Detailed information for compound 906070

Basic information

Technical information
  • TDR Targets ID: 906070
  • Name: N-(5-chloro-2-methylphenyl)-3-(1,3-dioxoisoin dol-2-yl)propanamide
  • MW: 342.776 | Formula: C18H15ClN2O3
  • H donors: 1 H acceptors: 3 LogP: 2.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(Cl)ccc1C)CCN1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C18H15ClN2O3/c1-11-6-7-12(19)10-15(11)20-16(22)8-9-21-17(23)13-4-2-3-5-14(13)18(21)24/h2-7,10H,8-9H2,1H3,(H,20,22)
  • InChiKey: NASTUFSEMNRGHT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-chloro-2-methyl-phenyl)-3-(1,3-dioxoisoindolin-2-yl)propanamide
  • N-(5-chloro-2-methylphenyl)-3-(1,3-dioxo-2-isoindolinyl)propanamide
  • N-(5-chloro-2-methyl-phenyl)-3-(1,3-diketoisoindolin-2-yl)propionamide
  • N-(5-chloro-2-methyl-phenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide
  • ZINC00045197
  • AF-399/11786039
  • ST5322996
  • Oprea1_179416
  • Oprea1_857564

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.056 0.3201
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0053 0.1749 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.056 0.3201
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.056 0.086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.056 0.3201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.056 0.3201
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0028 0.056 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.056 0.3201
Brugia malayi Cathepsin L-like precursor 0.0028 0.056 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Echinococcus multilocularis cysteine protease 0.0028 0.056 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0053 0.1749 1
Onchocerca volvulus Cathepsin L homolog 0.0028 0.056 0.5406
Giardia lamblia Cathepsin B precursor 0.0053 0.1749 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0884 0.1359
Brugia malayi Cathepsin L-like precursor 0.002 0.0178 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Onchocerca volvulus 0.0035 0.0884 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.056 0.086
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0884 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.056 0.086
Onchocerca volvulus 0.0028 0.056 0.5406
Schistosoma mansoni hypothetical protein 0.0033 0.079 0.1215
Brugia malayi Cathepsin L-like precursor 0.0028 0.056 0.086
Loa Loa (eye worm) hypothetical protein 0.0035 0.0884 0.1116
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0884 0.5056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0178 0.1018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Echinococcus multilocularis cathepsin b 0.0151 0.6506 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0884 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.153 0.2137
Brugia malayi Cathepsin L-like cysteine proteinase 0.002 0.0178 0.0274
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0053 0.1749 0.2688
Echinococcus granulosus cathepsin l1 0.002 0.0178 0.0274
Plasmodium vivax vivapain-2 0.0028 0.056 0.6331
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.153 0.2352
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.056 0.086
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0028 0.056 0.0603
Brugia malayi cathepsin B-like cysteine proteinase 0.0151 0.6506 1
Brugia malayi cathepsin L-like precursor 0.002 0.0178 0.0274
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0884 0.1359
Trypanosoma cruzi cruzipain precursor, putative 0.0028 0.056 0.086
Trichomonas vaginalis esterase, putative 0.0035 0.0884 0.5056
Brugia malayi beta-lactamase family protein 0.0035 0.0884 0.1359
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.002 0.0178 0.0274
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.056 0.086
Echinococcus multilocularis cathepsin b 0.0151 0.6506 1
Loa Loa (eye worm) fibroinase 0.0028 0.056 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.6506 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.6506 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0178 0.0274
Echinococcus granulosus cathepsin l cysteine peptidase 0.0028 0.056 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Mycobacterium ulcerans lipase LipD 0.0035 0.0884 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.6506 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.153 0.2352
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0884 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0884 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.056 1
Onchocerca volvulus 0.0035 0.0884 1
Brugia malayi Cathepsin L-like precursor 0.0028 0.056 0.086
Onchocerca volvulus Cathepsin F homolog 0.0028 0.056 0.5406
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0151 0.6506 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0884 0.1116
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.056 0.086
Onchocerca volvulus 0.0028 0.056 0.5406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Brugia malayi beta-lactamase family protein 0.0035 0.0884 0.1359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0884 0.5056
Brugia malayi Cathepsin L-like precursor 0.0028 0.056 0.086
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.079 0.1215
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0028 0.056 1
Plasmodium vivax vivapain-2 0.0028 0.056 0.6331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.056 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Loa Loa (eye worm) beta-lactamase 0.0035 0.0884 0.1116
Giardia lamblia Cathepsin B precursor 0.0053 0.1749 0.5
Leishmania major hypothetical protein, conserved 0.0035 0.0884 0.2728
Loa Loa (eye worm) hypothetical protein 0.0035 0.0884 0.1116
Loa Loa (eye worm) hypothetical protein 0.0035 0.0884 0.1116
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.056 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Onchocerca volvulus 0.0028 0.056 0.5406
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.056 0.086
Loa Loa (eye worm) hypothetical protein 0.0033 0.079 0.0968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Onchocerca volvulus Cathepsin L homolog 0.0028 0.056 0.5406
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0884 0.1359
Onchocerca volvulus 0.0028 0.056 0.5406
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0178 0.3182
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.056 0.3201
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0884 0.5056
Plasmodium falciparum cysteine proteinase falcipain 3 0.0028 0.056 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Toxoplasma gondii ABC1 family protein 0.0035 0.0884 0.2728
Onchocerca volvulus 0.0028 0.056 0.5406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0884 0.5056
Mycobacterium ulcerans hypothetical protein 0.0035 0.0884 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.056 0.086
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0884 0.1359
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.056 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Mycobacterium leprae Probable lipase LipE 0.0035 0.0884 0.5
Echinococcus multilocularis cysteine protease 0.0028 0.056 0.086
Loa Loa (eye worm) cathepsin B 0.0053 0.1749 0.2482
Onchocerca volvulus 0.0035 0.0884 1
Onchocerca volvulus 0.0028 0.056 0.5406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0884 0.5056
Brugia malayi Cathepsin L-like precursor 0.0028 0.056 0.086
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.056 0.0603
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0884 0.1359
Giardia lamblia Cathepsin B precursor 0.0053 0.1749 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0884 0.5056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0884 0.1116
Onchocerca volvulus 0.0028 0.056 0.5406
Echinococcus granulosus cathepsin l1 0.0028 0.056 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Loa Loa (eye worm) hypothetical protein 0.0035 0.0884 0.1116
Entamoeba histolytica cysteine protease, putative 0.0028 0.056 1
Toxoplasma gondii cathepsin B 0.0053 0.1749 1
Brugia malayi Cathepsin L-like precursor 0.0028 0.056 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Echinococcus granulosus cathepsin b 0.0151 0.6506 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0151 0.6506 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.056 0.3201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.056 0.3201
Echinococcus granulosus cathepsin L cysteine proteinase 0.0028 0.056 0.086
Loa Loa (eye worm) ctsf protein 0.0028 0.056 0.0603
Loa Loa (eye worm) hypothetical protein 0.0151 0.6506 1
Echinococcus granulosus cathepsin b 0.0151 0.6506 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.153 0.2137
Trypanosoma brucei cysteine peptidase C (CPC) 0.0053 0.1749 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Brugia malayi Cathepsin L-like precursor 0.002 0.0178 0.0274
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0884 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0884 0.1359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Brugia malayi beta-lactamase 0.0035 0.0884 0.1359
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.056 0.3201
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.056 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0178 0.1018
Loa Loa (eye worm) hypothetical protein 0.0028 0.056 0.0603
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.056 1
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.056 0.086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.056 0.3201
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.1749 0.2688
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0884 0.1116
Loa Loa (eye worm) cysteine protease 0.0028 0.056 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.056 0.3201
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0884 0.1359

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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