FC(Oc1ccccc1NC(=O)C(Oc1ccc(cc1Cl)Cl)C)F
InChi: 1S/C16H13Cl2F2NO3/c1-9(23-13-7-6-10(17)8-11(13)18)15(22)21-12-4-2-3-5-14(12)24-16(19)20/h2-9,16H,1H3,(H,21,22)
InChiKey: HFQJZYDXKOKKAL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2,4-dichlorophenoxy)-N-[2-(difluoromethoxy)phenyl]propionamide
STK259145

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glutamate receptor NMDA	0.0079	0.1081	0.3079
Toxoplasma gondii	DNA topoisomerase 2, putative	0.014	0.2431	0.6994
Treponema pallidum	sodium- and chloride- dependent transporter	0.0181	0.3352	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.4098	1
Leishmania major	acetyltransferase-like protein	0.0104	0.1637	0.3962
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0031	0.0016	0.0046
Trypanosoma brucei	MATE efflux family protein, putative	0.0068	0.0846	0.0419
Brugia malayi	Trypsin family protein	0.0037	0.0151	0.0136
Chlamydia trachomatis	DNA gyrase subunit B	0.0082	0.114	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3352	0.8171
Onchocerca volvulus		0.0037	0.0151	0.0332
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0132	0.2264	0.5585
Onchocerca volvulus		0.0043	0.0288	0.0665
Brugia malayi	Probable DNA topoisomerase II	0.014	0.2431	0.2419
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0181	0.3352	0.8171
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.0846	0.1361
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0181	0.3352	0.7523
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0276	0.5449	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0151	0.0391
Echinococcus multilocularis	nmda type glutamate receptor	0.012	0.1997	0.5725
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0041	0.0249	0.0675
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0231	0.445	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0297	0.5913	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.4098	1
Schistosoma mansoni	ATP-binding cassette transporter	0.0048	0.0388	0.0839
Plasmodium vivax	thioredoxin reductase, putative	0.0063	0.0731	0.2103
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Onchocerca volvulus		0.0215	0.4098	1
Trypanosoma brucei	membrane transporter protein, putative	0.0068	0.0846	0.0419
Loa Loa (eye worm)	hypothetical protein	0.005	0.0431	0.1017
Echinococcus multilocularis	Multi antimicrobial extrusion protein MatE	0.0062	0.0713	0.2016
Plasmodium vivax	topoisomerase I, putative	0.0187	0.3475	1
Echinococcus granulosus	transmembrane protease serine 3	0.0037	0.0151	0.0392
Brugia malayi	Muscle positioning protein 4	0.0043	0.0288	0.0272
Brugia malayi	Trypsin-like protease protein 5	0.0037	0.0151	0.0136
Loa Loa (eye worm)	serotonin transporter b	0.0181	0.3352	0.8171
Brugia malayi	SEA domain containing protein	0.0043	0.0288	0.0272
Onchocerca volvulus		0.0043	0.0288	0.0665
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Entamoeba histolytica	DNA topoisomerase II, putative	0.014	0.2431	0.5
Toxoplasma gondii	hypothetical protein	0.0031	0.0016	0.0046
Loa Loa (eye worm)	trypsin family protein	0.0037	0.0151	0.0332
Brugia malayi	hypothetical protein	0.0037	0.0151	0.0136
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.0846	0.1361
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0151	0.0305
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0151	0.0392
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Echinococcus granulosus	glutamate receptor 2	0.0059	0.0641	0.1806
Schistosoma mansoni	hypothetical protein	0.0037	0.0151	0.0305
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0063	0.0731	0.2066
Loa Loa (eye worm)	DNA topoisomerase I	0.0187	0.3475	0.8474
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.0846	0.1361
Onchocerca volvulus		0.0043	0.0288	0.0665
Toxoplasma gondii	kringle domain-containing protein	0.005	0.0431	0.1241
Schistosoma mansoni	DNA topoisomerase II	0.014	0.2431	0.5446
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0082	0.114	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0181	0.3352	0.3341
Trypanosoma cruzi	DNA topoisomerase IB, large subunit, putative	0.0187	0.3475	1
Toxoplasma gondii	hypothetical protein	0.0031	0.0016	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0151	0.0332
Onchocerca volvulus		0.005	0.0431	0.1017
Toxoplasma gondii	DNA topoisomerase I, putative	0.0187	0.3475	1
Onchocerca volvulus		0.0043	0.0288	0.0665
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0103	0.1611	0.461
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0031	0.0016	0.0046
Schistosoma mansoni	glutamate receptor kainate	0.0048	0.0388	0.0839
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0037	0.0151	0.0305
Leishmania major	DNA topoisomerase IB, large subunit	0.0187	0.3475	1
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.014	0.2431	0.2419
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0226	0.0474
Trypanosoma brucei	DNA topoisomerase IB, large subunit	0.0187	0.3475	1
Loa Loa (eye worm)	TOPoisomerase family member	0.014	0.2431	0.5915
Loa Loa (eye worm)	hypothetical protein	0.0095	0.143	0.3463
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0297	0.5913	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0288	0.0665
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0132	0.2264	0.6019
Plasmodium falciparum	topoisomerase I	0.0187	0.3475	1
Schistosoma mansoni	hypothetical protein	0.005	0.0431	0.0937
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Echinococcus granulosus	DNA topoisomerase 1	0.0187	0.3475	1
Plasmodium vivax	DNA topoisomerase II, putative	0.014	0.2431	0.6994
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0103	0.1611	0.461
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0151	0.0256
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0157	0.281	0.7813
Brugia malayi	Trypsin family protein	0.0215	0.4098	0.4089
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0059	0.0641	0.1806
Echinococcus multilocularis	tissue type plasminogen activator	0.005	0.0431	0.1201
Loa Loa (eye worm)	TK/ROR protein kinase	0.005	0.0431	0.1017
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0151	0.0305
Onchocerca volvulus		0.0043	0.0288	0.0665
Schistosoma mansoni	glutamate receptor NMDA	0.0103	0.1611	0.3597
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0059	0.0641	0.1806
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0132	0.2264	0.6019
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0151	0.0331
Echinococcus granulosus	nmda type glutamate receptor	0.012	0.1997	0.5725
Mycobacterium ulcerans	acetyltransferase	0.0104	0.1637	0.2769
Schistosoma mansoni	hypothetical protein	0.0043	0.0288	0.0613
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0059	0.0641	0.1806
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0031	0.0016	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0095	0.143	0.3463
Schistosoma mansoni	hypothetical protein	0.0085	0.1226	0.2728
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0036	0.0139	0.5
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0594	0.1415
Echinococcus granulosus	Mastin	0.0037	0.0151	0.0392
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0016	0.0046
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0059	0.0641	0.1806
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.0846	0.1361
Echinococcus multilocularis	serotonin transporter	0.0181	0.3352	0.9642
Plasmodium falciparum	transporter, putative	0.0031	0.0016	0.0046
Brugia malayi	glutathione reductase	0.0063	0.0731	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0043	0.0067
Mycobacterium ulcerans	DNA gyrase subunit B	0.0082	0.114	0.1928
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0037	0.0151	0.0392
Brugia malayi	Thioredoxin reductase	0.0063	0.0731	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3352	0.8171
Plasmodium falciparum	DNA topoisomerase 2	0.014	0.2431	0.6994
Onchocerca volvulus		0.0037	0.0151	0.0332
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0037	0.0151	0.0136
Schistosoma mansoni	copper/topaquinone oxidase	0.0085	0.1226	0.2728
Trypanosoma brucei	membrane transporter protein, putative	0.0068	0.0846	0.0419
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.0846	0.1361
Onchocerca volvulus		0.0178	0.3281	0.7998
Toxoplasma gondii	hypothetical protein	0.0043	0.0289	0.0833
Echinococcus multilocularis	Mastin	0.0037	0.0151	0.0392
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0059	0.0641	0.1806
Plasmodium falciparum	cysteine repeat modular protein 1	0.005	0.0431	0.1241
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0094	0.1427	0.3455
Echinococcus granulosus	thioredoxin glutathione reductase	0.0063	0.0731	0.2066
Brugia malayi	Protein kinase domain containing protein	0.005	0.0431	0.0416
Brugia malayi	Trypsin family protein	0.0037	0.0151	0.0136
Echinococcus granulosus	amiloride sensitive amine oxidase	0.0085	0.1226	0.3496
Schistosoma mansoni	hypothetical protein	0.0037	0.0151	0.0305
Loa Loa (eye worm)	glutamate receptor 2	0.0048	0.0388	0.0911
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0132	0.2264	0.5585
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0094	0.1427	0.3455
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.005	0.0431	0.1241
Schistosoma mansoni	DNA topoisomerase type I	0.0187	0.3475	0.7802
Toxoplasma gondii	thioredoxin reductase	0.0063	0.0731	0.2103
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.014	0.2431	0.698
Schistosoma mansoni	sodium/chloride dependent transporter	0.0181	0.3352	0.7523
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0151	0.0332
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0063	0.0731	0.1341
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0151	0.0135
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0215	0.4098	0.9208
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0151	0.0332
Echinococcus multilocularis	multidrug and toxin extrusion protein 2	0.0068	0.0846	0.2399
Plasmodium falciparum	amino acid transporter, putative	0.0031	0.0016	0.0046
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0037	0.0151	0.0392
Echinococcus granulosus	multidrug and toxin extrusion protein 2	0.0068	0.0846	0.2399
Brugia malayi	DNA topoisomerase I	0.0187	0.3475	0.3465
Brugia malayi	Glutamate receptor 2 precursor	0.0048	0.0388	0.0372
Echinococcus granulosus	enteropeptidase	0.0037	0.0151	0.0392
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0151	0.0305
Trichomonas vaginalis	DNA topoisomerase II, putative	0.014	0.2431	1
Plasmodium vivax	amine transporter, putative	0.0031	0.0016	0.0046
Leishmania major	trypanothione reductase	0.0063	0.0731	0.0984
Brugia malayi	Kringle domain containing protein	0.005	0.0431	0.0416
Echinococcus multilocularis	transmembrane protease serine 3	0.0037	0.0151	0.0392
Plasmodium vivax	DNA gyrase subunit B, putative	0.0082	0.114	0.3279
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0037	0.0151	0.0392
Echinococcus multilocularis	glutamate receptor 2	0.0048	0.0388	0.1075
Echinococcus granulosus	serotonin transporter	0.0181	0.3352	0.9642
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0151	0.0332
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.014	0.2431	0.2419
Schistosoma mansoni	glutamate receptor NMDA	0.0138	0.2388	0.535
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0094	0.1427	0.3455
Trypanosoma brucei	DNA topoisomerase ii	0.0157	0.281	0.7575
Onchocerca volvulus		0.0037	0.0151	0.0332
Echinococcus granulosus	nmda type glutamate receptor	0.009	0.1334	0.3811
Echinococcus granulosus	tissue type plasminogen activator	0.005	0.0431	0.1201
Schistosoma mansoni	glutamate receptor AMPA	0.0048	0.0388	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0288	0.0665
Trypanosoma cruzi	membrane transporter protein, putative	0.0068	0.0846	0.1361
Plasmodium falciparum	DNA gyrase subunit B	0.0082	0.114	0.3279
Chlamydia trachomatis	DNA gyrase subunit B	0.0064	0.0761	0.6674
Echinococcus multilocularis	glycoprotein Antigen 5	0.0037	0.0151	0.0392
Onchocerca volvulus		0.0037	0.0151	0.0332
Plasmodium vivax	glutathione reductase, putative	0.0063	0.0731	0.2103
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0045	0.0329	0.0706
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0059	0.0641	0.1806
Loa Loa (eye worm)	thioredoxin reductase	0.0063	0.0731	0.1751
Schistosoma mansoni	DNA topoisomerase type I	0.0187	0.3475	0.7802
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0594	0.1415
Trypanosoma cruzi	trypanothione reductase, putative	0.0063	0.0731	0.0984
Schistosoma mansoni	glutamate receptor AMPA	0.0048	0.0388	0.0839
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0157	0.281	0.7813
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0059	0.0641	0.1806
Brugia malayi	Glutamate receptor 1 precursor	0.0048	0.0388	0.0372
Loa Loa (eye worm)	DOMON domain-containing protein	0.0043	0.0288	0.0665
Echinococcus multilocularis	amiloride sensitive amine oxidase	0.0085	0.1226	0.3496
Loa Loa (eye worm)	norepinephrine transporter	0.0181	0.3352	0.8171
Schistosoma mansoni	glutamate receptor kainate	0.0048	0.0388	0.0839
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.014	0.2431	0.698
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0082	0.114	0.3279
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0082	0.114	0.34
Plasmodium falciparum	glutathione reductase	0.0063	0.0731	0.2103
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Echinococcus multilocularis	DNA topoisomerase 1	0.0187	0.3475	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0059	0.0641	0.1806
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0031	0.0016	0.014
Brugia malayi	Trypsin family protein	0.0037	0.0151	0.0136
Leishmania major	hypothetical protein, conserved	0.0068	0.0846	0.1361
Leishmania major	mitochondrial DNA topoisomerase II	0.0157	0.281	0.7813
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0226	0.0474
Echinococcus granulosus	glutamate receptor 2	0.0037	0.0147	0.0379
Onchocerca volvulus		0.0181	0.3352	0.8171
Plasmodium falciparum	thioredoxin reductase	0.0063	0.0731	0.2103
Echinococcus multilocularis	glutamate receptor 2	0.0059	0.0641	0.1806
Trypanosoma brucei	membrane transporter protein, putative	0.0068	0.0846	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3352	0.8171
Leishmania major	hypothetical protein, conserved	0.0068	0.0846	0.1361
Schistosoma mansoni	DNA topoisomerase type I	0.0187	0.3475	0.7802
Schistosoma mansoni	amine GPCR	0.0187	0.3477	0.7806
Schistosoma mansoni	multidrug resistance protein	0.0068	0.0846	0.1871
Echinococcus granulosus	glutamate receptor NMDA	0.0079	0.1081	0.3079
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0082	0.114	0.2091
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0151	0.0391
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0151	0.0305
Leishmania major	DNA topoisomerase ii	0.0132	0.2264	0.6019
Onchocerca volvulus		0.0037	0.0151	0.0332
Echinococcus granulosus	glycoprotein Antigen 5	0.0037	0.0151	0.0392
Loa Loa (eye worm)	glutamate receptor 1	0.0048	0.0388	0.0911
Loa Loa (eye worm)	glutathione reductase	0.0063	0.0731	0.1751
Echinococcus multilocularis	glutamate receptor 2	0.0037	0.0147	0.0379
Echinococcus multilocularis	nmda type glutamate receptor	0.009	0.1334	0.3811
Giardia lamblia	DNA topoisomerase II	0.0132	0.2269	0.5
Schistosoma mansoni	glutamate receptor kainate	0.0048	0.0388	0.0839
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0151	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0151	0.0332
Echinococcus multilocularis	enteropeptidase	0.0037	0.0151	0.0392

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 903098